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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Use of infliximab in the prevention and delay of colectomy in severe steroid dependant and refractory ulcerative colitis显示文摘AIM: To determine if infliximab can prevent or delay surgery in refractory ulcerative colitis (UC). METHODS: UC patients who failed to have their disease controlled with conventional therapies and were to undergo colectomy if infliximab failed to induce a clinical improvement were reviewed. Patients were primarily treated with a single 5 mg/kg infliximab dose. The Colitis Activity Index (CAI) was used to determine response and remission. Data of 8 wk response and colectomy rates at 6 mo and 12 mo were collected. RESULTS: Fifteen patients were included, 7 with UC unresponsive or intolerant to Ⅳ hydrocortisone, and 8 with active disease despite oral steroids (all but one with therapeutic dosage and duration of immunomodulation). All the Ⅳ hydrocortisone-resistant/intolerant patients had been on azathioprine/6-MP < 8 wk. At 8 wk, infliximab induced a response in 86.7% (13/15) with 40% in remission (6/15). Within 6 mo of treatment 26.7% (4/15) had undergone colectomy and surgery was avoided in 46.6% (7/15) at 12 mo. The colectomy rate at 12 mo in those on immunomodulatory therapy < 8 wk at time of infliximab was 12.5% (1/8) compared with 100% (7/7) in patients who were on long-term maintenance immunomodulators (P < 0.02). CONCLUSION: Infliximab prevented colectomy due to active disease in immunomodulatory-na?ve, refractory UC patients comparable to the use of Cyclosporine. In patients, however, on effective dosage and duration of immunomodulation at time of infliximab therapy colectomy was not avoided. | Robert P Willert Ian Craig Lawrance | 2008 | World Journal of Gastroenterology2008，14，16： | 5 |
| 3 | Metallic debris from metal-on-metal total hip arthroplasty regulates periprosthetic tissues显示文摘The era of metal-on-metal(MoM) total hip arthroplasty has left the orthopaedic community with valuable insights and lessons on periprosthetic tissue reactions to metallic debris. Various terms have been used to describe the tissue reactions. Sometimes the nomenclature can be confusing. We present a review of the concepts introduced by Willert and Semlitsch in 1977,along with further developments made in the understanding of periprosthetic tissue reactions to metallic debris. We propose that periprosthetic tissue reactions be thought of as(1) gross(metallosis, necrosis, cyst formation and pseudotumour);(2) histological(macrophage-dominated, lymphocyte-dominated or mixed);and(3) molecular(expression of inflammatory mediators and cytokines such as interleukin-6 and tumor necrosis factor-alpha). Taper corrosion and modularity are discussed, along with future research directions to elucidate the antigen-presenting pathways and materi-al-specific biomarkers which may allow early detection and intervention in a patient with adverse periprosthetic tissue reactions to metal wear debris. | Christoph H Lohmann Gurpal Singh Hans-Georg Willert Gottfried H Buchhorn | 2014 | World Journal of Orthopedics2014，5，5： | 3 |
| 4 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 5 | β-catenin: a key mediator of Wnt signaling显示文摘 | Karl Willert Roel Nusse | 1998 | Current Opinion in Genetics & Development1998，，1： | 2 |
| 6 | Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers显示文摘 | Heidi Salloch Anke Reinacher-Schick Karsten Schulmann Christian Pox J?rg Willert Andrea Tannapfel Stefan Heringlake Timm O. Goecke Stefan Aretz Susanne Stemmler Wolff Schmiegel | 2010 | International Journal of Colorectal Disease2010，，1： | 2 |
| 7 | Digital Particle Image Velocimetry显示文摘 | Willert C E Gharib M | 1991 | Experiments in Fluids1991，10，： | 1 |
| 8 | Application of particle image velocimetry to a transonic centrifugal compressor 显示文摘 | Voges M Beversdorff M Willert C Krain H | 2007 | Experiments in Fluids2007，43，23： | 1 |
| 9 | β-catenin:a key mediator of Wnt signaling显示文摘 | Willert K Nusse R | 1998 | Curr Opin Genet Dev1998，8，1： | 1 |
| 10 | Digital Particle Image velocimetry显示文摘 | Willert C E Gharib M | 1991 | Exp Fluids1991，，10： | 1 |
| 11 | Combination of gemcit- abine and docetaxel in treatment of children and young adults with refractory bone sarcoma 显示文摘 | Navid F Willert JR MeCarville MB | 2008 | Cancer2008，113，2： | 1 |
| 12 | Topological sparse learning of dynamic form patterns显示文摘 | Guthier T Willert V Eggert J | 2014 | Neural Computation2014，27，1： | 1 |
| 13 | Gas exchange responses of a mangrove species, Avicennia marina, to waterlogged and drained conditions显示文摘 | G. Naidoo H. Rogalla D. J. von Willert | 1997 | Hydrobiologia (-)1997，，1： | 1 |
| 14 | Wnt pro-teins are lipid- Modified and can act as stem cell growth factors 显示文摘 | Willert K Brown JD Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 15 | Writ proteins arelipid-modified and can act as stem cell growth factors显示文摘 | Willert K Brown J D Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 16 | Preparation of polymer particles in nonaqueous direct and inverse miniemulsions显示文摘 | Landfester K Willert M Antonietti M | 2000 | Macromolecules2000，33，7： | 1 |
| 17 | Peripheral and central mechanisms of visceral sensitization in man 显示文摘 | Anand P Aziz Q Willert R | 2007 | Neurogastroenterol Motil2007，19，1： | 1 |
| 18 | Recent Applications of Particle Image Velocimetry in Aerodynamic Research显示文摘 | Christian Willert Markus Rafel Jiirgen Kompenhans | 1996 | Flow Measuring Instrument1996，7，34： | 1 |
| 19 | Reactions of the articular capsule to wear products of artificial joint prostheses显示文摘 | Willert HG | 1977 | J Biomed Mater Res1977，11，： | 1 |
| 20 | Low salinities adversely affect photosynthetic performance of the mangrove,Avicennia marina显示文摘 | Tuffers A Naidoo G von Willert D J | 2001 | Wetlands Ecology and Management2001，9，3： | 1 |
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