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| 1 | Geochemistry, Geochronology and Lu-Hf Isotopes of Peraluminous Granitic Porphyry from the Walegen Au Deposit, West Qinling Terrane显示文摘Walegen Au deposit is closely correlated with granitic intrusions of Triassic age, which are composed of granite and quartz porphyries. Both granite porphyry and quartz porphyry consist of quartz, feldspar and muscovite as primary minerals. Weakly peraluminous granite porphyry(A/CNK=1.10–1.15) is enriched in LREE, depleted in HREE with Nb-Ta-Ti anomalies, and displays subduction-related geochemistry. Quartz porphyry is strongly peraluminous(A/CNK=1.64–2.81) with highly evolved components, characterized by lower TiO_2, REE contents, Mg~#, K/Rb, Nb/Ta, Zr/Hf ratios and higher Rb/Sr ratios than the granite porphyry. REE patterns of quartz porphyry exhibit lanthanide tetrad effect, resulting from mineral fractionation or participation of fluids with enriched F and Cl. LAICP-MS zircon U-Pb dating indicates quartz porphyry formed at 233±3 Ma. The ages of relict zircons from Triassic magmatic rocks match well with the detrital zircons from regional area. In addition, ε_(Hf)(t) values of Triassic magmatic zircons from the granite and quartz porphyries are -14.2 to -9.1(with an exception of +4.1) and -10.8 to -8.6 respectively, indicating a crustal-dominant source. Regionally, numerous Middle Triassic granitoids were previously reported to be formed under the consumption of Paleotethyan Ocean. These facts indicate that the granitic porphyries from Walegen Au deposit may have been formed in the processes of the closing of Paleotethyan Ocean, which could correlate with the arc-related magmatism in the Kunlun orogen to the west and the Qinling orogen to the east. | GUO Xianqing YAN Zhen Jonathan C.AITCHISON FU Changlei WANG Zongqi | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 3 |
| 2 | Key CO_(2)capture technology of pure oxygen exhaust gas combustion for syngas-fueled high-temperature fuel cells显示文摘Integrated gasification fuel cells(IGFCs)integrating high-temperature solid oxide fuel cell technology with CO_(2)capture processes represents highly-efficient power systems with negligible CO_(2)emissions.Flame burning with pure oxygen is an ideal method for fuel cell exhaust gas treatment,and this report describes experimental and numerical studies regarding an oxy-combustor for treating the exhaust gas of a 10 kW IGFC system anode.The applied simulation method was verified based on experiments,and the key performance indices of the combustor were studied under various conditions.It was determined that 315 K was the ideal condensation temperature to obtain flame stability.Under these pure oxygen flame burning conditions,CO was almost completely converted,and the dry mole fraction of CO_(2)after burning was C 0.958 when there was up to 5%excess O_(2).Overall,5%excess O_(2)was recommended to maximize CO_(2)capture and promote other environmental considerations.Additionally,the optimal tangential fuel jet angle to control the liner temperature was approximately 25°.The total fuel utilization had to be high enough to maintain the oxygen flame temperature of the anode exhaust gas below 1800 K to ensure that the system was environmentally friendly.The results presented herein have great value for designing IGFCs coupled with CO_(2)capture systems. | Hanlin Wang Qilong Lei Pingping Li Changlei Liu Yunpeng Xue Xuewei Zhang Chufu Li Zhibin Yang | 2021 | International Journal of Coal Science & Technology2021，8，3： | 3 |
| 3 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells显示文摘Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.In this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular endothelium.Results show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated apoptosis.These effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,BAPTA-AM.Blockade of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]i.Comparing to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell apoptosis.Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD.In summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and Orai1.Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases. | Kai Yang Shiyun Liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 2 |
| 4 | Dense PZT thick films derived from sol -gel based nano composite process显示文摘 | WANG Zhihong ZHU Weiguang ZAHO Changlei | 2003 | Mater Sci Eng2003，99，： | 1 |
| 5 | Dense PZT thick films derived from Sol-Gel based nanocornposite process 显示文摘 | WANG Zhihong ZHU Weiguang ZHAO Changlei | 2003 | Materials Science and Engineering B2003，99，： | 1 |
| 6 | Design of five-axis CNC Based on Linux 显示文摘 | Wang Changlei Cao Shunkun | 2011 | International Conference on Computer Science and Network Technology2011，，： | 1 |
| 7 | Quantitative Analysis of Kerr Nonlinearity and Kerr-Like Nonlinearity Induced via Terahertz Generation in ZnTe 显示文摘 | ZHEN TIAN CHANGLEI WANG QIRONG XING | 2008 | Applied Physics Letters2008，92，04： | 1 |
| 8 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 9 | Analysis and Design of Terahertz Photonic Crystal Fibers by an Effective-Index Method 显示文摘 | YANFENG LI CHANGLEI WANG NING ZHANG | 2006 | Applied Optics2006，45，33： | 1 |
| 10 | Dense PZT thick films derived from sol-gel based nanocomposite process显示文摘 | Zhihong Wang Weiguang Zhu Changlei Zhao | 2003 | Mater Sci & Eng2003，99，： | 1 |
| 11 | All-in-one photoelectric logic gates by Dember photodetectors显示文摘Photoelectric logic gates(PELGs) are the key component in integrated electronics due to their abilities of signal conversion and logic operations. However, traditional PELGs with fixed architectures can realize only very limited logic functions with relatively low on–off ratios. We present a self-driving polarized photodetector driven by the Dember effect, which yields ambipolar photocurrents through photonic modulation by a nested grating. The ambipolar response is realized by exciting the whispering-gallery mode and localized surface plasmon resonances,which leads to reverse spatial carrier generation and therefore the contrary photocurrent assisted by the Dember effect. We further design a full-functional PELG, which enables all five basic logic functions(“AND”, “OR”,“NOT”, “NAND”, and “NOR”) simultaneously in a single device by using one source and one photodetector only. Such an all-in-one PELG exhibits a strong robustness against structure size, incident wavelength, light power, and half-wave plate modulation, paving a way to the realization of ultracompact high-performance PELGs. | GUOYANG CAO CHANGLEI WANG YU LUO XIAOFENG LI | 2023 | Photonics Research2023，11，7： | 0 |
| 12 | Suppression of deep‑level traps via semicarbazide hydrochloride additives for high‑performance tin‑based perovskite solar cells显示文摘Tin perovskites with exemplary optoelectronic properties ofer potential application in lead-free perovskite solar cells.However,Sn vacancies and undercoordinated Sn ions on the tin perovskite surfaces can create deep-level traps,leading to nonradiative recombination and absorption of nucleophilic O_(2)molecules,impeding further device efciency and stability.Here,in this study,a new additive of semicarbazide hydrochloride(SEM-HCl)with a N–C=O functional group was introduced into the perovskite precursor to fabricate high-quality flms with a low concentration of deep-level trap densities.This,in turn,serves to prevent undesirable interaction between photogenerated carriers and adsorbed oxygen molecules in the device’s operational environment,ultimately reducing the proliferation of superoxide entities.As the result,the SEM-HCl-derived devices show a peak efciency of 10.9%with improved device stability.These unencapsulated devices maintain almost 100%of their initial efciencies after working for 100 h under continuous AM1.5 illumination conditions. | Wenbo Jia Yi Jing Han Zhang Baoyan Tian Huabo Huang Changlei Wang Ligang Xu | 2023 | Frontiers of Optoelectronics2023，16，4： | 0 |
| 13 | Skin Retention Determination and Clinical Efficacy Evaluation of a Novel High Oil-Contained Hpr Transfersome Permeable Formulation显示文摘In order to increase the skin retention of HPR(Hydroxypinacone Retinoate),a novel high oil-contained HPR transfersome WL-HPR1130 was prepared.Conventional essence containing HPR was used as the control group,WL-HPR1130 essence was used as the experimental group,the skin retention of HPR were determined respectively.The anti-wrinkle efficacy of WL-HPR1130 essence was evaluated at the same time.The retention of HPR was 11.40μg/cm2 in the experimental group and 1.41μg/cm2 in the control group,which was 8.08 times higher than the control group.The wrinkles and fine lines were significantly reduced and smoothed after 2 and 4 weeks by experimental group sample.The average length,width and depth of wrinkles were decreased by 14.26%,18.31%,7.17%after 2 weeks,and were decreased by 29.39%,38.25%,8.60%after 4 weeks.The average length,width and depth of fine lines were decreased by 22.35%,12.60%,8.00%after 2 weeks,and were decreased by 27.10%,20.24%and 15.90%after 4 weeks,which has a significant visual changes.WLHPR1130,a novel high oil-contained HPR transfersome formulation,can significantly increase the retention of HPR in the skin.And the WL-HPR1130 essence have remarkable anti-wrinkle and smooth fine lines effects. | Wang Jiaqi Ma Chaolong Tian Meixiang Sun Changlei Gong Jinkang | 2022 | China Detergent & Cosmetics2022，7，4： | 0 |
| 14 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 15 | Flexible thermoelectric generator and energy management electronics powered by body heat显示文摘Uninterrupted,efficient power supplies have posed a significant hurdle to the ubiquitous adoption of wearable devices,despite their potential for revolutionizing human‒machine interactions.This challenge is further compounded by the requirement of these devices to supply dependable energy for data-intensive sensing and transmission.Traditional thermoelectric solutions fail to deliver satisfactory performance under conditions of extremely low voltages.Here,we present a novel solution of a wearable thermoelectric generator integrated with an energy management system,which is capable of powering sensors and Bluetooth by harnessing body heat.Distinct from previous works,our innovation lies in its ability to consistently operate even with a minimal temperature difference(i.e.,4 K)between the human skin and the ambient environment,ensuring reliable data transmission within a time as short as 1.6 s.Furthermore,our system can recharge utilizing body heat under ultralow voltage conditions(30 mV).Our developed system provides a novel pathway for the continuous,reliable monitoring of self-contained wearable devices without depending on batteries. | Shuai Yang Yumei Li Ling Deng Song Tian Ye Yao Fan Yang Changlei Feng Jun Dai Ping Wang Mingyuan Gao | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
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