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| 1 | Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica显示文摘Aquaporin-4 (AQP4 ) 是在整个中央神经系统在星形细胞,以及在肾,肺,胃和骨胳的肌肉表示的水选择的 transporter。二 AQP4 isoforms 由其他的 spicing, M1 和 M23 AQP4 生产了,形式 heterotetramers 在称为粒子(OAP ) 的直角的数组的超分子的结构集合在房间血浆膜。AQP4 空的老鼠的显型分析在大脑和针的绳索水显示 AQP4 的参与平衡,星形细胞迁居,神经信号 transduction 和 neuroinflammation。AQP4 空的老鼠表明减少的大脑在细胞毒素的服的浮肿,但是增加的大脑在 vasogenic 浮肿和脑水肿胀大胀大。AQP4 缺乏也增加抓住持续时间,损害 glial 结疤,并且减少自体免疫的 neuroinflammation 的严厉。每这些显型根据在 AQP4 缺乏的减少的星形细胞水渗透是多半可解释的。AQP4 也涉及 neuroinflammatory demyelinating 疾病 neuromyelitis optica (NMO ) ,在指向 AQP4 的自身抗体(NMO-IgG ) 生产星形细胞损坏和发炎的地方。管理 NMO-IgG 和人由 intracerebral 注射补充的老鼠与 neuroinflammation, demyelination, perivascular 补充免职和 glial fibrillary 的损失开发典型 NMO 损害酸的蛋白质和 AQP4 immunoreactivity。我们的调查结果建议基于 AQP4 的治疗学的潜在的实用程序包括为大脑胀大,损害和癫痫的治疗的 AQP4 水运输功能的小分子的调节的人,以及小分子或对为 NMO 的治疗的 AQP4 有约束力的 NMO-IgG 的 monoclonal 抗体 blockers。 | Alan S VERKMAN Julien RATELADE Andrea ROSSI Hua ZHANG Lukmanee TRADTRANTIP | 2011 | Acta Pharmacologica Sinica2011，32，6： | 17 |
| 2 | Therapeutic options for the management of pancreatic cancer显示文摘Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause of death in the United States, resulting in an estimated 38460 deaths annually. With few screening tools available to detect this disease at an early stage, 94% of patients will die within five years of diagnosis. Despite decades of research that have led to a better understanding of the molecular and cellular signaling pathways in pancreatic cancer cells, few effective therapies have been developed to target these pathways. Other treatment options have included more sophisticated pancreatic cancer surgeries and combination therapies. While outcomes have improved modestly for these patients, more effective treatmentsare desperately needed. One of the greatest challenges in the future of treating this malignancy will be to develop therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cells in addition to pancreatic cancer cells. Recent advances in targeting pancreatic stellate cells and the stroma have encouraged researchers to shift their focus to the role of desmoplasia in pancreatic cancer pathobiology in the hopes of developing newer-generation therapies. By combining novel agents with current cytotoxic chemotherapies and radiation therapy and personalizing them to each patient based on specific biomarkers, the goal of prolonging a patient's life could be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential of therapeutic options. | Maria L Rossi Azeem A Rehman Christopher S Gondi | 2014 | World Journal of Gastroenterology2014，20，32： | 13 |
| 3 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 4 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 5 | A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat 显示文摘 | Cioli V Putzolu S Rossi V | 1980 | Toxicol Appl Pharmacol1980，54，2： | 2 |
| 6 | Chemoresisrant myeloma: phase Ⅱ clinical study with low dose thalidomide plus high-dose dexamethasone显示文摘 | BERNARDESCHI P DENTICO P ROSSI S | 2004 | Chemother2004，16，5： | 1 |
| 7 | Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-repeffusion injury: involvement of cytokine/chemokines and PMN 显示文摘 | Di Filippo C Rossi F Rossi S | 2004 | J Leukoc Biol2004，75，3： | 1 |
| 8 | Numberof lymph nodemetastases and its prognostic significance in early gastric cancer: multicenter Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg Oncol2006，94，4： | 1 |
| 9 | Critical temperatures for xylogenesis in conifers of cold climates显示文摘 | Rossi S Deslauries A Gricar J | 2008 | Glob Ecol Biogeogr2008，17，6： | 1 |
| 10 | (Ti,Cr)N and Ti/TiN PVD coatings on 304 stainless steel substrates: texture and resid- ual stress显示文摘 | LEONI M SCARDI P ROSSI S | 1999 | Thin Solid Films1999，345，2： | 1 |
| 11 | Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode显示文摘 | ROSSI S BUSCARINI E GARBAGNATI F | 1998 | AJR1998，170，4： | 1 |
| 12 | Gastrointestinal stromal tumors: from a surgical to a molecular approach 显示文摘 | Rossi CR Mocellin S Mencarelli R | 2003 | Int J Cancer2003，107，2： | 1 |
| 13 | Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer显示文摘 | Rossi A Ciafre S Balsamo M | 2006 | Cancer Res2006，66，15： | 1 |
| 14 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid显示文摘 | Rossi M Goggin F L Milligan S B | 1995 | Proceedings of the National Academy of Sciences USA1995，95，： | 1 |
| 15 | Selective oxidation of D-glucose on gold catalyst显示文摘 | Biella S Prati L Rossi M | 2002 | Journal of catalysis2002，206，2： | 1 |
| 16 | Utility of the immunohis-tochemieal detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody 显示文摘 | Rossi S Orvieto E Fudanetto A | 2004 | Mod Pathol2004，17，： | 1 |
| 17 | Circulating tumor cells: the ' leukemic phase' of solid cancers显示文摘 | Mocellin S Keilholz U Rossi CR | 2006 | Trends Mol Med2006，12，3： | 1 |
| 18 | Omega-3 polyunsaturated fatty acid from extruded linseed influences the fatty acid composition and sensory characteristics of dry-cured ham form heavy pigs显示文摘 | Musella M Cannata S Rossi R | 2009 | J Anim Sci2009，87，： | 1 |
| 19 | l Percutaneous radio-frequency interstitial thermal ablation in the treatment ofsmall hepatocellular carcinoma显示文摘 | Rossi S D iStasi M Buscarini E et a | 2005 | Cancer J Sci Am2005，，1： | 1 |
| 20 | Efficacy and safety of once- weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，23： | 1 |
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