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| 1 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 2 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 3 | Geochemistry, Petrology and Mineralogy of Coal Measure Shales in the Middle Jurassic Yanan Formation from Northeastern Ordos Basin, China: Implications for Shale Gas Accumulation显示文摘The Jurassic Yanan Formation is one of the most important coal-producing formations and hydrocarbon source rocks in the Ordos Basin, North China. To evaluate the shale gas potential of the Yanan shale, a total of 48 samples from north Ordos Basin were sampled, and their geochemical, petrological, mineralogical and pore characteristics were investigated. It was found that the shale samples are a suite of early mature source rock. The total organic carbon(TOC) content ranges from 0.33% to 24.12% and the hydrogen index(HI) ranges from 43.31 mg/g to 330.58 mg/g. The relationship between Tmax and HI indicates the organic matter is type Ⅱ-Ⅲ. This conclusion is also supported by the organic petrological examination results, which shows that the kerogen is mainly liptinite and vitrinite. Minerals in the samples are composed mainly of quartz, clay and feldspar, and the clay minerals are composed of prevailing kaolinite, illite/smectite, chlorite and a small amount of illite. Under scanning electron microscope, OM pores in the Yanan shale are scarce except pores come from the kerogen intrinsic texture or clay aggregates within the organic particles. As the weak compaction caused by shallow burial depth, interparticle pores and intraparticle pores are common, the hydrocarbon storage capacity of the Yanan shale was improved. According to evaluation, the Yanan shale is considered as a good shale gas reservoir, but its hydrocarbon potential is more dependent on biogenic and coal-derived gas as the thermogenic gas is limited by the lower thermal maturity. | CHEN Qian YAN Xiangbin GUO Yuanling HONG Taiyuan NIE Haikuan ZHANG Jinchuan TANG Xuan LI Wanjun LIU Chong | 2018 | Acta Geologica Sinica(English Edition)2018，92，6： | 2 |
| 4 | New approximate formula for arrhenius temperature integral显示文摘 | Liu Yuwen Zhang Hen | 2003 | Thermochim Acta2003，408，： | 1 |
| 5 | Kinetic studies of the calcination of ammonium metavanadate by thermal methods显示文摘 | Liu Yuwen Yang Xi | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 6 | New temperature integral approximate formula for nonisothermal kinetic analysis显示文摘 | Liu Yuwen Zhang Hen | 2003 | J Therm Anal Cal2003，74，： | 1 |
| 7 | L characteristics of energy transfer between Ce3+ and Eu2+ in NaMgPO4 phosphor显示文摘 | Tang Wanjun Chen Donghua Yang Haijian | 2011 | Appl Phys A2011，103，： | 1 |
| 8 | Combustion synthesis and luminescent properties of CaTiO3 : Pr, Al persistent phosphors 显示文摘 | Shengyu Yin Donghua chen Wanjun Tang | 2006 | Alloys Compd2006，19，： | 1 |
| 9 | Luminescence studies on SrMgAl10017 : Eu,Dy phosphor crystals显示文摘 | Tang Wanjun Chen Donghua Wu Ming | 2009 | Optics & Laser Technology2009，41，1： | 1 |
| 10 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 11 | Kinetic studies of thecalcination of ammonium metavandate by thermal methods显示文摘 | Tang Wanjun Liu Yuwen Yang Xi | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 12 | Synthesis and luminescence properties of Eu 3+ -activated NaLa(MoO 4 )(WO 4 ) phosphor显示文摘 | Zeng Lu Tang Wanjun | 2011 | Ceramics International2011，，： | 1 |
| 13 | Kinetic studies on the pyrolysis of chitin and chitosan显示文摘 | Tang Wanjun Wang Cunxin Chen Donghua | 2005 | Polymer Degradation and Stability2005，87，： | 1 |
| 14 | Tracing infiltration and recharge using stable isotope in Taihang Mt., North China显示文摘 | Fadong Li Xianfang Song Changyuan Tang Changming Liu Jingjie Yu Wanjun Zhang | 2007 | Environmental Geology2007，，3： | 1 |
| 15 | Combustion synthesis and luminescent properties of CaTiO3:Pr,Al persistent phosphors显示文摘 | Shengyu Yin Donghua chen Wanjun Tang | 2006 | Alloys Compd2006，19，： | 1 |
| 16 | Luminescence studies on SrMgAl10O17: Eu, Dy phosphor crystals 显示文摘 | TANG Wanjun CHEN Donghua WU Ming | 2009 | Optics & Laser Tech- nology2009，41，1： | 1 |
| 17 | Synthesis and luminescence properties of Eu3+-activated NaLa(MoO4)(WO4) phosphor显示文摘 | Zeng Lu Tang Wanjun | 2012 | Ceramics International2012，38，1： | 1 |
| 18 | Synthesis of CaTiO3 : Pr Persistent Phosphors by a modified solid-state reaction 显示文摘 | Yin Shengyu Chen Donghua Tang Wanjun | 2007 | Materials Science and Engineering :B2007，136，： | 1 |
| 19 | Synthesis of CaTiO3 :Pr, Al phosphors by sol-gel method and their luminescence properties显示文摘 | Yin Shengyu Chen Donghua Tang Wanjun | 2007 | J Mater Sci2007，42，： | 1 |
| 20 | Immunological Markers for Central Nervous System Glia显示文摘Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and microglia.They contribute more than half of the total cells of the CNS,and are essential for neural development and functioning.Studies on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular markers.However,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible confusion.Here,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression. | Hao Huang Wanjun He Tao Tang Mengsheng Qiu | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
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