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| 1 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 2 | Spatio-temporal Variation of Soil Respiration and Its Driving Factors in Semi-arid Regions of North China显示文摘Soil respiration(SR) is the second-largest flux in ecosystem carbon cycling. Due to the large spatio-temporal variability of environmental factors, SR varied among different vegetation types, thereby impeding accurate estimation of CO_2 emissions via SR. However, studies on spatio-temporal variation of SR are still scarce for semi-arid regions of North China. In this study, we conducted 12-month SR measurements in six land-use types, including two secondary forests(Populus tomentosa(PT) and Robinia pseudoacacia(RP)), three artificial plantations(Armeniaca sibirica(AS), Punica granatum(PG) and Ziziphus jujuba(ZJ)) and one natural grassland(GR), to quantify spatio-temporal variation of SR and distinguish its controlling factors. Results indicated that SR exhibited distinct seasonal patterns for the six sites. Soil respiration peaked in August 2012 and bottomed in April 2013. The temporal coefficient of variation(CV) of SR for the six sites ranged from 76.98% to 94.08%, while the spatial CV of SR ranged from 20.28% to 72.97% across the 12-month measurement. Soil temperature and soil moisture were the major controlling factors of temporal variation of SR in the six sites, while spatial variation in SR was mainly caused by the differences in soil total nitrogen(STN), soil organic carbon(SOC), net photosynthesis rate, and fine root biomass. Our results show that the annual average SR and Q_(10)(temperature sensitivity of soil respiration) values tended to decrease from secondary forests and grassland to plantations, indicating that the conversion of natural ecosystems to man-made ecosystems may reduce CO_2 emissions and SR temperature sensitivity. Due to the high spatio-temporal variation of SR in our study area, care should be taken when converting secondary forests and grassland to plantations from the point view of accurately quantifying CO_2 emissions via SR at regional scales. | ZENG Xinhua SONG Yigang ZHANG Wanjun HE Shengbing | 2018 | Chinese Geographical Science2018，28，1： | 3 |
| 3 | Fe-porphyrin:A redox-related biosensor of hydrogen molecule显示文摘Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so far.Herein,we originally reveal that Fe-porphyrin is a H_(2)-targeted molecule.We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of CO.These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials. | Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He | 2023 | Nano Research2023，16，2： | 1 |
| 4 | Effect of Gas Injection on Fluid Flow in Mold显示文摘A mathematical and physical model was adopted to compute the fluid flow distribution in case of localgas holdup in mold. The photography was used to show the fluid field. The predicted flow patterns show. reasonableagreement with experiment observations using actual water model. | Jiongming Zhang Wanjun Wang Jicheng He Baokuan Li (Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 1 00083, China)(Northeastern University, Xi’an, China) | 1998 | International Journal of Minerals,Metallurgy and Materials1998，12，1： | 1 |
| 5 | Pd-Catalyzed Ortho-Directed C-H Glycosylation of Arenes Using N-linked Bidentate Auxiliaries显示文摘Main observation and conclusion A set of Pd-catalyzed ortho-directed C-H glycosylation reactions with glycosyl chloride donors using various N-linked bidentate auxil-iaries has been developed for synthesis of C-aryglycosides.A broad range of pyranose and furanose moieties can be installed on the ortho position of arylamine,carbazole,indole and benzylamine type substrates in high yield and with high regio-and diastereoselec-tivity.These auxiliaries can be readily installed and removed under relatively mild conditions. | Quanquan Wang Wanjun Zhu Qikai Sun Gang He Gong Chen | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 6 | Immunological Markers for Central Nervous System Glia显示文摘Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and microglia.They contribute more than half of the total cells of the CNS,and are essential for neural development and functioning.Studies on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular markers.However,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible confusion.Here,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression. | Hao Huang Wanjun He Tao Tang Mengsheng Qiu | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
| 7 | ASBase:The universal database for aggregate science显示文摘This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://gffzzf21103ad36c048aahwkucf65qxo6b6cbx.ffgz.tsg.suse.edu.cn/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms. | Junyi Gong Wanjun Gong BoWu Haoran Wang Wei He Zhongyang Dai Yangzhong Li Yong Liu Zhiming Wang Xiaojun Tuo Jacky W.Y.Lam Zijie Qiu Zheng Zhao Ben Zhong Tang | 2023 | Aggregate2023，4，1： | 0 |
| 8 | Fuzzy Extensive Economical Control显示文摘FuzzyExtensiveEconomicalControlHeZhongxiong&HuWanjunAutomationSystemlnstitute,NorthernJiaotongUniversity,Beijing100044,P.R.Ch... | He Zhongxiong & Hu Wanjun ( Automation System lnstitute, Northern Jiaotong University,Beijing 100044, P. R. China ) | 1997 | Journal of Systems Engineering and Electronics1997，8，1： | 0 |
| 9 | Enhanced micro/nano-tribological performance in partially crystallized 60NiTi film显示文摘The microstructure,mechanical and micro/nano-tribological properties of the 60NiTi film annealed at different temperature were investigated.The results reveal that annealing as-deposited 60NiTi film at 300,375,and 600℃ for 1 h leads to structural relaxation,partial crystallization and full crystallization,respectively.Compared with the structurally relaxed structure,the partially crystallized structure exhibits increased hardness but decreased elastic modulus.This is because that the elastic modulus is reduced by Voigt model while the hardness is improved by composite effect.Due to the highest hardness and ratio of hardness to elastic modulus(H/E),the partially crystallized 60NiTi film has the lowest penetration depth and residual depth(i.e.,groove depth).Besides,the results also reveal that ductile plowing is the dominant wear mechanism for all the annealed 60NiTi films.Under the condition of the ductile plowing,coefficient of friction and wear resistance are related to penetration depth and residual depth,respectively.Therefore,the partially crystallized 60NiTi film shows the best tribological performance at the micro/nano-scale.The current work not only highlights the important roles of hardness and H/E in improving the micro/nano-tribological properties but also concludes an efficient and simple method for simultaneously increasing hardness and H/E. | Wanjun HE Qunfeng ZENG | 2021 | Friction2021，9，6： | 0 |
| 10 | Synthesis of 2-Deoxy-C-Glycosides via Iridium-Catalyzed sp^(2)and sp^(3)C-H Glycosylation with Unfunctionalized Glycals显示文摘A new protocol for the synthesis of 2-deoxy-C-aryl-glycosides and 2-deoxy-C-alkyl-glycosides via iridium-catalyzed directed C—H glycosylation with glycals is reported.The method is amenable for both the C_(2)C—H glycosylation of indoles and the methyl C—H glycosylation of secondary methyl amines under the control of an N-linked benzoxazole directing group.The benzoxazole group can be cleanly removed by the treatment of KOH or LiAlH_(4). | Wanjun Zhu Qikai Sun Hai Chang Hui-Xing Zhang Quanquan Wang Gong Chen Gang He | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 11 | A New Coronavirus Estimation Global Score for Predicting Mortality During Hospitalization in Patients with COVID-19显示文摘Objective:Coronavirus disease 2019(COVID-19)exists as a pandemic.Mortality during hospitalization is multifactorial,and there is urgent need for a risk stratification model to predict in-hospital death among COVID-19 patients.Here we aimed to construct a risk score system for early identification of COVID-19 patients at high probability of dying during in-hospital treatment.Methods:In this retrospective analysis,a total of 821 confirmed COVID-19 patients from 3 centers were assigned to developmental(n=411,between January 14,2020 and February 11,2020)and validation(n=410,between February 14,2020 and March 13,2020)groups.Based on demographic,symptomatic,and laboratory variables,a new Coronavirus estimation global(CORE-G)score for prediction of in-hospital death was established from the developmental group,and its performance was then evaluated in the validation group.Results:The CORE-G score consisted of 18 variables(5 demographics,2 symptoms,and 11 laboratory measurements)with a sum of 69.5 points.Goodness-of-fit tests indicated that the model performed well in the developmental group(H=3.210,P=0.880),and it was well validated in the validation group(H=6.948,P=0.542).The areas under the receiver operating characteristic curves were 0.955 in the developmental group(sensitivity,94.1%;specificity,83.4%)and 0.937 in the validation group(sensitivity,87.2%;specificity,84.2%).The mortality rate was not significantly different between the developmental(n=85,20.7%)and validation(n=94,22.9%,P=0.608)groups.Conclusions:The CORE-G score provides an estimate of the risk of in-hospital death.This is the first step toward the clinical use of the CORE-G score for predicting outcome in COVID-19 patients. | Hesong Zeng Xingwei He Wanjun Liu Jing Kan Liqun He Jinhe Zhao Cynthia Chen Junjie Zhang Shaoliang Chen | 2022 | Cardiology Discovery2022，2，2： | 0 |
| 12 | Total Synthesis of C-α-Mannosyl Tryptophan via Palladium-Catalyzed C-H Glycosylation显示文摘The C2-α-mannosyl-tryptophan amino acid is produced by a unique posttranslational modification(PTM)of proteins and poses a significant synthetic challenge.A new strategy based on Pd-catalyzed auxiliary-directed remote C-H glycosylation of tryptophan was developed,which generates the C2-α-mannopyranose(Man)-Trp unit in a highly efficient and stereoselective fashion.Density functional theory(DFT)computational studies support a concerted oxidative addition mechanism for the stereospecific functionalization of a Pd(II)palladacycle intermediate with anα-mannosyl chloride donor.The utility of this method was demonstrated in the first total synthesis of insect C-glycopeptide hormone Cam-HrTH-I. | Quanquan Wang Yue Fu Wanjun Zhu Shuang An Qianyi Zhou Shou-Fei Zhu Gang He Peng Liu Gong Chen | 2021 | CCS Chemistry2021，3，6： | 0 |
| 13 | Antiviral Abidol is Associated with the Reduction of In-Hospital Mortality in COVID-19 Patients显示文摘Objective:Coronavirus disease 2019(COVID-19)is a global public health crisis.There are no specific antiviral agents for the treatment of SARS-CoV-2.Information regarding the effect of Abidol on in-hospital mortality is scarce.The present study aimed to evaluate the treatment effect of Abidol for patients with COVID-19 before and after propensity score matching(PSM).Methods:This retrospective cohort study analyzed 1019 patients with confirmed COVID-19 in China from December 22,2019 to March 13,2020.Patients were divided to Abidol(200mg,tid,5-7days,n=788,77.3%)and No-Abidol(n=231,22.7%)groups.The primary outcome was the mortality during hospitalization.Results:Among 1019 COVID-19 patients,the age was(60.4±14.5)years.Abidol-treated patients,compared with No-Abidoltreated patients,had a shorter duration from onset of symptoms to admission,less frequent renal dysfunction,lower white blood cell counts(lymphocytes<0.8)and erythrocyte sending rate,lower interleukin-6,higher platelet counts and plasma IgG and oxygen saturation,and less frequent myocardial injury.The mortality during hospitalization before PSM was 17.9% in Abidol group and 34.6% in No-Abidol(hazard ratio(HR)=2.610,95% confident interval(CI):1.980–3.440),all seen in severe and critical patients.After PSM,the in-hospital death was 13.6% in Abidol and 28.6% in No-Abidol group(HR=2.728,95%CI:1.598–4.659).Conclusions:Abidol-treatment results in less in-hospital death for severe and critical patients with COVID-19.Further randomized study is warranted to confirm the findings from this study. | Hesong Zeng Xingwei He Wanjun Liu Jing Kan Liqun He Jinhe Zhao Cynthia Chen Junjie Zhang Shaoliang Chen | 2021 | Cardiology Discovery2021，1，1： | 0 |
| 14 | Super-resolution imaging of the dynamic cleavage of intercellular tunneling nanotubes显示文摘As a new method of cell-cell communication,tunneling nanotubes(TNTs)play important roles in cell-cell signaling and mass exchanges.However,a lack of powerful tools to visualize dynamic TNTs with high temporal/spatial resolution restricts the exploration of their formation and cleavage,hindering the complete understanding of its mechanism.Herein,we present the first example of using stochastic optical reconstruction microscopy(STORM)to observe the tube-like structures of TNTs linking live cells with an easily prepared fluorescent dye.Because of this new imaging microscopy,the cleavage process of TNTs was observed with a high spatial resolution. | Wanjun GONG Wenhui PAN Ying HE Meina HUANG Jianguo ZHANG Zhenyu GU Dan ZHANG Zhigang YANG Junie QU | 2020 | Frontiers of Optoelectronics2020，13，4： | 0 |
| 15 | Loading rate and holding load dependent room temperature nanoindentation creep behavior of 60NiTi alloy:Individual and coupling effects显示文摘60NiTi alloy is highly promising for aerospace bearings and mechanisms.Shock load that is inevitably generated during launching process brings about an quick loading process and transient load duration,and may further results in an unnoticed but detrimental creep deformation.On this account,the nanoindentation creep behavior of solution-treated 60NiTi alloy at room temperature and the corresponding influencing mechanism were studied.The results show that creep displacement was dominated by strain rate at the very beginning of holding stage.Strain rate and flow stress at the very beginning of holding stage were increased with an increased loading rate but declined with increasing holding load or with simultaneously increasing loading rate and holding load.The underlying mechanisms were provided as nucleation and absorption of geometrically necessary dislocations(GNDs)associated with strain gradient plasticity theory rather than the model based on the consumption of creep deformation at loading stage. | Wanjun He Qunfeng Zeng Chao Yan Jianing Zhu Danli Zhang Jiangnan Cao | 2022 | Journal of Materials Science & Technology2022，，6： | 0 |
| 16 | Palladium-Catalyzed O- and N-Glycosylation with Glycosyl Chlorides显示文摘Despite the significant progress in carbohydrate chemistry,there remains a pressing need for efficient and practical glycosylationmethods using simple glycosyl donors and with high atom economy.Herein,a new protocol for glycosylation with glycosyl chloride donors under palladium-catalyzed conditions is developed.PdII complex serves as a Lewis acid to promote the activation of glycosyl chloride for the formation of oxocarbeniumion intermediate.This new method is operationally simple,robust,and enables efficient synthesis of both O-and N-glycosides with a broad substrate scope.In particular,it offers an easy access to a range of N-ribonucleoside analogs. | Shuang An Quanquan Wang Wanjun Zhu Qikai Sun Gang He Gong Chen | 2021 | CCS Chemistry2021，3，7： | 0 |
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