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| 1 | Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells显示文摘Objective:To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline(TG)for reducing the H_2O_2induced toxicity in H9c2 cells.Methods:Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX kit.RNA extraction and cDNA synthesized according to the kit manufacture protocol.Apoptosis was measured by the Flowcytometry,general PCR and qPCR.Results:It was found that the TG significantly rescued the morphology of the H9c2 cells.Treatment of cells with TG attenuated H_2O_2 induced cell deaths and improved the antioxidant activity.In addition,TG regulated the apoptotic gene caspase-3,caspase-9 and anti-apoptotic gene Bcl-2.Bcl-XL during H_2O_2 induced oxidative stress in H9c2 cells.These results were comparable with quercetin treatment.For evident,flow cytometer results also confirmed the TG significantly reduced the H_2O_2 induced necrosis and apoptosis in H9c2 cells.However,further increment of TG concentration against H_2O_2 could induce the necrosis and apoptosis along with H_2O_2.Conclusions:It is suggested that less than 125μM of TG could protect the cells from H_2O_2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL expression.Therefore,we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future. | Soundharrajan Ilavenil Da Hye Kim Young-Il Jeong Mariadhas Valan Arasu Mayakrishnan Vijayakumar Ponnuraj Nagendra Prabhu Srisesharam Srigopalram Ki Choon Choi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，4： | 6 |
| 2 | Nitrogen-and Oxygen-Containing Porous Ultrafine Carbon Nanofiber:A Highly Flexible Electrode Material for Supercapacitor显示文摘Herein, we report a simple and effective preparation of ultrafine CNFs(u-CNFs) with high surface area via electrospinning of two immiscible polymers [polyacrylonitrile(PAN) and poly(methyl methacrylate)(PMMA)] followed by calcination at high temperature in an inert atmosphere. Various electrospinning conditions were optimized in detail. Four different kinds of PAN/PMMA ratios(10/0, 7:3, 5:5 and 3:7)were chosen and found that the PAN/PMMA ratio of 3:7(PAN/PMMA-3:7) is the optimum one. BET analysis showed the specific surface area of the u-CNFs-3:7 was 467.57 m^2/g with an excellent pore volume(1.15 cm^3g^(-1)) and an average pore size(9.48 nm): it is about 25 times higher than the conventional CNFs(c-CNFs). TEM and FE-SEM images confirmed the ultrafine structure of the CNFs with a thinner fiber diameter of ~50 nm. The graphitic nature and atomic arrangement of the u-CNFs were investigated by Raman and XPS analyses. For the supercapacitor application, unlike the common electrode preparation methods,the u-CNFs-3:7 was used without any activation, chemical or mechanical modifications. The u-CNFs-3:7 showed a better specific capacitance of 86 F/g in 1 mol/L H_2SO_4 when compared to pure CNFs. The excellent physicochemical properties make the u-CNFs-3:7 an alternative choice to the existing CNFs for the supercapacitors. | Kai Wei Kyu-Oh Kim Kyung-Hun Song Chang-Yong Kang Jung soon Lee Mayakrishnan Gopiraman Ick-Soo Kim | 2017 | Journal of Materials Science & Technology2017，33，5： | 4 |
| 3 | Free radical scavenging potential of Lagenaria siceraria(Molina) Standl fruits extract显示文摘Objective:To elucidate free radical scavenging activity of ethanolic extract Lagenaria siceraria (L.siceraria)(Molina) fruit.Methods:The free radical scavenging activity of the L siceraria (Molina) fruit extract was assayed by usingα,α-diphenyl-β-picrylhydrazyl(DPPH). 2,20-azinobis 3-ethyl henzothiazoline-6-sulfonate(ABTS),FRAP,reducing power,chelating ability andβ-carotene bleaching assay.Results:The IC50values of DPPH and ABTS radicalscavenging activity was found to be 1.95 mg/mL and 19 mg/mL,respectively.In ferrous chelation assay,the percentage of inhibition was found to be 89.21%.The reducing power of ethanolic extract of L siceraria(Molina) fruit was 0.068 at 1 mg/mL and increased to 0.192 at 5 mg/mL Theβ-carotene linoleate bleaching assay was 46.7%at 5 mg/mL and antioxidant activity using FRAP at 0.305 for 1 mg/mL to 0.969 for 5 mg/mL Conclusions:The results indicate that L siceraria (Molina) fruit could be an important sources of natural radical scavengers. | Vijayakumar Mayakrishnan Selvi Veluswamy Krishnakumari Shanmuga Sundaram Priya Kannappan Noorlidah Abdullah | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 3 |
| 4 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 5 | Effects of pH on electrospun PVA/acid-treated MWNT composite nanofibers显示文摘 | Hyunsik Bang Mayakrishnan Gopiraman Byoung-Suhk Kim Soon-Ho Kim Ick-Soo Kim | 2012 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2012，，： | 1 |
| 6 | Cardioprotective activity of polysaccharides derived frommarine algae: An overview显示文摘 | Mayakrishnan V Kannappan P Abdullah N | 2013 | Trends in Food Science &Technology2013，30，2： | 1 |
| 7 | A Simple Method for the Fabrication of Metallic Copper NanospheresDecorated Cellulose Nanofiber Composite显示文摘Herein, we report a new and simple method for the preparation of metallic copper nanospheres decorated cellulose nano?ber composite(CuN Ss/CNFs). Initially, the cellulose acetate nano?bers(CANFs were electrospun followed by deacetylation and anionization to produce functional anionic cellulos nano?bers(f-CNFs). The Cu Cl_2 precursor was deposited on the f-CNFs(Cu Cl_2/CNFs) by a simple dippin method. Then the CuCl_2/CNFs were reduced under vacuum by using aluminum foil to produce the CuN Ss CNFs. The resultant Cu NSs/CNFs composite was characterized by various microscopic and spectroscopi methods. Fourier transform infrared spectroscopy(FT-IR) con?rmed the successful functionalization o anionic groups with the CNFs. The ?eld emission scanning electron microscopy(FE-SEM) and transmis sion electron microscope(TEM) results con?rmed the formation of Cu NSs on the surface of CNFs. From the scanning electron microscopy-energy dispersive spectroscopy(SEM-EDS) analysis, the weight per centage of Cu was found to be 23.5 wt%. The successful reduction of Cu O to metallic Cu was con?rme by X-ray photoemission spectroscopy(XPS) and X-ray diffraction(XRD) analyses. Mechanism has bee proposed for the formation of metallic Cu sphere on CNFs. | Hyunsik Bang Ke Ma Kai Wei Chang-Yong Kang Byoung-Suhk Kim Mayakrishnan Gopiraman Jung Soon Lee Ick-Soo Kim | 2016 | Journal of Materials Science & Technology2016，32，7： | 0 |
| 8 | Inhibition behavior of Tragia involucrata L. phenolic compounds against acidic medium corrosion in low carbon steel surface显示文摘The antioxidant and anticorrosive effect of Tragia involucrate L.(T. involucrate L.) was evaluated to aid in finding new compounds which can be used for various purposes. The total phenolic(TPC) and flavonoid content(TFC),antioxidant activity(DPPH, reducing potential and phosphomolybdenum), and electrochemical measurements,Fourier transform infrared(FT-IR), UV–visible(UV–vis) spectral analysis, scanning electron microscopy/energydispersive X-ray spectroscopy(SEM–EDX) and atomic force microscopy(AFM) were done to analyze the potency and also the inhibition efficiency of T. involucrate L. against 1 mol·L^(-1) HCl on low carbon steel. The TPC(145.21 mg GAE·g^(-1)), TFC(52.32 mg QCE·g^(-1)) and antioxidant activities were found to be significant. The electrochemical studies performed by AC impedance measurements showed significant changes in impedance spectra without causing any change in Nyquist plots. An increase in charge transfer resistance(Rct) values, a blockage in active sites exhibiting cathodic and anodic inhibition shows the action of inhibitor on low carbon steel. This was later confirmed by FT-IR and UV–vis which showed variation in absorption band at 270 nm and273 nm(before immersion) and 208 and 281 nm(after immersion). The same was tested again by SEM–EDX through altered strength of iron and oxygen bands and using AFM by analyzing the change in average roughness values of low carbon steel before(61.65 nm) and after(97.87 nm) exposure to blank acid without inhibitor, while it was shifted to 81.58 nm in acid with inhibitor. All these results showed strong evidence adding values to T. involucrate L. plant extract in inhibiting corrosion on low carbon steel and by promoting antioxidant importance of the extract which helps in scavenging free radicals. | Ill-Min Chung Seung-Hyun Kim Venkatesan Hemapriya Kathirvel Kalaiselvi Mayakrishnan Prabakaran | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 0 |
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