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| 1 | Transplantation of Human Bone Marrow Mesenchymal Stem Cell Ameliorates the Autoimmune Pathogenesis in MRL/lpr Mice显示文摘Recent evidence indicates that mesenchymal stem cells (MSC) possess immunosuppressive properties both in vitro and in vivo. We previously demonstrated the functional abnormality of bone marrow derived MSC in patients with systemic lupus erythematosus (SLE). In this study, we aimed to investigate whether transplantation of human bone marrow derived MSC affects the autoimmune pathogenesis in MRL/lpr mice. We found that human MSC from healthy donors reduced the proliferation of T lymphocytes from MRL/lpr mice in a dose-dependent fashion. Two weeks after in vivo transfer of MSC, we detected significantly reduced serum levels of anti ds-DNA antibodies and 24 hour proteinuria in MRL/lpr mice as compared with control groups without MSC transplantation. Moreover, flow cytometric analysis revealed markedly reduced number of CD4+ T cells while increased Th1 subpopulation in MSC group and MSC + CTX group when compared with controls. Histopathological examination showed significantly reduced renal pathology in MSC-treated mice. Immunohistochemical studies further revealed reduced expression of TGF-β, FN, VEGF and the deposition of complement C3 in renal tissue after MSC and MSC + CTX treatment. Taken together, we have demonstrated that transplantation of human MSC can significantly inhibit the autoimmune progression in MRL/lpr mice. | Kangxing Zhou Huayong Zhang Ouyang Jin Xuebing Feng Genhong Yao Yayi Hou Lingyun Sun | 2008 | Cellular & Molecular Immunology2008，5，6： | 59 |
| 2 | The regulation of the Treg/Th 17 balance by mesenchyma stem cells in human systemic lupus erythematosus显示文摘 | Dandan Wang Saisai Huang Xinran Yuan Jun Liang Renju Xu Genhong Yao Xuebing Feng Lingyun Sun | 2017 | Cellular & Molecular Immunology2017，14，5： | 44 |
| 3 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 4 | Mizoribine versus mycophenolate mofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis显示文摘 | Feng Xuebing Gu Fei Chen Weiwei Liu Yan Wei Hua Liu Lin Yin Songlou Da Zhanyun Sun Lingyun | 2014 | Chinese Medical Journal2014，，21： | 5 |
| 5 | A Comparative Study of Charging Voltage Curve Analysis and State of Health Estimation of Lithium-ion Batteries in Electric Vehicle显示文摘Lithium-ion(Li-ion)cells degrade after repeated cycling and the cell capacity fades while its resistance increases.Degra-dation of Li-ion cells is caused by a variety of physical and chemical mechanisms and it is strongly influenced by factors including the electrode materials used,the working conditions and the battery temperature.At present,charging voltage curve analysis methods are widely used in studies of battery characteristics and the constant current charging voltage curves can be used to analyze battery aging mechanisms and estimate a battery’s state of health(SOH)via methods such as incremental capacity(IC)analysis.In this paper,a method to fit and analyze the charging voltage curve based on a neural network is proposed and is compared to the existing point counting method and the polynomial curve fitting method.The neuron parameters of the trained neural network model are used to analyze the battery capacity relative to the phase change reactions that occur inside the batteries.This method is suitable for different types of batteries and could be used in battery management systems for online battery modeling,analysis and diagnosis. | Xuebing Han Xuning Feng Minggao Ouyang Languang Lu Jianqiu Li Yuejiu Zheng Zhe Li | 2019 | Automotive Innovation2019，2，4： | 3 |
| 6 | Enhancement of the enzymatic digestibility of sugarcane bagasse by alkali-per?acetic acid pretreatment显示文摘 | Zhao Xuebing Peng Feng Cheng Keke | 2009 | Enzyme and Microbial Technolo?gy2009，44，1： | 1 |
| 7 | Enhancement of the enzymatic digestibility of sugarcane bagasse by alkali–peracetic acid pretreatment显示文摘 | Xuebing Zhao Feng Peng Keke Cheng Dehua Liu | 2008 | Enzyme and Microbial Technology2008，，1： | 1 |
| 8 | Association of increased interferon-inducible gene expression with dis- ease activity and lupus nephritis in patients with systemic lupus erythematosus 显示文摘 | Feng Xuebing Wu Hui Grossman JM | 2006 | Arthritis Rheum2006，54，9： | 1 |
| 9 | Reversing Effect of Sorcin in the Drug Resistance of Human Nasopharyngeal Carcinoma显示文摘 | Xuebing Liu Lei Chen Bin Feng Gang Liu | 2014 | Anat. Rec2014，，2： | 1 |
| 10 | In-depth investigation of the exothermic reactions between lithiated graphite and electrolyte in lithium-ion battery显示文摘Thermal runaway is a critical issue for the large application of lithium-ion batteries.Exothermic reactions between lithiated graphite and electrolyte play a crucial role in the thermal runaway of lithium-ion batteries.However,the role of each component in the electrolyte during the exothermic reactions with lithiated graphite has not been fully understood.In this paper,the exothermic reactions between lithiated graphite and electrolyte of lithium-ion battery are investigated through differential scanning calorimetry(DSC) and evolved gas analysis.The lithiated graphite in the presence of electrolyte exhibit three exothermic peaks during DSC test.The reactions between lithiated graphite and LiPF_(6) and ethylene carbonate are found to be responsible for the first two exothermic peaks,while the third exothermic peak is attributed to the reaction between lithiated graphite and binder.In contrast,diethylene carbonate and ethyl methyl carbonate contribute little to the total heat generation of graphite-electrolyte reactions.The reaction mechanism between lithiated graphite and electrolyte,including the major reaction equations and gas products,are summarized.Finally,DSC tests on samples with various amounts of electrolyte are performed to clarify the quantitative relationship between lithiated graphite and electrolyte during the exothermic reactions.2.5 mg of lithiated graphite (Li_(0.8627)C_(6)) can fully react with around 7.2 mg electrolyte,releasing a heat generation of 2491 J g^(-1).The results presented in this study can provide useful guidance for the safety improvement of lithium-ion batteries. | Yuejiu Zheng Zhihe Shi Dongsheng Ren Jie Chen Xiang Liu Xuning Feng Li Wang Xuebing Han Languang Lu Xiangming He Minggao Ouyang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 11 | Enhancement of the enzymatic digestibility of sugarcane bagasse by alkali- peracetic acid pretreatment显示文摘 | Zhao Xuebing Peng Feng Cheng Keke | 2009 | Enzyme and Microbial Technology2009，44，： | 1 |
| 12 | Enhancement of the enzymatic digestibility of sugarcane bagasse by alkali-peracetic acid pretreatment 显示文摘 | XUEBING ZHAOA FENG PENGB KEKE CHENG et al | 2009 | Enzyme and Microbial Technology Enzyme and Microbial Technology2009，44，1： | 1 |
| 13 | MSCs relieve SLE by modulation of Th17 cells through MMPs–CCL2–CCR2–IL-17 pathway显示文摘Objective:To explore the modulation of mesenchymal stem cells(MSCs)on T helper 17(Th17)cells in systemic lupus erythematosus(SLE)and underlying mechanism.Methods:The concentration of matrix metalloproteinases(MMPs),CC chemokine ligand-2(CCL2),and interleukin-17(IL-17)in the serum of SLE patients and mice were detected by enzyme-linked immunosorbent assay.The expression of CCR2 and IL-17 of T lymphocytes were determined by flow cytometry.The effects of MSCs on Th17 cells were analyzed in lupus mice and coculture system in vitro.Results:The levels of MMPs,CCL2,IL-17,CCR2,and percentages of Th17 cells were significantly increased in SLE patients.These molecules and numbers of Th17 cells were downregulated by umbilical cord-derived MSCs(UC-MSCs)which relieve SLE disease.CCL2 neutralizing antibody blocked the effects of MSCs on Th17 cells.MMPs reversed the function of CCL2.Conclusion:The beneficial effects of MSCs on SLE patients rely on secreting MMPs,which reverse the activity of CCL2 to inhibit Th17 cells,suggesting the crucial MSCs–MMP–CCL2–CCR2–Th17–IL-17 pathway in SLE. | Bo Jiang Genhong Yao Xiaojun Tang Xi Yang Xuebing Feng | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 14 | Hydrogenation of Alkenes Catalyzed by Rare-Earth Metal Phosphinophosphinidene Complexes:1,2-Addition/Elimination Versusσ-Bond Metathesis Mechanism显示文摘Rare-earth metal complexes have been used as catalysts for many types of reactions.However,the mechanistic studies showed that basically,these various reactions proceeded withσ-bond metathesis of RE–E bond(RE:rare-earth metals;E:main group elements)or RE ions acting as Lewis acid centers to activate the polar functional groups of the substrates.In this article,a lutetium phosphinophosphinidene complex,with Lu=P double-bond character,was synthesized and structurally characterized. | Bin Feng Hao-Yu Zhang Hongling Qin Qian Peng Xuebing Leng Yaofeng Chen | 2022 | CCS Chemistry2022，4，10： | 0 |
| 15 | Parameter-independent error correction for potential measurements by reference electrode in lithium-ion batteries显示文摘The safety monitoring of lithium-ion batteries(LIBs) is of great significance for realizing all-climate and full-lifespan battery management. In-situ measurement of anode potential with implanted reference electrodes(REs) has proven to be effective to monitor and avoid the occurrence of severe side reactions like Li plating to ensure the safe and fast charging. However, the intrinsic measurement errors caused by local blocking effects, which also can be referred to as potential artefacts, are seldom taken into consideration in existing studies, yet they highly dominate the correctness of conclusions inferred from REs. In this study, aiming at exploring the physical origin of the measurement errors and ensure reliable potential monitoring, electrochemical and post-mortem tests are conducted using commercial pouch cells with implanted REs. Corresponding electrochemical model which describes the blocking effects, is established to validate the abnormal absence of lithium plating that predicted by measured anode potentials under various charging rates. Theoretical derivation is further presented to explain the error sources, which can be attributed to increased local liquid potential of the RE position. Most importantly, with the guidance of error analysis, a novel parameter-independent error correction method for RE measurements is proposed for the first time, which is proven to be adequate to estimate the real anode potentials and deduce the critical C-rate of Li plating with extra safety margin. After error correction, the resulting critical C-rates are all within the range of 0.55 ± 0.03 C, which is close to the C-rate of 0.6–0.7 C obtained from experiments. In addition, this error correction method can be performed conveniently with only some simple RE measurements of polarization voltages, totally independent of battery electrochemical and geometric parameters. This study provides highly practical error correction method for RE measurements in real LIBs, substantially facilitating the fast diagnosis and safety evaluation of Li plating during charging of LIBs. | Yalun Li Xinlei Gao Xuning Feng Xuebing Han Jiuyu Du Languang Lu Minggao Ouyang | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 16 | Targeted treatment strategy for patients with severe pulmonary hypertension secondary to connective tissue diseases显示文摘Background:Pulmonary arterial hypertension(PAH)associated with connective tissue diseases(CTD)(CTD-PAH)remains a difficult challenge in clinical practice.We aimed to evaluate the effects of targeted vasodilators in patients with severe CTD-PAH.Methods:The data of 53 patients with severe CTD-PAH hospitalized at the Department of Rheumatology and Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,were retrospectively reviewed.Patients were followed up for an average of 2 years to track their outcomes.The efficacy of treatment and the survival rate of patients with severe CTD-PAH were determined.Results:Among the causes of severe CTD-PAH,systemic lupus erythematosus(SLE)was the most common(39.6%),and the age at onset in patients with SLE-PAH was younger than that of patients with other CTD.Bosentan was more effective than sildenafil in reducing pulmonary artery pressure,improving cardiac function,and increasing survival time.Combination therapy with targeted vasodilators significantly improved the prognosis of patients with severe CTD-PAH compared with monotherapy.Conclusions:Patients with severe CTD-PAH should be treated early with targeted vasodilators.In this study,bosentan was superior to sildenafil.Combined treatment might be an option for severe CTD-PAH. | Bo Jiang Chun Wang Yansheng Jin Guanjun Guo Kangxing Zhou Xuebing Feng Genhong Yao | 2023 | Rheumatology & Autoimmunity2023，3，3： | 0 |
| 17 | Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma显示文摘Alternative RNA splicing is one of the most important mechanisms of posttranscriptional gene regulation,which contributes to protein diversity in eukaryotes.It is well known that RNA splicing dysregulation is a critical mechanism in tumor pathogenesis and the rationale for the promising splice-switching therapeutics for cancer treatment.Although we have a comprehensive understanding of DNA mutations,abnormal gene expression profiles,epigenomics,and proteomics in lung adenocarcinoma(LUAD),little is known about its aberrant alternative splicing profles.Here,based on the multi-omics data generated from over 1000 samples,we systematically studied the RNA splicing alterations in LUAD and revealed their biological and clinical implications.We identifed 3688 aberrant alternative splicing events(AASEs)in LUAD,most of which were alternative promoter and exon skip.The specific regulatory roles of RNA binding proteins,somatic mutations,and DNA methylations on AASEs were comprehensively interrogated.We dissected the functional implications of AASEs and concluded that AASEs mainly affected biological processes related to tumor proliferation and metastasis.We also found that one subtype of LUAD with a particular AASEs pattern was immunogenic and had a better prognosis and response rate to immunotherapy.These findings revealed novel events related to tumorigenesis and tumor immune microenvironment and laid the foundation for the development of splice-switching therapies forLUAD. | Quanyou Wu Lin Feng Yaru Wang Yousheng Mao Xuebing Di Kaitai Zhang Shujun Cheng Ting Xiao | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 0 |
| 18 | Thermal Runaway Characteristics and Modeling of LiFePO4 Power Battery for Electric Vehicles显示文摘LiFePO_(4)(LFP)lithium-ion batteries have gained widespread use in electric vehicles due to their safety and longevity,but thermal runaway(TR)incidents still have been reported.This paper explores the TR characteristics and modeling of LFP batteries at different states of charge(SOC).Adiabatic tests reveal that TR severity increases with SOC,and five stages are identified based on battery temperature evolution.Reaction kinetics parameters of exothermic reactions in each TR stage are extracted,and TR models for LFP batteries are established.The models accurately simulate TR behaviors at different SOCs,and the simulated TR characteristic temperatures also agree well with the experimental results,with errors of TR characteristic temperatures less than 3%.The prediction errors of TR characteristic temperatures under oven test conditions are also less than 1%.The results provide a comprehensive understanding of TR in LFP batteries,which is useful for battery safety design and optimization. | Tao Sun Luyan Wang Dongsheng Ren Zhihe Shi Jie Chen Yuejiu Zheng Xuning Feng Xuebing Han Languang Lu Li Wang Xiangming He Minggao Ouyang | 2023 | Automotive Innovation2023，6，3： | 0 |
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