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| 1 | Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study显示文摘AIM:To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.METHODS:Between March and June 2013,a sameday bowel preparation was implemented in our endoscopy unit.The preparation consisted of a semi-liquid,fiber-free diet one day prior to the procedure,with two bisacodyl tablets after lunch and dinner,and 250 mL of Senna alkaloid with 1.5 L of drinking water at 6 am the day of the procedure.The quality control parameters of colonoscopy were evaluated and implemented according to the guidelines of the American Society for Gastrointestinal Endoscopy.The pre-procedure,duringprocedure and post-procedure patient data were collected and analyzed:(1) pre-procedure(age,gender,comorbid diseases,colonoscopy indications,complete lack of compliance with the bowel preparation protocol);(2) during-procedure(sedation dose,duration of colonoscopy,withdrawal time,cecal intubation rate,polyp detection rate,Boston Bowel Preparation Scores and presence of foam and clear liquid); and(3) postprocedure(visual analogue scale score,pain during the procedure,patient satisfaction and premature withdrawal due to the insufficient bowel preparation).RESULTS:A total of 75 patients were included in this study with a mean age of 54.64 ± 13.29 years; 53.3%(40/75) were female and 46.7%(35/75) were male.A complete lack of compliance with the bowel preparation protocol was seen in 6.7% of patients(5/75).The mean total duration of colonoscopy was 16.12 ± 6.51 min,and the mean withdrawal time was 8.89 ± 4.07 min.The cecal intubation rate was 93.8%(61/64) and the polyp detection rate was 40%(30/75).The mean Boston Bowel Preparation Score was 7.38 ± 1.81,with the following distribution:right colon,2.34 ± 0.89; transverse colon,2.52 ± 0.67; left colon,2.52 ± 0.63.The mean visual analogue scale score was 4.59 ± 1.57.Due to insufficient bowel preparation,seven patients(7/75; 9.3%) were asked to repeat the procedure.Of these,five patients had poor or modest compliance with the protocol,and two patients reported constipation.Premature withdrawal due to insufficient bowel preparation was 2.7%(2/75).The overall satisfaction with the protocol was 86.7%(65/75),with patients reporting they would prefer the same protocol in a repeat procedure.CONCLUSION:The same-day administration of Senna alkaloids appears to be a safe and effective bowel cleansing protocol for colonoscopy procedures. | Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal Servet Tali Zeki Ozsoy Mustafa Sahin | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 2 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 3 | The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway显示文摘 | Tali Lang Camden Lo Narelle Skinner Stephen Locarnini Kumar Visvanathan Ashley Mansell | 2011 | Journal of Hepatology2011，，4： | 3 |
| 4 | Flash-boiling atomization显示文摘 | Eran Sher Tali Bar-Kohany Alexander Rashkovan | 2007 | Progress in Energy and Combustion Science2007，，4： | 2 |
| 5 | Nicotinic receptors:allosteric transitions and therapeutic targets in the nervous system显示文摘 | Taly A Corringer PJ Guedin D | | 0，，： | 1 |
| 6 | Post-stroke depression:prevalence and relationship with disability in chronic stroke survivors显示文摘 | Srivastava A Taly AB Gupta A | 2010 | Ann Indian Acad Neurol2010，13，2： | 1 |
| 7 | Diffusion-weighted ima- ging of the spine with a non-carr-purcell-meiboom-gill single-shot fast spin-echo sequence: initial experience显示文摘 | Oner A Y Tali T Celikyay F | 2007 | AJNR2007，28，3： | 1 |
| 8 | Spinal in fections显示文摘 | Tali ET | 2004 | Eur J Radiol2004，50，2： | 1 |
| 9 | Wilson's disease ^31 pand ^1 H MR speclroscopy and clinical ton'elation 显示文摘 | Sinha S Taly AB Ravishankar S el al | 2010 | Neuro- radiology2010，52，11： | 1 |
| 10 | Multiplex picodr- oplet digital PCR to detect KRAS mutations in circu- lating DNA from the plasma of colorectal cancer pa- tients显示文摘 | Taly V Pekin D Benhaim L | 2013 | Clin Chem2013，59，12： | 1 |
| 11 | Nicotinic receptors:allosteric transitions and therapeutic targets in the nervous system显示文摘 | Taly A Corringer P J Guedin D Lestage P Changeux J P | 2009 | Nat Rev Drug Discov2009，8，： | 1 |
| 12 | Spinal infections显示文摘 | Tali E T | 2004 | Eur J Radiol2004，50，2： | 1 |
| 13 | Spinal infections 显示文摘 | Tali E T | 2004 | Eur J Radiol2004，50，2： | 1 |
| 14 | Wilson's disease: An Indian perspectivel显示文摘 | TALY A B PRASHANTH L K SINHA S | 2009 | Neurolo- gy India2009，57，： | 1 |
| 15 | Cystic acoustic schwannomas : MR characteristics 显示文摘 | Tali ET Yuh WT Nguyen HD | 1993 | AJNR Am J Neuroradiol1993，14，5： | 1 |
| 16 | Clinical and magnetic resonance imaging findings in patients with Leigh syndrome and SURF1 mutations显示文摘 | Kothari Sonam Nahid Akthar Khan Parayil Sankaran Bindu Arun B. Taly N. Gayathri M.M. Srinivas Bharath C. Govindaraju H.R. Arvinda Madhu Nagappa Sanjib Sinha K. Thangaraj | 2013 | Brain and Development2013，，： | 1 |
| 17 | Rehabilitation interven?tions to improve locomotor outcome in chronic stroke survi?vors: A prospective, repeated-measure study显示文摘 | Srivastava A Taly AB Gupta A | 2015 | Neurol India2015，63，3： | 1 |
| 18 | Withdrawal of penicillamine from zinc sulphatepenicillamine maintenance therapy in Wilson' s disease: promising, safe and cheap 显示文摘 | Sinha S Taly AB | 2008 | Journal of the Neurological Sciences2008，264，12： | 1 |
| 19 | Sturge-Weber-Dimitri disease without facial nevus 显示文摘 | Taly AB Nagaraja D Das S | 1987 | Neurology1987，37，6： | 1 |
| 20 | Post-stroke depression : Prevalence and relationship with disability in chronic stroke survivors显示文摘 | Srivastava A Taly AB Gupta A | 2010 | Ann Indian Acad Neurol2010，13，2： | 1 |
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