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| 1 | Metallothionein:An overview显示文摘Metallothioneins (MTs) were discovered in 1957 by Margoshes and Vallee and identified as low-molecular weight and sulphydryl rich proteins. It is not surprising that most mammalian tissues contain age related basal levels of MTs since they are involved in metalloregulatory processes that include cell growth and multiplication. In an effort to understand the biology of this intriguing tumor, various biomarkers such as oncogenes, p53 tumor suppressor gene, waf 1 protein, proliferating cell nuclear antigen, telomerase, microsatellite markers and cytogenetic changes have been examined. One biomarker which has recently shown to be expressed in various human tumors but still less reported in carcinoma is MT. Immunohistochemical detection of MT proteins in cold acetone-fixed paraffin embedded liver sections was performed by the streptavidin-avidin-biotin immuno- peroxidase complex method. | N Thirumoorthy KT Manisenthil Kumar A Shyam Sundar L Panayappan Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 3 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 4 | Current focus of stem cell application in retinal repair显示文摘The relevance of retinal diseases, both in society's economy and in the quality of people's life who suffer with them, has made stem cell therapy an interesting topic forresearch. Embryonic stem cells(ESCs), induced pluripotent stem cells(i PSCs) and adipose derived mesenchymal stem cells(ADMSCs) are the focus in current endeavors as a source of different retinal cells, such as photoreceptors and retinal pigment epithelial cells. The aim is to apply them for cell replacement as an option for treating retinal diseases which so far are untreatable in their advanced stage. ESCs, despite the great potential for differentiation, have the dangerous risk of teratoma formation as well as ethical issues, which must be resolved before starting a clinical trial. i PSCs, like ESCs, are able to differentiate in to several types of retinal cells. However, the process to get them for personalized cell therapy has a high cost in terms of time and money. Researchers are working to resolve this since i PSCs seem to be a realistic option for treating retinal diseases. ADMSCs have the advantage that the procedures to obtain them are easier. Despite advancements in stem cell application, there are still several challenges that need to be overcome before transferring the research results to clinical application. This paper reviews recent research achievements of the applications of these three types of stem cells as well as clinical trials currently based on them. | Maria L Alonso-Alonso Girish Kumar Srivastava | 2015 | World Journal of Stem Cells2015，7，3： | 8 |
| 5 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 6 | Perspectives of pluripotent stem cells in livestock显示文摘The recent progress in derivation of pluripotent stem cells(PSCs)from farm animals opens new approaches not only for reproduction,genetic engineering,treatment and conservation of these species,but also for screening novel drugs for their efficacy and toxicity,and modelling of human diseases.Initial attempts to derive PSCs from the inner cell mass of blastocyst stages in farm animals were largely unsuccessful as either the cells survived for only a few passages,or lost their cellular potency;indicating that the protocols which allowed the derivation of murine or human embryonic stem(ES)cells were not sufficient to support the maintenance of ES cells from farm animals.This scenario changed by the innovation of induced pluripotency and by the development of the 3 inhibitor culture conditions to support naïve pluripotency in ES cells from livestock species.However,the long-term culture of livestock PSCs while maintaining the full pluripotency is still challenging,and requires further refinements.Here,we review the current achievements in the derivation of PSCs from farm animals,and discuss the potential application areas. | Dharmendra Kumar Thirumala R Talluri Naresh L Selokar Iqbal Hyder Wilfried A Ku | 2021 | World Journal of Stem Cells2021，13，1： | 4 |
| 7 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 8 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 9 | 米糠油同时脱胶脱蜡物理精炼新技术显示文摘对米糠油同时脱胶脱蜡物理精炼新工艺进行了小试研究,并在此基础上进行了生产试验。毛米糠油与氯化钙水溶液混合,在低温下结晶(20℃)使水化磷脂和非水化磷脂与蜡一起沉析分离,随后进行脱色和冬化(20℃)处理,进一步将磷脂含量降到5mg/kg以下,再经物理精炼,即可使成品精炼米糠油满足市售商品对其色泽(10~12罗维朋值,25.4mm槽)、游离脂肪酸含量(〈0.25%)和浊点(4~5℃)的要求;且中性油损失少。米糠油含有多种生物活性物质,如谷维素,VE和甾醇。本工艺可在最终产品中保留80%以上的生物活性物质。 | Rajam L Soban Kumar D R Sundaresan A Arumughan C 武丽荣(译) | 2006 | 中国油脂2006，31，7： | 3 |
| 10 | Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma显示文摘瞄准:评估牛角属 procera 的弄干的乳胶(DL ) 的反癌症性质,热带药用的植物,在肝细胞癌并且到的 X15-myc 转基因的老鼠模型阐明它在房间文化的行动的机制。方法:小转基因的老鼠口头上地为 15 wk 用 DL (为 5 d/wk 的 400 mg/kg ) 的水的暂停被喂,他们的肝在 20 wk 为组织病理学说的变化被检验。脉管的内皮生长因素(VEGF ) 的浆液层次也在这些动物被测量。描绘活跃部分, DL 被提取,石油醚由甲醇列在后面。methanolic 摘录是用非极、极的溶剂的联合的硅胶 G 列上的亚 fractionated,十一部分被获得。每部分用 tetrazolium (MTT ) 在肝细胞瘤(Huh7 )(AML12 ) 和 non-hepatoma (COS-1 ) 房间行和非转变的 hepatocytes 上为细胞毒素的效果被分析试金。最后,细胞死亡的机制被测量 Bcl2 的层次调查, caspase 3 并且 DNA 破碎。结果:老鼠的 DL 处理对 hepatocarcinogenesis 显示出完全的保护。没有不利效果在这些动物被观察。浆液 VEGF 水平显著地作为与对照动物相比在对待的老鼠被降低。当 AML12 房间被节省时,房间文化研究表明 methanolic 在 Huh-7 和 COS-1 房间 DL 以及它的部分提取 8 导致的广泛的细胞死亡。这被 DNA 的广泛的破碎在 Huh-7 和 COS-1 房间伴随。在象 Bcl2 和 caspase 那样的 apoptosis 的正规标记的层次的没有变化 3 被观察。结论:C 的 DL。procera 与 apoptosis 的常规小径由于它的可辨的目标和不干涉为反癌症治疗有潜力。 | Tenzin Choedon Ganeshan Mathan Soneera Arya Vijay L Kumar Vijay Kumar | 2006 | World Journal of Gastroenterology2006，12，16： | 3 |
| 11 | A novel stereoselective synthesis of(Z)-3-Iodo-3-alken-1-one from 2-alkyn-1-one显示文摘 | Luo F T Kumar K A Hsich L C | 1994 | Tetrahedron Lett1994，36，16： | 3 |
| 12 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 13 | Artificial neural network based peak load forecasting using conjugate gradient methods显示文摘 | Mohan Saiti L Kumar Soni M | 2002 | IEEE Trans on Power Systems2002，17，3： | 2 |
| 14 | N-methyl-D-aspartate receptors: Transient loss of nr1/nr2a/nr2b subunits after traumatic brain injury in a rodentmodel显示文摘 | KUMAR A ZOU L YUAN X | 2002 | Neurosci Res2002，67，6： | 1 |
| 15 | Adsorption and desorption characteristics of hydrophobic pesticide endosulfan in four Indian soils 显示文摘 | Kumar M Philip L | 2006 | Chemosphere2006，62，7： | 1 |
| 16 | Comparative analysis of genetic diversity among Indian populations of Scirpophaga incertulas by ISSR-PCR and RAPD-PCR显示文摘 | Kumar L S Sawant A S Gupta V S | 2001 | Biochem Genet2001，39，： | 1 |
| 17 | Assessing Reseller Performance from the Perspective of the Supplier显示文摘 | KUMAR N STERN L W ACHROL R S | 1992 | Journal of Marketing Research1992，29，5： | 1 |
| 18 | Changes in soil nutrient content and enzymatic activity under conventional and zero-tillage practices in an Indian sandy clay loam soil 显示文摘 | MINA B L SAHA S KUMAR N | 2008 | Nutrient cycling in Agroecosystems2008，82，： | 1 |
| 19 | Graft copolymerization of acrylonitrilc onto Cassia tora gum with eerie ammonium nitrate - nitricaeid as a redox initiator显示文摘 | Sharma B R Kumar V Soni P L | 2003 | Journal of Applied Polymer Science2003，，1： | 1 |
| 20 | Flexible energy storage devices based on nanocomposite paper显示文摘 | Victor L Pushparaj Manikoth M Shaijumon Ashavani Kumar | 2007 | PNAS2007，104，13： | 1 |
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