|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells显示文摘Objective:To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline(TG)for reducing the H_2O_2induced toxicity in H9c2 cells.Methods:Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX kit.RNA extraction and cDNA synthesized according to the kit manufacture protocol.Apoptosis was measured by the Flowcytometry,general PCR and qPCR.Results:It was found that the TG significantly rescued the morphology of the H9c2 cells.Treatment of cells with TG attenuated H_2O_2 induced cell deaths and improved the antioxidant activity.In addition,TG regulated the apoptotic gene caspase-3,caspase-9 and anti-apoptotic gene Bcl-2.Bcl-XL during H_2O_2 induced oxidative stress in H9c2 cells.These results were comparable with quercetin treatment.For evident,flow cytometer results also confirmed the TG significantly reduced the H_2O_2 induced necrosis and apoptosis in H9c2 cells.However,further increment of TG concentration against H_2O_2 could induce the necrosis and apoptosis along with H_2O_2.Conclusions:It is suggested that less than 125μM of TG could protect the cells from H_2O_2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL expression.Therefore,we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future. | Soundharrajan Ilavenil Da Hye Kim Young-Il Jeong Mariadhas Valan Arasu Mayakrishnan Vijayakumar Ponnuraj Nagendra Prabhu Srisesharam Srigopalram Ki Choon Choi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，4： | 6 |
| 2 | Characterization and phylogenetic analysis of novel polyene type antimicrobial metabolite producing actinomycetes from marine sediments:Bay of Bengal India显示文摘Objective:To isolate and indentify the promising antimicrobial metabolite producing Streptomyces strains from marine sediment samples from Andraprudesh coast of India.Methods:Antagonistic aetinomycetes were isolated by starch casein agar medium and modified nutrient agar medium with 1%glucose used as a base for primary screening.Significant antimicrobial metabolite producing strains were selected and identified by using biochemical and 16S rDNA level.Minimum inhibitory concentrations of the organic extracts were done by using broth micro dilution method.Results:Among the 210 actinomyeetes,64.3%exhibited activity against Gram positive bacteria,48.5%showed activity towards Cram negative bacteria,38.8%exhibited both Cram positive and negative bacteria and 80.85%isolates revealed significant antifungal activity.However,five isolates AP-5,AP-18,AP-41 and AP-70 showed significant antimicrobial activity.The analysis of cell wall hydrolysates showed the presence of LL-diaminopimelic acid and glycine in all the isolates.Sequencing analysis indicated that the isolates shared 98.5%-99.8%sequence identity to the 16S rDNA gene sequences of the Streptomyces taxons.The antimicrobial substances were extracted using hexane and ethyl acetate from spent medium in which strains were cultivated at 30X for five days.The antimicrobial activity was assessed using broth micro dilution technique.Each of the culture extracts from these five strains showed a typical polyenelike property.The lowest minimum inhibitory concentrations of ethyl acetate extracts against Escherichia coli and Cumularia lunula were 67.5 and 125.0μg/mL,respectively.Conclusions:It can be concluded that hexane and ethyl acetate soluble extracellular products of novel isolates are effective against pathogenic bacteria and fungi. | Valan Arasu M Asha KRT Duraipandiyan V Ignacimuthu S Agastian P | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 3 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 4 | Influence of different LED lamps on the production of phenolic compounds in common and Tartary buckwheat sprouts显示文摘 | Sang-Won Lee Jeong Min Seo Min-Ki Lee Jin-Hyuk Chun Paulrayer Antonisamy Mariadhas Valan Arasu Tatsuro Suzuki Naif Abdullah Al-Dhabi Sun-Ju Kim | 2014 | Industrial Crops & Products2014，，： | 2 |
| 5 | Antimicrobial activity of Streptomyces spp. ERI-26 recovered from Western Ghats of Tamil Nadu显示文摘 | M. Valan Arasu V. Duraipandiyan P. Agastian S. Ignacimuthu | 2008 | Journal de Mycologie Médicale2008，，3： | 2 |
| 6 | Searching the Web显示文摘 | | 2001 | ACM Transactions on Internet Technology2001，1，1： | 1 |
| 7 | Molecular analysis of antigens targeted by protective antibodies in rapid expulsion of Trichinella spiralis显示文摘 | Arasu P Ellis LA Iglesias R | 1994 | Mol Biochem Parasitol1994，65，： | 1 |
| 8 | Phenylalanine and LED lights enhance phenolic compound production in Tartary buckwheat sprouts显示文摘 | SEO J M ARASU M V KIM Y B | 2015 | Food chemistry2015，177，： | 1 |
| 9 | Almost difference sets and their sequences with optimal autocorrelation显示文摘 | ARASU K T DING C HELLESETH T | 2001 | IEEE Transactions on Information Theory2001，47，7： | 1 |
| 10 | Stream:the stanford stream data manager显示文摘 | Arasu A Babcock B Babu S | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 11 | Searching the Web显示文摘 | ARASU A CHO Jung-hoo GARCIA-MOLINA H | 2001 | ACM Transactions on Internet Technology2001，1，1： | 1 |
| 12 | In vitro antimicrobial activity of Streptomyces spp. ERI-3 isolated from Western Ghats rock soil (India)显示文摘 | M. Valan Arasu V. Duraipandiyan P. Agastian S. Ignacimuthu | 2008 | Journal de Mycologie Médicale2008，，1： | 1 |
| 13 | Molecular analysis of antigens targeted by protective antibodies in rapid expulsion of Trichinella spiralis 显示文摘 | Arasu P Ellis LA Iglesias R | 1994 | Mol Biocbem Parasitol1994，65，2： | 1 |
| 14 | Serum sclerostin and risk of hip fracture in older Caucasian women显示文摘 | ARASU A CAWTHON PM LUI LY | 2012 | Journal of Clin- ical Endocrinology & Metabolism2012，97，6： | 1 |
| 15 | The CQL continuous query language:Semantic foundations and query execution显示文摘 | Arasu A Babu S Widom J | 2006 | The VLDB Journal-The International Journal on Very Large Data Bases2006，15，2： | 1 |
| 16 | STREAM:the stanford stream data manager显示文摘 | Arasu A Babcock B | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 17 | On a class of almost perfect sequences 显示文摘 | Arasu K T Ma S L Voss N J | 1997 | Journal of Algebra1997，192，2： | 1 |
| 18 | The CQL continuous query language: semantic foundations and query execution 显示文摘 | ARASU A BABU S WIDOM J | 2006 | The International JoumaT on Very Large Data Bases2006，15，2： | 1 |
| 19 | STREAM:The Stanford Stream Data Manager显示文摘 | A Arasu B Babcock | 2003 | IEEE Data Engineering Bulletin2003，26，1： | 1 |
| 20 | Two-dimensional quaternary arrays显示文摘 | ARASU K L LAUNEY W D | 2001 | IEEE Trans Inform Theory2001，47，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员