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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 3 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 4 | Evidence of Nonequilibr iumProcesses in Rapid Solidification of Undercooled metals显示文摘 | Willnecker R,Herlach D M,Feuerbacher B | 1989 | Phys Rev Lett1989，62，27： | 1 |
| 5 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 6 | Management of acute pancreatitis from surgery to interventional intensive care显示文摘 | Wemer J Feuerbach S Uhl W | 2005 | Gut2005，54，3： | 1 |
| 7 | Gamma-lactams--a novel scaffold for highly po- tent and selective α7 nicotinic acetylcholine receptor agonists 显示文摘 | ENZ A FEUERBACH D FREDERIKSEN M U | 2009 | Bioorg Med Chem Lett2009，19，5： | 1 |
| 8 | Superselective arterial embolisation with a liquid polyvinyl alcohol copolymer in patients with acute gastrointestinal haemorrhage显示文摘 | Markus Lenhart Christian Paetzel Michael Sackmann Hans Schneider Ernst Michael Jung Andreas G. Schreyer Stefan Feuerbach Niels Zorger | 2010 | European Radiology2010，，8： | 1 |
| 9 | Microstructure evolution of immiscible alloys during cooling through the micibility gap 显示文摘 | Zhao J Z Ratke L Feuerbacher B | 1998 | Model Simul Mater Sci Eng1998，，6： | 1 |
| 10 | Cloning,expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor显示文摘 | Feuerbach D Fehlmann D Nunn C | 2000 | Neuropharmacology2000，39，8： | 1 |
| 11 | Functional char- acterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors显示文摘 | Kalkman HO Feuerbach D Lotcher E | 2003 | Life Sci2003，73，9： | 1 |
| 12 | Pharmacological characterisation of the goldfish somatostatin sst5 receptor显示文摘 | Nunn C Feuerbach D Lin X | 2002 | Eur J Pharmacol2002，436，3： | 1 |
| 13 | The amyloid precursor-like protein 2 associates with the major histocompatibility complex class Ⅰ molecule K(d)显示文摘 | Sester M Feuerbach D Frank R | 2000 | J Biol Chem2000，275，5： | 1 |
| 14 | JN403, in vitro characterization of a novel nicotinic acetylcholine receptor or7 selective agonist 显示文摘 | FEUERBACH D NOZULAK J LINGENHOEHL K | 2007 | Neurosci Lett2007，416，1： | 1 |
| 15 | Management of acute panereatitis:from surgery to interventional intensive care显示文摘 | Werner J Feuerbach S Uhl W | 2005 | Gut2005，54，3： | 1 |
| 16 | Long-term follow-up of patients with necrotizing pancreatitis treated by percutaneous necrosectomy显示文摘 | Endlicher E Volk M Feuerbach S | 2003 | Hepatogastroenterology2003，50，54： | 1 |
| 17 | Novel type of dislocation observed in an Al-Pd-Mn quasicrystal approximant显示文摘 | Klein H Feuerbacher M Schall P Urban K | 1999 | Phys Rev Lett1999，82，： | 1 |
| 18 | Microstructure evolution of immiscible alloys during cooling through the miscibility gap显示文摘 | Zhao J Z Ratke L Feuerbacher B | 1998 | Modelling and Simulation in Materials Science and Engineering1998，6，2： | 1 |
| 19 | Evidence for a transition from to thermally controlled solidification in metallic alloys 显示文摘 | ECKLER K COCHRANE R F HERLACH D M FEUERBACHER B JURISCH M | 1992 | Physical Review B1992，45，： | 1 |
| 20 | Role of computed tomography and magnetic resonance imaging in the diagnosis of hepatitis and liver cirrhosis显示文摘 | Lenhart M Feuerbach S | 2005 | Schweiz Rundsch Med Prax2005，94，16： | 1 |
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