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| 1 | Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells显示文摘Objective:To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline(TG)for reducing the H_2O_2induced toxicity in H9c2 cells.Methods:Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX kit.RNA extraction and cDNA synthesized according to the kit manufacture protocol.Apoptosis was measured by the Flowcytometry,general PCR and qPCR.Results:It was found that the TG significantly rescued the morphology of the H9c2 cells.Treatment of cells with TG attenuated H_2O_2 induced cell deaths and improved the antioxidant activity.In addition,TG regulated the apoptotic gene caspase-3,caspase-9 and anti-apoptotic gene Bcl-2.Bcl-XL during H_2O_2 induced oxidative stress in H9c2 cells.These results were comparable with quercetin treatment.For evident,flow cytometer results also confirmed the TG significantly reduced the H_2O_2 induced necrosis and apoptosis in H9c2 cells.However,further increment of TG concentration against H_2O_2 could induce the necrosis and apoptosis along with H_2O_2.Conclusions:It is suggested that less than 125μM of TG could protect the cells from H_2O_2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL expression.Therefore,we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future. | Soundharrajan Ilavenil Da Hye Kim Young-Il Jeong Mariadhas Valan Arasu Mayakrishnan Vijayakumar Ponnuraj Nagendra Prabhu Srisesharam Srigopalram Ki Choon Choi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，4： | 6 |
| 2 | Metal organic framework-combustion: A one-pot strategy to NiO nanoparticles with excellent anode properties for lithium ion batteries显示文摘NiO nanoparticles with average particles size of 30 nm are synthesized using a one-pot metal–organic framework-combustion(MOF-C) technique, for use as an anode material in rechargeable lithium ion batteries(LIBs). The structural and electronic properties of these nanoparticles are studied using various techniques, including powder X-ray diffraction(PXRD), transmission electron microscopy(TEM), scanning electron microscopy(SEM), X-ray photoelectron spectroscopy(XPS), and N_2 adsorption/desorption studies. The as-synthesized NiO nanoparticles sustained reversible stable capacities of 748 and 410 mAh/g at applied current densities of 500 and 1000 m A/g, respectively, after 100 cycles. Furthermore, the anode displays a notable rate capability, achieving a stable capacity of ~200 mAh/g at a high current density of10 A/g. These results indicate that the size of the NiO nanoparticles and their high surface area influence their electrochemical properties. Specifically, this combustion strategy is clearly favorable for improving the cyclability and rate capability of various metal oxides in rechargeable battery electrodes. | Vaiyapuri Soundharrajan Balaji Sambandam Jinju Song Sungjin Kim Jeonggeun Jo Pham Tung Duong Seokhun Kim Vinod Mathew Jaekook Kim | 2018 | Journal of Energy Chemistry2018，27，1： | 4 |
| 3 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 4 | Nutraceuticals as potential therapeutic agents for colon cancer: a review显示文摘Colon cancer is a world-wide health problem and the second-most dangerous type of cancer,affecting both men and women.The modern diet and lifestyles,with high meat consumption and excessive alcohol use,along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide.As a result,there is a need to develop novel and environmentally benign drug therapies for colon cancer.Currently,nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer,diabetes and Alzheimer's disease.Nutraceuticals are derived from various natural sources such as medicinal plants,marine organisms,vegetables and fruits.Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression.These dietary substances target different molecular aspects of colon cancer development.Accordingly,this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis. | Palaniselvam Kuppusamy Mashitah M.Yusoff Gaanty Pragas Maniam Solachuddin Jauhari Arief Ichwan Ilavenil Soundharrajan Natanamurugaraj Govindan | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 2 |
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