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| 1 | Global and Regional Surface Nitrogen Balances in Intensive Agricultural Production Systems for the Period 1970-2030显示文摘Global nitrogen (N) budgets for intensive agricultural systems were compiled for a 0.5 by 0.5 degree resolution. These budgets include N inputs (N fertilizer, animal manure, biological N fixation and atmospheric N deposition) and outputs (N removal from the field in harvested crops and grass and grass consumption by grazing animals, ammonia volatilization,denitrification and leaching). Data for the historical years 1970 and 1995 and a projection for 2030 were used to study changes in the recovery of N and the different loss terms for intensive agricultural systems. The results indicate that the overall system N recovery and fertilizer use efficiency slowly increased in the industrialized countries between 1970 and 1995, the values for developing countries have decreased in the same period. For the coming three decades our results indicate a rapid increase in both the industrialized and developing countries. High values of > 80% for fertilizer use efficiency may be related to surface N balance deficits, implying a depletion of soil N and loss of soil fertility. The projected intensification in most developing countries will cause a gradual shift from deficits to surpluses in the coming decades.The projected fast growth of crop and livestock production, and intensification and associated increase in fertilizer inputs will cause a major increase in the surface N balance surplus in the coming three decades. This implies increasing losses of N compounds to air (ammonia, nitrous oxide and nitric oxide), and groundwater and surface water (nitrate). | A. F. BOUWMAN G.Van DRECHT K. W. Van der HOEK | 2005 | Pedosphere2005，15，2： | 17 |
| 2 | Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner显示文摘AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain reaction.OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines.OPN expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture.Huh-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth.Expression of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and immunohistochemistry.RESULTS:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B and-C.OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue.Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium.Transfer of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner.Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect.OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative effect.CONCLUSION:This study demonstrates that OPN plays a significant role in the proliferation of HCC through interaction with the cell surface receptor CD44.Modulation of this interaction could represent a novel strategy for the control of HCC. | Renee J Phillips Karla J Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard | 2012 | World Journal of Gastroenterology2012，18，26： | 12 |
| 3 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 4 | Nucleoside plus nucleotide analogs and cessation of hepatitis B immunoglobulin after liver transplantation in chronic hepatitis B is safe and effective显示文摘 | D.J.W. Wesdorp M. Knoester A.E. Braat M.J. Coenraad A.C.T.M. Vossen E.C.J. Claas B. van Hoek | 2013 | Journal of Clinical Virology2013，，： | 7 |
| 5 | Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study显示文摘 | Francesco U.S. Mattace-Raso Tischa J.M. van der Cammen Albert Hofman Nicole M. van Popele Michiel L. Bos Maarten A.D.H. Schalekamp Roland Asmar Robert S. Reneman Arnold P.G. Hoeks Monique M.B. Breteler Jacqueline C.M. Witteman | 2006 | Circulation2006，，5： | 2 |
| 6 | Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity显示文摘 | M.‐C. Kleinegris M. H. A. Bos M. Roest Y. Henskens A. Cate‐Hoek C. Van Deursen H. M. H. Spronk P. H. Reitsma P. G. De Groot H. Cate G. Koek | 2014 | J Thromb Haemost2014，，10： | 2 |
| 7 | Protein energy malnutrition predicts complications in liver cirrhosis显示文摘 | Ellen J. Huisman Evelien J. Trip Peter D. Siersema Bart van Hoek Karel J. van Erpecum | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 2 |
| 8 | Toward Carbon-Neutral Water Systems:Insights from Global Cities显示文摘Many cities have pledged to achieve carbon neutrality.The urban water industry can also contribute its share to a carbon-neutral future.Using a multi-city time-series analysis approach,this study aims to assess the progress and lessons learned from the greenhouse gas(GHG)emissions management of urban water systems in four global cities:Amsterdam,Melbourne,New York City,and Tokyo.These cities are advanced in setting GHG emissions reduction targets and reporting GHG emissions in their water industries.All four cities have reduced the GHG emissions in their water industries,compared with those from more than a decade ago(i.e.,the latest three-year moving averages are 13%–32%lower),although the emissions have“rebounded”multiple times over the years.The emissions reductions were mainly due to various engineering opportunities such as solar and mini-hydro power generation,biogas valorization,sludge digestion and incineration optimization,and aeration system optimization.These cities have recognized the many challenges in reaching carbon-neutrality goals,which include fluctuating water demand and rainfall,more carbon-intensive flood-prevention and water-supply strategies,meeting new air and water quality standards,and revising GHG emissions accounting methods.This study has also shown that it is difficult for the water industry to achieve carbon neutrality on its own.A collaborative approach with other sectors is needed when aiming toward the city’s carbon-neutrality goal.Such an approach involves expanding the usual system boundary of the water industry to externally tap into both engineering and non-engineering opportunities. | Ka Leung Lam Gang Liu Anne Marieke Motelica-Wagenaar Jan Peter van der Hoek | 2022 | Engineering2022，8，7： | 2 |
| 9 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 10 | Risk factors for infection after liver transplantation显示文摘 | Bart van Hoek Bert-Jan de Rooij Hein W. Verspaget | 2012 | Best Practice & Research Clinical Gastroenterology2012，，1： | 2 |
| 11 | Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Occlusion and Cavernous Transformation显示文摘 | Alexandra Wils Edwin van der Linden Bart van Hoek Peter M.T. Pattynama | 2009 | Journal of Clinical Gastroenterology2009，，10： | 2 |
| 12 | A prototype web-based analysis platform for drought monitoring and early warning显示文摘It has long been recognized that an effective drought monitoring and early warning system,which provides functions for real-time condition monitoring and prediction,risk assessment,information dissemination and response recommendation,is very important for the preparedness for and mitigation of drought impacts.In this article,we review the currently existing drought monitor and early warning systems,discuss applicable remote sensing datasets and drought indicators and present the development of a web-based quasi-real-time Global Drought Monitoring&Analysis Platform(Web-GDMAP).The Web-GDMAP is built upon a series of indicators derived from multi-source satellite remote sensing data and various other sources of data.From a technical perspective,the Web-GDMAP system includes a series of components from data storage,model implementation and distribution,to client-side visualization and user intuitive interaction.From a theoretical perspective,the Web-GDMAP system integrates multi-indicators on different aspects of drought,including anomalies in precipitation,anomalies in land surface thermal and vegetation conditions,water deficit of soil and plants,etc.Several case studies on applying the developed Web-GDMAP in the Asian region are demonstrated.Further improvements and perspectives are discussed. | Mattijn van Hoek Jie Zhou Li Jia Jing Lu Chaolei Zheng Guangcheng Hu Massimo Menenti | 2020 | International Journal of Digital Earth2020，13，7： | 2 |
| 13 | The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘 | J P van der Hoek J A M H Hofman A Graveland | 1999 | Water Science and Technology1999，40，9： | 1 |
| 14 | The contribution of performance measurement to the expansion of third party logistics alliances in the supply chain显示文摘 | | 2001 | International Journal of Operations & Production Management2001，21，12： | 1 |
| 15 | An RBP4 promoter polymorphism increases risk of type 2 diabetes显示文摘 | van Hoek M Dehghan A Zillikens MC | 2008 | Diabetologia2008，51，8： | 1 |
| 16 | Limitations of Doppler spectral broadening in the early detection of carotid artery disease due to the size of the sample volume显示文摘 | van Merode T Hick P Hoeks AP | 1983 | Ultrasound Med Biol1983，9，6： | 1 |
| 17 | Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review 显示文摘 | van Hoek I Daminet S | 2009 | Gen Comp Endocrinol2009，160，3： | 1 |
| 18 | 显示文摘 | Cheng A van Hoek AN Yenger M | 1997 | Nature1997，387，： | 1 |
| 19 | The rediscovery of postponement a literature review and directions for research 显示文摘 | RI van Hoek | 2001 | Journal of Operations Management2001，，19： | 1 |
| 20 | A general fractional white noise theory and applications to finance显示文摘 | Robert Elliot J John Van Der Hoek | 2003 | Mathematical Finance2003，13，2： | 1 |
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