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| 1 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 2 | Atypical antipsychotic properties of blonanserin, a novel dopamine D 2 and 5-HT 2A antagonist显示文摘 | Yukihiro Ohno Motoki Okano Junta Imaki Ayaka Tatara Takahiro Okumura Saki Shimizu | 2010 | Pharmacology Biochemistry and Behavior2010，，2： | 1 |
| 3 | Multichannel and high-density hybrid integrated light source with a laser diode array on a silicon optical waveguide platform for interchip optical interconnection显示文摘A hybrid integrated light source was developed with a configuration in which a laser diode(LD)array was mounted on a silicon optical waveguide platform for interchip optical interconnection.This integrated light source is composed of 13-channel stripes with a pitch of 20 or 30μm.The output power of each LD in the 400 or 600-μm long LD array was over 40 mW at room temperature without cooling.An output power uniformity was 1.3 dB including an LD array power uniformity.The use of a SiON waveguide with a spot size converter resulted in an optical coupling loss of 1 dB between an LD and SiON waveguide.The integrated light source including 52 output ports demonstrated a reduction in the footprint per channel.We also demonstrated a light source with over 100 output ports in which the number of output ports is increased by using a waveguide splitter and multichip bonding.These integrated light sources are practical candidates for use with photonic integrated circuits for high-density optical interconnection. | Takanori Shimizu Nobuaki Hatori Makoto Okano Masashige Ishizaka Yutaka Urino Tsuyoshi Yamamoto Masahiko Mori Takahiro Nakamura Yashuhiko Arakawa | 2014 | Photonics Research2014，2，3： | 1 |
| 4 | Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model显示文摘 | Masashi Kawamura Shigeru Miyagawa Kenji Miki Atsuhiro Saito Satsuki Fukushima Takahiro Higuchi Takuji Kawamura Toru Kuratani Takashi Daimon Tatsuya Shimizu Teruo Okano Yoshiki Sawa | 2012 | Circulation ( suppl )2012，，11： | 1 |
| 5 | Wireless capsule endoscopy in pediatric patients: the first series from Japan显示文摘 | Daisuke Tokuhara Kenji Watanabe Yoshiyuki Okano Akio Tada Kazumi Yamato Takahiro Mochizuki Junji Takaya Tsunekazu Yamano Tetsuo Arakawa | 2010 | Journal of Gastroenterology2010，，7： | 1 |
| 6 | Wireless capsule endoscopy in pediatric patients: the first series from Japan显示文摘 | Daisuke Tokuhara Kenji Watanabe Yoshiyuki Okano Akio Tada Kazumi Yamato Takahiro Mochizuki Junji Takaya Tsunekazu Yamano Tetsuo Arakawa | 2010 | Journal of Gastroenterology2010，，7： | 1 |
| 7 | Restricted infection of murine cytomegalovirus (MCMV) in neonatal mice with MCMV-induced sensorineural hearing loss显示文摘 | Kazufumi Ikuta Hiroshi Ogawa Hiromi Hashimoto Wataru Okano Akiko Tani Etsuko Sato Isao Kosugi Takahiro Kobayashi Koichi Omori Tatsuo Suzutani | 2015 | Journal of Clinical Virology2015，，： | 1 |
| 8 | Leadless cardiac pacemaker implantations after infected pacemaker system removals in octogenarians显示文摘Background Management of pacemaker(PM)infections among advanced aged patients possesses particular clinical challenges due to higher rates of concurrent cardiovascular disease and medical comorbidities.Novel leadless cardiac pacemakers(LCPs)may provide new opportunities for better management options in this population,however,there is limited data especially in Asian populations to guide the decision making.Methods We reviewed 11 octogenarians(median age:86[minimum 82–maximum 90]years;male:73%;median body mass index(BMI):20.1 kg/m^(2))who received Micra Transcatheter Pacing System(Medtronic Inc,Minneapolis,MN)implantations following transvenous lead extractions(TLEs)for PM infections.Results All patients had more than two medical comorbidities(average 3.7 comorbidities).The indications for LCP implantations were atrioventricular block in four patients,atrial fibrillation bradycardia in five,and sinus node dysfunction in two.Eight patients(73%)were bridged with temporary pacing using active fixation leads(median interval of 14.0 days),while one with severe dementia underwent a concomitant LCP implantation and TLE during the same procedure.Successful TLEs and LCP implantations were successfully accomplished in all without any complications.The median time from the TLE procedure to discharge was 22 days(minimum 7–maximum 136).All patients remained free of infections during a mean follow-up period of 17.2±6.5 months.Conclusions LCP implantations were safe and effective after removing the entire infectious PM system in all octogenarians.The novel LCP technology may offer an alternative option for considering a re-implantation strategy after transvenous PM infections in elderly patients,particularly those with severe frailty and PM dependency. | Satoshi Higuchi Ayako Okada Morio Shoda Daigo Yagishita Satoshi Saito Miwa Kanai Shohei Kataoka Kyoichiro Yazaki Hiroaki Tabata Hideki Kobayashi Wataru Shoin Takahiro Okano Koji Yoshie Koichiro Ejima Koichiro Kuwahara Nobuhisa Hagiwara | 2021 | Journal of Geriatric Cardiology2021，18，7： | 0 |
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