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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Assisted circulation using the TandemHeart during very high-risk PCI of the unprotected left main coronary artery in patients declined for CABG显示文摘 | Vranckx P Schultz CJ Eindhoven JA | | 0，，： | 1 |
| 3 | Current management of primary central nervous system lymphoma显示文摘 | Schultz CJ Bovi J | 2010 | Int J Radiat Oncol Biol Phys2010，76，3： | 1 |
| 4 | Current management of primary central nervous system lymphoma显示文摘 | Schultz CJ Bovi J | 2010 | Int J Radiat Oncol Biol Phys2010，76，3： | 1 |
| 5 | Assisted circulation using the Tandem Heart during very high-risk PCI of the unprotected left main coronary artery in patients declined for CABG显示文摘 | Vranckx P Schultz CJ Valgimigli M | 2009 | Catheter Cardiovasc Interv2009，74，2： | 1 |
| 6 | Current management of primary central nervous system lymphoma显示文摘 | Schultz CJ Bovi J | 2010 | Int J Radiat Oncol Biol Phys2010，76，3： | 1 |
| 7 | Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity显示文摘 | Deng M Williams CJ Schultz RM | 2005 | Dev Biol2005，278，2： | 1 |
| 8 | Werner′s syndrome a review of its symptomatology,natural history,pathologic features,genetics and relationship to the natural aging process显示文摘 | Epstein CJ Martin GM Schultz AL | 1966 | Medicine(Baltimore)1966，45，3： | 1 |
| 9 | Initial experience of FDG-PET-CT guided IMRT of head-and-neck carcinoma显示文摘 | Wang D Schultz CJ Jursinic PA | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 10 | Perilipins,ADRP,and other proteins that associate with intracellular neutral lipid droplets in animal cells显示文摘 | Londos C Brasaemle DL Schultz CJ | 1999 | Semin Cell Dev Biol1999，10，1： | 1 |
| 11 | Current management of primary central nervous system lymphoma显示文摘 | Schultz CJ Bovi J | 2010 | Int J Radiat Oncol Biol Phys2010，76，3： | 1 |
| 12 | The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion显示文摘 | Londos C Brasaemle DL Schultz CJ | 1999 | Semin Cell Dev Biol1999，，10： | 1 |
| 13 | On the control of lipolysis in adipocytes显示文摘 | Londos C Brasaemle DL Schultz CJ | 1999 | Ann NY Acad Sci1999，892，： | 1 |
| 14 | On the control of lipolysis in adipocytes 显示文摘 | Londos C Brasaemle DL Schultz CJ | 1999 | Ann NY Acad Sci1999，892，： | 1 |
| 15 | On the control of lipolysis in adipocytes 显示文摘 | Londos C Brasacmle DL Schultz CJ | 1999 | Ann N Y Acad Sci1999，892，： | 1 |
| 16 | On the control of lipolysis in adipocytes显示文摘 | Londos C Brasaemle DL Schultz CJ | 1999 | Ann N Y Acad Sci1999，892，： | 1 |
| 17 | Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis显示文摘 | Nuis RJ Van Mieghem NM Schultz CJ | | 0，，16： | 1 |
| 18 | Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis显示文摘 | Nuis RJ Van Mieghem NM Schultz CJ | 2011 | Eur Heart J2011，32，16： | 1 |
| 19 | Wemer's syndrome a review of its symptomatology,natural history,pathologic features,genetics and relationship to the natural aging process显示文摘 | EPSTEIN CJ MARTIN GM SCHULTZ AL MOTULSKY AG | 1966 | Medicine1966，45，3： | 1 |
| 20 | Microalbuminuria prevalence varies with age,sex and puberty in children with type 1 diabetes followed from diagnosis in longitudinal study显示文摘 | Schultz CJ Gale EAM Konopelska-Bahu T | 1999 | Diabetes Care1999，22，3： | 1 |
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