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| 1 | Transcutaneous perianal sonography:A sensitive method for the detection of perianal inflammatory lesions in Crohn's disease显示文摘AIM: Pelvic magnetic resonance imaging (MRI) and endoanalultrasound which are established imaging methods forperianal inflammatory lesions in patients with Crohn'sdisease require expensive specialized equipments andexpertise. We investigated the feasibility and sensitivity oftranscutaneous perianal ultrasound (PAUS) using regularultrasound probes in the imaging of perianal inflammatorylesions. The sonographic findings were correlated to pelvicMRI-scans.METHODS: We performed PAUS in 25 patients with Crohn'sdisease and clinical signs of perianal inflammatory disease.VCChin a median of 10 d (range 0-75) these patients underwentMRI of the pelvis. Regular convex and linear high resolutionprobes were used for PAUS. The sonographic findings werecorrelated to the MRI findings by blinded investigators.RESULTS: The sonographic investigations were welltolerated by all patients. Fistulae typically presented ashypoechoic tracks. Twenty-nine fistulae were detected in22 patients. Abscesses were detected in 7 patients andpresented as hypo- or anechoic formations. Twenty-six of29 fistulae and 6 of 7 abscesses could be confirmed byMRI. Kappa statistics showed an excellent agreement(kappa>0.83) between the two imaging methods.CONCLUSION: PAUS is a simple, painless, feasible, real-time method that can be performed without specific patientpreparation which is comparable in its sensitivity to pelvicMRI in the detection of perianal fistulae and/or abscesses.PAUS can especially be recommended as a screening toolin acute perianal disorders such as perianal abscess andfor follow-up studies of perianal inflammatory disease. | Jochen Wedemeyer Timm Kirchhoff Gernot Sellge Oliver Bachmann Joachim Lotz Michael Galanski Michael P.Manns Michael J.Gebel Jrg S.Bleck | 2004 | World Journal of Gastroenterology2004，10，19： | 8 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers显示文摘 | Heidi Salloch Anke Reinacher-Schick Karsten Schulmann Christian Pox J?rg Willert Andrea Tannapfel Stefan Heringlake Timm O. Goecke Stefan Aretz Susanne Stemmler Wolff Schmiegel | 2010 | International Journal of Colorectal Disease2010，，1： | 2 |
| 4 | Analysis of atrial and ventricular performance by tissue Doppler imging in patients with atrial septal defects before and after surgical and catheter closure显示文摘 | Abd E1 Rahman MY Hui W Timme J | 2005 | Echocardiography2005，22，7： | 1 |
| 5 | Promising preclinical activity of 2-methoxyestradiol in multiple myeloma 显示文摘 | Dingli D Timm M Russell S J | 2002 | Clin Cancer Res2002，8，： | 1 |
| 6 | The impact of education on the use of physical restraints in the acute care setting显示文摘 | Smith NH Timms J Parker VG | 2003 | J Contin Educ Nurs2003，34，1： | 1 |
| 7 | Difference gel electrophoresis显示文摘 | Timms J F Cramer R | 2008 | Pro- teomics2008，8，2324： | 1 |
| 8 | Co-transformed,diploid Lolium perenne (perennial ryegrass),Lolium multiflorm (Italian ryegrass) and Lolium temulentum (darnel) plants produced by microprojectile bombardment显示文摘 | Dalton S J Bettany A J E Timms E | 1999 | Plant Cell Reports1999，18，： | 1 |
| 9 | A mil- limeter-wave antenna amplitude and phase measurement system 显示文摘 | SMITH S L ARCHER J W TIMMS G P | 2012 | IEEE Transactions on Antennas & Propaga- tion2012，60，4： | 1 |
| 10 | Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis显示文摘 | Valdes AM Loughlin J Timms KM | | 0，，06： | 1 |
| 11 | Additive electro- plating technology as a post CMOS process for the production of MEMS acceleration threshold switches for transportation applica- tions 显示文摘 | MICHAELIS S TIMME H J WYCISK M | 2000 | Journal of Mieromechanies and Microengineering2000，10，2： | 1 |
| 12 | Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes显示文摘 | Kim AY Kuntzen T Timm J | | 0，，： | 1 |
| 13 | Quantifying the impact of cation exchange on long term solute transport in a clay-rich aquitard 显示文摘 | Timms W A Hendry M J | 2007 | Journal of Hydrology2007，332，： | 1 |
| 14 | Additive electroplating technology as a post-CMOS process for the production of MEMS accelerationthreshold switches for transportation applications显示文摘 | Michaelis S Timme H J Wycisk M el al | 2000 | Journal of Micromechanics and Microengineering2000，10，2： | 1 |
| 15 | Structural and kinetic charac- terization of thymidine kinase from leishmania major显示文摘 | Timm J Boseh-Navarrete C Reeio E | 2015 | PLoS Negl Trop Dis2015，9，5： | 1 |
| 16 | Transgenic plants of Lolium multiflorum,Lolium perenne,Festuca arundinacea and Agrostis stolonifera by silicon carbide fibre-mediated transformation of cell suspension cultures显示文摘 | Dalton S J Bettany A J E Timms E | 1998 | Plant Science Limerick1998，132，1： | 1 |
| 17 | Additive Electroplating Technology As a Post-CMOS Process for the Production of MEMS Acceleration-threshold Switches for Transportation Applications 显示文摘 | Michaelis S Timme H J Wycisk M | 2000 | Journal of Micromechanics and Microengineering2000，10，2： | 1 |
| 18 | Spontaneous control of HCV is associated with expression of HLA-B57 and preservation of targeted epitopes 显示文摘 | Kim AY Kuntzen T Timm J | 2011 | Gastroenterology2011，140，2： | 1 |
| 19 | Narrative medicine and emer- ging clinical practice显示文摘 | Reichert J Solan B Timm C | 2008 | Literature and Medicine2008，，2： | 1 |
| 20 | Transgenic plants of Lolium multiflorum , Lolium perenne, Festuca arundina-cea and Agrostis stolonifera by silicon carbide fibre-mediated transformation of cell suspension cultures显示文摘 | Dalton S J Bettany A J E Timms E | 1998 | Plant Science1998，132，： | 1 |
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