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| 1 | The contribution of Chinese exports to climate change显示文摘 | Christopher L. Weber Glen P. Peters Dabo Guan Klaus Hubacek | 2008 | Energy Policy2008，，9： | 4 |
| 2 | Noninvasive model including right ventricular speckle tracking for the evaluation of pulmonary hypertension显示文摘AIM To find parameters from transthorathic echocardiography(TTE) including speckle-tracking(ST) analysis of the right ventricle(RV) to identify precapillary pulmonary hypertension(PH).METHODS Forty-four patients with suspected PH undergoing right heart catheterization(RHC) were consecutively included(mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction(LVEF) was calculated by Simpsons rule from 4Ch. Systolic pulmonary artery pressure(s PAP) was assessed with continuous wave Doppler of systolic tricuspid regurgitant velocity and regarded raised with values ≥ 30 mmH g as a surrogate parameter for RA pressure. A concomitantly elevated PCWP was considered a means to discriminate between the precapillary and postcapillary form of PH. PCWP was considered elevated when the E/e' ratio was > 12 as a surrogate for LV diastolic pressure. E/e' ratio was measured by gauging systolic and diastolic velocities of the lateral and septal mitral valve annulus using TDI mode. The results were then averaged with conventional measurement of mitral valve inflow. Furthermore, functional testing with six minutes walking distance(6MWD), ECG-RV stress signs, NT pro-BNP and other laboratory values were assessed.RESULTS PH was confirmed in 34 patients(precapillary PH, n = 15, postcapillary PH, n = 19). TTE showed significant differences in E/e' ratio(precapillary PH: 12.3 ± 4.4, postcapillary PH: 17.3 ± 10.3, no PH: 12.1 ± 4.5, P = 0.02), LV volumes(ESV: 25.0 ± 15.0 mL, 49.9 ± 29.5 m L, 32.2 ± 13.6 m L, P = 0.027; EDV: 73.6 ± 24.0 mL, 110.6 ± 31.8 mL, 87.8 ± 33.0 mL, P = 0.021) and systolic pulmonary arterial pressure(sP AP: 61.2 ± 22.3 mm Hg, 53.6 ± 20.1 mm Hg, 31.2 ± 24.6 mm Hg, P = 0.001). STRV analysis showed significant differences for apical RV longitudinal strain(RVAS: -7.5% ± 5.6%, -13.3% ± 4.3%, -14.3% ± 6.3%, P = 0.03). NT pro-BNP was higher in patients with postcapillary PH(4677.0 ± 7764.1 pg/m L, precapillary PH: 1980.3 ± 3432.1 pg/mL, no PH: 367.5 ± 420.4 pg/mL, P = 0.03). Patients with precapillary PH presented significantly more often with ECG RV-stress signs(P = 0.001). Receiver operating characteristics curve analyses displayed the most significant area under the curve(AUC) for RVAS(cut-off < -6.5%, AUC 0.91, P < 0.001), sPAP(cut-off > 33 mmH g, AUC 0.86, P < 0.001) and ECG RV stress signs(AUC 0.83, P < 0.001). The combination of these parameters had a sensitivity of 82.8% and a specificity of 17.2% to detect precapillary PH. CONCLUSION The combination of non-invasive measurements allows feasible assessment of PH and seems beneficial for the differentiation between the pre- and postcapillary form of this disease. | Yossra Mahran Robert Schueler Marcel Weber Carmen Pizarro Georg Nickenig Dirk Skowasch Christoph Hammerstingl | 2016 | World Journal of Cardiology2016，8，8： | 4 |
| 3 | The role of information and financial reporting in corporate governance and debt contracting显示文摘 | Christopher S. Armstrong Wayne R. Guay Joseph P. Weber | 2010 | Journal of Accounting and Economics2010，，2： | 4 |
| 4 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 5 | The effects of 12 weeks of functional strength training on muscle strength,volume and activity upon exposure to elevated Gz forces in high-performance aircraft personnel显示文摘Background:Technological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel,including inducing neck and back pain.The purpose of this study was to examine the effects of 12 weeks of functional strength training on 1)the volume and strength of the neck and shoulder muscles and 2)muscular activity upon exposure to helmets of different masses and elevated Gz forces in a long-arm centrifuge in high-performance aircraft personnel.Methods:Eighteen participants underwent 12 weeks of functional strength training(n=12)or the control protocol(n=6)without additional strength training.Pre-and post-intervention tests included evaluations of isometric strength of the head extensor muscles,flexion,and lateral flexion and rotation,as well as magnetic resonance imaging(MRI)to measure the volume of the m.sternocleidomastoideus,m.trapezius,and deep neck muscles.Furthermore,during a long-arm centrifuge(+1.4 and+3Gz)protocol,the muscular activity levels of the m.sternocleidomastoideus,m.trapezius and m.erector spinae muscles were assessed without a flight helmet,with a helmet,and with a helmet and night vision goggles.Each participant’s perception of muscular strain was noted immediately after the long-arm centrifuge protocol.Results:The maximal isometric strength in all exercises and muscle volumes increased in the training group but not the control group(P<0.05).Relative muscle activity(%MVC)with a helmet decreased after the intervention in the training but not the control group(P=0.01).Relative muscle activity while wearing a helmet and night vision goggles was higher after intervention in the control group than in the training group(P<0.01).The perceived muscular strain of the neck muscles induced by the long-arm centrifuge did not differ between the groups.Conclusions:Twelve weeks of functional strength training improves the maximal isometric strength and volume of neck and shoulder muscles and leads to lower relative muscle activation upon exposure to elevated Gz forces in a long-arm centrifuge. | Monika Rausch Frank Weber Sven Kühn Carla Ledderhos Christoph Zinner Billy Sperlich | 2021 | Military Medical Research2021，8，4： | 4 |
| 6 | Treatment strategies for proximal femur fractures in osteoporotic patients显示文摘 | Felix Bonnaire Henry Zenker Christoph Lill Andreas T. Weber Berend Linke | 2005 | Osteoporosis International2005，，2： | 2 |
| 7 | The drivers of Chinese CO 2 emissions from 1980 to 2030显示文摘 | Dabo Guan Klaus Hubacek Christopher L. Weber Glen P. Peters David M. Reiner | 2008 | Global Environmental Change2008，，4： | 2 |
| 8 | Modelling lifestyle effects on energy demand and related emissions显示文摘 | Christoph Weber Adriaan Perrels | 2000 | Energy Policy2000，，8： | 2 |
| 9 | Medium and Long-term Outcomes After Pneumatic Dilation or Laparoscopic Heller Myotomy for Achalasia: A Meta-analysis显示文摘 | Cynthia E. Weber Christopher S. Davis Holly J. Kramer Jeff T. Gibbs Lourdes Robles Piero Marco Fisichella | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，4： | 1 |
| 10 | Modelling Lifestyle Effects on Energy Demand and Related Emissions显示文摘 | Weber Christoph Perrels Adrlaan | 2000 | Energy Policy2000，，28： | 1 |
| 11 | The drivers of Chinese CO2 emissions from 1980 to 2030显示文摘 | Guan Dabo Hubacek Klaus Weber Christopher L | 2008 | Global Environmental Change2008，18，： | 1 |
| 12 | Modelling lifestyle effects on energy demand and related emissions显示文摘 | Christoph Weber Adriaan Perrels | | 0，，： | 1 |
| 13 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 14 | The contribution of Chinese exports to climate change显示文摘 | Weber Christopher L Peters Glen P Da B Guan | 2008 | Energy Policy2008，，36： | 1 |
| 15 | Tight Junction Pore and Leak Pathways: A Dynamic Duo显示文摘 | Le Shen Christopher R. Weber David R. Raleigh Dan Yu Jerrold R. Turner | 2011 | Annual Review of Physiology2011，，： | 1 |
| 16 | Quantifying the global and dis- tributional aspects of American household carbon footprint 显示文摘 | Christopher L Weber H S | 2008 | Ecological Economics2008，，66： | 1 |
| 17 | The Contribution of Chinese Export to Climate Change显示文摘 | Christophe L Weber Glen P Peters Dabo Guan | 2008 | Energy Policy2008，，36： | 1 |
| 18 | Modelling lifestyle effects on energy demand and related emissions 显示文摘 | WEBER CHRISTOPH ADRIAAN PERRELS | 2000 | Energy Policy2000，28，8： | 1 |
| 19 | Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene显示文摘 | Christophe M. Olinger Bernard Weber Jesse A. Otegbayo Wim Ammerlaan Natascha Taelem-Brulé Claude P. Muller | 2007 | Medical Microbiology and Immunology2007，，4： | 1 |
| 20 | The drivers of Chinese CO 2 emissions from 1980 to 2030显示文摘 | Dabo Guan Klaus Hubacek Christopher L. Weber Glen P. Peters David M. Reiner | 2008 | Global Environmental Change2008，，4： | 1 |
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