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| 1 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 2 | Pathogen Spectrum of Hand,Foot,and Mouth Disease Based on Laboratory Surveillance—China,2018显示文摘What is already known about this topic?Enterovirus 71(EV-A71)is the main causative pathogen for severe and fatal patients with Hand,Foot,and Mouth Disease(HFMD)in China's Mainland from 2008 to 2017.Non-EV-A71 and non-CV-A16(other enterovirus)serotypes were the major causativeserotypes for mild HFMD in years of 2013,2015,and 2017.What is added by this report?In 2018,other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%.However,at the national level,only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and CVA10.What are the limitations for public health practice?Further identification of other enterovirus serotypes is highly recommended for provincial CDCs,especially for severe HFMD.Studies contributing to a multivalent vaccine for HFMD should be prioritized. | Fengfeng Liu Minrui Ren Shumin Chen Taoran Nie Jinzhao Cui Lu Ran Zhongjie Li Zhaorui Chang | 2020 | China CDC weekly2020，2，11： | 8 |
| 3 | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination显示文摘The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG^(2+))OPCs was significantly higher than that in mature CC1^+ oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases. | Yanqing Shi Qi Shao Zhenghao Li Ginez A. Gonzalez Fengfeng Lu Dan Wang Yingyan Pu Aijun Huang Chao Zhao Cheng He Li Cao | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 4 | Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice显示文摘The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells(OPCs) to differentiate, since OPCs and oligodendrocytelineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid(SA) is mainly derived from star anise, and is reported to have antiinfluenza, anti-oxidation, and anti-tumor effects. In the present study, we found that SA significantly promoted the differentiation of cultured rat OPCs without affecting their proliferation and apoptosis. In mice, SA exerted therapeutic effects on experimental autoimmune encephalomyelitis(EAE), such as alleviating clinical EAE scores, inhibiting inflammation, and reducing demyelination in the CNS. SA also promoted the differentiation of OPCs as well as their remyelination after lysolecithin-induced demyelination.Furthermore, we showed that the promotion effect of SA on OPC differentiation was associated with the up-regulation of phosphorylated m TOR. Taken together, our resultsdemonstrated that SA could act as a potential drug candidate for the treatment of demyelinating diseases. | Fengfeng Lu Dou Yin Yingyan Pu Weili Liu Zhenghao Li Qi Shao Cheng He Li Cao | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 5 | Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility显示文摘Pathogen infection is the main cause of human morbidity and death.Traditional antibiotics usually sterilize bacteria in chemical ways,which tends to develop serious antibiotic resistance.Cationic polymers exhibit good bacterial inhibition with less resistance,but often face severe cytotoxicity toward normal cells.The optimization of polymeric antimicrobials for enhanced bactericidal capacity and improved biocompatibility is quite meaningful.In addition,photodynamic therapy(PDT) is a therapeutic modality with less susceptibility to develop resistance.Herein,a typical commercial polymeric antimicrobial,polyhexamethylene guanidine(PHMG) was selected for current proof-of-concept optimization due to its excellent bactericidal capacity but moderate biocompatibility.Eosin-Y(EoS)was copolymerized to afford EoS-labeled polymer conjugates,poly(2-(dimethylamino) ethyl methacrylate-co-eosin),P(DMAEMA-co-EoS),which was conjugated with PHMG to afford a novel polymeric antimicrobial,P(DMAEMA-co-EoS)-b-PHMG-b-P(DMAEMA-co-EoS),noted as PEoS-PHMG.It could efficiently kill broad-spectrum bacteria by physical damage and photodynamic therapy.Compared with PHMG,the bacterial inhibition of PEoS-PHMG was potentiated after the functionalization.Furthermore,PEoS-PHMG exhibited low cytotoxicity and minimal hemolysis,which was demonstrated by cell viability assays toward LO2 cells and RAW 264.7 cells as well as hemolytic assays against red blood cells.These results confirmed that the resultant PEoS-PHMG could act as promising alternative antibacterial materials with excellent broad-spectrum bacterial inhibition and favorable biocompatibility. | Fengfeng Xiao Bing Cao Liewei Wen Yanhong Su Meixiao Zhan Ligong Lu Xianglong Hu | 2020 | Chinese Chemical Letters2020，31，9： | 2 |
| 6 | A Contrastive Study of Political Speeches in Presidential Election of Interpersonal Meaning显示文摘 | Pengsun JIN Fengfeng LU | 2013 | Studies in Literature and Language2013，，3： | 1 |
| 7 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China(Edition 8)显示文摘BACKGROUND Since the release of Protocol for Prevention and Control of COVID-19(Edition 7),coronavirus disease 2019(COVID-19)control and prevention has been facing new challenges in China with evolving domestic and global epidemiological situations.Since September 2020,China has experienced more than 20 local outbreak waves,all of which were able to be contained within a few weeks. | Fengfeng Liu Canjun Zheng Liping Wang Mengjie Geng Hui Chen Sheng Zhou Lu Ran Zhongjie Li Yanping Zhang Zijian Feng George FGao Zhaorui Chang | 2021 | China CDC weekly2021，3，25： | 1 |
| 8 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
| 9 | Underlying mechanism of hemodynamics and intracranial aneurysm显示文摘In modern society,subarachnoid hemorrhage,mostly caused by intracranial aneurysm rupture,is accompanied by high disability and mortality rate,which has become a major threat to human health.Till now,the etiology of intracranial aneurysm has not been entirely clarified.In recent years,more and more studies focus on the relationship between hemodynamics and intracranial aneurysm.Under the physiological condition,the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood vessels.When the blood vessels are stimulated by the continuous abnormal blood flow,the functional structure of the blood vessels changes,which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial aneurysm.This review will focus on the relationship between hemodynamics and intracranial aneurysms,will discuss the mechanism of occurrence and development of intracranial aneurysms,and will provide a new perspective for the research and treatment of intracranial aneurysms. | Haishuang Tang Qingsong Wang Fengfeng Xu Xiaoxi Zhang Zhangwei Zeng Yazhou Yan Zhiwen Lu Gaici Xue Qiao Zuo Yin Luo Jianmin Liu Qinghai Huang | 2022 | Chinese Neurosurgical Journal2022，8，2： | 1 |
| 10 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China (Edition 7)显示文摘After coronavirus disease 2019(COVID-19),previously known as pneumonia of unknown etiology(PUE)and 2019 novel coronavirus(2019-nCoV),was first discovered in Wuhan City,Hubei Province,the Chinese government took measures to stop the spread of the epidemic nationwide and interrupted local transmission in China(1–2).Although there have been several localized outbreaks that were caused by overseas importation of the virus—including Heilongjiang,Jilin,Beijing,Liaoning,and other provincial-level administrative divisions(PLADs)—these outbreaks have been stopped within two to four weeks and were limited in scope to less than ten cases or a few hundred cases for each event.With the COVID-19 pandemic still uncontrolled globally,the threat of importing the virus continues unabated and still threatens China’s population,virtually all of which is susceptible. | Canjun Zheng Zhaorui Chang Fengfeng Liu Mengjie Geng Hui Chen Jingwei Jiang Sheng Zhou Lu Ran Zhongjie Li Zijian Feng George F.Gao Liping Wang | 2020 | China CDC weekly2020，2，47： | 1 |
| 11 | Liver cell therapies:cellular sources and grafting strategies显示文摘The liver has a complex cellular composition and a remarkable regenerative capacity.The primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells,endothelia and various hemopoietic cell populations.The regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates,the extracellular matrix,working synergistically with soluble paracrine and systemic signals.In recent years,with the rapid development of genetic sequencing technologies,research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively explored.Meanwhile breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases,offering potential solutions to the chronic shortage of livers and alternatives to liver transplantation.This review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and repair.Recent advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies. | Wencheng Zhang Yangyang Cui Yuan Du Yong Yang Ting Fang Fengfeng Lu Weixia Kong Canjun Xiao Jun Shi Lola M.Reid Zhiying He | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 12 | Biomarker records of D5-6 columns in the eastern Antarctic Peninsula waters:responses of planktonic communities and bio-pump structures to sea ice global warming in the past centenary显示文摘Molecular biomarkers(e.g.,isoprenoid glycerol dialkyl glycerol tetraethers(iGDGTs)and proxies,such as di-unsaturated to tri-unsaturated highly branched isoprenoids(D/T)ratio,total organic carbon,δ^(13)C and ice-rafted debris(IRD))were used to reconstruct the dominant phytoplankton(diatoms,dinoflagellates and coccolithophores),phytoplankton and zooplankton productivity,biological pump structure,and archaea assemblage(Euryarchaeota and Crenarchaeota)from a marine sediment core(D5-6)dated with^(210)Pb(1922–2012).We characterized the environmental response to sea ice variations/global warming off the eastern Antarctic Peninsula.The results showed that(1)the biomarkers brassicasterol(average=519.79 ng·g^(-1)),dinosterol(average=129.68 ng·g^(-1))and C37 alkenones(average=40.53 ng·g^(-1))reconstructed phytoplankton(average=690.00 ng·g^(-1))and zooplankton(cholesterol average=669.25 ng·g^(-1))productivity.The relative contribution to productivity by different phytoplankton groups was diatoms>dinoflagellates>coccolithophores.This is consistent with field surveys showing that diatoms dominate the phytoplankton in waters adjacent to the Antarctic Peninsula.(2)The relative abundances of different highly branched isoprenoids reflected the contributions of sea ice algae and open water phytoplankton(D/T=1.2–30.15).Phytoplankton productivity and sea ice showed a good linear relationship with a negative correlation,indicating that more open water during periods of warming and reduced sea ice cover led to an enhanced biological pump.(3)Over the past 100 years,phytoplankton productivity and zooplankton biomass increased.This trend was particularly evident in the last 50 years,corresponding to increased global warming,and showed a negative correlation with IRD and D/T.This suggests that with decreasing sea ice coverage in a warming climate,diatom biomass greatly increased.Coccolithophore/diatom values and the ratio of C37 alkenones to total phytoplankton productivity decreased,indicating the proportion of coccolithophores in the phytoplankton community decreased.The reduction in coccolithophores changes the phytoplankton assemblage and affects the overall efficiency of the biological pump and carbon storage.(4)The results also showed that the abundance of iGDGTs and archaea phyla(Euryarchaeota and Crenarchaeota)showed consistent changes over the past 100 years in response to global warming.Since 1972,trends in archaea,phytoplankton and zooplankton showed variations but a consistent decline.Whether their response to the changing climate off the Antarctic Peninsula involves interactions and influence among different marine biological groups remains an open question.As a result of global warming and reductions in Antarctic sea ice,the relative effectiveness of the Antarctic biological pump can significantly affect global ocean carbon storage. | YANG Dan ZHANG Haisheng HAN Zhengbing HAN Xibin ZHANG Yicheng CHEN Wensheng LIU Qian PAN Jianming FAN Gaojing LE Fengfeng LU Bing HUANG Jing | 2021 | Advances in Polar Science2021，32，1： | 0 |
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