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| 1 | Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells显示文摘Objective:To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline(TG)for reducing the H_2O_2induced toxicity in H9c2 cells.Methods:Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX kit.RNA extraction and cDNA synthesized according to the kit manufacture protocol.Apoptosis was measured by the Flowcytometry,general PCR and qPCR.Results:It was found that the TG significantly rescued the morphology of the H9c2 cells.Treatment of cells with TG attenuated H_2O_2 induced cell deaths and improved the antioxidant activity.In addition,TG regulated the apoptotic gene caspase-3,caspase-9 and anti-apoptotic gene Bcl-2.Bcl-XL during H_2O_2 induced oxidative stress in H9c2 cells.These results were comparable with quercetin treatment.For evident,flow cytometer results also confirmed the TG significantly reduced the H_2O_2 induced necrosis and apoptosis in H9c2 cells.However,further increment of TG concentration against H_2O_2 could induce the necrosis and apoptosis along with H_2O_2.Conclusions:It is suggested that less than 125μM of TG could protect the cells from H_2O_2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL expression.Therefore,we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future. | Soundharrajan Ilavenil Da Hye Kim Young-Il Jeong Mariadhas Valan Arasu Mayakrishnan Vijayakumar Ponnuraj Nagendra Prabhu Srisesharam Srigopalram Ki Choon Choi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，4： | 6 |
| 2 | Characterization and phylogenetic analysis of novel polyene type antimicrobial metabolite producing actinomycetes from marine sediments:Bay of Bengal India显示文摘Objective:To isolate and indentify the promising antimicrobial metabolite producing Streptomyces strains from marine sediment samples from Andraprudesh coast of India.Methods:Antagonistic aetinomycetes were isolated by starch casein agar medium and modified nutrient agar medium with 1%glucose used as a base for primary screening.Significant antimicrobial metabolite producing strains were selected and identified by using biochemical and 16S rDNA level.Minimum inhibitory concentrations of the organic extracts were done by using broth micro dilution method.Results:Among the 210 actinomyeetes,64.3%exhibited activity against Gram positive bacteria,48.5%showed activity towards Cram negative bacteria,38.8%exhibited both Cram positive and negative bacteria and 80.85%isolates revealed significant antifungal activity.However,five isolates AP-5,AP-18,AP-41 and AP-70 showed significant antimicrobial activity.The analysis of cell wall hydrolysates showed the presence of LL-diaminopimelic acid and glycine in all the isolates.Sequencing analysis indicated that the isolates shared 98.5%-99.8%sequence identity to the 16S rDNA gene sequences of the Streptomyces taxons.The antimicrobial substances were extracted using hexane and ethyl acetate from spent medium in which strains were cultivated at 30X for five days.The antimicrobial activity was assessed using broth micro dilution technique.Each of the culture extracts from these five strains showed a typical polyenelike property.The lowest minimum inhibitory concentrations of ethyl acetate extracts against Escherichia coli and Cumularia lunula were 67.5 and 125.0μg/mL,respectively.Conclusions:It can be concluded that hexane and ethyl acetate soluble extracellular products of novel isolates are effective against pathogenic bacteria and fungi. | Valan Arasu M Asha KRT Duraipandiyan V Ignacimuthu S Agastian P | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 3 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 4 | Influence of different LED lamps on the production of phenolic compounds in common and Tartary buckwheat sprouts显示文摘 | Sang-Won Lee Jeong Min Seo Min-Ki Lee Jin-Hyuk Chun Paulrayer Antonisamy Mariadhas Valan Arasu Tatsuro Suzuki Naif Abdullah Al-Dhabi Sun-Ju Kim | 2014 | Industrial Crops & Products2014，，： | 2 |
| 5 | Antimicrobial activity of Streptomyces spp. ERI-26 recovered from Western Ghats of Tamil Nadu显示文摘 | M. Valan Arasu V. Duraipandiyan P. Agastian S. Ignacimuthu | 2008 | Journal de Mycologie Médicale2008，，3： | 2 |
| 6 | The effect of posterior bridging of C-1 on craniovertebra! junction surgery 显示文摘 | Senoglu M Gtim~valan Y Ytiksel KZ | 2006 | J Neurosurg Spine2006，5，1： | 1 |
| 7 | Meth- odology of physical-activity and energy-expenditure as- sessment: a review显示文摘 | Valanou E M Bamia C Trichopoulou A | 2006 | Journal of Public Health2006，14，2： | 1 |
| 8 | In vitro antimicrobial activity of Streptomyces spp. ERI-3 isolated from Western Ghats rock soil (India)显示文摘 | M. Valan Arasu V. Duraipandiyan P. Agastian S. Ignacimuthu | 2008 | Journal de Mycologie Médicale2008，，1： | 1 |
| 9 | Numerical study on melting of paraffin wax with Al203 in a square enclosure 显示文摘 | VALAN A A MUJUMDAR A S | 2012 | International Communications in Heat and Mass Transfer2012，39，1： | 1 |
| 10 | Inhibition of matrix met- alloproteinase by chemically modified tetracyclines in sepsis 显示文摘 | Maitra S R Bhaduri S Valane P D | 2003 | Shack2003，20，3： | 1 |
| 11 | 显示文摘 | Allcock H R Kugel R L Valan K J | 1966 | Inorganic Chemistry1966，5，10： | 1 |
| 12 | Microwave dielectric properties of CaTiO3-NdAlO3 ceramics 显示文摘 | Jancar B Suvorov D Valan M | 2001 | J Mater Sci Let2001，20，： | 1 |
| 13 | Phosphonitrilic compounds VI : high molecular weight poly(alkoxy-and aryloxyphosphazenes) 显示文摘 | Allcock H R Kugel R L Valan K J | 1966 | Inorganic Chemistry1966，5，10： | 1 |
| 14 | Inhibition of matrix metallopro- teinases by chemically modified tetracyclines in sepsis 显示文摘 | Maitra SR Bhaduri S Valane PD | 2003 | Shock2003，20，3： | 1 |
| 15 | Methodology of physical activity and energy- expenditure assessment: a review显示文摘 | VALANOU E M BAMIA C TRICHOPOULOU A | 2006 | J Public Health2006，14，2： | 1 |
| 16 | FPGA based multilevel cascaded inverters with SVPWM algorithm for photovoltaic system显示文摘 | M. Valan Rajkumar P.S. Manoharan | 2013 | Solar Energy2013，，： | 1 |
| 17 | Accuracy and reliability of buccal bone height and thickness measurements from cone-beam computed tomography imaging显示文摘 | Timock AM Valane C Terry N | 2011 | Am J Orthod Dentofacial Orthop2011，140，5： | 1 |
| 18 | PhosphonitriUic compounds Ⅵ: high molecular weight poly (alkoxy-and aryloxyphosphazenes) 显示文摘 | Allcock H R Kugel R L Valan K J | 1966 | Inorganic Chemistry1966，5，10： | 1 |
| 19 | Phosphonitrilic compounds Vl, High molecular weight poly( alkoxy and atyloxyphoephazene) 显示文摘 | Allcock H R Kugel R L Valan K J | 1966 | Inorg Chem1966，5，： | 1 |
| 20 | Laparoscopic radical prostatectomy:The montsouris experience显示文摘 | Guillonneau B Valan cien G | 2000 | J Urol2000，163，： | 1 |
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