|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Branched tetraether lipids in Chinese soils:Evaluating the fidelity of MBT/CBT proxies as paleoenvironmental proxies显示文摘The ubiquitous occurrence of branched glycerol dialkyl glycerol tetraethers(br GDGTs) in soils has allowed development of new proxies for reconstruction of past climate and environment. The methylation and cyclization degrees of br GDGTs, expressed as MBT and CBT, respectively, are reported to be mainly controlled by mean annual air temperature(MAAT) and soil p H. However, the br GDGT-derived temperatures and soil p H scatter widely when data from different environmental conditions are considered. In this study, we collected over 300 soil samples from China, which are representative of humid(Xishuangbanna, Guangzhou, and Shanghai), semi-arid(Dongying) and semi-arid/arid(Lanzhou, Tibetan Plateau) regions. Collectively we have the most extensive dataset that broadly characterizes the distribution of br GDGTs according to climate zones in China. The overall data demonstrate that the MBT/CBT derived temperatures better match the measured MAATs in humid and non-alkaline regions than those from regions of low MAP(<400 mm/yr) and above neutral soil p H(>7.0–7.5). Similarly, CBT describes soil p H much better in humid and non-alkaline soils than in semi-arid/arid and alkaline soils; the semi-arid/arid and alkaline soils tend to show a positive correlation between soil p H and CBT, which contradicts that in the humid and non-alkaline soils. While soil p H, MAAT and mean annual precipitation(MAP) are dominating factors controlling the br GDGT distribution across all climate zones, conductivity, total organic carbon and total nitrogen, as well as soil water content can also play an important role locally. Removing br GDGT-II resulted in a revised CBT index that provides more accurate estimation of p H, especially in semi-arid/arid and alkaline soils. The overall Chinese dataset demonstrates that continental air temperature derived from br GDGT-proxies can vastly deviate from real measurements and should be used with extreme caution in paleo-climate or-environment studies. | ZHENG FengFeng ZHANG ChuanLun CHEN YuFei LI FuYan MA CenLing PU Yang ZHU YuanQing WANG YongLi LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 3 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 4 | Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system显示文摘 | Ming Ma Fengfeng Zhuang Xiongbing Hu Bolun Wang Xian-Zi Wen Jia-Fu Ji Jianzhong Jeff Xi | 2017 | Cell Research2017，27，4： | 7 |
| 5 | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination显示文摘The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG^(2+))OPCs was significantly higher than that in mature CC1^+ oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases. | Yanqing Shi Qi Shao Zhenghao Li Ginez A. Gonzalez Fengfeng Lu Dan Wang Yingyan Pu Aijun Huang Chao Zhao Cheng He Li Cao | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 6 | Development of a new ferulic acid certified reference material for use in clinical chemistry and pharmaceutical analysis显示文摘This study compares the results of three certified methods,namely differential scanning calorimetry(DSC),the mass balance(MB) method and coulometric titrimetry(CT),in the purity assessment of ferulic acid certified reference material(CRM).Purity and expanded uncertainty as determined by the three methods were respectively 99.81%,0.16%;99.79%,0.16%;and 99.81%,0.26%with,in all cases,a coverage factor(k) of 2(P ? 95%).The purity results are consistent indicating that the combination of DSC,the MB method and CT provides a confident assessment of the purity of suitable CRMs like ferulic acid. | Dezhi Yang Fengfeng Wang Li Zhang Ningbo Gong Yang Lv | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 4 |
| 7 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 8 | Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) emissions from electric arc furnaces for steelmaking显示文摘The proportion of steel produced using electric arc furnaces(EAFs)is increasing.In this study,polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)concentrations and patterns in stack gas samples from three typical EAFs in steelmaking plants were determined to allow the contributions of EAFs in steelmaking plants to PCDD/Fs emissions in China to be assessed.Samples collection was accomplished by adopting the automatic isokinetic sampling technique,then the PCDD/Fs congeners concentrations were analyzed qualitatively and quantitatively by isotope dilution high-resolution gas chromatography high-resolution mass spectrometry(HRGC-HRMS).The mean PCDD/Fs mass concentrations in stack gases emitted during the scrap preheating phase of plants E1,E2,and E3 were 0.48,385.55,and 0.34 ng Nm^-3,respectively,and the total toxic equivalent(WHO2005-TEQ)concentrations were 0.05,33.16,and 0.03 ng Nm^-3,respectively.The PCDD/Fs mass concentration in stack gases emitted during the melting phase at plant E3 was 0.12 ng Nm^-3(0.02 ng WHO2005-TEQ Nm^-3).The operational temperature of the bag filter of the preheating in the E2 EAF was as high as 230℃,which is conducive to the generation of PCDD/Fs,whether the temperature in the bag filter of E1(150℃)and E3(120℃)are not.Moreover,the bag filter temperature is suggested to be best controlled to below 150℃.The emission factors(EF)for PCDD/Fs released into the air during the scrap preheating phase for plants E1,E2,and E3 were 0.13,52,and 0.10 mg WHO2005-TEQ t1,respectively,and the EF for the smelting phase from plant E3 was 0.14 mg WHO2005-TEQ t1.The emission factor in E2 is 5 times higher than the highest current UNEP toolkit factor for EAFs(10 mg TEQ/tonne steel).Therefore,an update for the UNEP toolkit emission factor for a few case plants is suggested.Several congeners,including 2,3,7,8-TeCDF,1,2,3,4,6,7,8-HpCDF,and 1,2,3,4,6,7,8-HpCDD,were dominant during the preheating phase,while 2,3,7,8-TeCDF,1,2,3,7,8-PeCDF,and 2,3,4,7,8-PeCDF were dominant during the smelting phase.The monitoring data from the case plants helps to better understand the PCDD/Fs emissions of EAFs using preheating process stages.However,a more complete emission inventory requires more case investigations on the PCDD/Fs emissions from representative EAFs steelmaking plants. | Qiuting Yang Lili Yang Jia Shen Yuanping Yang Minxiang Wang Xiaoyun Liu Xuejing Shen Changliang Li Jia Xu Fengfeng Li Da Li Guorui Liu Minghui Zheng | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 9 | Glass fiber supported BiOI thin-film fixed-bed photocatalytic reactor for water decontamination under solar light irradiation显示文摘BiOI powder has been proved to be an efficient photocatalyst, but the difficulty in removing it from water after reaction limits its application in real water treatment. To solve this problem,a thin-film fixed-bed reactor(TFFBR) was set-up by developing a BiOI thin film on glass fiber cloth(GFC). The composition and structure of the as-prepared films were characterized with X-ray diffraction, X-ray photoelectron spectroscopy, field emission microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. The BiOI thin film was made by painting a silica sol containing BiOI on GFC, which could be tailored to desired sizes to accommodate the TFFBR. The mass of BiOI on the GFC increased with the number of iterations of the painting process. SiO2 sol glued the BiOI particles tightly onto the GFC,making the thin film strong enough to resist fluid flushing in the TFFBR. The photocatalytic activity of the BiOI thin film was investigated by degrading bisphenol A(BPA) under simulated sunlight. Ninety eight percent of BPA(20 mg/L in 2 L) was degraded by the BiOI thin film sample of seven layers(GFC-7) on the TFFBR within 8 hr irradiation. The GFC-7 displayed good photocatalytic ability toward artificial sewage containing BPA in a wide pH range(5–9),and also demonstrated excellent durability and reusability. The working conditions were optimized and it was found that the thickness of the fluid film and residence time over the thin film were key factors affecting the photocatalytic efficiency. | Yonghua Zhang Guoqiang Shan Fengfeng Dong Chenshuai Wang Lingyan Zhu | 2019 | Journal of Environmental Sciences2019，31，6： | 2 |
| 10 | Estimation of leaf area index from high resolution ZY-3 satellite imagery in a catchment dominated by Larix principis-rupprechtii,northern China显示文摘Leaf area index(LAI) is a key factor that determines a forest ecosystem's net primary production and energy exchange between the atmosphere and land surfaces.LAI can be measured in many ways, but there has been little research to compare LAI estimated by different methods. In this study, we compared the LAI results from two different approaches, i.e., the dimidiate pixel model(DPM) and an empirical statistic model(ESM) using ZY-3 high-accuracy satellite images validated by field data. We explored the relationship of LAI of Larix principis-rupprechtii Mayr plantations with topographic conditions. The results show that DPM improves the simulation of LAI(r = 0.86,RMSE = 0.57) compared with ESM(r = 0.62, RMSE =0.79). We further concluded that elevation and slope significantly affect the distribution of LAI. The maximum peak of LAI appeared at an aspect of east and southeast at an elevation of 1700–2000 m. Our results suggest that ZY-3 can satisfy the needs of quantitative monitoring of leaf area indices in small-scale catchment areas. DPM provides a simple and accurate method to obtain forest vegetation parameters in the case of non-ground measurement points. | Tian Wang Fengfeng Kang Hairong Han Xiaoqin Cheng Jiang Zhu Wensong Zhou | 2019 | Journal of Forestry Research2019，30，2： | 2 |
| 11 | The biology of bone morphogenetic protein signaling pathway in cerebrovascular system显示文摘Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different tissues.Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function.The disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern society.In recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system.This review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases. | Haishuang Tang Xiaoxi Zhang Gaici Xue Fengfeng Xu Qingsong Wang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu Qiao Zuo | 2021 | Chinese Neurosurgical Journal2021，7，4： | 2 |
| 12 | Emergence of superconductivity from fully incoherent normal state in an iron-based superconductor (Ba_(0.6)K_(0.4))Fe_2As_2显示文摘In unconventional superconductors, it is generally believed that understanding the physical properties of the normal state is a pre-requisite for understanding the superconductivity mechanism. In conventional superconductors like niobium or lead, the normal state is a Fermi liquid with a well-defined Fermi surface and well-defined quasipartcles along the Fermi surface. Superconductivity is realized in this case by the Fermi surface instability in the superconducting state and the formation and condensation of the electron pairs(Cooper pairing). The high temperature cuprate superconductors, on the other hand, represent another extreme case that superconductivity can be realized in the underdoped region where there is neither well-defined Fermi surface due to the pseudogap formation nor quasiparticles near the antinodal regions in the normal state. Here we report a novel scenario that superconductivity is realized in a system with well-defined Fermi surface but without quasiparticles along the Fermi surface in the normal state.High resolution laser-based angle-resolved photoemission measurements have been performed on an optimally-doped iron-based superconductor(Ba_(0.6)K_(0.4))Fe_2As_2. We find that, while sharp superconducting coherence peaks emerge in the superconducting state on the hole-like Fermi surface sheets, no quasiparticle peak is present in the normal state. Its electronic behaviours deviate strongly from a Fermi liquid system. The superconducting gap of such a system exhibits an unusual temperature dependence that it is nearly a constant in the superconducting state and abruptly closes at Tc. These observations have provided a new platform to study unconventional superconductivity in a non-Fermi liquid system. | Jianwei Huang Lin Zhao Cong Li Qiang Gao Jing Liu Yong Hu Yu Xu Yongqing Cai Dingsong Wu Ying Ding Cheng Hu Huaxue Zhou Xiaoli Dong Guodong Liu Qingyan Wang Shenjin Zhang Zhimin Wang Fengfeng Zhang Feng Yang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2019 | Science Bulletin2019，64，1： | 1 |
| 13 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China(Edition 8)显示文摘BACKGROUND Since the release of Protocol for Prevention and Control of COVID-19(Edition 7),coronavirus disease 2019(COVID-19)control and prevention has been facing new challenges in China with evolving domestic and global epidemiological situations.Since September 2020,China has experienced more than 20 local outbreak waves,all of which were able to be contained within a few weeks. | Fengfeng Liu Canjun Zheng Liping Wang Mengjie Geng Hui Chen Sheng Zhou Lu Ran Zhongjie Li Yanping Zhang Zijian Feng George FGao Zhaorui Chang | 2021 | China CDC weekly2021，3，25： | 1 |
| 14 | The effect of oxygen on the epitaxial growth of diamond显示文摘We studied the effect of oxygen on the growth quality of diamond epitaxial layers. After oxygen is added during the growth of the diamond epitaxial layer, as the thickness of the epitaxial layer increases, the full width at half maximum of the rocking curve of the(004) plane of diamond epitaxial layer increases continuously, and, in addition, the intensities of both the Raman peaks and the free exciton emission peaks of the diamond epitaxial layer decrease continuously. These experimental results demonstrate that as the thickness of the diamond epitaxial layer increases, the quality of the diamond epitaxial layer degrades. The strong etching effect of the OH radical groups in the plasma on the diamond epilayers leads to the degradation of their crystallinity. | Meng Gong Yanan Chen Wancheng Yu Peng Jin Zhanguo Wang Zhimin Wang Shenjin Zhang Feng Yang Fengfeng Zhang Qinjun Peng Zuyan Xu | 2018 | Journal of Semiconductors2018，39，12： | 1 |
| 15 | Effect of germination time on physicochemical properties of brown rice flour and starch from different rice cultivars显示文摘 | Fengfeng Wu Haiying Chen Na Yang Jinpeng Wang Xiang Duan Zhengyu Jin Xueming Xu | 2013 | Journal of Cereal Science2013，，： | 1 |
| 16 | Tunable light emission from carbon dots by controlling surface defects显示文摘Carbon dots(CDs)are metal-free fluorescent materials that can be used in optical and electronic devices,but few studies have focused on one-step synthesis routes for CDs with tunable color and high photoluminescence quantum yield(PLQY).Herein,CDs with tunable light emission were synthesized using a novel amide-assisted solvothermal approach.The as-prepared CDs were well dispersed and homogeneous,with average diameters of approximately 2.0–4.0 nm,depending on the dopants.Owing to the surface states with different ratios of nitrogen-and oxygen-related species,different CDs can exhibit blue,green,red,or white emission with relatively high PLQYs of 61.6%,41.3%,29.1%and 19.7%,respectively.XPS measurements,in conjunction with DFT calculations,indicate that nitrogen substitution(pyridinic/pyrrolic nitrogen)dominates the blue emission,while introducing oxygen functional groups lowered the LUMO energy level,which resulted in redder emission.In addition,the CDs are demonstrated as a bioimaging probe in both in vitro and in vivo assays,and the white light CDs have been demonstrated to be potential fluorescent materials for white-light-emitting diode(WLED). | Huijun Li Sancan Han Bowen Lyu Ting Hong Shibo Zhi Ling Xu Fengfeng Xue Liman Sai Junhe Yang Xianying Wang Bin He | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 17 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
| 18 | Psychological stress induced hippocampus zinc dyshomeostasis and depression-like behavior in rats显示文摘 | Xiao Dou Xue Tian Yuanyuan Zheng Junlong Huang Zhilei Shen Hongxia Li Xiaoli Wang Fengfeng Mo Wanyin Wang Shi Wang Hui Shen | 2014 | Behavioural Brain Research2014，，： | 1 |
| 19 | Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis显示文摘 | Humphreys Benjamin D Xu Fengfeng Sabbisetti Venkata Grgic Ivica Naini Said Movahedi Wang Ningning Chen Guochun Xiao Sheng Patel Dhruti Henderson Joel M Ichimura Takaharu Mou Shan Soeung Savuth McMahon Andrew P Kuchroo Vijay K Bonventre Jos | 2013 | Journal of Clinical Investigation2013，，： | 1 |
| 20 | A parallel robotic attachment and its remote manipulation显示文摘 | Wang Lihui Xi Fengfeng Zhang Dan | 2006 | Robotics and Computer- Integrated Manufacturing2006，22，56： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员