| 1 | RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities显示文摘RING finger protein 152(RNF152)is a novel RING finger protein and has not been well characterized.We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity.It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain.RNF152 is localized in lysosomes and co-localized with LAMP3,a lysosome marker.Moreover,over-expression of RNF152 in Hela cells induces apoptosis.These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities.It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis. | Songling Zhang Wei Wu Yanfang Wu Jiyan Zheng Talin Suo Hong Tang Jie Tang | 2010 | Protein & Cell2010，1，7： | 1 |
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