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| 1 | A gist of gastrointestinal stromal tumors: A review显示文摘Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. | Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar Perumal UP Srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan | 2013 | World Journal of Gastrointestinal Oncology2013，5，6： | 27 |
| 2 | Visual outcome after removal of silicone oil in patients undergoing retinectomy for complex retinal detachment显示文摘AIM:To evaluate the functional outcome after removal of silicone oil(ROSO)in patients undergoing retinectomy for complex retinal detachment.·METHODS:We performed a retrospective case note review of patients who underwent ROSO after retinectomy for complex retinal detachment.Patients with less than 6mo follow up and recurrent retinal detachment following ROSO were excluded.·RESULTS:Thirty-six patients were included.The mean best corrected visual acuity(BCVA)pre-ROSO was1.13 log MAR(SD 0.5).The mean BCVA 3mo following ROSO was 1.16 log MAR(SD 0.53),6mo following ROSO1.13(SD 0.63),and 12mo following ROSO 1.18(SD 0.69).At 12mo after ROSO,the BCVA improved in 38.9%of patients,remained unchanged in 25%,and deteriorated in 36.1%,although there was no statistical significant difference in BCVA after ROSO at 3,6 and 12mo(P=0.93).The size of retinectomy ranged from 15°to 270°(SD 53)and did not influence the visual outcome(P=0.11).·CONCLUSION:There was no statistically significant difference in BCVA between pre-and post-ROSO following retinectomy for complex retinal detachment.There was no statistical difference in visual outcome related to the size of the retinectomy. | Roger Wong Marco De Luca Manoharan Shunmugam Tom Williamson Alistair Laidlaw Valeria Vaccaro | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 7 |
| 3 | Incidental gall bladder cancers:Are they truly incidental?显示文摘AIM: To seek and analyze features suggestive of gallbladder cancer(GBC) on preoperative imaging and intraoperative findings in patients diagnosed as having incidental GBC(IGBC). METHODS: The study was conducted on 79 patients of IGBC managed in our department over a 10-year period(2003-2012). Review of preoperative imaging and operative notes was done to ascertain any suspicion of malignancy-in-retrospect.RESULTS: Of the 79 patients, Ultrasound abdomen showed diffuse thickening, not suspicious of malignancy in 5 patients, and diffuse suspicious thickening was seen in 4 patients. Focal thickening suspicious of malignancy was present in 24 patients. Preoperative computed tomography/magnetic resonance imaging was done in 9 patients for suspicion of malignancy. In 5 patients, dif-ficult Cholecystectomy was encountered due to dense/inflammatory adhesions. Intraoperative findings showed focal thickening of the gallbladder and a gallbladder mass in 9 and 17 patients respectively. On overall analysis, 37 patients had preoperative imaging or intraoperative findings suggestive of malignancy, which was either a missed GBC or an unsuspected/unexpected GBC. In 42(53.2%) patients, there was no evidence suggestive of malignancy and was an unanticipated diagnosis.CONCLUSION: Our study highlights a potential and not-so-rare pitfall of Laparoscopic Cholecystectomy. A greater awareness of this clinical entity along with a high index of suspicion and a low threshold for conversion to open procedure, especially in endemic areas may avert avoidable patient morbidity and mortality. | Ashwin Rammohan Sathya D Cherukuri Jeswanth Sathyanesan Ravichandran Palaniappan Manoharan Govindan | 2014 | World Journal of Gastrointestinal Oncology2014，6，12： | 5 |
| 4 | A survey on future research about electron beam welding for aerospace applications显示文摘Electron beam welding plays an important role in the aerospace industry where components like sensors,gears,actuators and air frames used in aircraft and rocket engines were welded using this technique.Welding is normally performed in a vacuum to avoid the scatter of electron due to the presence of gas molecules in the atmosphere and hence electron beam welding process provides the greater results.But still joining of dissimilar metals is challenging.This paper represents review of process,generation and distribution of heat source various input parameters,materials,microstructure,mechanical strength and the possibilities of joining dissimilar metals using electron beam welding. | Ajith Raj Rajendran Dev Anand Manoharan | 2018 | China Welding2018，27，1： | 4 |
| 5 | Diffusion weighted imaging in gynecological malignancies-present and future显示文摘The management of gynaecological malignancies has undergone a significant change in recent years with our improved understanding of cancer biogenetics, development of new treatment regimens and enhanced screening. Due to the rapid blooming of newer methods and techniques in gynaecology, surgery and oncology the scope and the role of imaging has also widened. Functional imaging in the form of diffusion weighted imaging(DWI) has been recently found to be very useful in assessing various tumours. Its ability to identify changes in the molecular level has dramatically changed the diagnostic approach of radiologists which was solely based on morphological criteria. It can improve the diagnostic accuracy of conventional magnetic resonance imaging, lend a hand in assessing tumour response to treatment regimens and detect tumour recurrence with better spatial resolution, negative radiation and diagnostic accuracy compared to positron emission tomography scan. The ability to quantify the diffusion has also lead to potential prediction of tumour aggressiveness and grade which directly correlate with the patient prognosis and management. Hence, it has become imperative for a radiologist to understand the concepts of DWI and its present and evolving role. In this article we present a brief description of the basics of DWI followed by its role in evaluation of female gynaecological malignancies. | Dinesh Manoharan Chandan J Das Ankita Aggarwal Arun K Gupta | 2016 | World Journal of Radiology2016，8，3： | 4 |
| 6 | 丛枝菌根真菌促进南美蟛蜞菊生长及对难溶磷的吸收显示文摘为了解2种丛枝菌根真菌(AMF)摩西管柄囊霉(Funneliformis mosseae,FM)和地表球囊霉(Glomus versiforme,GV)对入侵植物南美蟛蜞菊(Wedelia trilobata)的生长和对难溶性磷酸盐利用的影响,采用沙培盆栽方式,研究了南美蟛蜞菊在接种AMF与添加难溶性磷酸盐的生长和磷含量的变化。结果表明,在磷限制环境下FM对南美蟛蜞菊的侵染率达55%~69%,GV的侵染率达到63%~80%。添加难溶性磷酸盐后,2种AMF均促进了南美蟛蜞菊茎的伸长(FM:+46%;GV:+65%)、总生物量的增加(FM:+27.2%;GV:+40%)和磷含量的增加(FM:+36.6%;GV:+40.7%)。对比FM,GV对植物利用难溶性磷有更显著的促进作用。因此,南美蟛蜞菊与2种AMF形成的共生体系可以促进植物生长和对营养资源的利用,提高对难溶性磷的吸收效率可能使得南美蟛蜞菊在营养贫乏的环境中更好地建立种群。 | 李琴 陈琪 贺芙蓉 BHARANI Manoharan 戴志聪 祁珊珊 杜道林 | 2020 | 热带亚热带植物学报2020，28，4： | 4 |
| 7 | Implications of the presence of an aberrant right hepatic artery in patients undergoing pancreaticoduodenectomy显示文摘AIM:To analyze the differences in outcomes and the clinical impact following pancreatoduodenectomy(PD)in patients with and without aberrant right hepatic artery(aRHA).METHODS:All patients undergoing PD between January 2008 and December 2012 were divided into two groups,one with aRHA and the other without.These groups were compared to identify differences in the intraoperative variables,the oncological clearance and the postoperative morbidity,mortality and hospital stay.RESULTS:A total of 225 patients underwent PD,of which 43(19.1%)patients were found to have eitheraccessory or replaced right hepatic arteries(aRHA group).The aRHA was preserved in 79%of the patients.There was no significant difference in the intraoperative blood loss but operative time was prolonged,reflecting the complexity of the procedure[420±44(240-540)min vs 480±45(300-600)min,P<0.05)].There were no differences in the incidence of postoperative complications(pancreatic leak,pancreatic fistula,delayed gastric emptying and mortality)and hospital stay.Oncological clearance in the form of positive resection margins[13(7.1%)vs 3(6.9%)]and lymph node yield were also similar in the two groups.CONCLUSION:An aRHA is found in approximately one fifth of patients undergoing PD.Preservation is technically possible in most patients and can increase the operative complexity but does not negatively affect the safety or oncological outcomes of the procedure. | Ashwin Rammohan Ravichandran Palaniappan Anbalagan Pitchaimuthu Kamalakannan Rajendran Senthil Kumar Perumal Kesavan Balaraman Ravi Ramasamy Jeswanth Sathyanesan Manoharan Govindan | 2014 | World Journal of Gastrointestinal Surgery2014，6，1： | 3 |
| 8 | Selection of Machining Datum and Allocation of Tolerance through Tolerance Charting Technique显示文摘Tolerance charting is an effective tool to determine the optimal allocation of working dimensions and working tolerances such that the blueprint dimensions and tolerances can be achieved to accomplish the cost objectives.The selection of machining datum and allocation of tolerances are critical in any machining process planning as they directly affect any setup methods/machine tools selection and machining time.This paper mainly focuses on the selection of optimum machining datums and machining tolerances simultaneously in process planning.A dynamic tolerance charting constraint scheme is developed and implemented in the optimization procedure.An optimization model is formulated for selecting machining datum and tolerances and implemented with an algorithm namely Elitist Non-Dominated Sorting Genetic Algorithm(NSGA-II).The computational results indicate that the proposed methodology is capable and robust in finding the optimal machining datum set and tolerances. | THILAK Manoharan SIVAKUMAR Karuppan JAYAPRAKASH Govindharajalu | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 2 |
| 9 | Long term surgical treatment outcome of talar body fracture显示文摘lObjectiveTalar 身体破裂是稀罕的并且有差的处理结果。学习是报导关上的 talardome fractures.MethodsEight 的长期的外科的治疗结果的这的目的关上了 talar 身体破裂,在我们的水平与小碎片 cancellous 螺丝钉或 Herbert 螺丝钉由开的减小和内部固定对待我损伤中心回顾地被分析。脚(antero 以后、侧面、倾斜的看法) 和脚关节的外科手术前、手术后的拍(antero 以后,侧面并且榫眼看法) 被获得。病人被跟随在上面放射学地并且机能上地(脚功能索引, FFI ) 在 3 以后,星期, 6 个星期, 3 个月, 6 个月然后 annually.ResultsThere 是五压碎破裂并且三砍破裂(二 sagittal 砍并且一个花冠砍) ,与 5 年的平均后续。没有早复杂并发症在这些病人被注意。迟了的复杂并发症在四个病人在 talar 身体的六个病人和 osteonecrosis 包括了 subtalar/ankle 关节的 osteoarthrosis。在功能的评价以后,在 5 年以后的吝啬的 FFI 是 104.63 个点,更坏的结果在压碎损害和花冠被注意砍破裂。Sagittal 砍破裂有对通过手术对待的 talar 身体破裂随后的复杂并发症是的好功能、放射学的 outcome.ConclusionsLate 不可避免尽管准确减小和僵硬固定被完成,因此,病人们应当关于不利结果被建议。尽管压碎和花冠砍,破裂有差的结果, sagittal 损害在长期的评估上有好预后。 | Ramesh Kumar Sen Sujit Kumar Tripathy Shakthivel RR Manoharan Vibhu Krishnan Tajir Tamuk Vanyambadi Jagadeesh | 2011 | Chinese Journal of Traumatology2011，14，5： | 2 |
| 10 | Molecular characterization and antibacterial effect of endophytic actinomycetes Nocardiopsis sp. GRG1 (KT235640) from brown algae against MDR strains of uropathogens显示文摘Our study is to evaluate the potential bioactive compound of Nocardiopsis sp.GRG1(KT235640)and its antibacterial activity against multi drug resistant strains(MDRS)on urinary tract infections(UTIs).Two brown algae samples were collected and were subjected to isolation of endophytic actinomycetes.100 strains of actinomycetes were isolated from algal samples based on observation of morphology and physiological characters.40 strains were active in antagonistic activity against various clinical pathogens.Among the strains,10 showed better antimicrobial activity against MDRS on UTIs.The secondary metabolite of Nocardiopsis sp.GRG1(KT235640)has showed tremendous antibacterial activity against UTI pathogens compared to other strains.Influence of various growth parameters were used for synthesis of secondary metabolites,such as optimum pH 7,incubation time 5e7 days,temperature(30C),salinity(5%),fructose and mannitol as the suitable carbon and nitrogen sources.At 100 μg/ml concentration MIC of Nocardiopsis sp.GRG1(KT235640)showed highest percentage of inhibition against Proteus mirabilis(85%),and E.coli,Staphylococcus auerues,Psuedomonas aeroginasa,Enterobactor sp and Coagulinase negative staphylococci 78e85%respectively. | Govindan Rajivgandhi Ramachandran Vijayan Marikani Kannan Malairaja Santhanakrishnan Natesan Manoharan | 2016 | Bioactive Materials2016，1，2： | 2 |
| 11 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 2 |
| 12 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 13 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘 | Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne | 2010 | Journal of the American College of Cardiology2010，，3： | 2 |
| 14 | Assessment of renal artery stenosis severity by pressure gradient measure- ments显示文摘 | Bruyne DB Manoharan G Pijls NH | 2006 | J Am Coil Cardiol2006，48，9： | 1 |
| 15 | Ordered macroporous materials by colloidal Assembly:A possible route to photonic bandgap materials显示文摘 | Subramanian G Manoharan V N Thorne J D | 1999 | Adv Mater1999，11，15： | 1 |
| 16 | Attenuation correction of myocardial SPECT studies using low resolution computed tomography images显示文摘 | Tonge CM Manoharan M Lawson RS | 2005 | Nucl Med Commun2005，26，： | 1 |
| 17 | Severity of coro-nary arterial stenoses responsible for acute coronary syn-dromes显示文摘 | Manoharan G Ntalianis A Muller 0 | 2009 | Am J Cardiol2009，103，9： | 1 |
| 18 | Bland thrombus associ- ation with tumour thrombus in renal cell carcinoma:a- nalysis of surgical significance and role of inferior vena caval interruption显示文摘 | Ayyathurai R Gareia-Roig M Gorin M A Gonzdlez J Manoharan M Kava B R | 2012 | BJU Int2012，110，： | 1 |
| 19 | In- vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts显示文摘 | JAYARAMAN S MANOHARAN M S ILLANCHEZIAN S | 2008 | Tropical Journal of Pharmaceutical Research2008，7，4： | 1 |
| 20 | - 5-year follow-up of the DEFER Study 显示文摘 | Pijls NH Van Schaardenburgh P Manoharan Percutaneous coronary intervention of {unctionally nonsignificant stenosis | 2007 | JArn Coil Cardiol2007，49，21： | 1 |
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