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| 1 | Key CO_(2)capture technology of pure oxygen exhaust gas combustion for syngas-fueled high-temperature fuel cells显示文摘Integrated gasification fuel cells(IGFCs)integrating high-temperature solid oxide fuel cell technology with CO_(2)capture processes represents highly-efficient power systems with negligible CO_(2)emissions.Flame burning with pure oxygen is an ideal method for fuel cell exhaust gas treatment,and this report describes experimental and numerical studies regarding an oxy-combustor for treating the exhaust gas of a 10 kW IGFC system anode.The applied simulation method was verified based on experiments,and the key performance indices of the combustor were studied under various conditions.It was determined that 315 K was the ideal condensation temperature to obtain flame stability.Under these pure oxygen flame burning conditions,CO was almost completely converted,and the dry mole fraction of CO_(2)after burning was C 0.958 when there was up to 5%excess O_(2).Overall,5%excess O_(2)was recommended to maximize CO_(2)capture and promote other environmental considerations.Additionally,the optimal tangential fuel jet angle to control the liner temperature was approximately 25°.The total fuel utilization had to be high enough to maintain the oxygen flame temperature of the anode exhaust gas below 1800 K to ensure that the system was environmentally friendly.The results presented herein have great value for designing IGFCs coupled with CO_(2)capture systems. | Hanlin Wang Qilong Lei Pingping Li Changlei Liu Yunpeng Xue Xuewei Zhang Chufu Li Zhibin Yang | 2021 | International Journal of Coal Science & Technology2021，8，3： | 3 |
| 2 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells显示文摘Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.In this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular endothelium.Results show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated apoptosis.These effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,BAPTA-AM.Blockade of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]i.Comparing to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell apoptosis.Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD.In summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and Orai1.Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases. | Kai Yang Shiyun Liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 2 |
| 3 | Spatial-temporal coverage optimiza- tion for wireless sensor networks显示文摘 | LIU Changlei CAO Guohong | 2011 | IEEE Transactions on Mobile Computing2011，10，5： | 1 |
| 4 | Numerical simulation on the distribution evolution of overburden fractured zone in coal mining and its visual detection显示文摘 | Zhao Tongbin Liu Changlei Xiao Ziyi | | 0，，： | 1 |
| 5 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 6 | Construction of NiCo_(2)O_(4) nanoflake arrays on cellulose-derived carbon nanofibers as a freestanding electrode for high-performance supercapacitors显示文摘Cellulose has a wide range of applications in many fields due to their naturally degradable and low-cost characteristics,but few studies can achieve cellulose-nanofibers by conventional electrospinning.Herein,we demonstrate that the freestanding cellulose-based carbon nanofibers are successfully obtained by a special design of electrospinning firstly,pre-oxidation and high-temperature carbonization(1600℃),which display a superior electrical conductivity of 31.2 S·cm^(-1)and larger specific surface area of 35.61 m^(2)·g^(-1)than that of the polyacrylonitrile-based carbon nanofibers(electrical conductivity of 18.5 S·cm^(-1),specific surface area of 12 m^(2)·g^(-1).The NiCo_(2)O_(4)nanoflake arrays are grown uniformly on the cellulose-based carbon nanofibers successfully by a facile one-step solvothermal and calcination method.The as-prepared cellulose-based carbon nanofibers/NiCo_(2)O_(4)nanoflake arrays are directly used as electrodes to achieve a high specific capacitance of 1010 F·g^(-1)at 1 A·g^(-1)and a good cycling stability with 90.84%capacitance retention after 3000 times at 10 A·g^(-1).Furthermore,the all-solid-state symmetric supercapacitors assembled from the cellulose-based carbon nanofibers/NiCo_(2)O_(4)deliver a high energy density of 62 W·h·kg(-1) at a power density of 1200 W·kg^(-1).Six all-solid-state symmetric supercapacitors in series can also power a‘DHU’logo consisted of 36 light emitting diodes,confirming that the cellulose-based carbon nanofiber is a promising carbon matrix material for energy storage devices. | Xuepeng Ni Kunming Li Changlei Li Qianqian Wu Chenglin Liu Huifang Chen Qilin Wu Anqi Ju | 2023 | Frontiers of Chemical Science and Engineering2023，17，6： | 0 |
| 7 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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