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		题名	作者	年代	出处	被引量
	1	Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations显示文摘Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EGFR.	Jill Wykosky Tim Fenton Frank Furnari Webster K. Cavenee	2011	Chinese Journal of Cancer2011，30，1：	24
	2	Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma显示文摘	Matthias Lechner Tim Fenton James West	2013	Genome Med2013，5，2：	1
	3	Functions and regulation of the 70<ce:hsp sp='0.25'/>kDa ribosomal S6 kinases显示文摘	Tim R. Fenton Ivan T. Gout	2010	International Journal of Biochemistry and Cell Biology2010，，1：	1

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