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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning显示文摘 | Juliana G. Franco Patrícia C. Lisboa Natália S. Lima Taline A.S. Amaral Nayara Peixoto-Silva Angela C. Resende Elaine Oliveira Magna C.F. Passos Egberto G. Moura | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 2 |
| 3 | Field emission displays: a critical review显示文摘 | Talin A A Dean K A Jaskie J E | 2001 | Solid-State Electronics2001，45，6： | 1 |
| 4 | Electrodeposition of Ni from low-temperature sulfamate electrolytes:Ⅰ:electrochemistry and film stress显示文摘 | KELLY J J GOODS S H TALIN A A | 2006 | Journal of The Electrochemical Society2006，153，5： | 1 |
| 5 | Field emission display: A critical review 显示文摘 | Talin A A Dean K A Jaskie J E | 2001 | Solid-State Electronics2001，45，6： | 1 |
| 6 | DRB4-Dependent TAS3 trans -Acting siRNAs Control Leaf Morphology through AGO7显示文摘 | Xavier Adenot Taline Elmayan Dominique Lauressergues Stéphanie Boutet Nicolas Bouché Virginie Gasciolli Hervé Vaucheret | 2006 | Current Biology2006，，9： | 1 |
| 7 | Field emission display: a critical review 显示文摘 | Talin A A Dean K A Jaskie J E | 2001 | Solid-State Electronics2001，45，3： | 1 |
| 8 | Highly aligned, template-free growth and characterization of vertical GaN nanowires on sapphire by metal-organic chemical vapour deposition 显示文摘 | Wang G T Talin A A Werder D J | 2006 | Nanotechnology2006，17，23： | 1 |
| 9 | Thermal stability of Ni-Mn electrodeposits显示文摘 | TALIN A A MARQUIS E A GOODS S H | 2006 | Acta Materialia2006，，54： | 1 |
| 10 | Field emission displays: a critical review 显示文摘 | Talin A A Dean K A Jaskie J E | 2001 | Solid-State Electronics2001，45，： | 1 |
| 11 | 显示文摘 | Kelly J J Goods S H Talin A A | 2006 | Journal of the Electrochemical Society2006，153，5： | 1 |
| 12 | Impaired Timing and Frequency Discrimination in High-functioning Autism Spectrum Disorders显示文摘 | Anjali Bhatara Talin Babikian Elizabeth Laugeson Raffi Tachdjian Yvonne S. Sininger | 2013 | Journal of Autism and Developmental Disorders2013，，10： | 1 |
| 13 | RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities显示文摘RING finger protein 152(RNF152)is a novel RING finger protein and has not been well characterized.We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity.It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain.RNF152 is localized in lysosomes and co-localized with LAMP3,a lysosome marker.Moreover,over-expression of RNF152 in Hela cells induces apoptosis.These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities.It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis. | Songling Zhang Wei Wu Yanfang Wu Jiyan Zheng Talin Suo Hong Tang Jie Tang | 2010 | Protein & Cell2010，1，7： | 1 |
| 14 | Comparison of optic nerve head mea-surements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy显示文摘 | Joel S Gadi W Taline F | 2003 | Am J ophthalmol2003，135，1： | 1 |
| 15 | Development of a Chlamydiatrachomatis bacterial ghost vaccine to fight human blindness显示文摘 | Eko FO Talin BA Lubitz W | 2008 | Hum Vaccine2008，4，3： | 1 |
| 16 | Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy显示文摘 | Joel S Gadi Woll Taline F | 2003 | Am J ophthalmol2003，135，1： | 1 |
| 17 | S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity显示文摘 | Zheng Yang Wei Xing Yan Hong Cai Nicodemus Tedla Chris Armishaw Nick Di Girolamo Hong Wei Wang Taline Hampartzoumian Jodie L. Simpson Peter G. Gibson John Hunt Prue Hart J. Margaret Hughes Michael A. Perry Paul F. Alewood Carolyn L. Geczy | 2007 | The Journal of Allergy and Clinical Immunology2007，，1： | 1 |
| 18 | Comparison of optic nerve head measurements obtained by op-tical coherence t?mogr^)hy and confocal scanning laser oph-thalmoscopy 显示文摘 | Joel S Gadi W Taline F Hertzmark E Aydin A Fqjimoto JG | 2003 | Am J Ophthalmol2003，135，1： | 1 |
| 19 | Development of a Chlamydia trachomatis bacterial ghost vaccine tofight human blindness显示文摘 | Eko F O Talin B A Lubitz W | 2008 | Hum Vaccin2008，4，3： | 1 |
| 20 | Field emission displays:a critical review显示文摘 | Talin A A Dean K A Jaskie J E | 2001 | Solid State Electronics2001，45，： | 1 |
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