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| 1 | 离子通道、磷酸化和哺乳动物精子获能显示文摘有性生殖动物需要精子和卵子之间进行精心协调的交流才能产生新的个体。精子获能是发生在女性生殖系统中的生殖细胞成熟的一个复杂现象,让精子能够和卵子联结并融合,是哺乳动物生育的必要条件。精子获能过程包括了质膜重组、离子渗透调节、胆固醇减少和许多蛋白质磷酸化状态的变化。研究精子离子通道的新工具能用更好的时空解析度将细胞内的离子变化和蛋白图像化,这些工具正在一步步阐明离子运输和磷酸化状态中的一系列调节是如何引起获能的。最近的证据表明有两条平行的通路调节引起获能的磷酸化发生。其中一条通路要求蛋白激酶A活化,另一条通路需要丝氨酸/苏氨酸磷酸酶失活。本文综述了精子获能所要求的离子运输参与和磷酸化信号处理。理解导致生育的分子机制,对于人们应对男性不育率升高、开发安全的以雄性配子为基础的避孕药、通过辅助生殖策略保持生物多样性都至关重要。 | Pablo E Visconti Dario Krapf Jose Luis de la Vega-Beltran Juan Jose Acevedo Alberto Darszon | 2011 | Asian Journal of Andrology2011，13，3： | 19 |
| 2 | Low efficacy of levofloxacin-doxycycline-based third-line triple therapy for Helicobacter pylori eradication in Italy显示文摘AIM:To evaluate a levofloxacin-doxycycline-based triple therapy with or without a susceptibility culture test in non-responders to Helicobacter pylori(H.pylori) eradication.METHODS:A total of 142(99 women,43 men; mean 53.0 ± 12.7 years) non-responders to more than two H.pylori eradication therapies underwent susceptibility culture tests or were treated with a seven-day triple therapy consisting of esomeprazole,20 mg b.i.d.,levofloxacin,500 mg b.i.d.,and doxycycline,100 mg b.i.d.,randomly associated with(n = 71) or without(n = 71) Lactobacillus casei DG.H.pylori status was checked in all patients at enrollment and at least 8 wk after the end of therapy.Compliance and tolerability of regimens were also assessed.RESULTS:H.pylori eradication was achieved in < 50% of patients [per prototol(PP) = 49%; intention to treat(ITT) = 46%].Eradication rate was higher in patients administered probiotics than in those without(PP = 55% vs 43%; ITT = 54% vs 40%).Estimated primary resistance to levofloxacin was 18% and multiple resistance was 31%.Therapy was well tolerated,and side effects were generally mild,with only one patient experiencing severe effects.CONCLUSION:Third-line levofloxacin-doxycycline triple therapy had a low H.pylori eradication efficacy,though the success and tolerability of this treatment may be enhanced with probiotics. | Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Emanuela Visconti Manuela Coppola Carla Fontana Marco Favaro Francesco Pallone | 2015 | World Journal of Gastroenterology2015，21，21： | 5 |
| 3 | Renal biopsy:Still a landmark for the nephrologist显示文摘Renal biopsy was performed for the first time more than one century ago, but its clinical use was routinely introduced in the 1950s. It is still an essential tool for diagnosis and choice of treatment of several primary or secondary kidney diseases. Moreover, it may help to know the expected time of end stage renal disease. The indications are represented by nephritic and/or nephrotic syndrome and rapidly progressive acute renal failure of unknown origin. Nowadays, it is performed mainly by nephrologists and radiologists using a 14-18 gauges needle with automated spring-loaded biopsy device, under realtime ultrasound guidance. Bleeding is the major primary complication that in rare cases may lead to retroperitoneal haemorrhage and need for surgical intervention and/or death. For this reason, careful evaluation of risks and benefits must be taken into account, and all procedures to minimize the risk of complications must be observed. After biopsy, an observation time of 12-24 h is necessary, whilst a prolonged observation may be needed rarely. In some cases it could be safer to use different techniques to reduce the risk of complications, such as laparoscopic or transjugular renal biopsy in patients with coagulopathy or alternative approaches in obese patients. Despite progress in medicine over the years with the introduction of more advanced molecular biology techniques, renal biopsy is still an irreplaceable tool for nephrologists. | Luca Visconti Valeria Cernaro Carlo Alberto Ricciardi Viviana Lacava Vincenzo Pellicanò Antonio Lacquaniti Michele Buemi Domenico Santoro | 2016 | World Journal of Nephrology2016，5，4： | 3 |
| 4 | Topographic patterns of vascular disease: HOX proteins as determining factors?显示文摘Steadily increasing evidence supports the idea that genetic diversities in the vascular bed are, in addition to hemodynamic influences, a major contributing factor in determining region-specific cardiovascular disease susceptibility. Members of the phylogenetically highly conserved Hox gene family of developmental regulators have to be viewed as prime candidates for determining these regional genetic differences in the vasculature. During embryonic patterning, the regionally distinct and precisely choreographed expression patterns of HOX transcription factors are essential for the correct specification of positional identities. Apparently, these topographic patterns are to some degree retained in certain adult tissues, including the circulatory system. While an understanding of the functional significance of these localized Hox activities in adult blood vessels is only beginning to emerge, an argument can be made for a role of Hox genes in the maintenance of vessel wall homeostasis and functional integrity on the one hand, and in regulating the development and progression of regionally restricted vascular pathologies, on the other. Initial functional studies in animal models, as well as data from clinical studies provide some level of support for this view. The data suggest that putative genetic regulatory networks of Hox-dependent cardiovascular disease processes include genes of diverse functional categories(extracellular matrix remodeling, transmembrane signaling, cell cycle control, inflammatory response, transcriptional control, etc.), as potential targets in both vascular smooth muscle and endothelial cells, as well as cell populations residing in the adventitia. | Richard P Visconti Alexander Awgulewitsch | 2015 | World Journal of Biological Chemistry2015，6，3： | 2 |
| 5 | Cystatin C and Contrast-Induced Acute Kidney Injury显示文摘 | Carlo Briguori Gabriella Visconti Natalia V. Rivera Amelia Focaccio Bruno Golia Rosalia Giannone Diletta Castaldo Francesca De Micco Bruno Ricciardelli Antonio Colombo | 2010 | Circulation2010，，19： | 2 |
| 6 | Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17β-estradiol levels in mural granulosa cell cultures显示文摘 | F Minervini M.E Dell’Aquila F Maritato P Minoia A Visconti | 2001 | Toxicology in Vitro2001，，4： | 2 |
| 7 | Novel Approaches for Preventing or Limiting Events (Naples) II Trial显示文摘 | Carlo Briguori Gabriella Visconti Amelia Focaccio Bruno Golia Alaide Chieffo Alfredo Castelli Marco Mussardo Matteo Montorfano Bruno Ricciardelli Antonio Colombo | 2009 | Journal of the American College of Cardiology2009，，23： | 2 |
| 8 | Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high-performance liquid chromatography 显示文摘 | Angelo Visconti Michelangelo Pascale Gianluca Centonze | 1999 | Journal of Chromatography A1999，864，： | 1 |
| 9 | Novel approaches for preventing or limiting events(Naples)Ⅱ trial:impact of a single high loading dose of atorvastation on periprocedural myocardial infarction显示文摘 | Briguori C Visconti G Focaccio A | 2009 | J Am Coll Cardiol2009，54，23： | 1 |
| 10 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 11 | Human mesenchymal stem cells from adipose tissue: differentiation into hepatic lineage显示文摘 | R TALENS - VISCONTI A BONORA R JOVER | 2007 | Toxicol In Vitro2007，21，： | 1 |
| 12 | Novel approaches for pre- venting or limiting events (Naples) II trial : impact of a single high load- ing dose of atorvastatin on periprocedural myocardial infarction 显示文摘 | Briguori C Visconti G Focaccio A | 2009 | J Am Coil Cardiol2009，54，23： | 1 |
| 13 | Cystatin C and contrast- induced acute kidney injury显示文摘 | Briguofi C Visconti G Rivera NV | 2010 | Circulafion2010，121，19： | 1 |
| 14 | Current analytical methods for trichothecene my- cotoxins in cereals 显示文摘 | Veronica M T Lattanzio Michelangelo Pascale Angelo Visconti | 2009 | Trends in Analytical Chemistry2009，28，6： | 1 |
| 15 | Analysis of T-2 and HT-2 toxins in cereal grains by immunoaffinity clean-up and liquid chromatography with fluorescence detection显示文摘 | Angelo Visconti Veronica Maria Teresa Lattanzio Michelangelo Pascale Miriam Haidukowski | 2005 | Journal of Chromatography A2005，，1： | 1 |
| 16 | Functional cloningof genes regulating apoptosis in neuronal cells 显示文摘 | Roberta Visconti Luciano D’Adamio | 2007 | Methods inMolecular Biology2007，399，： | 1 |
| 17 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 18 | Novel approaches for preventing or limiting events (Naples) Ⅱ trial : impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction 显示文摘 | Briguori C Visconti G Focaccio A | 2009 | J Am Coll Cardiol2009，54，23： | 1 |
| 19 | Overex-pression of Hoxcl3 in differentiatingkeratinocytes resultsin downregulation of a novel hair keratin gene cluster andalopecia显示文摘 | Tkatchenko A V Visconti R P Shang L | 2001 | Development2001，128，： | 1 |
| 20 | Janus kinases and signal transducers and activators of transcription:their roles in cytokine signaling,development and immunoregulation显示文摘 | Ortmann RA Cheng T Visconti R | | 0，，01： | 1 |
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