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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Evaluation of characteristics of left-sided colorectal perfusion in elderly patients by angiography显示文摘BACKGROUND Handling of the inferior mesenteric artery(IMA)and maintaining anastomotic perfusion are important in radical resection of left-sided colorectal cancer.However,the branching of this artery and the drainage patterns of this vein vary among individuals,and the characteristics and perfusion region of this artery in elderly patients remain unclear.AIM To evaluate the characteristics and perfusion region of the IMA in elderly patients using angiography.METHODS We enrolled 154 patients(>65 years old)who underwent digital subtraction angiography of the IMA.The characteristics,bifurcation,and distribution of the IMA and termination of the anastomotic perfusion of the left colon and rectum were examined using digital subtraction angiography.Collateral arterial arches and the IMA hemoperfusion region were also recorded.Perfusion regions were cross-referenced with clinical and anatomical features by the univariate analysis.RESULTS Of 154 patients,25(16.2%)had IMA lesions.The left colic artery arose independently from the IMA in 44.2%of patients,shared a trunk with the sigmoid artery in 35.1%,shared an opening with the sigmoid and superior rectal arteries in 16.9%,and was absent in 5.1%.The IMA perfusion region stopped at the splenic flexure in 50(32.5%)patients.The collateral circulation existed in the colonic perfusion region,including the marginal artery(Drummond’s artery),the ascending branch of the left colonic artery to supply the transverse colon,and the arc of Riolan with a frequency of 100%,22.7%,and 1.9%,respectively.The IMA perfusion region was independently associated with the comorbidity of atherosclerosis,IMA atherosclerotic lesion,branching pattern,collateral circulation,and marginal artery integrity.CONCLUSION The IMA and its branches are prone to arteriosclerosis,and IMA perfusion may be interrupted at the splenic flexure in elderly patients.The applicability and precision of preoperative angiography for evaluating the IMA branching and perfusion patterns could facilitate geriatric laparoscopic left-sided colorectal cancer surgery with suspicion of poor IMA perfusion. | Chao Zhang Ang Li Tao Luo Yu Li Fei Li Jia Li | 2020 | World Journal of Gastroenterology2020，26，24： | 7 |
| 3 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 4 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 5 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 6 | All roads lead to Rome-a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease显示文摘Age-related neurodegenerative disorders such as Alzheimer’s disease(AD)have become a critical public health issue due to the significantly extended human lifespan,leading to considerable economic and social burdens.Traditional therapies for AD such as medicine and surgery remain ineffective,impractical,and expensive.Many studies have shown that a variety of bioactive substances released by physical exercise(called“exerkines”)help to maintain and improve the normal functions of the brain in terms of cognition,emotion,and psychomotor coordination.Increasing evidence suggests that exerkines may exert beneficial effects in AD as well.This review summarizes the neuroprotective effects of exerkines in AD,focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise.The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages,genders,and health conditions. | Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 7 | Experimental investigation on a cavity-step-actuated supersonic oscillating jet显示文摘Wind tunnel testing is conducted at different back pressures in a vacuum-type wind tunnel for a novel supersonic fluidic oscillator which consists of a two-dimensional Laval nozzle, a rectangular cavity and a backward step, to obtain its characteristics and the conditions for jet oscillating. The experimental results show that periodic asymmetrical flipping of the supersonic jet appears over certain nozzle pressure ratio(NPR) range according to schlieren visualization and pressure fluctuations. The jet flipping appears only when the jet is over expanded. The normalized average amplitude of the lateral pressure difference acting on the roofs of the cavity and the step varies around 0.2 while the periodic flipping appears. The supersonic jet periodic flipping frequencies obtained from the experiments agree well with those from the modified Rossiter mode for cavity-step acoustic resonance, but further investigations are needed to discover the underlying mechanism for the jet flipping. | Luo Xiaochen Sun Bo Wang Xiang'ang | 2017 | Chinese Journal of Aeronautics2017，30，1： | 2 |
| 8 | Determination of lincomycin residues in salmon tissues by gas chromatography with nitrogen- phosphorus detection显示文摘 | Luo W Yin B Ang C Y W | 1996 | J Chromatography B Biomed Appl1996，687，2： | 1 |
| 9 | Rapid method for the determination of ampicillin residues in animal muscle tissues by hish-performance liquid chromatography with fluorescence detection显示文摘 | Luo W Ang C Y Thompson H C Jr | 1997 | J Chromatogr B Biomed Sci Appl1997，694，2： | 1 |
| 10 | Upcycling of phosphogypsum waste for efficient zinc-ion batteries显示文摘Zinc metal is a promising anode material for next-generation aqueous batteries,but its practical application is limited by the formation of zinc dendrite.To prevent zinc dendrite growth,various Zn^(2+)-conducting but water-isolating solid-electrolyte interphase(SEI)films have been developed,however,the required high-purity chemical materials are extremely expensive.In this work,phosphogypsum(PG),an industrial byproduct produced from the phosphoric acid industry,is employed as a multifunctional protective layer to navigate uniform zinc deposition.Theoretical and experimental results demonstrate that PG-derived CaSO_(4)2H_(2)O can act as an artificial SEI layer to provide fast channels for Zn^(2+)transport.Moreover,CaSO_(4)2H_(2)O could release calcium ions(Ca^(2+))due to its relatively high Kspvalue,which have a higher binding energy than that of Zn^(2+)on the Zn surface,thus preferentially adsorbing to the tips of the protuberances to force zinc ions to nucleate at inert region.As a result,the Zn@PG anode achieves a high Coulombic efficiency of 99.5%during 500 cycles and long-time stability over 1000 hours at 1 m A cm^(-2).Our findings will not only construct a low-cost artificial SEI film for practical metal batteries,but also achieve a high-value utilization of phosphogypsum waste. | Huanwen Wang Can Luo Yinyin Qian Caihong Yang Xiaojun Shi Yansheng Gong Rui Wang Beibei He Jun Jin Aidong Tang Edison Huixiang Ang Huaming Yang | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 11 | Rapid determination of ampicillin in bovine milk by liquid chromatography with fluorescence detection显示文摘 | Ang C Y Luo W | 1997 | J AOAC Int1997，80，1： | 1 |
| 12 | Rapid determination of ampicillin in bovine milk by liquid chromatography with fluorescence detection显示文摘 | ANG C Y LUO W | 1997 | Journal of Aoac International1997，80，1： | 1 |
| 13 | Travelling-wave ther-moacoustic bigh-temperature heat pump for industrial waste heat re~covery 显示文摘 | Zhao Yang Yang Zhuo Luo Krt^ang | 2014 | Energy2014，77，1： | 1 |
| 14 | Effect of preform architecture on the mechanical properties of 2D C/C composites prepared using rapid directional diffused CVI processes 显示文摘 | Luo R Y Y ang C L Cheng J W | 2002 | Carbon2002，40，12： | 1 |
| 15 | Rapid determination of ampicillin in bovine milk by liquid chromatography with fluorescence detection显示文摘 | Ang CY Luo W | 1997 | J AOAC Int1997，80，1： | 1 |
| 16 | A bridging study between liquid chromatography and microbial inhibition assay method for determining amoxicillin residues in catfish muscle显示文摘 | Ang C Y W Luo W H Kiessling C R | 1998 | Journal of AOAC International1998，81，1： | 1 |
| 17 | Determination oflincomycin residues in salmon tissues by gas chromatography with nitrogen-phosphorus detection显示文摘 | LUO W YIN B ANG C Y | 1996 | Journal of Chromatography B:Biomedical Sciences and Applications1996，687，2： | 1 |
| 18 | Rapid method for the determination of ampicillin residues in animal muscle tissues by high-performance liquid chromatography with fluorescence detection显示文摘 | Luo W Ang C Y W Thompson Jr H C | 1997 | J Chromatogr B Biomed Sci Appli1997，694，2： | 1 |
| 19 | Simultaneous determination of Amoxicillin and Ampicillin in bovine milk by HPLC with Fluorescence detection显示文摘 | Luo W H Ang C Y W Deck J | 1997 | Journal of Agricultural and Food Chemistry1997，45，： | 1 |
| 20 | Deter-mination of lincomycin residues in salmon tissues by gaschromatography with nitrogen-phosphorus detection显示文摘 | LUO Wenhong YIN Binzhi ANG C Y W | 1996 | JChromatogr B:Biomed Appl1996，687，2： | 1 |
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