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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Patient comfort and quality in colonoscopy显示文摘AIM: To explore the relationship of patient comfort and experience to commonly used performance indicators for colonoscopy. METHODS: All colonoscopies performed in our four endoscopy centres are recorded in two reporting systems that log key performance indicators. From 2008 to 2011, all procedures performed by qualified endoscopists were evaluated; procedures performed by trainees were excluded. The following variables were measured: Caecal intubation rate (CIR), nurse-reported comfort levels (NRCL) on a scale from 1 to 5, polyp detection rate (PDR), patient experience of the procedure (worse than expected, as expected, better than expected), and use of sedation and analgesia. Pearson' s correlation coefficient was used to identify relationships between performance indicators.RESULTS: A total of 17027 colonoscopies were performed by 23 independent endoscopists between 2008 and 2011. Caecal intubation rate varied from 79.0% to 97.8%, with 18 out of 23 endoscopists achieving a CIR of > 90%. The percentage of patients experiencing significant discomfort during their procedure (defined as NRCL of 4 or 5) ranged from 3.9% to 19.2% with an average of 7.7%. CIR was negatively correlated with NRCL-45 (r=-0.61, P < 0.005), and with poor patient experience (r=-0.54, P < 0.01). The average dose of midazolam (mean 1.9 mg, with a range of 1.1 to 3.5 mg) given by the endoscopist was negatively correlated with CIR (r=-0.59, P < 0.01). CIR was positively correlated with PDR (r=0.44, P < 0.05), and with the numbers of procedures performed by the endoscopists (r=0.64, P < 0.01). CONCLUSION: The best colonoscopists have a higher CIR, use less sedation, cause less discomfort and find more polyps. Measuring patient comfort is valuable in monitoring performance. | Vivian E Ekkelenkamp Kevin Dowler Roland M Valori Paul Dunckley | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 3 | The Global Rating Scale in clinical practice: A comprehensive quality assurance programme for endoscopy departments显示文摘 | Jerome Sint Nicolaas Vincent de Jonge Robert A. de Man Frank ter Borg Djuna L. Cahen Willem Moolenaar Mark F.J. Stolk Antonie J.P. van Tilburg Roland M. Valori Monique E. van Leerdam Ernst J. Kuipers | 2012 | Digestive and Liver Disease2012，，11： | 1 |
| 4 | Abdominoperineal resection: laparoscopie versus conventional显示文摘 | Ramos JR Petrosemolo RH Valory EA | 1997 | Surg Laparosc Endosc1997，7，2： | 1 |
| 5 | Systemic delivery of scAAV9 ex- pressing SMN prolongs survival in a model of spinal muscular atrophy 显示文摘 | Valori CF Ning K Wyles M | 2010 | Sci Transl Med2010，2，35： | 1 |
| 6 | Promoting medical tourism to India:Messages,images,and the marketing of international patient travel显示文摘 | Valorie A | | 0，，05： | 1 |
| 7 | PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons显示文摘 | Ning K Drepper C Valori CF | 2010 | Hum Mol Genet2010，16，： | 1 |
| 8 | Apolipoprotein E Polymorphism and Age at Onset of Alzheimer’s Disease in a Quadriethnic Sample显示文摘 | Kwon Oh Dae Khaleeq Aisha Chan Wenyaw Pavlik Valory N Doody Rachelle S | 2011 | Dementia and Geriatric Cognitive Disorders2011，，6： | 1 |
| 9 | Abdminoperineal re- section: laparoscopic versus conventional 显示文摘 | Enker JR Petrosemolo RH Valory EA | 2007 | Surg Laparosc Eng dosc2007，132，7： | 1 |
| 10 | Interleukin 10 Deficiency Exacerbates Toll-Like Receptor 3–Induced Preeclampsia-Like Symptoms in Mice显示文摘 | Piyali Chatterjee Valorie L. Chiasson Shelley E. Kopriva Kristina J. Young Victor Chatterjee Kathleen A. Jones Brett M. Mitchell | 2011 | Hypertension2011，，3： | 1 |
| 11 | Development and applications of non-HIV-based lentiviral vectors in neurological disorders 显示文摘 | Valori C F Ning K Wyles M | 2008 | Curr Gene Ther2008，8，6： | 1 |
| 12 | E-S-QUAL:A Multipleitem Scale for Assessing Electronic Service Quality 显示文摘 | Parasuraman A Valorie A Zeithaml Arving Malhotra | 2005 | Journal of Service Research2005，7，3： | 1 |
| 13 | Focal degeneration of astrocytes in amyotrophic lateral sclerosis显示文摘 | Rossi D Brambilla L Valori CF | 2008 | Cell Death&Differentiation2008，15，11： | 1 |
| 14 | Abdomino perineal resection:laparoscopic versus conventional显示文摘 | Ramos J R Petrosemolo R H Valory E A | 1997 | Surg LaparoscEndosc1997，7，2： | 1 |
| 15 | Life-Threatening Tumors of the Heart in Fetal and Postnatal Age显示文摘 | Angela Pucci Gianni Botta Noemi Sina Maria Tibaldi Andrea Valori Enrico Grosso Andrea Zonta Mauro Giudici Gabriella Agnoletti Laura Bergamasco Pietro A. Abbruzzese Giovanni Bartoloni | 2012 | The Journal of Pediatrics2012，，： | 1 |
| 16 | On the interpretation of 1H 2-dimensional NMR relaxation exchange spectra in cements: Is there exchange between pores with two characteristic sizes or Fe3+ concentrations? 显示文摘 | VALORI A RODIN V MCDONALD P J | 2010 | Cem Concr Res2010，40，13： | 1 |
| 17 | Absence of effects of Ketanserin on renal prostacyclin and thromboxane A2 in essential hypertension显示文摘 | GAMBINI G ROSSI S VALORI C | 1991 | Eur Heart J1991，12，4： | 1 |
| 18 | Effects of different types of stress and of 'prokinetic' drugs on the control of the tasting motor complex in humans显示文摘 | Valori RM Kumar D Wingate DL | | 0，，06： | 1 |
| 19 | Nonlinar effects in a discrete - time dynamic model of a stock market 显示文摘 | Valori V | 2000 | Chaos Solitons and Fractal2000，11，： | 1 |
| 20 | Exploring the altered daily geographies and lifeworlds of women living with fibromyalgia syndrome: A mixed-method approach显示文摘 | Valorie A. Crooks | 2006 | Social Science & Medicine2006，，3： | 1 |
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