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| 1 | 永定河对北京西山岩溶水和玉泉山泉的影响显示文摘岩溶介质赋水各向异性使岩溶含水层具有不均一性和复杂性,增加了刻画地下水流场的难度和不确定性。为深入理解岩溶水系统不均一性,基于水化学和同位素数据研究了西山岩溶水系统补径排路径,为厘清岩溶水流场特征提供了新的依据。水化学和同位素证据表明西山岩溶区有3个补给源区:军庄、潭柘寺降水补给区和永定河渗漏补给区,每个补给区各自具有独立的径流通道。军庄补给区为降水和河水补给,降水补给向温泉—永丰屯方向径流;入渗河水补给沿永定河断裂向南东方向径流,在古城一带转向北东方向补给玉泉山泉。潭柘寺降水补给沿八宝山断裂北侧经回民公墓,八宝山朝四季青方向径流。自北而南可分为军庄—永丰屯径流带、永定河—香山径流带、潭柘寺—八宝山—四季青径流带。潭柘寺和永定河是西山岩溶水和重要补给源区,对玉泉山泉有直接影响。 | 秦大军 孙杰 郭艺 李露 Mohammed Haji 王东东 刘文才 | 2019 | 工程地质学报2019，27，1： | 16 |
| 2 | 药物溶出/吸收仿生系统研究丹酚酸B缓释片释放规律显示文摘目的:应用药物溶出/吸收仿生系统(drug dissolution/absorption simulating system,DDASS)研究丹酚酸B缓释片的体外释放规律,为中药活性成分缓控释制剂的设计提供新技术。方法:分别采用DDASS法和我国药典收载的桨法对丹酚酸B固体制剂进行体外释放度试验,高效液相色谱法定量,SPSS软件对累积释放度进行释放模型拟合。改进DDASS装置使研究对象从药物固体粉末或颗粒剂扩展到片剂、胶囊剂等多种剂型,分别评价丹酚酸B缓释片DDASS改进前、后和桨法中释放规律的相关性。结果:丹酚酸B原料药及其缓释片在改进前DDASS模型中释药过程符合Weibull方程;而丹酚酸B缓释片在改进后DDASS模型中释药过程符合一级动力学方程,与桨法评价结果一致。DDASS改进前、后与桨法释药规律相关性水平r值分别为0.7884(r5,0.05r5,0.001)。结论:丹酚酸B缓释片释药规律研究显示改进后DDASS法与桨法之间存在更为显著相关性。较之桨法,DDASS法模拟了一个连续动态的、更接近人体消化道环境的释药过程,表明该法评价药物固体制剂释药特性研究的合理性,为药物剂型设计研究提供了新的技术平台。 | 李自强 刘志东 顾慧 刘睿 Haji Juma 何新 | 2010 | 药物评价研究2010，33，5： | 15 |
| 3 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 4 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 5 | 玉符河对济南岩溶水化学过程的影响研究显示文摘玉符河是济南岩溶地下水重要补给源,对济南保泉和供水具有重要意义。本文以2015年玉符河入渗补给试验为例,利用水化学和同位素方法分析了河水入渗对岩溶水矿物组分溶解及离子成分的影响、河水入渗后的渗流路径、影响范围等问题。结果表明,玉符河至城区泉群,水化学类型由SO_4-Ca-Mg型逐渐过渡到HCO_3-Ca型;河水的入渗导致岩溶地下水中方解石和白云石饱和指数减小,石膏的饱和指数几乎不变;水化学和同位素数据表明催马—蛮子庄一带岩溶水中河水比例为48%。在空间分布上,河岸东侧3km范围内河水入渗补给量占比可达50%。在河道东侧8km处,河水入渗补给量占比为5%。在靠近城区泉群一带,河水入渗补给量占比更低,<5%。本次观测结果表明,河道补水尚未对城区泉群有明显影响。本研究为济南岩溶水资源评价和保泉方案的制定提供依据。 | 李宝学 秦大军 郭艺 刘文才 Mohammed Haji 林琳 管清花 | 2017 | 工程地质学报2017，25，1： | 11 |
| 6 | E-commerce development in rural and remote areas of BRICS countries显示文摘E-commerce plays an essential role in modern trade today.It is expected that e-commerce volume amounted to 29 trillion USD in the world in 2017,and would grow with the spread of the Internet and information and communication technologies(ICTs).Brazil,Russia,India,China and South Africa(BRICS),together with many others,consider e-commerce a means to facilitate rapid,inclusive and sustainable economic growth,improving the living standards and alleviating poverty.This article examines areas for potential cooperation by BRICS countries in e-commerce development across rural and remote areas to fight poverty.It analyses the current state of e-commerce development in rural and remote areas in each of the BRICS countries,including cases of public and private initiatives to support it.The article also defines the opportunities which e-commerce brings to people living in rural and remote areas.Moreover,it evaluates the existing challenges and risks.The article concludes that despite the rapid e-commerce development in BRICS countries,and significant opportunities created,there are still issues of disproportionate e-commerce in varied regions and the lack of BRICS cooperation in this sphere.Based on a comparative and normative in-depth,systematic analysis,the article develops a set of recommendations for deepening BRICS countries'cooperation in the following areas:infrastructure in rural and remote regions;education;consumer protection;online dispute resolution;coordinated policy in the international scene,including representation of BRICS countries in international indexes,such as the Organization of Economic Co-operation and Development(OECD)Digital Services Trade Restrictiveness Index(STRI). | Karine HAJI | 2021 | Journal of Integrative Agriculture2021，20，4： | 8 |
| 7 | 药物溶出仿生系统研究黄芩苷固体制剂的释放规律显示文摘目的:应用连续动态的药物溶出仿生系统(drug dissolution si mulating system,DDSS)研究黄芩苷原料药及其普通片、缓释片、固体脂质纳米粒冻干粉等三种固体制剂的体外释放特性,为药物剂型设计研究提供新技术和新方法。方法:分别采用连续动态的DDSS和桨法体外释放度实验,对黄芩苷三种不同固体制剂进行体外释放度研究。以高效液相色谱法测定含量,用SPSS软件对数据进行模型拟合,从拟合方程中提取T50、Td、m等溶出参数,并对两种溶出系统的释药规律进行相关性评价。结果:黄芩苷普通片及其缓释片在两种溶出系统中释放特性分别都符合Weibull、Higuchi方程。分别对黄芩苷普通片及其缓释片在两种溶出系统中释放结果进行相关性评价,相关水平r值各为0.975、0.9995,均大于临界值(r4,0.01=0.917),即相关性良好。黄芩苷原料药和固体脂质纳米粒冻干粉在连续动态DDSS的释放特性均符合Weibull方程。结论:该DDSS模拟了一个连续动态的、更接近人体消化道环境的释药过程,其体外溶出度研究结果与《中华人民共和国药典》(2005年版二部)溶出度测定法(桨法)的良好相关性表明该DDSS作为评价药物固体制剂释药特性研究的合理性,为药物剂型设计研究提供了新的技术平台。 | 祝诚诚 李自强 刘志东 高国义 HAJI Juma 舒乐欣 何新 | 2010 | 中国临床药理学与治疗学2010，15，1： | 7 |
| 8 | Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase显示文摘Two new 24-methyl lanostane triterpenoids,hispindic acids A and B(1 and 2),and a new phenolic compound,hispinine(7),along with nine known compounds(3-6,and 8-12),were isolated from the fruiting bodies of Inonotus hispidus.Their structures were elucidated based on the extensive analysis of spectroscopic data(NMR and HRMS).Hispindic acid A(1) possesses an unusual formyl group at C-30.Compounds 1,3-4,and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control,8-methoxypsoralen,at 50 | Qing Ren Xue-Ying Lu Jian-Xin Han Haji Akber Aisa Tao Yuan | 2017 | Chinese Chemical Letters2017，28，5： | 7 |
| 9 | A new model to predict roadheader performance using rock mass properties显示文摘 | Yazdani-Chamzini ABDOLREZA SIAMAK Haji Yakhchali | 2013 | Journal of Coal Science & Engineering(China)2013，19，1： | 7 |
| 10 | 单纯性先天缺牙患者BMP2/BMP4基因位点分析显示文摘目的:对BMP2/BMP4基因在单纯性先天缺牙患者中的基因表达进行观察,探讨其在先天缺牙疾病中可能的发病机制。方法:提取单纯性先天缺牙患者40例及其家系成员外周静脉血基因组DNA,另选择100例非先天缺牙患者作为对照,应用聚合酶链式反应(PCR)扩增BMP2/BMP4基因编码外显子,纯化、测序,应用DNASTAR软件对测序结果进行对比分析。采用SPSS13.0软件包对数据进行统计学处理。结果:40例先天缺牙患者中,共检测到BMP2/BMP4基因5个突变位点,其中BMP2基因4个突变点:3个错义突变c.109T>G,c.166C>G,c.570A>T,检出率分别为7.5%、2.5%和95%;1个同义突变(c.261A>G),检出率为100%。3个为db SNP数据库中已报道过的多态位点:BMP2SNPs c.109T>G p.Ser37Ala;c.261A>G p.Ser87Ser;c.570A>T p.Arg190Ser;家系先证者BMP2 c.166C>G突变在正常对照组未检出,db SNP数据库未报道,也未被收录于致病基因数据库,为新突变位点。BMP4基因检测出错义突变c.455T>C,检出率为55%,为db SNP数据库中已报道过的多态位点。与对照组等位基因及基因型比较,无显著差异。结论:单纯性先天缺牙可能与BMP2/BMP4基因检出SNPs相关。BMP2c.166C>G杂合突变是新发现的突变,可能是单纯性先天缺牙家系的致病突变。 | 邹川 高清平 Hussam Haji Bakrv 王巍 白新娜 何芳奇 | 2015 | 上海口腔医学2015，24，1： | 5 |
| 11 | Alkaloids of Nitraria sibirica Pall. decrease hypertension and albuminuria in angiotensin II-salt hypertension显示文摘In traditional Chinese medicine, Nitraria sibirica Pall.(Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica(NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet(ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl(ANG/HS; and ANG/HS plus injection of NSTA(1 mg·kg-1·d-1, i.p.). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1(sICAM-1) and monocyte chemoattractant protein-1(MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers. | Mahinur Bakri YI Yang CHEN Ling-Dan Haji Akber Aisa WANG Mong-Heng | 2014 | Chinese Journal of Natural Medicines2014，12，4： | 5 |
| 12 | Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in ovariectomized rats显示文摘 | Hai-rong MA Jie WANG Hong-xue QI Yan-hua GAO Li-juan PANG Yi YANG Zhen-hua WANG Ming-jun DUAN Hua CHEN Xu CAO Haji Akber AISA | 2013 | Acta Pharmacologica Sinica2013，34，3： | 5 |
| 13 | Inverse changes in plasma tetranectin and titin levels in patients with type 2 diabetes mellitus: a potential predictor of acute myocardial infarction?显示文摘使用 biomarkers 预言尖锐心肌的梗塞(AMI ) 的早干预将有效地减少全球心脏病发生,特别地在有类型 2 糖尿病 mellitus (T2DM ) 的高风险的病人之中。试图由检测识别潜在的 biomarkers 的这研究在没有 AMI,与那些比较跟随 AMI 的发作的 T2DM 病人在血浆蛋白质的层次变化。没有 AMI 的志愿者 T2DM 病人(控制;n=10 ) 并且有 AMI (n=10 ) 的 T2DM 病人被招募。从这些病人的血浆样品与在二个组之间的水平变化为蛋白质经由二维的胶化电气泳动(2DE ) 被评估到屏幕。胶化图象上的许多点用 Progenesis SameSpots 被分析并且使分析遭到了到假发现率(FDR ) 。有至少 1.5 褶层的统计上重要的变化的蛋白质点为集体 spectrometry (MS ) 被选择分析。由于强壮的心脏的连接, tetranectin 和 titin 被 enzymelinked immunosorbent 试金(ELISA ) 评估。在二个组之间的调整 P 值和褶层变化与显著地改变的丰富导致了 34 个蛋白质点的鉴定。在 MS 分析之上, 17 血浆蛋白质被识别:tetranectin, titin, clusterin, haptoglobin, myosin-13,锌 fnger 蛋白质 445, DNA 修理蛋白质 RAD50,浆液白朊, apolipoprotein A-IV, caspase-6, aminoacyl tRNA synthase 复杂交往的多功能的蛋白质 1, serotransferrin,松香油绑定蛋白质 4, transthyretin, alpha-1-antitrypsin, apolipoprotein A-I 和浆液淀粉的 A。在在控制和 AMI 组之间的 tetranectin 和 titin 的变化的可比较的模式用 ELISA 被证实。在摘要,在血浆的 tetranectin 和 titin 看起来仔细在 T2DM 病人之中与 AMI 的发作被联系并且能为一个心脏的事件的预言被用作潜在的 biomarkers,尽管这在未来的队研究要求确认。 | Mohd Aizat Abdul RAHIM Zubaidah Haji Abdul RAHIM Wan Azman WAN AHMAD Marina Mohd BAKRI Muhammad Dzafir ISMAI Onn Haji HASHIM | 2018 | Acta Pharmacologica Sinica2018，39，7： | 4 |
| 14 | 马来西亚番荔枝科紫玉盘属(Uvaria Linn.)、杯冠木属(Cyathostemma Griff.)和 Ellipeia Hook. f. et Thomson叶的比较解剖学(英文)显示文摘对紫玉盘属8种,杯冠木属3种和Ellipeia属 1种进行了叶的比较研究,以调查不同种之间解剖 学的不同点,这对种的鉴别和了解它们的分类学意义可能是有用的。有意义的解剖学特征是:末端石细 胞,表皮细胞的晶簇,毛状体,在中脉和叶柄的薄壁组织内的短石细胞以及中脉和叶柄横切面的形状。 有某些特征仅出现在某些种中,这对种的鉴别是有用的。结果亦显示这三个属的联系十分紧密。 | Khatijah Haji HUSSIN Noraishah Abu SAMAH Kamarudin MAT-SALLEH | 2000 | 热带亚热带植物学报2000，8，3： | 4 |
| 15 | Hydrodynamic characteristics of a typical karst spring system based on time series analysis in northern China显示文摘In order to study the hydrodynamic characteristics of the karst aquifers in northern China,time series analyses(correlation and spectral analysis in addition with hydrograph recession analysis)are applied on Baotu Spring and Heihu Spring in Jinan karst spring system,a typical karst spring system in northern China.Results show that the auto-correlation coefficient of spring water level reaches the value of 0.2 after 123 days and 117 days for Baotu Spring and Heihu Spring,respectively.The regulation time obtained from the simple spectral density function in the same period is 187 days and 175 days for Baotu Spring and Heihu Spring.The auto-correlation coefficient of spring water level reaches the value of 0.2 in 34-82 days,and regulation time ranges among 40-59 days for every single hydrological year.The delay time between precipitation and spring water level obtained from cross correlation function is around 56 days for the period of 2012-2019,and varies among 30-79 days for every single hydrological year.In addition,the spectral bands in cross amplitude functions and gain functions are small with 0.02,and the values in the coherence functions are small.All these behaviors illustrate that Jinan karst spring system has a strong memory effect,large storage capacity,noticeable regulation effect,and time series analysis is a useful tool for studying the hydrodynamic characteristics of karst spring system in northern China. | Yi Guo Feng Wang Da-jun Qin Zhan-feng Zhao Fu-ping Gan Bai-kun Yan Juan Bai Haji Muhammed | 2021 | China Geology2021，4，3： | 3 |
| 16 | NUMERICAL PREDICTIONS AND EXPERIMENTAL VALIDATIONS OF DUCTILE DAMAGE EVOLUTION IN SHEET METAL FORMING PROCESSES显示文摘Prediction of forming limit in sheet metal forming is among the most important challenges confronting researchers. In this paper, a fully coupled elastic-plastic-damage model has been developed and implemented into an explicit code. Due to the adoption of the plane stress and finite strain theories, model can predict deformation and damage of parts quickly and accurately. Also, damage initiation, propagation, and fracture in some operations are predicted and validated with experiments. It is concluded that finite strain combined with continuum damage mechanics can be used as a quick tool to predict ductile damage, fracture, and forming limits in sheet metal forming processes. | Farhad Haji Aboutalebi Mahmoud Farzin Mohammad Mashayekhi | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 3 |
| 17 | LOT SIZING WITH NON-ZERO SETUP TIMES FOR REWORK显示文摘在这篇论文,我们考虑安排有缺点的项目在每个产品的任何生产跑在被生产的问题的单个机器多产品许多。在在每个产品的正常生产以后的每个周期,机器是为一样的产品然后 rework 过程开始的有缺陷者的 rework 的安装。我们假设安装预定因为象 rework 进程一样的正常生产进程是非零。进一步,我们认为等待的时间有缺陷者花费了为重做。这篇论文有二个目的。第一个目的是为一个单个产品获得经济批数量(EBQ ) 。第二个目的是扩大第一个目的结果到多产品盒子。采用安排我们获得的政策的普通周期最佳的批为每个产品缩放以便每统一时间系统花费的总数被最小化。 | Rasoul HAJI Alireza HAJI Mehdi SAJADIFAR Saeed ZOLFAGHARI | 2008 | Journal of Systems Science and Systems Engineering2008，17，2： | 2 |
| 18 | The role of remote ischemic preconditioning in organ protection after cardiac surgery: a meta-analysis显示文摘 | Nur A.B. Haji Mohd Yasin Peter Herbison Pankaj Saxena Slavica Praporski Igor E. Konstantinov | 2014 | Journal of Surgical Research2014，，1： | 2 |
| 19 | Use of 2-(tert-butoxy)-N-(3-carbamothioylphenyl)acetamide and graphene oxide for separation and preconcentration of Fe(Ⅲ),Ni(Ⅱ),Cu(Ⅱ) and Zn(Ⅱ) ions in different samples显示文摘A simple and selective method using a column packed with graphene oxide(GO) as a solid phase extractant has been developed for the multi-element preconcentration of Fe(Ⅲ),Ni(Ⅱ),Cu(Ⅱ) and Zn(Ⅱ)ions prior to flame atomic absorption spectrometric determinations.The method is based on the sorption of mentioned ions on synthesized GO using 2-(tert-butoxy)-N-(3-carbamothioylphenyl)acetamide as a chelating agent.Several parameters on the extraction and complex formation were optimized.Under the optimized conditions(pH 6,flow rate 9 mL/min),metal ions were retained on the column,then quantitatively eluted by HNO3solution(5 mL,3.0 mol/L).The preconcentration factor was calculated as250.The detection limits for the analyte ions of interest were found in the range of 0.11 ng/mL(Ni2+) to0.63 ng/mL(Cu2+).The column packed with GO was adequate for metal ions separation in matrixes containing alkali,alkaline earth,transition and heavy metal ions. | Mohammad Reza Pourjavid Ali Akbari Sehat Majid Haji Hosseini Mohammad Rezaee Masoud Arabieh Seyed Reza Yousefi Mohammad Reza Jamali | 2014 | Chinese Chemical Letters2014，25，5： | 2 |
| 20 | The changing epidemiology pattern and frequency distribution of hepatitis C virus in Pakistan显示文摘 | Sadia Butt Muhammad Idrees Haji Akbar Irshad ur Rehman Zunaira Awan Samia Afzal Abrar Hussain Muhammad Shahid Sobia Manzoor Shazia Rafique | 2010 | Infection Genetics and Evolution2010，，5： | 2 |
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