|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Environmental factors that control microbial perchlorate reduction 显示文摘 | Chaudhuri S K O' Conner S M Gustavson R L Achenbach L A Coates J D | 2002 | Applied and Environment Microbiology2002，68，9： | 1 |
| 3 | Mutation of nucleotide 1762 in the core promoter region during hepatitis B seroconversion and its relation to liver damage in HBeAg carriers显示文摘 | Gustavson C Mardbery K | 1998 | J Med Virol1998，55，2： | 1 |
| 4 | Precision Rotation Measurements with an Atom Interferometer Gyroscope显示文摘 | Bouyer P Kasevich M A | 1997 | Physical Review Letters1997，78，11： | 1 |
| 5 | Mutation of nu-cleotide 1762 in the core promoter region during hepatitis B seroconversion and its relation to liver damage in HBeAg car-riers显示文摘 | Gustavson C Mardbery K | 1998 | J Med Virol1998，55，2： | 1 |
| 6 | Rotation sensing with a dual atom-interferometer Sagnac gyroscope显示文摘 | Gustavson T L Landragin A Kasevich M A | 2000 | Classical and Quantum Gravity2000，17，12： | 1 |
| 7 | Rotation sensing with a dual atom interferometer sagnac gyroscope显示文摘 | Gustavson T L Landragin A Kasevich M A | | 0，，： | 1 |
| 8 | Rotationsensing with a dual atom-interferometer Sagnac gyroscope 显示文摘 | Gustavson T L Landragin A Kasevich M A | 2000 | Classical and Quantum Gravity2000，17，12： | 1 |
| 9 | Mutation of nucleotide 1762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in hepatitis B e antigen carriers显示文摘 | Lindh M Gustavson C Mardberg K | 1998 | J Med Viral1998，55，： | 1 |
| 10 | Limits to wind power utilization显示文摘 | M R Gustavson | 1979 | Science1979，204，： | 1 |
| 11 | Limits to wind Power utilization显示文摘 | Gustavson M R | 1979 | Science1979，204，： | 1 |
| 12 | Dispersion strengthened Co-Cr-Mo alloy for medical implants显示文摘 | WANG K K BERLIN R M GUSTAVSON L J | 1999 | ASTM Special Technical Publication1999，1365，： | 1 |
| 13 | Environmental factors that control microbial perchlorate reduction 显示文摘 | Chaudhuri S K Connor S M Gustavson R L | 2002 | Applied and Environmental Microbiology2002，68，12： | 1 |
| 14 | Precision rotation meas- urements with an atom interferometer gyroscope 显示文摘 | Gustavson T L Bouyer P Kasevich M A | 1997 | Physical Re- view Letters1997，78，11： | 1 |
| 15 | Rotation sensing with a dual atom-interferometer Sagnac gyroscope显示文摘 | Gustavson T L Landragin A Kasevich M A | 2000 | Classical Quant Grav2000，17，12： | 1 |
| 16 | Precision rotation measurements with an atom interferometer gyroscope显示文摘 | Gustavson T L Bouyer P Kasevich M A | 1997 | Phys RevLett1997，78，11： | 1 |
| 17 | Mutation of nucleotide 1762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damge in hepatitis B e antigen carriers显示文摘 | LINDH M GUSTAVSON C MARDBERG K | 1998 | J Med Viral1998，55，1： | 1 |
| 18 | Mutation of nucleotide 1762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in hepatitis B e antigen carriers显示文摘 | Lindh M Gustavson C Mardberg K | 1998 | J Med Virol1998，55，3： | 1 |
| 19 | Mutation of nucleotide 1,762 in the core promoter region during hepatitis Be seroconversion and its relation to liver damage in hepatitis Be antigen carriers显示文摘 | Lindh M Gustavson C Mardberg K | | 0，，： | 1 |
| 20 | Limits to wind power utilization显示文摘 | GUSTAVSON M R | 1979 | Science1979，24，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员