|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surgical management of necrotizing pancreatitis:An overview显示文摘Necrotizing pancreatitis is an uncommon yet serious complication of acute pancreatitis with mortality rates reported up to 15%that reach 30%in case of infection.Traditionally open surgical debridement was the only tool in our disposal to manage this serious clinical entity.This approach is however associated with poor outcomes.Management has now shifted away from open surgical debridement to a more conservative management and minimally invasive approaches.Contemporary approach to patients with necrotizing pancreatitis and/or infectious pancreatitis is summarized in the 3Ds:Delay,Drain and Debride.Patients can be managed in the intensive care unit and any intervention should be delayed.Percutaneous drainage can be utilized first and early in the course of the disease,followed by endoscopic drainage or video assisted retroperitoneoscopic drainage if necrosectomy is deemed necessary.Open surgery is now less frequently performed and should be reserved for cases refractory to any other approach.The management of necrotizing pancreatitis therefore requires a multidisciplinary dynamic model of approach rather than being a surgical disease. | George Kokosis Alexander Perez Theodore N Pappas | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Multispecies probiotic protects gut barrier function in experimental models显示文摘AIM:To investigate the effect of the probiotic combination Lactibiane Tolerance?(LT)on epithelial barrier function in vitro and in vivo.METHODS:The effect of the multispecies probiotic LT was assessed on several models of epithelial barrier function both in vitro(in basal and inflammatory conditions)and in vivo[visceral hypersensitivity induced by chronic stress or by colonic perfusion of a fecal supernatant(FSN)from patients with irritable bowel syndrome(IBS)].In vitro,we measured the permeability of confluent T84 cell monolayers incubated with or without LT by evaluating the paracellular flux of macromolecules,in basal conditions and after stimulation with lipopolysaccharide(LPS)or with conditioned medium of colonic biopsies from IBS patients(IBS-CM).In vivo,male C57/Bl6 mice received orally NaCl or LT for 15 d and were submitted to water avoidance stress(WAS)before evaluating visceral sensitivity by measuring the myoelectrical activity of the abdominal muscle and the paracellular permeability with 51Cr-EDTA.Permeability and sensitivity were also measured after colonic instillation of FSN.Tight-junctions were assessed by immunoblotting and TLR-4 expression was evaluated by immunohistochemistry RESULTS:Incubation of T84 cell monolayers with LT in basal conditions had no significant effect on permeability(P>0.05 vs culture medium).By contrast,addition of LT bacterial bodies(LT)completely prevented the LPS-induced increase in paracellular permeability(P<0.01 vs LPS 10 ng/mL(LPS 10);P<0.01 vs LPS 100ng/mL(LPS 100),P>0.05 vs culture medium).The effect was dose dependent as addition of 109 LT bacterial bodies induced a stronger decrease in absorbance than 106 LT(109 LT+LPS 10:-20.1%±13.4,P<0.01vs LPS 10;106 LT+LPS 10:-11.6%±6.2,P<0.01 vs LPS 10;109 LT+LPS 100:-14.4%±5.5,P<0.01 vs LPS 100;106 LT+LPS 100:-11.6%±7.3,P<0.05 vs LPS 100).Moreover,the increase in paracellular permeability induced by culturing T84 cells with conditioned medium of colonic biopsies from IBS patients(IBS-CM)was completely inhibited in the presence of 109 LT(P<0.01 vs IBS-CM).LT also significantly prevented the epithelial disruption induced by intracolonic infusion of fecal supernatant from IBS patients(P<0.01 vs IBS FSN)or water avoidance stress P<0.01 vs WAS)in C57/Bl6 mice and increased the expression of occludin in vitro and in vivo,as assessed by immnunoblotting.The WAS-induced effect on visceral sensitivity was prevented by LT treatment since values obtained for all steps of colorectal distension were significantly(P<0.01)different from the WAS group.Finally,LT downregulated the response mediated through TLR-4 in vitro(decrease in tumor necrosis factorαsecretion in response to LPS:-65.8%for 109 LT and-52.5%for 106LT,P<0.01 vs LPS)and in vivo(inhibition of WAS induced an increase in TLR-4 expression in the LT treated mice colon,P<0.01 vs WAS).CONCLUSION:The probiotic LT mix prevented the disruption to the epithelial barrier induced by LPS,stress or colonic soluble factors from IBS patients and prevented visceral hypersensitivity. | Mylene Nébot-Vivinus Cherryl Harkat Hanene Bzioueche Christel Cartier Raffaella Plichon-Dainese Lara Moussa Helene Eutamene Dorsa Pishvaie Sophie Holowacz Christian Seyrig Thierry Piche Vassilia Theodorou | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 3 | Gastric Cancer: Epidemiologic Aspects显示文摘 | Carlos A. González Núria Sala Theodore Rokkas | 2013 | Helicobacter2013，，： | 4 |
| 4 | Blood glucose and heart failure in nondiabetic patients显示文摘 | Christopher N Theodore L | 2005 | Diabetes Care2005，28，3： | 1 |
| 5 | Surgery and permanent 125I seed paraspinal brachytherapy for malignant tumors with spinal cord compression显示文摘 | Rogers CL Theodore N Dickman CA | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 6 | Cities and the Geographies of 'Actual- ly Existing Neoliberalism' 显示文摘 | Brenner N Theodore N | 2002 | Antipode2002，34，3： | 1 |
| 7 | Blood glucose and heart failure in nondi- abetic patients显示文摘 | Christopher N Theodore L | 2005 | Diabetes Care2005，28，3： | 1 |
| 8 | Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma显示文摘 | Jocelyn H. Wright Melissa M. Johnson Masami Shimizu‐Albergine Renay L. Bauer Brian J. Hayes James Surapisitchat Kelly L. Hudkins Kimberly J. Riehle Simon C. Johnson Matthew M. Yeh Theodor K. Bammler Richard P. Beyer Debra G. Gilbertson Charles E. Alpers N | 2014 | Int. J. Cancer2014，，4： | 1 |
| 9 | Intraoperative Iso-C C-arm navigation in cervical spinal surgery:review of the first 52 cases显示文摘 | Hott JS Papadopoulos SM Theodore N | | 0，，24： | 1 |
| 10 | Detailed molecular structure of a vinyl polymer glass 显示文摘 | THEODOROU D N SUTER U W | 1985 | Macromolecules1985，18，7： | 1 |
| 11 | Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection 显示文摘 | Barteneva N Theodor I Peterson EM | 1996 | Infect Immun1996，64，11： | 1 |
| 12 | Excitation-emission-matrix fluorescence spectroscopy applied to humic acid bands in coral reefs显示文摘 | Matthews B J H Jones A C Theodorou N K | 1996 | Mar Chem1996，55，34： | 1 |
| 13 | Phase equilibria of mixtures containing chain molecules predicted through a novel simulation scheme显示文摘 | Spyriouni T Economou I G Theodorou D N | 1998 | Physical Review Letters1998，80，20： | 1 |
| 14 | Safety and Accuracy of Bedside External Ventricular Drain Placement显示文摘 | Kakarla UK Chang SW Theodore N | 2008 | Neurosurgery2008，63，： | 1 |
| 15 | Variegated Neoliberalization: Geographies, Pathways, Modalities显示文摘 | Brenner N Peck J Theodore N | 2010 | Global Networks2010，10，2： | 1 |
| 16 | Comparison of Three Nucleic Acid Amplification Tests for Detection of Chlamydia trachomatis in Urine Specimens 显示文摘 | Gaydos CA Theodore M Dalesio N | 2004 | Journal of Clinical Microbiology2004，42，7： | 1 |
| 17 | Ru l e-B a s e d Cont ex tAssessment in Smart Cities显示文摘 | Beibei Hu Theodore Patkos AbdelghaniCh i b a n i Ya c i ne A m i r a t | 2012 | Web Reasoning andRule Systems Lecture Notes in Computer Science2012，，7497： | 1 |
| 18 | Using expected values to simplify decision making under uncertainty显示文摘 | Ian Durbach N Theodor Stewart J | | 0，，： | 1 |
| 19 | Prediction of adsorption of aromatic hydrocarbons in silicalite from grand canonical Monte Carlo simulations with biased insertions显示文摘 | Snurr R Q Bell A T Theodorou D N | | 0，，： | 1 |
| 20 | A comparative study between acid-and alkali-aided processing and surimi processing for the recovery of proteins from channel catfish muscle 显示文摘 | Kristinsson HG Theodore AE Demir N et a/ | 2005 | Food Sci2005，70，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员