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| 1 | Production of bioactive ginsenoside compound K in metabolically engineered yeast显示文摘 | Xing Yan Yun Fan Wei Wei Pingping Wang Qunfang Liu Yongjun Wei Lei Zhang Guoping Zhao Jianmin Yue Zhihua Zhou | 2014 | Cell Research2014，24，6： | 81 |
| 2 | Characterization of Panax ginseng UDP- Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rhl in Metabolically Engineered Yeasts显示文摘人参皂甙,在人参(人参属人参) 的主要 pharmacologically 活跃的自然混合物,主要是 protopanaxadiol (PPD ) 和 protopanaxatriol (PPT ) 的 glycosylated 产品。uridine diphosphate glycosyltransferase (UGT ) 催化 PPT 生产 PPT 类型人参皂甙,还都没被报导。这里,我们显示出那 UGTPg1,它 regio 明确地被表明了到 glycosylate C20 -- PPD 的 OH,另外明确地 glycosylates C20 -- PPT 到的 OH 生产 bioactive 人参皂甙 F1。我们报导四新奇 UGT 基因从 P.ginseng 孤立的 characterizationof,分享高推出的氨基酸身份(>84%) 与 UGTPg1。我们明确地表明那 UGTPg100 glycosylates C6 -- PPT 的 OH 催化 PPT 生产 bioactive 人参皂甙 Rh1,和 UGTPg101 生产 F1,从 F1 由人参皂甙 Rg1 的产生列在后面。然而, UGTPg102 和 UGTPg103 被发现不在 PPT 上举办可检测的活动。通过结构的建模和指导地点的 mutagenesis,我们识别了可以在决定他们的活动和底层 regio 特性起重要作用的这些 UGT 的几关键氨基酸。而且,我们由介绍遗传上设计的生产 PPT 小径和 UGTPg1 或 UGTPg100 构造了酵母 recombinants 到 biosynthesize F1 和 Rh1。我们的学习经由合成生物学策略在酵母为 bioactive PPT 类型人参皂甙在人参属工厂,和 providesa 声音生产途径揭示 PPT 类型人参皂甙的可能的 biosynthetic 小径。 | Wei Wei Pingping Wang Yongjun Wei Qunfang Liu Chengshuai Yang Guoping Zhao Jianmin Yue Xing Yan Zhihua Zhou | 2015 | Molecular Plant2015，8，9： | 37 |
| 3 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 4 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 5 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 6 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 7 | Freeze-thaw Effects on Sorption/Desorption of Dissolved Organic Carbon in Wetland Soils显示文摘The effects of freeze-thaw cycles on sorption/desorption of dissolved organic carbon (DOC) in two wetland soils and one reclaimed wetland soil were investigated. DOC concentrations added were 0-600 mg/L. Laboratory incubations of sorption/desorption of DOC had been carried out at -15℃ for 10 h, and then at +5℃ for 13 h. Soil samples were refrozen and thawed subsequently for 5 cycles. Initial Mass model was used to describe sorption behavior of DOC. The results indicate that freeze-thaw cycles can significantly increase the sorption capacity of DOC and reduce the desorption capacity of DOC in the three soils. The freeze-thaw effects on desorption of DOC in soils increase with the increasing freeze-thaw cycles. The conversion of natural wetlands to soybean farmland can decrease the sorption capacity and increase the desorption capacity of DOC in soils. Global warming and reclamation may increase DOC release, and subsequently increase the loss of carbon and the emission of greenhouse gas. | YU Xiaofei ZHANG Yuxia ZHAO Hongmei LU Xianguo WANG Guoping | 2010 | Chinese Geographical Science2010，20，3： | 12 |
| 8 | Effects of Crude Oil Contamination on Soil Physical and Chemical Properties in Momoge Wetland of China显示文摘Large oilfields are often coincidentally located in major river deltas and wetlands,and potentially damage the structure,function and ecosystem service values of wetlands during oil exploration.In the present study,the effects of crude oil contamination during oil exploration on soil physical and chemical properties were investigated in marshes of the Momoge National Nature Reserve in Jilin Province,China.The concentrations of total petroleum hydrocarbons in the marsh soil near the oil wells are significantly higher than those in the adjacent control marsh.Soil water contents in oil-contaminated marshes are negatively correlated with soil temperature and are significantly lower than those in the control area,especially in fall.Crude oil contamination significantly increases the soil pH up to8.0,and reduces available phosphorus concentrations in the soil.The concentrations of total organic carbon are significantly different among sampling sites.Therefore,crude oil contamination could potentially alkalinize marsh soils,adversely affect soil fertility and physical properties,and cause deterioration of the marshes in the Momoge National Nature Reserve.Phyto-remediation by planting Calamagrostis angustifolia has the potential to simultaneously restore and remediate the petroleum hydrocarbon-contaminated wetlands.Crude oil contamination affects the soil physical and chemical properties,so developing an effective restoration program in the Momoge wetland is neccesary. | WANG Ying FENG Jiang LIN Qianxin LYU Xianguo WANG Xiaoyu WANG Guoping | 2013 | Chinese Geographical Science2013，23，6： | 12 |
| 9 | Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide显示文摘 | Jing Li Li Luo Xiaoyun Wang Bin Liao Guoping Li | 2009 | Cellular & Molecular Immunology2009，6，5： | 11 |
| 10 | Characteristic Analysis of UHVAC/DC Hybrid Power Grids and Construction of Power System Protection显示文摘Strong DC coupling with weak AC and large-scale renewable energy integration are the two significant characteristics of ultra-high-voltage AC/DC(UHVAC/DC)hybrid power grids in China.Strong coupling between AC and DC grids and the different integration performance of renewable energy sources have profoundly changed the stability characteristics of the power system.The traditional stability control system is inadequate for the stability control of UHVAC/DC power grids.This paper analyzes the requirements for constructing an integrated defense system in a UHVAC/DC hybrid power grid(i.e.power system protection).The definition,connotation,and designing principles of power system protection are put forward.The relationship between the power system protection and the traditional three-defense lines is investigated.The design principles,general hardware structure and main functions of a power system protection are presented.Key problems and technologies are specified in the construction of the power system protection. | Yinbiao Shu Guoping Chen Zhao Yu Jianyun Zhang Chao Wang Chao Zheng | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 11 |
| 11 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 12 | A Potential Disease Susceptibility Gene CsLOB of Citrus Is Targeted by a Major Virulence Effector PthA of Xanthomonas citri subsp, citri显示文摘Dear Editor, Citrus bacterial canker (CBC),one of the most destructive diseases of citrus,has a severe economic impact on citrus industries in tropical and subtropical countries (Das,2003).It has been widely known that Xanthomonas cirri subsp.cirri (Xcc) causes the CBC by transferring the type-Ⅲ effectors (T3SEs) to the interior of the plant cell through type-Ⅲ secretion system (T3S) to modulate transcription of host plants to trigger CBC disease (Schaad et al.,2006).Pathotype A,the Asiatic form of Xcc,has a wide host range,is pathogenic on almost all citrus varieties,and contains a major virulence gene pthA encoding a T3S-secreted transcriptional activator-like effector (TALE) that promotes cellular hypertrophy (Al-Saadi et al.,2007).However,the susceptibility gene in citrus being responsible for the CBC and matching PthA of Xcc is largely unknown. | Zheng Li Lifang Zou Gang Ye Li Xiong Zhiyuan Ji Muhammad Zakria Ni Hong Guoping Wang Gongyou Chen | 2014 | Molecular Plant2014，7，5： | 9 |
| 13 | Vegetation Development and Water Level Changes in Shenjiadian Peatland in Sanjiang Plain,Northeast China显示文摘This paper documents a 7800-year proxy record from the Shenjiadian peatland on the Sanjiang Plain in Northeast China.High-resolution plant macrofossil and colorimetric humification methods were used to reconstruct the vegetation and hydrologic history from a 193 cm-long sedimentary profile.Detrended correspondence analysis(DCA) was applied to transform the raw plant macrofossil data into latent indices of peatland water level.The vegetation community transited from an Equisetum fluviatile community to a Carex lasiocarpa community at approximately 3800 cal yr BP and was followed by a Carex-shrub community at approximately 480 cal yr BP.Based on the plant macrofossil DCA axis 1 scores and humification values,we distinguished four hydrologic periods:a wet period from 7800 cal yr BP to 4500 cal yr BP,dry periods up to 1600 cal yr BP,drier periods until 300 cal yr BP,and the driest period from 300 cal yr BP until the present.Through a comparison with other climate records,we suggest that the East Asian summer monsoon(EAM) was the main driving force for vegetation and water level changes to the Shenjiadian peatland through its impacts on precipitation. | WANG Chunling ZHAO Hongyan WANG Guoping | 2015 | Chinese Geographical Science2015，25，4： | 8 |
| 14 | New Nodosaurid Dinosaur from the Late Cretaceous of Lishui, Zhejiang Province, China显示文摘nodosaurid 恐龙的一个新类和种:Zhejiangosaurus lishuiensisgen。et sp。nov。此处被树立。它被由至少三真骶的 vertebrae,熔化形成 presacral 杆的 5 尾的背面的 vertebrae,从身体的中间的线的肠骨的长苗条的 preacetabular 过程的宽分叉,和定位在的 fourthtrochanter 组成的骶骨描绘大腿骨中间长度。 | LU Junchang JIN Xingsheng SHENG Yiming LI Yihong WANG Guoping Yoichi AZUMA | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 15 | Symptom selection for multi-label data of inquiry diagnosis in traditional Chinese medicine显示文摘In traditional Chinese medicine(TCM) diagnosis,a patient may be associated with more than one syndrome tags,and its computer-aided diagnosis is a typical application in the domain of multi-label learning of high-dimensional data.It is common that a great deal of symptoms can occur in traditional Chinese medical diagnosis,which affects the modeling of diagnostic algorithm.Feature selection entails choosing the smallest feature subset of relevant symptoms,and maximizing the generalization performance of the model.At present there are rare researches on feature selection on multi-label data.A hybrid optimization technique is introduced to symptom selection for multi-label data in TCM diagnosis in this paper,and modeling is made by means of four multi-label learning algorithms like k nearest neighbors,etc.We compare the performance of the algorithm with the current popular dimension reduction algorithms like MEFS(embedded feature selection for multi-Label learning),MDDM(multi-label dimensionality reduction via dependence maximization) on the UCI Yeast gene functional data set and an inquiry diagnosis dataset of coronary heart disease(CHD).Experimental results show that the algorithm we present has significantly improved the performance.In particular,the improvement on the average precision for the classifier is up to 10.62% and 14.54%.Syndrome inquiry modeling of CHD in TCM is realized in this paper,providing effective reference for the diagnosis of CHD and analysis of other multi-label data. | SHAO Huan LI GuoZheng LIU GuoPing WANG YiQin | 2013 | Science China(Information Sciences)2013，56，5： | 8 |
| 16 | Systematic optimization of the yeast cell factory for sustainable and high efficiency production of bioactive ginsenoside compound K显示文摘Ginsenoside Compound K(CK)has been recognized as a major functional component that is absorbed into the systemic circulation after oral administration of ginseng.CK demonstrates diverse bioactivities.A phase I clinical study indicated that CK was a potential candidate for arthritis therapy.However,a phase II clinical study was suspended because of the high cost associated with the present CK manufacturing approach,which is based on the traditional planting-extracting-biotransforming process.We previously elucidated the complete CK biosynthetic pathway and realized for the first time de novo biosynthesis of CK from glucose by engineered yeast.However,CK production was not sufficient for industrial application.Here,we systematically engineered Saccharomyces cerevisiae to achieve high titer production of CK from glucose using a previously constructed protopanaxadiol(PPD)-producing chassis,optimizing UGTPg1 expression,improving UDP-glucose biosynthesis,and tuning down UDP-glucose consumption.Our final engineered yeast strain produced CK with a titer of 5.74 g/L in fed-batch fermentation,which represents the highest CK production in microbes reported to date.Once scaled-up,this high titer de novo microbial biosynthesis platform will enable a robust and stable supply of CK,thus facilitating study and medical application of CK. | Pingping Wang Jiali Wang Guoping Zhao Xing Yan Zhihua Zhou | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 7 |
| 17 | MicroRNAs in heart and circulation during physical exercise显示文摘Exercise training is beneficial to the cardiovascular system. MicroRNAs(miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression. Exercise training alters the expression levels of large amounts of miRNAs in the heart. In addition, circulating miRNAs appear to be regulated by exercise training. In this review, we will summarize recent advances in the regulation of miRNAs during physical exercise intervention in various cardiovascular diseases, including pathologic cardiac hypertrophy, myocardial fibrosis, ischemia-reperfusion injury, myocardial infarction, and heart failure. The regulatory role of circulating miRNAs after exercise training was also reviewed. In conclusion, miRNAs might be a valuable target for treatment of cardiovascular diseases and have great potential as biomarkers for assessment of physical performance. | Lijun Wang Yicheng Lv Guoping Li Junjie Xiao | 2018 | Journal of Sport and Health Science2018，7，4： | 7 |
| 18 | Mesozoic lithofacies palaeogeography and petroleum prospectivity in North Carnarvon Basin,Australia显示文摘The North Carnarvon Basin, which lies in the North West Shelf of Australia, is highly rich in gas resources. As a typical passive marginal basin, it experienced the pre-rifting, early rifting, main rifting, late rifting, post-rifting sagging and passive margin stages. The basin was mainly filled with thick Mesozoic-Cenozoic sediments, of which the Mesozoic hosts the principal source, reservoir and seal intervals. Mesozoic palaeogeography has an important control on the oil and gas distribution. Triassic gas-prone source rocks of deltaic origin deter-mine the high endowment of natural gases in the North Carnarvon Basin. The more restricted distribution of oil accumulations is controlled by oil source rocks in the Upper Jurassic Dingo Claystone. The Muderong Shale deposited in the Early Cretaceous marine transgression provides the effective regional seal for the underlying oil and gas reservoirs. | Tao Chongzhi Bai Guoping Liu Junlan Deng Chao Lu Xiaoxin Liu Houwu Wang Dapeng | 2013 | Journal of Palaeogeography2013，2，1： | 7 |
| 19 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 20 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
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