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| 1 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 12 |
| 2 | Underwater persistent bubble-assisted femtosecond laser ablation for hierarchical micro/nanostructuring显示文摘In this study,we demonstrate a technique termed underwater persistent bubble assisted femtosecond laser ablation in liquids(UPB-fs-LAL)that can greatly expand the boundaries of surface micro/nanostructuring through laser ablation because of its capability to create concentric circular macrostructures with millimeter-scale tails on silicon substrates.Long-tailed macrostructures are composed of layered fan-shaped(central angles of 45°–141°)hierarchical micro/nanostructures,which are produced by fan-shaped beams refracted at the mobile bubble interface(.50°light tilt,referred to as the vertical incident direction)during UPB-fs-LAL line-by-line scanning.Marangoni flow generated during UPB-fs-LAL induces bubble movements.Fast scanning(e.g.1mms−1)allows a long bubble movement(as long as 2mm),while slow scanning(e.g.0.1mms−1)prevents bubble movements.When persistent bubbles grow considerably(e.g.hundreds of microns in diameter)due to incubation effects,they become sticky and can cause both gas-phase and liquidphase laser ablation in the central and peripheral regions of the persistent bubbles.This generates low/high/ultrahigh spatial frequency laser-induced periodic surface structures(LSFLs/HSFLs/UHSFLs)with periods of 550–900,100–200,40–100 nm,which produce complex hierarchical surface structures.A period of 40 nm,less than 1/25th of the laser wavelength(1030 nm),is the finest laser-induced periodic surface structures(LIPSS)ever created on silicon.The NIR-MIR reflectance/transmittance of fan-shaped hierarchical structures obtained by UPB-fs-LAL at a small line interval(5μm versus 10μm)is extremely low,due to both their extremely high light trapping capacity and absorbance characteristics,which are results of the structures’additional layers and much finer HSFLs.In the absence of persistent bubbles,only grooves covered with HSFLs with periods larger than 100 nm are produced,illustrating the unique attenuation abilities of laser properties(e.g.repetition rate,energy,incident angle,etc)by persistent bubbles with different curvatures.This research represents a straightforward and cost-effective approach to diversifying the achievable hierarchical micro/nanostructures for a multitude of applications. | Dongshi Zhang Bikas Ranjan Takuo Tanaka Koji Sugioka | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 11 |
| 3 | Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach显示文摘We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin (B-hCG) and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features. | Yasumitsu Hirano Takuo Hara Hiroshi Nozawa Kaeko Oyama Naohiro Ohta Kenji Omura Go Watanabe Hideki Niwa | 2008 | World Journal of Gastroenterology2008，14，20： | 6 |
| 4 | Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis显示文摘There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis. | Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin Iwao Ono Eriko Ushiyama | 2009 | World Journal of Gastroenterology2009，15，17： | 5 |
| 5 | A white opaque substance-positive gastric hyperplastic polyp with dysplasia显示文摘The endoscopic findings of gastric hyperplastic polyps (HPs) with dysplasia have not been well-defined, and the clinical significance of these lesions, including their malignant potential, is unclear. In this report, we describe a case of a white opaque substance (WOS)positive gastric HP with dysplasia. A 76-year-old woman was referred to our hospital for endoscopic resection of a gastric HP. Upper endoscopy revealed a 25-mm whitish and reddish polypoid lesion on the greater curvature in the lower third of the stomach. The whitish part was diagnosed as a WOS using conventional and magnifying endoscopy with narrow band imaging. An examination of the biopsy specimen indicated that the lesion was a typical gastric HP. However, because of its color and the presence of a WOS, we suspected that this lesion was an atypical gastric HP. Therefore, we performed a polypectomy. Histopathologically, diffuse lowto high-grade dysplasia was found on the surface of the polyp. We performed immunohistochemical staining using a monoclonal antibody specific for adipophilin as a marker of lipid droplets (LDs). LDs were detected in approximately all of the neoplastic cells, especially in the surface epithelium of the intervening apical parts and were located in the subnuclear cytoplasm of the neoplastic cells. According to endoscopic and histopathological findings, the WOS-positive epithelium indicated dysplasia of the gastrointestinal phenotype, which could absorb lipids. The presence of a WOS in a gastric HP may be considered an endoscopic finding that is predictive of the neoplastic transformation of a gastric HP. We suggest that a WOS-positive gastric HP should be resected endoscopically to investigate its neoplastic transformation. | Hiroya Ueyama Kenshi Matsumoto Akihito Nagahara Ryosuke Gushima Takuo Hayashi Takashi Yao Sumio Watanabe | 2013 | World Journal of Gastroenterology2013，19，26： | 4 |
| 6 | Roles of lipoprotein receptors in the entry of hepatitis C virus显示文摘Infection by hepatitis C virus(HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multistep complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type Ⅰ and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection. | Jingya Lyu Hitomi Imachi Kensaku Fukunaga Takuo Yoshimoto Huanxiang Zhang Koji Murao | 2015 | World Journal of Hepatology2015，7，24： | 3 |
| 7 | 鞣质类物质的新分析法显示文摘鞣质为一大类多酚化合物,存在于多种植物中,经常与人们的日常生活打交道。从来,人们对这类化合物的认识,只以为它有止泻和止血的作用,而另一些人则认为鞣质是一种有毒物质,有些有致癌和肝中毒的作用,尽管另一些植物中的鞣质却能抗癌。 | Takuo O 史玉俊 | 1989 | 国外医药(植物药分册)1989，4，3： | 2 |
| 8 | A potential new serotype of Riemerella anatipestifer isolated from ducks in Thailand显示文摘 | Pornpen Pathanasophon Patchara Phuektes Tipa Tanticharoenyos Watcharachai Narongsak Takuo Sawada | 2002 | Avian Pathology2002，，3： | 2 |
| 9 | Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START)显示文摘 | Wasaburo Koizumi Yeul Hong Kim Masashi Fujii Hoon Kyo Kim Hiroshi Imamura Kyung Hee Lee Takuo Hara Hyun Cheol Chung Taroh Satoh Jae Yong Cho Hisashi Hosaka Akihito Tsuji Akinori Takagane Mikito Inokuchi Kazuaki Tanabe Tatsuya Okuno Mariko Ogura Kazuhiro Y | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 2 |
| 10 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 2 |
| 11 | Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura:A case report显示文摘对胸膜的恶意的独居的含纤维的肿瘤的手术后的双边的多重肺转移的全身的化疗上的一个 77 岁的人受不了瘙痒和黄疸。血检查显示出肝胆管酶的提高的层次。腹的计算断层摄影术在胰腺的头与外部改进显示出一个肿瘤,与 intra 肝、额外肝的胆汁管的膨胀伴随了。他作为把妨碍的黄疸被一个胰腺的头肿瘤引起了被诊断。胰腺的头肿瘤大概作为胸膜的恶意的独居的含纤维的肿瘤的转移被诊断,因为腹的 CT 上的胰腺的头肿瘤上的调查结果类似于胸膜的恶意的独居的含纤维的肿瘤的主要的肺损害上的那些。胰腺的肿瘤在胆总管的劣等的部分在金属性的斯滕特氏印模膏的培植以后很快成长了。病人死于肺的癌性淋巴管炎。尸体揭示了从胰腺的头传播了到肝的核的一个肿瘤。用显微镜,和骨胶原免职展出原子 atypicality 或分割的塑造锭子的房间被观察。Immunohistochemically 胰腺的头肿瘤房间为 alpha 光滑的肌肉肌动朊(alpha-SMA ) 或 CD117 染色是否定的,但是为 vimentin, CD34 和 CD99 积极。这些调查结果与胸膜的恶意的独居的含纤维的肿瘤上的那些一致。我们报导一个第二等的胰腺的肿瘤从胸膜的恶意的独居的含纤维的肿瘤引起的妨碍的黄疸的第一个案例。 | Norie Yamada Chiaki Okuse Masahito Nomoto Mayu Orita Yoshiki Katakura Toshiya Ishii Takuo Shinmyo Hiroaki Osada Ichiro Maeda Hiroshi Yotsuyanagi Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 12 | Phase II trial of nanoparticle albumin‐bound paclitaxel as second‐line chemotherapy for unresectable or recurrent gastric cancer显示文摘 | Yasutsuna Sasaki Tomohiro Nishina Hirofumi Yasui Masahiro Goto Kei Muro Akihito Tsuji Wasaburo Koizumi Yasushi Toh Takuo Hara Yoshinori Miyata | 2014 | Cancer Sci2014，，7： | 2 |
| 13 | A potential new serotype of Riemerella anatipestifer isolated from ducks in Thailand显示文摘 | Pornpen Pathanasophon Patchara Phuektes Tipa Tanticharoenyos Watcharachai Narongsak Takuo Sawada | 2002 | Avian Pathology2002，，3： | 2 |
| 14 | Cardiac output and circulating blood volume analysis by pulse dye-densitometry显示文摘 | Takehiko Iijima Takuo Aoyagi Yasuhide Iwao Junichi Masuda Masayoshi Fuse Naoki Kobayashi Hiroshi Sankawa | 1997 | Journal of Clinical Monitoring1997，，2： | 2 |
| 15 | Hepatoblastoma in a dog显示文摘 | Atsushi SHIGA Kinji SHIROTA Takuo SHIDA | 1997 | Vet Med Sci1997，59，12： | 1 |
| 16 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 1 |
| 17 | Studies on anticancer principles in Chinese medicines显示文摘 | Takuo K Masami Y | 1985 | Chem pharm Bull1985，33，12： | 1 |
| 18 | Charts for Estimating Strength Parameters from Slips in Homogeneous Slopes显示文摘 | Jiang Jingcai Takuo Yamagami | 2006 | Computers and Geotechnics2006，33，6： | 1 |
| 19 | Purification and antibacterial characterization of a novel isoform of the Manila clam lectin ( MGL -4) from the plasma of the Manila clam, Ruditapes philippinarum显示文摘 | Keisuke GT Takuo K Kiyokun M | 2008 | Comp Biochem Physiol2008，150，： | 1 |
| 20 | Plant species diversity in abandoned coppiceforests in a temperate deciduous forest area of central Japan显示文摘 | Takuo Nagaike | 2003 | Plant Ecology2003，166，： | 1 |
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