|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Roles of TGF-β family signaling in stem cell renewal and differentiation显示文摘转变生长因素(TGF )- 尾 s 和他们的家庭成员,包括骨头形态基因的蛋白质(BMP ) ,节并且 activins,在各种各样的器官,干细胞在起重要作用的发展和维护被含有。干细胞被他们自我更新的能力描绘并且区分了特别纸巾的房间产生,并且被分类进胚胎、体的干细胞。胚胎的茎(ES ) 房间自我更新无止境地并且贡献所有三主要细菌层的衍生物。相反,体的干细胞,能在各种各样的成年机关被识别,在大多数情况中为自强和区别展出有限能力。ES 房间和体的干细胞的多系区别能力为基因、恶意、退化的疾病为房间代替治疗打开了可能性。以便为治疗学的应用利用干细胞,理解调整干细胞的自强和区别的外来、内在的因素是必要的。更最近,导致了 pluripotent 茎(iPS ) 细胞从经由四个抄写因素的宫外的表示类似于 ES 细胞的老鼠和人的成纤维细胞被产生了。iPS 房间可以在再生药有一个优点,自从他们克服 immunogenicity 和 ES 房间的道德的争吵。而且,最近的研究在癌症,包括的白血病, glioma,和乳癌的各种各样的类型的形成和前进期间加亮癌症干细胞的参与。这里,我们在 ES 房间,体的干细胞,和癌症干细胞的维护和区别说明 TGF- 尾家庭成员的角色。 | Tetsuro Watabe Kohei Miyazono | 2009 | Cell Research2009，19，1： | 50 |
| 2 | The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage显示文摘在应力之上,肿瘤 suppressor p53 的水平显著地被提高,是众所周知的。然而尽管有广泛的研究,包含的内在的机制重要为导致压力的 p53 规定内部播放器仍然不充分被理解。我们人的 lincRNA-RoR (RoR ) 是 p53 的一个强壮的否定管理者的现在的证据。不同于通过 ubiquitin-proteasome 小径引起 p53 降级的 MDM2, RoR 通过和异构的原子 ribonucleoprotein 的直接相互作用压制 p53 翻译我(hnRNP 我) 。重要地,带 hnRNP 的一个 28 底 RoR 序列我有约束力的主题为 p53 压抑必要、足够。我们进一步证明 RoR 禁止调停 p53 的房间周期拘捕和 apoptosis。最后,我们表明 p53 transcriptionally 导致 RoR 表示的一个 RoR-p53 自动调整的反馈环。一起,这些结果建议 RoR-hnRNP I-p53 轴可以组成一个另外的监视网络让房间更好对各种各样的压力作出回应。 | Ali Zhang Nanjiang Zhou Jianguo Huang Qian Liu Koji Fukuda Ding Ma Zhaohui Lu Cunxue Bai Kounosuke Watabe Yin-Yuan Mo | 2013 | Cell Research2013，23，3： | 47 |
| 3 | 幽门螺杆菌抗体与血清胃蛋白酶原水平联合预测胃癌的发生:一项前瞻性内镜队列研究 | Watabe H. Mitsushima T. Yamaji Y. 成虹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，9： | 8 |
| 4 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 5 | Risk factors for small bowel angioectasia:The impact of visceral fat accumulation显示文摘AIM: To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.METHODS: We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding(OGIB) from January 2009 to September 2013. The visceral fat area(VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records.Logistic regression analysis was used to evaluate associations.RESULTS: Capsule endoscopy revealed small bowel angioectasia in 18/198(9.1%) patients with OGIB.Compared to patients without small bowel angioectasia,those with small bowel angioectasia had a significantly higher VFA(96 ± 76.0 cm2 vs 63.4 ±51.5 cm2, P = 0.016) and a higher prevalence of liver cirrhosis(61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia(22% vs 9%,P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio(OR) for each 10-cm2 increment = 1.1; [95% confidence interval(CI):1.02-1.19; P = 0.021] and liver cirrhosis(OR = 6.1,95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.CONCLUSION: VFA is positively associated with theprevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. | Atsuo Yamada Ryota Niikura Yuka Kobayashi Hirobumi Suzuki Shuntaro Yoshida Hirotsugu Watabe Yutaka Yamaji Yoshihiro Hirata Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，23： | 4 |
| 6 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 7 | Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study显示文摘AIM: To elucidate the association between small bowel diseases(SBDs) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHODS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative FOBT.RESULTS: CE revealed SBDs in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more days before CE(43% vs 25%, P = 0.20).CONCLUSION: The present study suggests that positive FOBT may be useful for predicting SBDs in patients with occult OGIB. Positive FOBT indicates higher likelihood of ulcers or tumors in patients with occult OGIB. Undergoing CE within a day after FOBT achieved a higher diagnostic yield for patients with occult OGIB. | Yuka Kobayashi Hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，1： | 2 |
| 8 | Adiponectin Inhibits Murine Pancreatic Cancer Growth显示文摘 | Motohiko Kato Kenji Watabe Masahiko Tsujii Tohru Funahashi Iichiro Shimomura Tetsuo Takehara | 2014 | Digestive Diseases and Sciences2014，，6： | 2 |
| 9 | CBF/CBV maps in normal volunteers studied with ^(15)O PET:a possible index of cerebral perfusion pressure显示文摘Local cerebral perfusion pressure(CPP) is a primary factor controlling cerebral circulation and previous studies have indicated that the ratio of cerebral blood flow(CBF) to cerebral blood volume(CBV) can be used as an index of the local CPP. In this study,we investigated whether the CBF/CBV ratio differs among different brain structures under physiological conditions, by means of O positron emission tomography. Nine healthy volunteers(5 men and 4women, mean age,47.0 ±1.2 years) were studied by H2 O bolus injection for CBF measurement and by C O inhalation for CBV measurement. The CBF/CBV ratio maps were created by dividing the CBF images by the CBV images after anatomical normalization.Regions of interest were placed on the CBF/CBV maps and comparing the regions. The mean CBF/CBV ratio was highest in the cerebellum(19.3 ± 5.2/min)' followed by the putamen(18.2 士 3.9), pons(16_4 土 4.6)' thalamus(14.5 土 3.3), cerebral cortices(13.2 土 2.4), and centrum semiovale(11.5 土 2.1).The cerebellum and putamen showed significantly higher CBF/CBV ratios than the cerebral cortices and centrum semiovale. We created maps of the CBF/CBV ratio in normal volunteers and demonstrated higher CBF/CBV ratios in the cerebellum and putamen than in the cerebral cortices and deep cerebral white matter. The CBF/CBV may reflect the local CPP and should be studied in hemodynamically compromised patients and in patients with risk factors for small-artery diseases of the brain. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 2 |
| 10 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada Takafumi Sugimoto Shintaro Kondo Miki Ohta Hirotsugu Watabe Shin Maeda Goichi Togo Yutaka Yamaji Keiji Ogura Makoto Okamoto Haruhiko Yoshida Takao Kawabe Tateo Kawase Masao Omata | 2008 | Diseases of the Colon & Rectum2008，，1： | 2 |
| 11 | The association between arteriosclerosis related diseases and diverticular bleeding显示文摘 | Tomoko Okamoto Hirotsugu Watabe Atsuo Yamada Yoshihiro Hirata Haruhiko Yoshida Kazuhiko Koike | 2012 | International Journal of Colorectal Disease2012，，9： | 2 |
| 12 | Experimental Studies on Debris Flow with Logs Focusing on Specific Weight Difference of Log Species显示文摘There are many experimental approaches,field investigations and numerical calculations for movements of woods in a clear water and debris flow.However,kinematic conditions for accumulated logs and the interactions between a main flow and logs have not been fully evaluated.Mitigations for woods need taking into account the characteristics of tree species such as conifer and broad-leaf trees and of shapes such as root swells and crown.In the present study,we focus on the differences in specific weight of conifer and broad-leaf trees with some moisture in a sediment-water mixture flow with narrow flow width,and consider that conifer and broad-leaf tree are floating and submerged solid phase,respectively.Flume tests are conducted in steady flow of clear and debris flow over a rigid bed in order to evaluate conifer and broad-leaf tree movement in clear water and debris flow.Experimental data indicates that dimensionless transverse diffusion coefficient can be 0.1 to 0.4 and 0.3 to 0.9 in flow direction.Those diffusive characteristics seem to be independent of Reynolds number and Froude number,but dependent of bed slope,i.e.,gravity,though detailed considerations are needed to discuss about flow characteristics such as spatial eddy structures,momentum transfer induced by interactions of logs and so on. | Haruki WATABE Takahiro ITOH Kazuhiko KAITSUKA Shigeki NISHIMURA | 2013 | Journal of Mountain Science2013，10，2： | 2 |
| 13 | Combined anterior and posterior instrumentation in severe fracture-dislocation of the lower cervical spine with help of navigation:a case report显示文摘 | Mizuno J Nakgawa H Watabe T | 2001 | J Clin Neurosci2001，8，5： | 1 |
| 14 | Monoclonal antibody raised against tetrodonic acid, a derivative of tetrodotoxin 显示文摘 | watabe S sato Y Nakayama M | 1989 | toxicon1989，27，2： | 1 |
| 15 | Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer显示文摘 | Reiter RE Gu Z Watabe T | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，4： | 1 |
| 16 | Reactive astrocytes promote the metastatic growth of breast cancer stem‐like cells by activating Notch signalling in brain显示文摘 | Fei Xing Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Andrew Wilber Yin‐Yuan Mo Brian E. Moore Wen Liu Koji Fukuda Megumi Iiizumi Sambad Sharma Yin Liu Kerui Wu Elizabeth Peralta Kounosuke Watabe | 2013 | EMBO Mol Med2013，，3： | 1 |
| 17 | Manual expression and electric breast pumping in the first 48 h after delivery 显示文摘 | Ohyama M Watabe H Hayasaka Y | 2010 | Pediatrics International2010，52，1： | 1 |
| 18 | Temperature-dependency of rigor-mortis of fish muscle: MyofibrillarMg2+-ATPase activity and Ca2+ uptake by sarcoplasmicreticulum显示文摘 | Watabe S Ushio H Iwamoto M | 1989 | Journal of Food Science1989，54，12： | 1 |
| 19 | Disturbed gastrointes-tinal motility and decreased interstitial cells of Cajal in diabeticdb/db mice 显示文摘 | Yamamoto T Watabe K Nakahara M | 2008 | J Gastroenterol Hepatol2008，23，4： | 1 |
| 20 | Use of porous hydroxyapatite graft containing recombinant human bone morphogenetic protein-2 for cervical fusion in a caprine model显示文摘 | TAKAHASHI T TOMINAGA T WATABE N | 1999 | J Neurosurg1999，90，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员