|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress显示文摘AIM To determine whether oral glutathione(GSH)administration can alleviate the effects of fasting-induced intestinal atrophy in the small intestinal mucosa. METHODS Rats were divided into eight groups.One group was fed ad libitum,another was fed ad libitum and received oral GSH,and six groups were administrated saline(SA)or GSH orally during fasting.Mucosal height,apoptosis,and cell proliferation in the jejunum were histologically evaluated.i NOS protein expression(by immunohistochemistry),nitrite levels(by high performance liquid chromatography,as a measure of NO production),8-hydroxydeoxyguanosine formation(by ELISA,indicating ROS levels),glutathione/oxidized glutathione(GSH/GSSG)ratio(by enzymatic colorimetric detection),andγ-glutamyl transpeptidase(Ggt1)mR NA levels in the jejunum(by semi-quantitative RT-PCR)were also estimated. RESULTS O r a l G S H a d m i n i s t r a t i o n w a s d e m o n s t r a t e d t o drastically reduce fasting-induced intestinal atrophy in the jejunum.In particular,jejunal mucosal height was enhanced in GSH-treated animals compared to SA-treated animals[527.2±6.9 for 50 mg/kg GSH,567.6±5.4 for 500 mg/kg GSH vs 483.1±4.9(μm),P<0.01at 72 h].This effect was consistent with decreasing changes in GSH-treated animals compared to SA-treated animals for iN OS protein staining[0.337±0.016for 50 mg/kg GSH,0.317±0.017 for 500 mg/kg GSH vs 0.430±0.023(area of staining part/area of tissue),P<0.01 at 72 h]and NO[2.99±0.29 for 50 mg/kg GSH,2.88±0.19 for 500 mg/kg GSH vs 5.34±0.35(nmol/g tissue),P<0.01 at 72 h]and ROS[3.92±0.46for 50 mg/kg GSH,4.58±0.29 for 500 mg/kg GSH vs6.42±0.52(8-OHdG pg/μg DNA),P<0.01,P<0.05at 72 h,respectively]levels as apoptosis mediators in the jejunum.Furthermore,oral GSH administration attenuated cell proliferation decreases in the fasting jejunum[182.5±1.9 for 500 mg/kg GSH vs 155.8±3.4(5-Brd U positive cells/10 crypts),P<0.01 at 72h].Notably,both GSH concentration and Ggt1 m RNA expression in the jejunum were also attenuated in rats following oral administration of GSH during fasting as compared with fasting alone[0.45±0.12 vs 0.97±0.06(nmol/mg tissue),P<0.01;1.01±0.11 vs 2.79±0.39(Ggt1 m RNA/Gapdh m RNA),P<0.01 for 500 mg/kg GSH at 48 h,respectively]. CONCLUSION Oral GSH administration during fasting enhances jejunal regenerative potential to minimize intestinal mucosal atrophy by diminishing fasting-mediated ROS generation and enterocyte apoptosis and enhancing cell proliferation. | Hiroyuki Uchida Yukari Nakajima Kazuo Ohtake Junta Ito Masahiko Morita Ayako Kamimura Jun Kobayashi | 2017 | World Journal of Gastroenterology2017，23，36： | 5 |
| 2 | Percutaneous MR-guided cryoablation for malignancies, with a focus on renal cell carcinoma显示文摘 | Takuji Mogami Junta Harada Kouichi Kishimoto Sajio Sumida | 2007 | International Journal of Clinical Oncology2007，，2： | 2 |
| 3 | 1个黑煤病菌新组合Metacapnodium neesii及其基于核酸序列的系统发育位置显示文摘2019年10月,在日本本州中部长野县的富士山冷杉树枝及树叶上采集到4种黑斑病致病菌标本,经鉴定为已知致病菌Capnobotrys neesii(Capnobotrys的模式种)。此外,通过单孢分离法培养出具有代表性的菌株JCM 39119,能产生具有瓶梗状的产孢细胞和分生孢子的念珠状菌丝、以及类似于在天然宿主上生长的分生孢子梗和小型分生孢子的菌丝。根据植物多形性真菌学名重新命名的原则,无性型类群C.neesii被划分至Metacapnodium,作为新组合Metacapnodium neesii。测定了JCM 39119菌株的nrL SU、nrS SU、ITS、RPB2和EFIa基因序列,并基于核糖体小亚基序列进行系统发育分析,将JCM 39119菌株定位在刺盾炱目Chaetothyriales的分类单元上,而非预期的煤炱目Capnodiales或格孢菌目Pleosporales分类单元。因此,必须进行进一步实验分析,通过对其他基因序列分析得到最终结论。本研究结果支持对以Metacapnodium为代表的假煤炱科Metacapnodiaceae的更高级别分类进行修订。 | Junta Sugiyama Kyung-Ok Nam Tsuyoshi Hosoya | 2020 | 菌物研究2020，18，4： | 2 |
| 4 | Spatial variability of nitrous oxide emissions and their soil -related determining factors in an agricultural field显示文摘 | Junta Y Takuji S Taku O | 2003 | Journal of Environmental Quality2003，32，： | 1 |
| 5 | Early growth of the autumn cohort of neon flying squid, Ommastrephes bartramii , in the North Pacific Ocean显示文摘 | Akihiko Yatsu Junta Mori | 2000 | Fisheries Research2000，，2： | 1 |
| 6 | Atypical antipsychotic properties of blonanserin, a novel dopamine D 2 and 5-HT 2A antagonist显示文摘 | Yukihiro Ohno Motoki Okano Junta Imaki Ayaka Tatara Takahiro Okumura Saki Shimizu | 2010 | Pharmacology Biochemistry and Behavior2010，，2： | 1 |
| 7 | Improvement of Thermal Environment in Railway Station Using Local Wind 显示文摘 | Nakamura Yuka Yamada Yuki Nakano Junta | 2011 | 12th International Conference on Indoor Air Quality and Climate2011，，1： | 1 |
| 8 | Discrete finger and palmar feature extraction for personal authentication 显示文摘 | Junta D Masaaki Y | 2005 | IEEE Transactions Instrumenta-tion and Measurement2005，54，6： | 1 |
| 9 | Archiascomycetes:detection of a major new lineage within the Ascomycota显示文摘 | HIROMI N JUNTA S | 1994 | Mycoscience1994，35，： | 1 |
| 10 | Current Status of Hepatocellular Carcinoma Treatment in Japan显示文摘 | Norihiro Kokudo Junta Nakajima Etsuro Hatano Kazushi Numata | 2012 | Clinical Drug Investigation2012，，2： | 1 |
| 11 | Solutions of the Broer-Kaup system through its trilinear form显示文摘 | Junkiehi Satsuma Kenji Kajiwara Junta Matsukidaira | 1992 | J Phys Soc Jan1992，61，： | 1 |
| 12 | Relatedness, phylogeny, and evolution of the fungi显示文摘 | Junta Sugiyama | 1998 | Mycoscience1998，，4： | 1 |
| 13 | Manganese( Ⅱ ) oxidation at mineral surfaces:a microscopic and spectroscopic study 显示文摘 | Junta J L Hochella M F Jr | 1994 | Geochimca et Cosmochimica Acta1994，58，22： | 1 |
| 14 | Manganese ( Ⅱ ) oxidation at mineral surfaces: A microscopic and spectroscopic study 显示文摘 | Junta J L Hochella M F Jr | 1994 | Geochim Cosmochim Acta1994，58，： | 1 |
| 15 | Kemel approaches for genie interaction extraetion显示文摘 | Seonho Kim Juntae Yoon Yang Jihoon | 2008 | Bioinformatics2008，24，1： | 1 |
| 16 | Evaluation of Thermal Comfort Using Combined Multi node Thermoregulation (65MN) and Radiation Models and Computational Fluid Dynamics (CFD 显示文摘 | Shin-ichi Tanabe Kozo Kobayashi Junta Nakano ect | 2002 | Energy and Buildings2002，34，： | 1 |
| 17 | Corrosion electrochemical characteristics of red ironoxide pigmented epoxy coatings on aluminum alloys 显示文摘 | Hu Jamming Zhang Junta Zhang Jianqing CioChuan | 2005 | Corrosion Science?2005，47，11： | 1 |
| 18 | Eradication of insulin resistance显示文摘 | Junta Imai Tetsuya Yamada Tokuo Saito Yasushi Ishigaki Yoshinori Hinokio Hidetoshi Kotake Yoshitomo Oka Hideki Katagiri | 2009 | The Lancet2009，，9685： | 1 |
| 19 | Hepatocyte transplantation in rats with decompensated cirrhosis 显示文摘 | Naoya K Masahiro I Junta N | 2000 | Hepatology2000，31，4： | 1 |
| 20 | Evaluation of thermal comfort using combined multi-node thermoregulation and radiation models and computational fluid dynamics显示文摘 | Shin-ichi Tanabe Kozo Kobayashi Junta Nakano | 2002 | Energy and Buildings2002，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员