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| 1 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018，39，6： | 8 |
| 2 | Cystic echinococcosis of the liver and lung treated by radiofrequency thermal ablation:An ex-vivo pilot experimental study in animal models显示文摘AIM:To evaluate radiofrequency thermal ablation (RTA) for treatment of cystic echinococcosis in animal models (explanted organs).METHODS:Infected livers and lungs from slaughtered animals,10 bovine and two ovine,were collected.Cysts were photographed,and their volume,cyst content,germinal layer adhesion status,wall calcification and presence of daughter or adjacent cysts were evaluated by ultrasound.Some cysts were treated with RTA at 150 W,80℃,7 min.Temperature was monitored inside and outside the cyst.A second needle was placed inside the cyst for pressure stabilization.After treatment,all cysts were sectioned and examined by histology.Cysts were defined as alive if a preserved germinal layer at histology was evident,and as successfully treated if the germinal layer was necrotic.RESULTS:The subjects of the study were 17 cysts (nine hepatic and eight pulmonary),who were treated with RTA.Pathology showed 100% success rate in both hepatic (9/9) and lung cysts (8/8);immediate volume reduction of at least 65%;layer of host tissue necrosis outside the cyst,with average extension of 0.64 cm for liver and 1.57 cm for lung;and endocyst attached to the pericystium both in hepatic and lung cysts with small and focal de novo endocyst detachment in just 3/9 hepatic cysts.CONCLUSION:RTA appears to be very effective in killing hydatid cysts of explanted liver and lung.Bile duct and bronchial wall necrosis,persistence of endocyst attached to pericystium,should help avoid or greatly decrease in vivo post-treatment fistula occurrence and consequent overlapping complications that are common after surgery or percutaneous aspiration,injection and reaspiration.In vivo studies are required to confirm and validate this new therapeutic approach. | Vincenzo Lamonaca Antonino Virga Marta Ida Minervini Roberta Di Stefano Alessio Provenzani Pietro Tagliareni Giovanna Fleres Angelo Luca Giovanni Vizzini Ugo Palazzo Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，26： | 6 |
| 3 | VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma显示文摘 | Francesca Lessi Chiara Maria Mazzanti Sara Tomei Claudio Cristofano Andrea Minervini Michele Menicagli Alessandro Apollo Lorenzo Masieri Paola Collecchi Riccardo Minervini Marco Carini Generoso Bevilacqua | 2014 | Medical Oncology2014，，3： | 2 |
| 4 | Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17β-estradiol levels in mural granulosa cell cultures显示文摘 | F Minervini M.E Dell’Aquila F Maritato P Minoia A Visconti | 2001 | Toxicology in Vitro2001，，4： | 2 |
| 5 | Laparoscopic vs open hemicolectomy for colon cancer显示文摘 | E. Lezoche F. Feliciotti A.M. Paganini M. Guerrieri A. De Sanctis S. Minervini R. Campagnacci | 2002 | Surgical Endoscopy2002，，4： | 2 |
| 6 | Open ver- sus laparoscopic partial nephrectomy for clinical tla renal mas- ses: a matched-pair comparison of 280 patients with trifecta out- comes (record project)显示文摘 | MINERVINI A SIENA G ANTONELLI A | 2014 | World J Urol2014，32，1： | 1 |
| 7 | Radiation olerance of complex oxides 显示文摘 | Sickafus K E Minervini L Grimes R W | 2000 | Science2000，289，： | 1 |
| 8 | Nonstoichiometry in A2B2O7 pyrochlores 显示文摘 | Stanek C R Minervini L Grimes R W | 2002 | Journal of American Ceramic society2002，85，11： | 1 |
| 9 | Simple enu- cleation for the treatment of renal angiomyolipoma显示文摘 | Minervini A Giubilei G Masieri L | 2007 | BJU Int2007，99，4： | 1 |
| 10 | Significance of the effective remnant liver volume in major hepatectomies 显示文摘 | Gruttadauria S Vasta F Minervini MI | 2005 | Ann Surg2005，71，3： | 1 |
| 11 | Comparison between multiparameter flow cytometry and WT1-RNA quantifieation in moni- toring minimal residual disease in acute myeloid leukemia without spe- cific molecular targets 显示文摘 | Rossi G Minervini MM Carella AM | 2012 | Leuk Res2012，36，4： | 1 |
| 12 | Histopathologic analysis of peritumoral pseudocapsule and surgical margin status after tumor enueleation for renal cell carcinoma 显示文摘 | Minervini A di Cristofano C Lapini A | 2009 | Eur Urol2009，55，： | 1 |
| 13 | The use of pre- con- toured plates in the treatment of C2 - C3 fractures of the distal humerus: clinical experience 显示文摘 | Celli A Donini MT Minervini C | 2008 | Chir Organi Mov2008，91，2： | 1 |
| 14 | Multiple ipsilateral renal tumors: retrospective analysis of surgical and oncological results of tumor enucleation vs radical nephrectomy 显示文摘 | Minervini A Semi S Giubilei G | 2009 | Eur J Surg On- col2009，35，： | 1 |
| 15 | Simple enucleation versus standard partial nephrectomy for clinical T1 renal masses: perioperative outcomes based on a matched-pair comparison of 396 patients (RECORd project)显示文摘 | Longo N Minervini A Antonelli A | 2014 | Eur J Surg Oneol2014，40，6： | 1 |
| 16 | Influence of mycotoxin zearalenone and its derivatives (alpha and beta zearalenol) on apoptosis and proliferation of cul- tured granulosa cells from equine ovaries 显示文摘 | Minervini F Giannoccaro A Fornelli F | 2006 | Reprod Biol Endoerinol2006，30，4： | 1 |
| 17 | Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus stratified by cardiovascular disease history and cardiovascular risk factors : analysis of 3 clinical trials 显示文摘 | Cook W Minervini G Bryzinski B | 2014 | Postgrad Med2014，126，6： | 1 |
| 18 | Open versus laparoscopic partial nephreetomy for clinical Tla renal masses: a matched-pair comparison of 280 patients with TRIFECTA outcomes (RECORd Project)显示文摘 | Minervini A Siena G Antonelli A | 2014 | World J Urol2014，32，1： | 1 |
| 19 | AngiotensinIConverting-Enzyme-Inhibitory and Antibacterial Peptides from Lactobacillus helveticus PR4 Proteinase-Hydrolyzed Caseins of Milk from Six Species显示文摘 | F Minervini F Algaron C G Rizzello | 2003 | Applied and Environmental Microbiology2003，69，9： | 1 |
| 20 | Our experience with retroperitoneal and transperitoneal laparoscopic pyeloplasty for pelvi-ureteric junction obstruction显示文摘 | Kim Davenport Minervini A Timoney A G | 2005 | Eur Urol2005，48，： | 1 |
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