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| 1 | Gene expression profiling:Canonical molecular changes and clinicopathological features in sporadic colorectal cancers显示文摘瞄准:为了调查其他或辅助的小径,在颜色包含了表面的肿瘤发生和肿瘤生长,可能决定在风险人口并且预言回答到治疗。方法:用微数组基因表示分析,我们在 84 分散的颜色相对正规分子的变化和 clinicopathological 特征分析了基因表示的模式表面的癌症病人,由肿瘤地点标准化了。差别的子集表示了基因被即时反向抄本的聚合酶链反应(RT-PCR ) 证实。结果:作为差别正在被表示识别的基因的最大的数字由 lymphovascular 或肿瘤房间并且由失配修理(MMR ) 的神经侵略由肿瘤地点,和下一个最大的数字缺点。在生物过程之中,有免疫力的反应显著地在在颜色期间观察的全部分子的变化被含有表面的肿瘤发生(P <
0.001 ) 。在 47 之中,差别表示了基因,(PISD, NIBP, BAI2, STOML1, MRPL21, MRPL16,和 MKKS ) 七最新被发现与肿瘤发生和肿瘤生长相关。最联系地点的分子的变化在基因表示上有不同效果,但是后者的效果有时是矛盾的。结论:我们证明几差别表示了基因在分散的颜色与正规分子的变化被联系表面的癌症,可能组成肿瘤发生的其他或辅助的小径。因为肿瘤地点是影响微分基因表示的主导的因素,地点特定的分析可以识别联系地点的小径并且提高班预言的精确性。 | Jin Cheon Kim Seon Young Kim Seon Ae Roh Dong-Hyung Cho Dae Dong Kim Jeong Hyun Kim Yong Sung Kim | 2008 | World Journal of Gastroenterology2008，14，43： | 36 |
| 2 | Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity显示文摘AIM:To observe the effects of traditional anti-inflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol.METHODS:Rats were pretreated with three different dosages of LF (500, 250 and 125 mg/kg) orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase and glutathione (GSH) levels, and collagen contents (marker of flexibility) were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol (once orally, 1 h before operation, 30 mg/kg) treated group in which the effects on RE were already conf irmed.RESULTS: Pylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects α-tocopherol.CONCLUSION: The results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease. | Sae-Kwang Ku Bu-Il Seo Ji-Ha Park Gyu-Yeol Park Young-Bae Seo Jae-Soo Kim Hyeung-Sik Lee Seong-Soo Roh | 2009 | World Journal of Gastroenterology2009，15，38： | 19 |
| 3 | Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A casecontrol study in Korea显示文摘AIM: To identify possible risk factors and their synergism for cholangiocarcinoma development.METHODS: A hospital-based, case-control study in which we included 276 cholangiocarcinoma patients [193 extrahepatic cholangiocarcinoma(ECC) and 83 intrahepatic cholangiocarcinoma(ICC)], diagnosed at a training hospital in Korea between 2007 and 2013, and 552 healthy controls matched 2:1 for age, sex, and date of diagnosis. Risk factors for cholangiocarcinoma and possible synergism between those factors were evaluated using conditional logistic regression and synergism index, respectively.RESULTS:There was an association between cholangiocarcinoma and hepatitis B virus(HBV) infection, diabetes mellitus(DM), cholecystolithiasis, choledocholithiasis, and hepatolithiasis, with the adjusted odds ratios(AORs) of 4.1, 2.6, 1.7, 12.4, and 39.9, respectively. Synergistic interaction on the additive model was investigated between HBV infection and DM(AOR = 12.2; 95%CI: 1.9-80.1). In the subgroup analyses, cholecystolithiasis, choledocholithiasis, hepatolithiasis, and DM were significant risk factors for ECC(AOR = 2.0, 18.1, 14.9, and 2.0, respectively), whereas choledocholithiasis, hepatolithiasis, HBV infection, and DM were risk factors for ICC(AOR = 8.6, 157.4, 5.3 and 4.9, respectively). Synergistic interaction was also observed between HBV infection and DM(OR = 22.7; 95%CI: 2.4-214.1). However, there was no synergistic interaction between other significant risk factors for cholangiocarcinoma.CONCLUSION: In this Korean study, HBV infection and DM were found to exert independent and synergistic effects on the risk for cholangiocarcinoma, including ICC. Exploring the underlying mechanismsfor such synergy may lead to the development of cholangiocarcinoma prevention strategies in high-risk individuals. | Ban Seok Lee Eun-Cheol Park Seung Woo Park Chung Mo Nam Jaehoon Roh | 2015 | World Journal of Gastroenterology2015，21，2： | 13 |
| 4 | Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoem bolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred afte the third arterial chemoembolization, report the clinica and radiological findings, and review the medica literature. | Chang Soo Choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh Suck Chei Choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh | 2008 | World Journal of Gastroenterology2008，14，30： | 10 |
| 5 | 垃圾气化分析及其对中国实现碳中和与无废城市建设的贡献显示文摘气化是实现化学利用碳资源(尤其是煤)生产化学品和燃料的关键工艺。目前,全球拥有超过272套气化装置,主要应用于煤化工,尤其在中国。由于在一个化工厂通过技术集成达到工业规模的集中生产可实现减少二氧化碳排放并促进碳密集型行业的循环经济,如废物管理、化学和交通行业,因此,近年来全球对垃圾气化的兴趣日益浓厚,尤其是那些在煤气化技术方面积累了丰富的人力资本和运营经验以及拥有完整Coal-to-X产品价值链的国家,如中国,在挖掘通过垃圾气化实现Waste-to-X的潜力方面处于独特的地位。具体而言,废弃物可用于补充煤气化生产如下产品:(1)具有较低或零碳足迹的化学品,具体取决于废物是来源于化石资源还是生物资源。(2)来自生物废弃物的零碳足迹的绿色“氢”,以补充或替代来自煤气化或蒸汽重整得到的“灰色”氢,以供给氢能汽车,并推动工业脱碳。(3)来自生物废弃物的CO_(2)中性合成液体燃料,用于交通工具,以补充或替代石油燃料和合成煤制液体燃料。然而,迄今为止,利用垃圾作为气化原料的操作经验有限,并且文献中也很少涉及以前和当前的工业垃圾气化经验。为了填补这些空白,本研究介绍了1980年代至2000年代德国的两项开创性技术发展—贝伦拉特(Berrenrath)和SVZ黑水泵(即Sekundärrohstoff-Verwertungszentrum:黑水泵二次原料回收中心),并分享了以下三种垃圾与煤共气化技术(即Waste&Coal-to-X)的相关认识和经验教训:固定床气化:鲁奇干法排渣技术以及BGL熔渣气化技术。流化床气化:高温温克勒(HTW-High Temperature Winkler)气化工艺。气流床气化:GSP(Gaskombinat Schwarze Pumpe),即西门子气化工艺。此外,本研究也总结了目前全球100%垃圾气化技术的发展,即Waste-to-X。在气化技术的三种类型中,研发领域和工业界均对流化床与气流床(作为后期气化)技术的结合产生了浓厚的兴趣,这里介绍三个相关技术的重大发展—Ebara-Ube、Enerkem和ThermoChem Recovery International的技术。除此之外,固定床气化工艺的发展也得到了关注,本文介绍了两个相关技术的重大发展—InEnTec(将固定床与等离子气化相结合)和Sierra Energy(改造传统高炉转炉进行垃圾气化)的技术。借鉴以往和当前的国际发展经验,凭借其庞大的气化规模和丰富的专业知识,逐步将垃圾作为原料融入到煤气化中可以作为中国迈向循环经济和无废城市的第一步。将垃圾与煤共气化技术作为通向垃圾气化的桥梁,不仅可以使中国利用现有的人力资本和基础设施,还可以创造新的就业和商业机会,并支持中国实现可持续的垃圾管理策略,即在进行焚烧和填埋之前先进行减量、再利用和再循环。然而,将煤气化技术直接用于垃圾气化具有挑战性并且充满了较大的风险。本研究分享了贝伦拉特和SVZ黑水泵在垃圾与煤共气化方面遇到的各种运行问题以及从中得到的最新认识。然后介绍了这些积累的经验及认识是如何被考虑并应用到德国弗莱贝格工业大学的能源化工所开发的Flexi技术当中,包括:基于BGL熔渣气化技术开发FlexiSlag固定床气化技术。基于GSP气化技术开发FlexiEntrained气流床气化技术。基于HTW气化技术开发FlexiCOORVED气化技术。目前,Flexi技术在德国弗莱贝格开展中试规模运行,其目标是实现:(1)多元原料气化(例如生物质、煤、石油焦、不同类型的废物);(2)100%垃圾气化;(3)灵活的目标产品(即调整配置得到最大化的合成气产出,其中可含有最大化或最小化的甲烷、焦油和油的含量)以支持全球向碳中和和无废城市转型。鉴于全球(包括中国)实现无废城市和碳中和的目标,垃圾气化技术的长远发展不仅要向100%垃圾气化发展,还必须满足以下可持续性标准才能做出实质性的贡献:(1)多元进料,能够灵活利用多种类型的(废物)原料。(2)碳回收率最大化,以确保垃圾中的碳转移到产品中,而不是在整个过程链中以CO_(2)的形式排放到环境中。(3)通过生产玻璃渣、从渣中回收金属和零废水排放,将环境影响降至最低。本研究最后根据上述三个可持续性标准对三种气化类型进行了定性的整体评价,阐述了它们在垃圾气化应用中的优势和劣势。 | LEE Roh Pin SEIDL Ludwig Georg HUANG Qiu-liang MEYER Bernd | 2021 | 燃料化学学报2021，49，8： | 10 |
| 6 | 结直肠癌的检出与治疗进展显示文摘近年在结直肠癌的检出与治疗中出现了一些强调联合应用多种检查方法的新技术和新观念,包括内镜超声显像、癌胚抗原与单克隆抗体等。对早期病例可采取更保守的手术,某些病例可加用术后放疗和自身肿瘤疫苗免疫疗法。随访则强调适当的措施与频度,强调早期发现复发和转移,以便采取能治愈的措施。 | Curley SA & Roh MS 卢光增 | 1991 | 国外医学(肿瘤学分册)1991，18，1： | 9 |
| 7 | Expression Analysis of Proline Metabolism-related Genes From Halophyte Arabis stelleri under Osmotic Stress Conditions显示文摘Arabis stelleri var.japonica evidenced stronger osmotic stress tolerance than Arabidopsis thaliana.Using an A.thaliana microarray chip,we determined changes in the expression of approximately 2 800 genes between A.stelleri plants treated with 0.2 M mannitol versus mock-treated plants.The most significant changes in the gene expression patterns were in genes defining cellular components or in genes associated with the endomembrane system,stimulus response,stress response,chemical stimulus response,and defense response.The expression patterns of three de novo proline biosynthesis enzymes were evaluated in A.stelleri var.japonica seedlings treated with 0.2 M mannitol,0.2 M sorbitol,and 0.2 M NaCl.The expression of 1-pyrroline-5-carboxylate synthetase was not affected by NaCl stress but was similarly induced by mannitol and sorbitol.The proline dehydrogenase gene,which is known to be repressed by dehydration stress and induced by free L-proline,was induced at an early stage by mannitol treatment,but the level of proline dehydrogenase was increased later by treatment with both mannitol and NaCl.The level of free L-proline accumulation increased progressively in response to treatments with mannitol,sorbitol,and NaCl.Mannitol induced L-proline accumulation more rapidly than NaCl or sorbitol.These findings demonstrate that the osmotic tolerance of the novel halophyte,Arabis stelleri,is associated with the accumulation of L-proline. | Yuchul Jung Jungan Park Yunjung Choi Jin-Gweon Yang Donggiun Kim Beom-Gi Kim Kyunghee Roh Dong-Hee Lee Chung-Kyoon Auh Sukchan Lee | 2010 | Journal of Integrative Plant Biology2010，52，10： | 7 |
| 8 | In situ synthesis of chemically bonded NaTi2(PO4)3/rGO 2D nanocomposite for high-rate sodium-ion batteries显示文摘阶段纯的 NaTi 2(PO4)3/reduced graphene 氧化物(rGO ) nanocomposite 用一个帮助微波的一个壶方法和随后的热处理被准备。使 Ti-O-C 契约结晶得好的 NaTi 2(PO4)3 nanoparticles (30-40 nm ) 一致地通过在 rGO 模板上被猛抛。在 NaTi 2(PO4)3 nanoparticles 和 rGO 之间的化学相互作用能在 rGO 表上使 NaTi 2(PO4)3 nanoparticles 不能调动,它可能为 nanocomposite 的优秀电气化学的表演负责。NaTi 2(PO4)3/rGO nanocomposite 展出了 128.6 妈慥祤猠慴整琠浥数慲畴敲愠档敩敶 ? 祢琠敨瀠潲潰敳 ? 污潧楲桴 ? 獩 ? 的一个特定的能力 ??? 愠摮琠瑯污戠捡整楲污挠畯瑮 ? 桔 ? 牴慥浴湥 ? 楷桴哖??? 鰰 ? 鰰吗?? | Ha-Kyung Roh Hyun-Kyung Kim Myeong-Seong Kim Dong-Hyun Kim Kyung Yoon Chung Kwang Chul Roh Kwang-Bum Kim | 2016 | Nano Research2016，9，6： | 7 |
| 9 | New lumped-mass-stick model based on modal characteristics of structures: development and application to a nuclear containment building显示文摘In this study, a new lumped-mass-stick model (LMSM) is developed based on the modal characteristics of a structure such as eigenvalues and eigenvectors. The simplified model, named the 'frequency adaptive lumped-massstick model,' hasonly a small number of stick elements and nodes to provide the same natural frequencies of the structure and is applied to a nuclear containment building. To investigate the numerical performance of the LMSM, a time history analysis is carried out on both the LMSM and the finite element model (FEM) for a nuclear containment building. A comparison of the results shows that the dynamic responses of the LMSM in terms of displacement and acceleration are almost identical to those of the FEM. In addition, the results in terms of floor response spectra at certain elevations are also in good agreement. | Hwasung Roh Huseok Lee Jong Seh Lee | 2013 | Earthquake Engineering and Engineering Vibration2013，12，2： | 7 |
| 10 | 超越政策过程中的倡议联盟框架显示文摘自从倡议联盟框架(ACF)从20世纪80年代作为一种公共政策框架被提出以来,大量关于倡议联盟框架的文献试图通过描述政策网络途径如何与政策过程理论相结合,以及通过检验群体动力学怎样影响政策后果来发展政策过程理论。然而,这些先前倡议联盟框架研究文献的局限性迫切要求本项研究开发一些超越当前倡议联盟框架的概念步骤以产生更好的政策过程理论。因此,本文集中于三个问题:(1)分析单位;(2)开发政策过程理论中的集体行动;(3)宏观层次的因素在将政策过程理论应用到不同文化形态中的作用。 | Young-Jung Kim Chul-Young Roh 黄丽 杨志军 | 2015 | 甘肃行政学院学报2015，，1： | 6 |
| 11 | Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma显示文摘AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the liver.METHODS:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May 2008.Among the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 d.RESULTS:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial response.The tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of PVTT.In addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor prognosis.The most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of HAIC.CONCLUSION:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis. | Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin Han Cho Young Hoon Kim Young Hoon Roh Hyung Sik Lee Young Min Choi Sang Young Han | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 12 | Simultaneous Paragonimus infection involving the breast and lung:A case report显示文摘BACKGROUND Paragonimiasis is a food-borne parasitic infection caused by lung flukes of the genus Paragonimus. Although the most common site of infection is the pleuropulmonary area, the parasite can also reach other parts of the body on its journey from the intestines to the lungs, ending up in locations such as the brain,abdomen, skin, and subcutaneous tissues. Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.CASE SUMMARY Here, we report a rare case of simultaneous breast and pulmonary paragonimiasis in a woman presenting painless breast mass and lung nodule with a history of eating raw trout. To confirm the diagnosis, serologic testing and tissue confirmation of the breast mass were performed. The patient was treated with surgical resection of the mass and praziquantel medication.CONCLUSION Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.Thus, thorough history-taking and clinical suspicion of parasitic infection are important. | Moon Young Oh Ajung Chu Jeong Hwan Park Jong Yoon Lee Eun Youn Roh Young Jun Chai Ki-Tae Hwang | 2019 | World Journal of Clinical Cases2019，7，24： | 5 |
| 13 | 静息性微出血与原发性脑内出血量有关显示文摘The authors performed a correlative radiologic study on the microbleeds and volume of intracerebral hemorrhage in the supratentorial ICH patients. In the patients with lobar or putaminal hemorrhage, the hemorrhage volumes increased more than twofold or threefold in the patients with microbleeds. Moreover, the presence of microbleeds was an independent risk factor for large-sized hemorrhage. These data show that microbleeds may be associated with a larger ICH volume. | Lee S. - H. Beom J. K. Roh J. - K. 牛亚利(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 5 |
| 14 | Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise显示文摘Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) disruption.Methods: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute exercise.Results: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption. | Hee-Tae Roh Su-Youn Cho Wi-Young So | 2017 | Journal of Sport and Health Science2017，6，2： | 4 |
| 15 | 阴道毛滴虫的分泌产物降低小鼠精子的体外受精能力显示文摘阴道毛滴虫感染是人类最常见的性传播感染之一,现在被认为是男性不育的重要原因。有关阴道毛滴虫的胞外聚合物对于精子影响的信息很少,尚没有关于精子功能完整性的令人信服的报道。为了研究胞外聚合物对于精子受精能力的影响,我们将胞外聚合物与小鼠精子孵育,观察精子活动力、顶体状况、低渗膨胀率以及体外受精率的变化.结果显示:胞外聚合物与小鼠精子孵育后,以浓度.时间依赖方式明显降低精子的活动力、活率以及功能完整性。对精子质量的影响还导致了体外受精率的下降。本文首次报道阴道毛滴虫的胞外聚合物对于精子体外受精能力直接负面影响的。还需要在人精子中进一步研究,以确定胞外聚合物是否对人精子体外受精能力具有类似的负面影响。 | Jaesook Roh Young-Su Lim Min-Young Seo Yuri Choi Jae-Sook Ryu | 2015 | Asian Journal of Andrology2015，17，2： | 4 |
| 16 | 韩国农业发展经验及对我国农业发展的启示显示文摘简要介绍了韩国亲环境农业在提升农业生产能力、提高农民生产积极性、提升农产品质量等方面的发展经验,以及在智能农场循环农业研究、热带作物种植技术研究、未来农业专业人才培养等领域的先进理念和技术。结合国内发展现状,提出了3项发展建议:加强农业科技人才培养,推进植保体系建设;完善农业补贴制度,提高农民种粮积极性;加强宣传引导监管,促进绿色农业发展。 | 陆明红 刘万才 赵清 邹寿发 周晨 Roh Hyeong Ⅱ 金春香 | 2020 | 中国植保导刊2020，40，3： | 4 |
| 17 | 吉林省图们江流域常见蜱类调查研究显示文摘目的了解吉林省图们江流域常见蜱类及分布。方法 2016-2018年每年4-9月在吉林省图们江流域延边朝鲜族自治州(延边州)珲春、图们、汪清、延吉、安图、和龙和龙井市7个市(县)采集游离蜱和动物寄生蜱,蜱放入平皿后运送到实验室进行形态学鉴定,Excel 2007软件进行数据整理与统计分析,χ2检验用于率的比较。结果共采集蜱15 866只,其中游离蜱11 440只,动物体表寄生蜱4 426只;森林革蜱、嗜群血蜱、日本血蜱、长角血蜱、全沟硬蜱和未鉴定种(部分若蜱和全部幼蜱)分别占16.96%、12.41%、18.04%、27.41%、21.50%和3.68%,隶属1科3属。森林革蜱在安图县、嗜群血蜱在龙井市分布较多,分别占67.72%(1 519/2 243)和55.73%(1 322/2 372);日本血蜱在和龙市和汪清县、长角血蜱在珲春和图们市、全沟硬蜱在延吉市和汪清县有较多分布,分别占40.92%(620/1 515)和30.35%(889/2 929)、83.02%(3 633/4 376)和70.86%(710/1 002)、64.94%(928/1 429)和56.67%(1 660/2 929),不同地区蜱种构成差异有统计学意义(均P<0.001)。结论吉林省图们江流域常见蜱种类多样,具有明显地域分布特征,在该地区应该采取针对性的蜱传疾病防控措施。 | 李基旭 Shin-Hyeong Cho Seong-Yoon Kim Jong-Yul Roh 金光俊 吴仲镐 全圣焕 廉哲浩 金光星 朴光明 郑基虎 | 2020 | 中国媒介生物学及控制杂志2020，31，4： | 3 |
| 18 | Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis显示文摘AIM To evaluate the anti-apoptotic effect of banhasasimtang(BHSST) on chronic acid reflux esophagitis(CARE) using a rat model.METHODS A surgically-induced CARE model was established in Sprague-Dawley rats. The modeled rats were divided into a treatment group or untreated group, and given BHSST(1 g/kg body weight per day) or water, respectively, for 15 consecutive days(n = 7 each group). Changes in expression of proteins related to nicotinamide adenine dinucleotide phosphate(NADPH) oxidase and apoptosis were assessed by western blotting. Changes in esophageal pathology were analyzed by gross and histological examinations.RESULTS The CARE exposure modeled rats showed increased levels of the NADPH oxidase subunit, NOX4 and p47 phox in the esophagus. The BHSST treatment completely resolved these CARE-related increases. The CARE rats also showed markers of cytokine stress, including elevated levels of TNF-α and reactive oxygen species as well as of the consequent increase in JNK activation, and subsequent decrease in pro-survival gene expression, such as of Bcl-2. BHSST treatment resolved the CARE-related changes. BHSST also exerted an antiapoptotic effect, as evidenced by altered expression of the apoptosis-related genes for bax, cytochrome c,and caspase 3. Finally, the BHSST treatment markedly ameliorated the CARE-related esophageal mucosal ulcerations. CONCLUSION In the rat model of CARE, BHSST can suppress development of esophageal mucosal ulceration via regulation of reactive oxygen species-dependent apoptosis. | Mi-Rae Shin Hyo-Jin An Bu-Il Seo Seong-Soo Roh | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 19 | Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer显示文摘AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were enrolled.All patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 Gy.Chemotherapy of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 mo.Expression of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were analyzed.The median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong intensity.VEGF expression was found in 64 out of 90 patients.Negative and weak intensities of IL-24 expression were classified as negative expression for analysis.IL-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient characteristics.Expression of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer. | Youngmin Choi Mee-Sook Roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 20 | Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer显示文摘 | Hyuk-Chan Kwon Sung Hyun Kim Sung Yong Oh Suee Lee Ji Hyun Lee Hong-Jo Choi Ki-Jae Park Mee Sook Roh Seung-Geun Kim Hyo-Jin Kim Jong Hoon Lee | 2012 | Biomarkers2012，，3： | 3 |
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