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| 1 | 中国大城市低收入邻里及其居民的贫困集聚度和贫困决定因素显示文摘基于2007年在中国6个大城市开展的大规模家庭户调查,采用FGT指数法和逻辑回归分析方法,探讨中国大城市低收入邻里及其居民的贫困集聚程度和决定因素。研究发现,老城衰败邻里的贫困集聚度最高,同时承受多重不利状况的下岗/失业人员的贫困集聚度也是最高;事实贫困、被剥夺感与社会福利分配之间存在不匹配现象。在贫困的决定因素方面,制度保障和市场薪酬对城市贫困的发生具有同等重要的作用,但对不同低收入邻里和不同社会群体又表现出不同的关联性。随着市场作用的加强,市场薪酬机制正在成为贫困产生的更为重要的决定性因素。 | 何深静 刘玉亭 吴缚龙 Chris Webster | 2010 | 地理学报2010，65，12： | 49 |
| 2 | 安徽石台县日本血吸虫病传染源调查显示文摘目的了解石台县血吸虫病传染源种类,指导当地防治工作。方法选择龙泉、垄上及源头3个流行村,开展人畜及野生动物的病原学查病,计算感染率及感染度。结果3个村感染日本血吸虫的宿主有人、狗、猫及野鼠,其中人感染率分别为0、1.01%和0.87%,野鼠和狗感染率分别在22.22~33.33%和4.35~26.47%。感染度以野鼠最高,达609.91(算术均数)和259.06(几何均数)。并在当地另一乡发现1只野兔感染血吸虫。结论当地血吸虫病流行可能与野鼠、狗等有关,但明确各种感染宿主在血吸虫病传播中的地位尚有待分子生物学研究。 | 吕大兵 汪天平 James Rudge 孙爱炎 方国仁 吴维铎 吴明耀 朱磊 汪峰峰 章乐生 操治国 Joanne Webster | 2007 | 热带病与寄生虫学2007，5，1： | 24 |
| 3 | Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations显示文摘Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EGFR. | Jill Wykosky Tim Fenton Frank Furnari Webster K. Cavenee | 2011 | Chinese Journal of Cancer2011，30，1： | 24 |
| 4 | The 2007 WHO Classification of Tumours of the Central Nervous System显示文摘 | David N. Louis Hiroko Ohgaki Otmar D. Wiestler Webster K. Cavenee Peter C. Burger Anne Jouvet Bernd W. Scheithauer Paul Kleihues | 2007 | Acta Neuropathologica2007，，2： | 13 |
| 5 | Fundamental motor skills,screen-time,and physical activity in preschoolers显示文摘Purpose: To examine the associations among preschoolers fundamental motor skills, screen-time, physical activity(PA), and sedentary behavior(SB).Methods: Children ages 3à4 years were enrolled in a prospective observational trial of PA. Trained assessors conducted the Test of Gross Motor Development-3 rd edition(TGMD-3), and the Movement Assessment Battery for Children-2 nd edition, and parent-reported child screen-time and sociodemographic information. Children wore an accelerometer for 7 days to examine SB and total PA(TPA). TPA was further characterized as moderateto-vigorous PA(MVPA) or vigorous PA(VPA). Mixed linear models were calculated, controlling for age(for TGMD-3), sex, household income, and accelerometer wear time(for accelerometry models), with childcare center as a random effect. The primary analysis reported on the cross-sectional baseline data of 126 children with complete fundamental motor skill and screen-time data; a subanalysis included 88 children with complete accelerometry data.Results: Children were 3.4 § 0.5 years of age(54% girls; 46% white, 42% African American, 12% other). A total of 48% lived in households at or below the federal poverty level. Children engaged in 5.1 § 3.6 h/day of screen-time. Children's screen-time was inversely related to the Movement Assessment Battery for Children-2 nd edition, manual dexterity skills percentile(b(SE) = ?1.7(0.8), p = 0.049). In the accelerometry subsample,children engaged in 5.9 § 0.9 h/day of TPA of which 1.7 § 0.6 h/day was MVPA. Boys engaged in more MVPA and VPA and less SB compared with girls(all p < 0.05). A higher TGMD-3, total score(b(SE) = 0.4(0.2), p = 0.017) and locomotor score(b(SE) = 0.7(0.3), p = 0.018) were associated with more VPA but not with TPA or MVPA. Screen-time and television in the bedroom were not related to SB, TPA, MVPA, or VPA.Conclusion: Children's motor skills were positively related to VPA but inversely related to screen-time. Further inquiry into the implications of high exposure to screen-time in young children is needed. | E.Kipling Webster Corby K.Martin Amanda E.Staiano | 2019 | Journal of Sport and Health Science2019，8，2： | 12 |
| 6 | Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance显示文摘Glioblastoma(GBM) is one of the most lethal human cancers. Genomic analyses define the molecular architecture of GBM and highlight a central function for mechanistic target of rapamycin(m TOR) signaling. m TOR kinase exists in two multiprotein complexes, namely, m TORC1 and m TORC2. These complexes differ in terms of function, regulation and rapamycin sensitivity. m TORC1 is well established as a cancer drug target, whereas the functions of m TORC2 in cancer, including GBM, remains poorly understood. This study reviews the recent findings that demonstrate a central function of m TORC2 in regulating tumor growth, metabolic reprogramming, and targeted therapy resistance in GBM, which makes m TORC2 as a critical GBM drug target. | Si-Han Wu Jun-Feng Bi Timothy Cloughesy Webster K.Cavenee Paul S.Mischel | 2014 | Cancer Biology & Medicine2014，11，4： | 4 |
| 7 | Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms显示文摘 | George J.M. Webster Stephanie Reignat Mala K. Maini Simon A. Whalley Graham S. Ogg Abigail King David Brown Peter L. Amlot Roger Williams Diego Vergani Geoffrey M. Dusheiko Antonio Bertoletti | 2000 | Hepatology2000，，5： | 4 |
| 8 | 辩驳和城市规划实践的科学理论基础显示文摘基于近期的个人经历,反思城市规划理论基础的现状,并建议对其方法论进行彻底修正。呼吁规划研究需要更严谨、更连续和更协作。当前的规划研究通常被描绘成对实务操作人员无关紧要,不能融会贯通地利用其他更具科学性的学科的大量现存研究成果来协助规划师们解决可持续、健康和经济发展等问题,几乎没有持续的知识积累,缺乏具有普遍意义的科学发现,很少有成功构建的理论,并且很可能包括过多的伪理论。指出城市规划依然是并将始终是一种根本上的文艺复兴活动。但它可以也应该是指导城市建设的领袖性学科,不过现在还急需科学复兴。 | Chris Webster 唐韵雯 汪轶溟 | 2013 | 城市规划学刊2013，，3： | 4 |
| 9 | Competition in remanufacturing and the effects of government subsidies显示文摘 | Supriya Mitra Scott Webster | 2007 | International Journal of Production Economics2007，，2： | 3 |
| 10 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 11 | Chemical and behavioral analysis of the cuticular hydrocarbons from Asian citrus psyllid, Diaphorina citri显示文摘Huanglongbing (HLB ) 是世界范围的柠檬的最破坏的疾病。亚洲柠檬 psyllid, Diaphorina citri Kuwayama (半翅类:Psyllidae ) ,住在韧皮部的细菌的向量, Candidatus Liberibacter asiaticus,它被假定在佛罗里达引起 HLB 柠檬。实验室和领域研究被进行检验男、女的 D 的行为的回答。citri 到他们的表皮的摘录。在 olfactometer 试金,更多的男 D。citri 比空白的控制被吸引到一,五,或 10 个女表皮的摘录等价物单位。结果在清楚或黄的陷井在引诱了, 10 个女表皮的摘录等价物单位吸引了的领域研究被证实成比例地更多的男性与男表皮的摘录或 unbaited 陷井比清楚的陷井引诱了。男、女的 D 的表皮的成分的分析。citri 在他们的表皮的摘录的化学作文揭示了性之间的差别。有从表皮的摘录识别的合成化学药品的实验室生物鉴定显示 dodecanoic 酸比干净空气吸引了更多的男性。与 dodecanoic 酸引诱的陷井没增加 D 的全部的钩子。作为与空白相比,在剂量的陷井测试了的 citri;然而, psyllid 钩子的性比率是在与装载测试的剂量(10.0 mg ) 的最高的诱惑引诱的陷井上偏导的男性。 | Rajinder S. Mann Russell L. Rouseff Jack Smoot Nandikeswara Rao Wendy L. Meyer Stephen L. Lapointe Paul S. Robbins Dong Cha Charles E. Linn Francis X. Webster Siddharth Tiwari Lukasz L. Stelinski | 2013 | Insect Science2013，20，3： | 3 |
| 12 | 功能及语篇结构的标注和可视化:基于协作性云计算平台的实现显示文摘本文针对目前标注工具在标注功能和语法篇章方面的不足,提出一个基于云计算平台的协作性标注框架。该框架充分发挥协作性平台的特性,建构于强大的数据库结构基础上,在标注过程中对功能和语篇信息提供即时可视化呈现,有望解决当前功能语料库标注的一部分难题,并为计算机辅助语言学习和教学作出一定贡献。 | 严恒斌 Jonathan Webster | 2011 | 北京科技大学学报(社会科学版)2011，27，4： | 3 |
| 13 | Green-Naghdi Theory,Part A:Green-Naghdi(GN) Equations for Shallow Water Waves显示文摘In this work,Green-Naghdi (GN) equations with general weight functions were derived in a simple way. A wave-absorbing beach was also considered in the general GN equations. A numerical solution for a level higher than 4 was not feasible in the past with the original GN equations. The GN equations for shallow water waves were simplified here, which make the application of high level (higher than 4) equations feasible. The linear dispersion relationships of the first seven levels were presented. The accuracy of dispersion relationships increased as the level increased. Level 7 GN equations are capable of simulating waves out to wave number times depth . Numerical simulation of nonlinear water waves was performed by use of Level 5 and 7 GN equations, which will be presented in the next paper. | William C. Webster Wenyang Duan Binbin Zhao | 2011 | Journal of Marine Science and Application2011，10，3： | 3 |
| 14 | Proteomic composition of the acrostyle" Novel approaches to identify cuticular proteins involved in virus-insect interactions显示文摘 | Craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest | 2017 | Insect Science2017，24，6： | 3 |
| 15 | Competition in remanufacturing and the effects of government subsidies显示文摘 | Supriya Mitra Scott Webster | 2007 | International Journal of Production Economics2007，，2： | 3 |
| 16 | Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks显示文摘Receptor tyrosine kinases(RTKs)such as the epidermal growth factor receptor(EGFR)regulate cellular homeostatic processes.EGFR activates downstream signaling cascades that promote tumor cell survival,proliferation and migration.Dysregulation of EGFR signaling as a consequence of overexpression,amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes.Consequently,concerted efforts have been mounted to develop therapeutic agents and strategies to effectively inhibit EGFR.However,limited therapeutic benefits to cancer patients have been derived from EGFR-targeted therapies.A well-documented obstacle to improved patient survival is the presence of EGFR-inhibitor resistant tumor cell variants within heterogeneous tumor cell masses.Here,we summarize the mechanisms by which tumors resist EGFR-targeted therapies and highlight the emerging role of microRNAs(miRs)as downstream effector molecules utilized by EGFR to promote tumor initiation,progression and that play a role in resistance to EGFR inhibitors.We also examine evidence supporting the utility of miRs as predictors of response to targeted therapies and novel therapeutic agents to circumvent EGFR-inhibitor resistance mechanisms. | German G.Gomez Jill Wykosky Ciro Zanca Frank B.Furnari Webster K.Cavenee | 2013 | Cancer Biology & Medicine2013，10，4： | 3 |
| 17 | Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants 显示文摘 | Gubareva L V Webster R G Hayden F G | 2001 | Antimicrob Agents Chemother2001，45，12： | 2 |
| 18 | Molecular genetic analysis of von Hippel-Lindau disease显示文摘 | Richards FM Webster AR McMahon R | 1998 | J Intern Med1998，243，： | 2 |
| 19 | In vitro assessment of individual and interactive effects of aromatic hydrocarbons on embroyonic development of the rat显示文摘 | Brown-Woodman PDC Webster WS Picker K | 1994 | Reprod Toxicol1994，8，： | 2 |
| 20 | 游客原真性感知与世界遗产资源原真性内涵集合式关系研究(英文)显示文摘游客原真性感知对于世界遗产资源的未来发展具有重要价值。本文基于原真性学说针对游客感知与世界遗产资源旅游发展内涵之间的关系进行了探讨。通过对世界遗产故宫博物院实证研究的结果表明:数学集合理论模型能够很好地模拟游客原真性感知与遗产资源发展内涵之间的内在联系,继而5种集合式关系被建立起来,即'相离关系'、'相交关系'、'包含关系I'、'包含关系II'和'重合关系'。根据调查样本的分配规律5种集合式关系可以被进一步分为主要集合式关系和次要集合式关系。使用双因素方差分析法从被调研游客的人口统计学特征(性别、年龄、受教育程度、游览频率和已有感知程度)出发,针对集合式关系进行研究的结果进一步显示:游客对于5种集合式关系类别的感知具有差异性。本论文研究成果对于基于原真性视角下的世界遗产资源发展成效评判以及从游客原真性感知出发提出世界遗产资源发展未来策略均具有实际意义。 | 陈享尔 蔡建明 杨振山 Natasha WEBSTER | 2014 | Journal of Resources and Ecology2014，5，1： | 2 |
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