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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Fabrication of Silver Nanowire Transparent Electrodes at Room Temperature显示文摘poly 绝缘包围的银 nanowires (AgNWs )(vinylpyrrolidone ) 被一个 polyol 过程综合了并且采用了同样透明的电极。AgNW 透明电极能被热处理在大约 200 点制作吗?? | Takehiro Tokuno Masaya Nogi Makoto Karakawa Jinting Jiu Thi Thi Nge Yoshio Aso Katsuaki Suganuma | 2011 | Nano Research2011，4，12： | 38 |
| 3 | CONFLICT ANALYSIS APPROACHES FOR INVESTIGATING ATTITUDES AND MISPERCEPTIONS IN THE WAR OF 1812显示文摘设计途径到为错误感觉和态度建模的正式系统在图模型的框架以内被采用让冲突分辨率系统地学习在美国和大 Britainin 顺序之间的 1812 的战争提供提高的卓见进战争的原因。更明确地,为偏爱,运动和稳定性概念的关系定义为描述态度被定义并且联系了涉及冲突的决定制造者的行为。到在 1812 的战争的决定制造者的俘获错误感觉,态度在一场亢奋的比赛的结构以内被学习。在图模型的范例以内的 Combiningattitudes 和错误感觉供应证明由英国和美国的态度的那误解可能贡献了这不干净的战争的爆发的灵活分析工具。 | Takehiro INOHARA Keith W. HIPEL Sean WALKER | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 29 |
| 4 | Benefits of early postoperative jejunal feeding in patients undergoing duodenohemipancreatectomy显示文摘瞄准:学习早手术后的肠内的营养是否减少复杂并发症的发生或改进营养的地位追随者 duodenohemipancreatectomy (DHP ) 。方法:我们学习了为一个 peri-ampullary 团经历了 DHP 的 39 个病人。23 个病人收到了全部的父母营养然后开始有在手术后的白天(邮政部门) 之间的营养的口头的吸入 7 和 14 [晚手术后的肠内的营养(LPEN ) 组] 。十六个病人开始有肠内的在手术以后整个空肠造口术导管日子喂[早手术后的肠内的营养(EPEN ) 组] 。在早手术后的阶段的复杂并发症和实验室数据的发生在在 LPEN 和 EPEN 组之间的比较被学习。结果:在 EPEN 组的白朊和全部的蛋白质的浆液层次比在 LPEN 组的那些显著地高。身体团索引的损失显著地作为与 LPEN 组相比在 EPEN 组被压制。在操作比在 LPEN 组在 EPEN 组更快显著地被恢复以后,淋巴细胞计数立即减少了。EPEN 组显著地比 LPEN 组显示出手术后的胰腺的管,以及住院的显著地更短的长度的更少发生。在在二个组之间的另外的手术后的复杂并发症的发生没有有效差量,例如推迟的胃的倒空,外科的地点感染,胆管炎,和小肠阻塞。结论:EPEN 是为为一个 peri-ampullary 团经历了 DHP 的病人的一个安全、有益的机会。 | Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Tekeki Sugimoto Toyokazu Akimori Tsutomu Namikawa Ken Okamoto Saburo Onishi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 5 | STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1显示文摘AIM:To estimate whether STI571 inhibits the expressionof vascular endothelial growth factor(VEGF)in thegastrointestinal stromal tumor(GIST)cells.METHODS:We used GIST cell line,GIST-T1.It hasa heterogenic 57-bp deletion in exon 11 to produce amutated c-KIT,which results in constitutive activationof c-KIT.Cells were treated with/without STI571 orstem cell factor(SCF).Transcription and expression ofVEGF were determined by RT-PCR and flow cytometryor Western blotting,respectively.Activated c-KIT wasestimated by immunoprecipitation analysis.Cell viabilitywas determined by MTT assay.RESULTS:Activation of c-KIT was inhibited bySTI571 treatment.VEGF was suppressed at both thetranscriptional and translational levels in a temporal anddose-dependent manner by STI571.SCF upregulatedthe expression of VEGF and it was inhibited by STI571.STI571 also reduced the cell viability of the GIST-T1cells,as determined by MTT assay.CONCLUSION:Activation of c-KIT in the GIST-T1regulated the expression of VEGF and it was inhibited bySTI571.STI571 has antitumor effects on the GIST cellswith respect to not only the inhibition of cell growth,butalso the suppression of VEGF expression. | Toufeng Jin Hajime Nakatani Takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya Kobayashi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，5： | 14 |
| 6 | Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients显示文摘瞄准:由于源于先进胃的癌症的腹膜炎 carcinomatosa 与腹水在病人在它的静脉内的管理以后在血浆和腹水检验 paclitaxel 集中。方法:有腹水的二个病人在这研究由于源于胃的癌症的腹膜炎 carcinomatosa 被包括。在血浆和腹水的 paclitaxel 集中为 72 h 被调查以防 1 和 168 h 以防 2 在静脉内的管理以后。结果:在血浆的 paclitaxel 集中在管理以后立即达到顶点,在 24 h 以内在 0.1 微摩尔(85 ng/mL ) 的阀值价值下面由快速的减少列在后面。相反,在腹水的 paclitaxel 集中在管理以后为 24 h 逐渐地增加了到与在血浆发现的水平一致的水平。在 24 h 以后,在腹水和血浆的 paclitaxel 的水平变得类似,与被维持直到 72 h 追随者管理的最佳的水平。结论:在腹水的 paclitaxel 的集中在静脉内的管理以后为多达 72 h 为癌症房间的治疗在最佳的水平以内被维持。Paclitaxel 是为胃的癌症的恶意的腹水的治疗的有希望的药。 | Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken Okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，9： | 14 |
| 7 | Relationship between perioperative glycemic control and postoperative infections显示文摘Perioperative hyperglycemia in critically ill surgery patients increases the risk of postoperative infection (POI), which is a common, and often costly, surgical complication. Hyperglycemia is associated with abnormalities in leukocyte function, including granulocyte adherence, impaired phagocytosis, delayed chemotaxis, and depressed bactericidal capacity. These leukocyte deficiencies are the cause ofinfection and improve with tight glycemic control, which leads to fewer POIs in critically ill surgical patients. Tight glycemic control, such as intensive insulin therapy, has a risk of hypoglycemia. In addition, the optimal targeted blood glucose range to reduce POI remains unknown. Since 2006, we have investigated tight perioperative blood glucose control using a closed-loop artificial endocrine pancreas system, to reduce POI and to avoid hypoglycemia. In this Topic Highlight, we review the relationship between perioperative glycemic control and POI, including the use of the artificial pancreas. | Kazuhiro Hanazaki Hiromichi Maeda Takehiro Okabayashi | 2009 | World Journal of Gastroenterology2009，15，33： | 13 |
| 8 | INTERRELATIONSHIPS AMONG NONCOOPERATIVE AND COALITION STABILITY CONCEPTS显示文摘Insightful theorems are established on interrelationships among coalition and noncooperative stability concepts defined within the paradigm of the Graph Model for Conflict Resolution.More specifically,the newly defined coalition stability definitions that are considered are coalition Nash stability(CNash),coalition general metarationality(CGMR),coalition symmetric metarationality (CSMR)and coalition sequential stability(CSEQ),along with their earlier-defined noncooperative versions.A range of interesting new theorems are derived to establish connections among these coalition stability concepts as well as between noncooperative and coalition stability definitions. Applications with respect to the games of Prisoner′s Dilemma and Chicken,as well as a groundwater contamination dispute,demonstrate how the various stability definitions can be applied in practice and confirm the validity of some of the theorems as well as point out,by example,certain types of relationships which cannot hold. | Takehiro INOHARA Keith W.HIPEL | 2008 | Journal of Systems Science and Systems Engineering2008，17，1： | 13 |
| 9 | High-velocity frictional behavior of Longmenshan fault gouge from Hongkou outcrop and its implications for dynamic weakening of fault during the 2008 Wenchuan earthquake显示文摘High-velocity friction experiments were conducted on clayey fault gouge collected from Hongkou outcrop of Beichuan fault,located at the southwestern part of Longmenshan fault system that caused the disastrous 2008 Wenchuan earthquake.The ultimate purpose of this study is to reproduce this earthquake by modeling based on measured frictional properties.Dry gouge of about 1 mm in thickness was deformed dry at slip rates of 0.01 to 1.3 m/s and at normal stresses of 0.61 to 3.04 MPa,using a rotary-shear high-velocity frictional testing machine.The gouge displays slip weakening behavior as initial peak friction decays towards steady-state values after a given displacement.Both peak friction and steady-state friction remain high at slow slip rates are examined and gouge only exhibits dramatic weakening at high slip rates,with steady-state friction coefficient values of about 0.1 to 0.2.Specific fracture energy ranges from 1 to 4 MN/m in our results and this is of the same order as seismically determined values.Low friction coefficients measured on experimental faults are in broad agreement with lack of thermal anomaly observed from temperature measurements in WFSD-1 drill hole(Wenchuan Earthquake Fault Scientific Drilling Project),which can be explained by even smaller friction coefficient for the Wenchuan earthquake fault.High-velocity friction experiments with pore water needs to be done to see if even smaller friction is attained or not.Shiny slickenside surfaces form at high slip rates,but not at slow slip rates. Slip zone with slickenside surface changes its color to dark brown and forms duplex-like microstructures,which are similar to those microstructures found in the fault gouges from the Hongkou outcrop.Detailed comparisons between experimentally deformed gouge samples and WFSD drill cores in the future will reveal how much we could reproduce the dynamic weakening processes in operation in fault zones during Wenchuan earthquake at present. | Tetsuhiro Togo Toshihiko Shimamoto Shengli Ma Takehiro Hirose | 2011 | Earthquake Science2011，24，3： | 12 |
| 10 | Concurrent systemic AA amyloidosis can discriminate primary sclerosing cholangitis from IgG4-associated cholangitis显示文摘Chronic hepatobiliary inflammatory diseases are not widely acknowledged as underlying disorders of systemic AA amyloidosis,except epidemic schistosomiasis.Among them,primary sclerosing cholangitis (PSC) might initiate amyloid A protein deposition in diverse tissues,giving rise to systemic amyloidosis,due to a progressive and unresolved inflammatory process,and its possible association with inflammatory bowel diseases.Nevertheless,only one such case has been reported in the literature to date.We report a 69-year-old Japanese woman with cirrhosis who was diagnosed with PSC complicated with systemic AA amyloidosis,without any evidence of other inflammatory disorders.As a result of cholestasis in conjunction with biliary strictures and increased serum IgG4,the presence of IgG4 + plasma cells was examined systemically,resulting in unexpected documentation of Congo-red-positive amyloid deposits,but not IgG4 + plasma cells,in the liver,stomach and salivary glands.Elevated serum IgG4 is the hallmark of IgG4-related disease,including IgG4-associated cholangitis,but it has also been demonstrated in certain patients with PSC.Amyloid A deposits in multiple organs associated with an indolent clinical course that progresses over many years might have a diagnostic value in discriminating PSC from IgG4-associated cholangitis. | Takehiro Kato Atsumasa Komori Sung-Kwan Bae Kiyoshi Migita Masahiro Ito Yasuhide Motoyoshi Seigo Abiru Hiromi Ishibashi | 2012 | World Journal of Gastroenterology2012，18，2： | 11 |
| 11 | Surgical outcome of adenosquamous carcinoma of the pancreas显示文摘Adenosquamous carcinoma is rare,accounting for 3%-4% of all pancreatic carcinoma cases. These tumors are characterized by the presence of variable proportions of mucin-producing glandular elements and squamous components,the latter of which should account for at least 30% of the tumor tissue. Recently,several reports have described cases of adenosquamous carcinoma of the pancreas. However,as the number of patients who undergo resection at a single institute is limited,large studies describing the clinicopathological features,therapeutic management,and surgical outcome for adenosquamous carcinoma of the pancreas are lacking. We performed a literature review of English articles retrieved from Medline using the keywords 'pancreas' and 'adenosquamous carcinoma'. Additional articles were obtained from references within the papers identif ied by the Medline search. Our subsequent review of the literature revealed that optimal adjuvant chemotherapy and/or radiotherapy regimens for adenosquamous carcinoma of the pancreas have not been established,and that curative surgical resection offers the only chance for long-term survival. Unfortunately,the prognosis of the 39 patients who underwent pancreatic resection for adenosquamous carcinoma was very poor,with a 3-year overall survival rate of 14.0% and a median survival time of 6.8 mo. Since the postoperative prognosis of adenosquamous carcinoma of the pancreas is currently worse than that of pancreatic adenocarcinoma,new adjuvant chemotherapies and/or radiation techniques should be investigated as they may prove indispensible to the improvement of surgical outcomes. | Takehiro Okabayashi Kazuhiro Hanazaki | 2008 | World Journal of Gastroenterology2008，14，44： | 9 |
| 12 | Metastatic bone cancer as a recurrence of early gastric cancer - characteristics and possible mechanisms显示文摘The surgical outcome of most early gastric cancer (EGC)is usually satisfactory. Some cases show bone metastasis even though the depth of cancer invasion is confined to the mucosa. The most frequent site for recurrence of EGC is the liver. Cases of EGC with bone metastasis are reviewed to clarify the clinicopathological characteristics of EGC giving rise to bone metastasis. Possible mechanisms and risk factors underlying this rare condition are proposed.Forty-six cases of bone metastasis from EGC are reviewed from published reports and meeting proceedings in Japan.This investigation suggests that risk factors for bone metastasis from EGC include depressed-type signet-ring cell carcinoma, poorly differentiated carcinoma, and/or the likely involvement of lymph node metastasis, even though the cancer is confined to the gastric mucosa. The risk factors do not include recurrence of EGC in the liver. We speculate that the mechanism of bone metastasis from EGC is via lymphatic channels and systemic circulation. Postoperative follow-up of cases should consider the development of bone metastasis from EGC. We propose the use of elevated alkaline phosphatase levels for the detection of bone metastasis and recommend bone scintigraphy in positive cases. | Michiya Kobayashi Takehiro Okabayashi Takeshi Sano Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 13 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 14 | Perioperative intensive insulin therapy using artificial endocrine pancreas in patients undergoing pancreatectomy显示文摘Perioperative glycemic control is important for reducing postoperative infectious complications. However, clinical trials have shown that efforts to maintain normoglycemia in intensive care unit patients result in deviation of glucose levels from the optimal range, and frequent attacks of hypoglycemia. Tight glycemic control is even more challenging in those undergoing pancreatic resection. Removal of lesions and surrounding normal pancreatic tissue often cause hormone deficiencies that lead to the destruction of glucose homeostasis, which is termed pancreatogenic diabetes. Pancreatogenic diabetes is characterized by the occurrence of hyperglycemia and iatrogenic severe hypoglycemia, which adversely effects patient recovery. Postoperatively, a variety of factors including surgical stress, inflammatory cytokines, sympathomimetic drug therapy, and aggressive nutritional support can also affect glycemic control. This review discusses the endocrine aspects of pancreatic resection and highlights postoperative glycemic control using a closed-loop system or artificial pancreas. In previous experiments, we have demonstrated the reliability of the artificial pancreas in dogs with total pancreatectomy, and its postoperative clinical use has been shown to be effectiveand safe, without the occurrence of hypoglycemic episodes, even in patients after total pancreatectomy. Considering the increasing requirement for tight perioperative glycemic control and the recognized risk of hypoglycemia, we propose the use of an artificial endocrine pancreas that is able to monitor continuously blood glucose concentrations with proven accuracy, and administer automatically substances to return blood glucose concentration to the optimal narrow range. | Hiromichi Maeda Takehiro Okabayashi Tomoaki Yatabe Koichi Yamashita Kazuhiro Hanazaki | 2009 | World Journal of Gastroenterology2009，15，33： | 9 |
| 15 | Surgical outcome of carcinosarcoma of the gall bladder:A review显示文摘Carcinosarcoma,which comprises less than one percent of all gall bladder neoplasms,is characterized by the presence of variable proportions of carcinomatous and sarcomatous elements.Recently,several reports have described patients suffering from carcinosarcoma of the gall bladder.However,there are no large studies regarding the clinicopathologic features,therapeutic management,and surgical outcome of this disease because the number of patients who undergo resection of gall bladder carcinosarcoma at a single institution is limited.A Medline search was performed using the keywords 'gall bladder' and 'carcinosarcoma'.Additional articles were obtained from references within the papers identified by the Medline search.Optimal adjuvant chemotherapy and/or radiotherapy protocols for carcinosarcoma of the gall bladder have not been established.Curative surgical resection offers the only chance for long-term survival from this disease.The outcome of 36 patients who underwent surgical resection for carcinosarcoma of the gall bladder was poor;the 3-year overall survival rate was only 31.0% and the median survival time was 7.0 mo.Since the postoperative prognosis of carcinosarcoma of the gall bladder is worse than that of adenocarcinoma,new adjuvant chemotherapies and/or radiation techniques are essential for improvement of surgical outcome. | Takehiro Okabayashi Zhao-Li Sun Robert A Montgomery Kazuhiro Hanazaki | 2009 | World Journal of Gastroenterology2009，15，39： | 9 |
| 16 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 17 | 通过水溶液还原法用抗坏血酸制备纳米铜颗粒(英文)显示文摘通过水溶液还原法用抗坏血酸还原Cu2+制备纳米铜颗粒,并研究溶液pH和Cu2O平均粒径对纳米铜颗粒制备的影响。在溶液pH值为3、5和7时,可制得铜颗粒,并且在pH=7时制得的铜颗粒粒径最小。在溶液pH为9和11时无法制得铜颗粒。Cu2O的平均粒径能影响铜粉的粒径。Cu2O的平均粒径越大,得到的铜颗粒越大。通过对反应过程中不同时间点收集的样品进行XRD分析,可探索出反应的进程。在反应过程中,Cu(OH)2首先作为前驱体出现,然后被还原为Cu2O,最后被还原为铜颗粒。 | 刘清明 Takehiro YASUNAMI Kensuke KURUDA Masazumi OKIDO | 2012 | Transactions of Nonferrous Metals Society of China2012，22，9： | 6 |
| 18 | DOMINATING ATTITUDES IN THE GRAPH MODEL FOR CONFLICT RESOLUTION显示文摘为分析称在冲突的制造者态度被介绍并且适用于达成一个 brownfield 性质的公平转移的问题的一个决定的重要性的正式方法论。他的对手的制造者态度在他他的自己的偏爱的考虑被表示的一个决定,以及那些。统治态度被用来建议在一个决定制造者由于他的态度在考虑多重观点的一种情形,他可以更重重地赞成一个观点。brownfield 获得冲突的分析说明这方法论揭示的卓见的类型。 | Sean Bernath WALKER Keith W.HIPEL Takehiro INOHARA | 2012 | Journal of Systems Science and Systems Engineering2012，21，3： | 6 |
| 19 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 20 | Comparison of pancreatic acinar cell carcinoma and adenocarcinoma using multidetector-row computed tomography显示文摘AIM:To distinguish acinar cell carcinoma(ACC)from pancreatic adenocarcinoma(AC)by comparing their computed tomography findings.METHODS:Patients with ACC and AC were identified on the basis of results obtained using surgically resected pancreatectomy specimens.The preoperative computer tomographic images of 6 acinar cell carcinoma patients and 67 pancreatic adenocarcinoma patients in 4 phases(non-contrast,arterial,portal venous,and delayed phase)were compared.The scan delay times were 40,70,and 120 s for each contrast-enhanced phase.The visual pattern,tomographic attenuation value,and time attenuation curve were assessed and compared between AC and ACC cases using the 2test,Wilcoxon signed-rank test,and Mann Whitney U test.RESULTS:The adenocarcinomas tended to be hypodense in all 4 phases.The acinar cell carcinomas also tended to be hypodense in the 3 contrast-enhancedphases,although their computed tomographic attenuation values were higher.Further,5 of the 6 acinar cell carcinomas(83%)were isodense in the non-contrast phase.The time attenuation curve of the adenocarcinomas showed a gradual increase through the 4 phases,and all adenocarcinomas showed peak enhancement during the delayed phase.The time attenuation curve of the acinar cell carcinomas showed peak enhancement during the portal venous phase in 4 cases and during the arterial phase in 2 cases.None of the 6 acinar cell carcinomas showed peak enhancement during the delayed phase.CONCLUSION:The tumor density in the non-contrast phase and time attenuation curve pattern clearly differ between acinar cell carcinomas and adenocarcinomas,and multidetector-row computed tomography can thus distinguish these tumors. | Tatsuaki Sumiyoshi Yasuo Shima Takehiro Okabayashi Akihito Kozuki Toshio Nakamura | 2013 | World Journal of Gastroenterology2013，19，34： | 5 |
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