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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 3 | Atorvastatin decreases vascular endothelial grouth factor in patients with coronary artery disease显示文摘 | Dulals J Frick M | 2002 | J AM Coll Cardiol2002，39，12： | 1 |
| 4 | Impaired chronotropic response to beta-stimulation in chronic coronary artery disease显示文摘 | Frick M H Huttunen J K Harkonen M | 1973 | The American Journal of Medicine1973，55，3： | 1 |
| 5 | High efficiency beam splitter for multifocal multiphoton microscopy 显示文摘 | NIELSEN T FRICKE M HELLWEG D | 2001 | J Microsc2001，201，3： | 1 |
| 6 | Oral tolerance with an HLA-peptide mimicking retinal autoantigen as a treatment of autoimmune uveitis显示文摘 | THURAR S R MARIAA D M FRICKE H | 1999 | Immunol Lett1999，68，： | 1 |
| 7 | Relationship of sonographic wall components of the brachial artery to hyper- tension and coronary atherosclerosis显示文摘 | Frick M Alber HF Rinner A | 2005 | Vasc Med2005，10，3： | 1 |
| 8 | Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging:results from the Stockholm Myocardial Infarction with Normal Coronaries study显示文摘 | Collste O Sorensson P Frick M | 2013 | Int J Med2013，273，2： | 1 |
| 9 | HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells 显示文摘 | DICHTL W DULAK J FRICK M | 2003 | Arterioscler Thromb Vase Biol2003，23，1： | 1 |
| 10 | Horizontal Well Damage Characteristion and Removal显示文摘 | Frick T P and Economides M J | 1975 | SPE21975，1993，： | 1 |
| 11 | Con- sistent interpretation of the results of through, out-diffusion and tracer profile analysis for trace anion diffusion in compacted montmorillonite显示文摘 | GLAUS M A FRICK S ROSSI R | 2011 | Journal of Contaminant Hydrology2011，123，： | 1 |
| 12 | Effect of timing of Cosynch on fertility of lactating Holstein cows after first postpar- tum and Resynch timed-AI services 显示文摘 | Sterry R A Jardon P W Fricke P M | 2007 | Theriogenoloby2007，67，7： | 1 |
| 13 | Differential gene expression in the rat hippocampus during learning of an operant conditioningtask显示文摘 | Rapanelli M Frick LR Zanutto BS | 2009 | Neuroscience2009，163，4： | 1 |
| 14 | HMG-CoA reductase ihibitors regulate inflammatory transcrption factors in human endothelial and vascular smooth muscle cells显示文摘 | Dichtl W Dulak J Frick M | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 15 | Continuous administration of pyridostigmine improves immobilization-induced neuromuscular weakness显示文摘 | Frick CG Helming M Martyn JA | | 0，，03： | 1 |
| 16 | Tumor patients in psychodynamic psychotherapy including daydreaming: can imagery enhance primary process and positive emotions? 显示文摘 | Frick E Stigler M Georg H | 2008 | Psychother Res2008，18，4： | 1 |
| 17 | Statins differentially regulate vascular endothelial growth factor synthesis inen- dothelial and vascular smooth muscle cells 显示文摘 | Frick M Dulak J Cisowski J | 2003 | Athero- sclerosis2003，170，2： | 1 |
| 18 | HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells显示文摘 | Dichtl W Dulak J Frick M | 2003 | Arteriosclerosis Thrombosis and Vascular Biology2003，23，1： | 1 |
| 19 | An Improved Modeling of Fractal Patterns in Matrix Acidzing and Their IMPact on Well Performance显示文摘 | Kurmayr M Frick T P Economides M J | 1992 | SPE 237891992，，： | 1 |
| 20 | Thermal processing of polycrystalline Ni-Ti shape memory alloys 显示文摘 | FRICK C P ORTEGA A M TYBER J MAKSOUND A E M MAIER H J LIU Y N GALL K | 2005 | Materials Science and Engineering A2005，405，12： | 1 |
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