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| 1 | Anthropogenic emission inventories in China:a review显示文摘The development of reliable anthropogenic emission inventories is essential for both understanding the sources of air pollution and designing effective air-pollution-control measures in China. However, it is challenging to quantify emissions in China accurately, given the variety of contributing sources, the complexity of the technology mix and the lack of reliable measurements. Over the last two decades,tremendous efforts have been made to improve the accuracy of emission inventories, and significant improvements have been realized. More reliable statistics and survey-based data have been used to reduce the uncertainties in activity rates and technology distributions. Local emission factors and source profiles covering various sources have been measured and reported. Based on these local databases, improved emission inventory models have been developed for power plants, large industrial plants and the residential,transportation and agricultural sectors. In this paper, we review the progress that has been made in developing inventories of anthropogenic emissions in China. We first highlight the major updates that have been made to emission inventory models and the underlying data by source category. We then summarize the sector-based estimates of emissions of different species contained in current inventories. The progress that has been made in the development of model-ready emissions is also presented. Finally, we suggest future directions for further improving the accuracy of emission inventories in China. | Meng Li Huan Liu Guannan Geng Chaopeng Hong Fei Liu Yu Song Dan Tong Bo Zheng Hongyang Cui Hanyang Man Qiang Zhang Kebin He | 2017 | National Science Review2017，4，6： | 100 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair显示文摘AIM To study the changes of endogenoustransforming growth factor β(TGFβ)and basicfibroblast growth factor(bFGF)in lung followingintestinal ischemia and reperfusion injury andtheir effects on lung injury and repair.METHODS Sixty Wistar rats were divided intofive groups,which underwent sham-operation,ischemia(45 minutes),and reperfusion(6,24and 48 hours,respectively)after ischemia(45minutes).Immunohistochemical method wasused to observe the localization and amounts ofboth growth factors.RESULTS Positive signals of both growthfactors could be found in normal lung,mainly inalveolar cells and endothelial cells of vein.Afterischemia and reperfusion insult,expressions ofboth growth factors were increased and theiramounts at 6 hours were larger than those ofnormal control or of 24 and 48 hours after insult.CONCLUSION The endogenous bFGF and TGF βexpression appears to be up-regulated in thelung following intestinal ischemia andreperfusion,suggesting that both growth factorsmay be involved in the process of lung injury andrepair. | Xiao Bing Fu Yin Hui Yang Tong Zhu Sun Xiao Man Gu Li Xian Jiang Xiao Oing Sun Zhi Yong Sheng Research Laboratory,304th Hospital of PLA,Beijing 100037,China | 2000 | World Journal of Gastroenterology2000，6，3： | 21 |
| 4 | A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean l O0-Seed Weight显示文摘栽培大豆可以在驯服期间失去某有用基因 loci。从野大豆的基因的基因渗入能拓宽基因背景并且改进大豆农学的特点。在这研究,通过 recombinant 的整个染色体的定序,生来的线人口源于在野大豆 ZYD7 和栽培大豆 HN44 之间的一个十字,并且为种子重量量的特点 loci 印射,我们发现从野大豆 ZYD7 的磷酸酶 2C-1 ( PP2C-1 )等位基因在种子重量/尺寸贡献增加。PP2C-1 可以由提高覆盖物的房间尺寸并且激活一个子集完成这功能播种特点相关的基因。我们发现 PP2C-1 与 GmBZR1 被联系, Arabidopsis BZR1 的大豆 ortholog,之一在发信号的 brassinosteroid (BR ) 给抄写因素调音,并且便于 dephosphorylated GmBZR1 的累积。相反,有在 N 终点的一些氨基酸的变化的 PP2C-2 等位基因没展出这功能。而且,我们证明 GmBZR1 能在转基因的植物支持种子重量 / 尺寸。通过栽培大豆就职的分析,我们发现 40% 检验就职没有 PP2C-1 等位基因,建议这些就职能被这等位基因的介绍改进。一起拿,我们的学习识别精英等位基因 PP2C-1,它能在由分子帮助繁殖的这等位基因的那操作可以增加的大豆,和针尖提高种子重量或尺寸在大豆的生产和另外的荚 / 庄稼。 | Xiang Lu Qing Xiong Tong Cheng Qing-Tian Li Xin-Lei Liu Ying-Dong Bi Wei Li Wan-Ke Zhang Biao Ma Yong-Cai Lai Wei-Guang Du Wei-Qun Man Shou-Yi Chen Jin-Song Zhang | 2017 | Molecular Plant2017，10，5： | 17 |
| 5 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 6 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 7 | Efficient and rapid generation of induced pluripotent stem :ells using an alternative culture medium显示文摘 | Xiao-yang Zhao Wei Li Zhuo Lv Lei Liu Man Tong Tang Hai Jie Hao Chang-long Guo Xia ng Wang Liu Wang Fanyi Zeng Qi Zhou | 2010 | Cell Research2010，20，3： | 9 |
| 8 | Electrolytic groundwater circulation well for trichloroethylene degradation in a simulated aquifer显示文摘An in situ groundwater remediation process, termed EGCW, was developed in this study by integrating in-well groundwater electrolysis into groundwater circulation well. Groundwater circulation carries electrolytically generated O2 and H2 into the impacted aquifer for in situ biodegradation of contaminants. In a two-dimensional tank filled with field sandy sediments,simulated trichloroethylene(TCE)-contaminated groundwater was circulated between an injection well with electrodes inside and a pumping well. Results from a 50-day EGCW experiment show that in-well electrolysis oxygenated most region near the injection well, and 10 mg/L TCE was mainly biodegraded aerobically to about 2.7 mg/L(73% removal) by the indigenous microbes. Aerobic TCE degradation was enhanced by the pulsed addition of acetate. Together with the proofs of stable carbon isotope fractionation(enrichment factor:-0.57‰–-1.53‰) and microbial community variation after EGCW treatment, aerobic cometabolism was proposed to be the most likely mechanism for TCE degradation. It is interesting to find that the intrinsic organic carbon in aquifer matrix could fuel the aerobic TCE degradation, particularly at low TCE concentrations. EGCW treatment is advantageous in terms of supplying appropriate dosages of electron acceptor(O_(2)) and donor(H_(2)) for in situ bioremediation because groundwater electrolysis and circulation are expedient and controllable. | YUAN SongHu LIU Yang ZHANG Peng TONG Man LIU Hui | 2021 | Science China(Technological Sciences)2021，64，2： | 6 |
| 9 | Derivation of embryonic stem cells from Brown Norway rats blastocysts显示文摘Knockout Brown Norway (BN) rat could be a useful disease model for human disorders,however,a failure to derive embryonic stem (ES) cells disturbs the further development of the model.In this study,we reported a case of successful derivation of the BN rat ES cells with the derivation efficiency comparable to that of Sprague Dawley (SD) rats.The BN rat ES cells expressed the key transcription factors,and were able to form embryonic bodies (EBs) when being differentiated in vitro.After injecting the BN rat ES cells into the SD rat blastocysts,high-contribution chimeric rats were generated and could survive to their adulthood.Our success in generating pluripotent rat ES cells will benefit the generation of the knockout rats in the future. | Xiaoyang Zhao Zhuo Lv Lei Liu Liu Wang Man Tong Qi Zhou | 2010 | Journal of Genetics and Genomics2010，37，7： | 5 |
| 10 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 11 | Corrigendum to Anthropogenic emission inventories in China:a review显示文摘In the Figure 4 of ‘Anthropogenic emission inventories in China:a review'(National Science Review,Volume 4,Issue 6, 2017,Pages 834-866,doi:10.1093/nsr/nwx150),the data for the MEIC vl.2 was incorrectly plotted.The corrected version of Figure 4 is presented below. | Meng Li Huan Liu Guannan Geng Chaopeng Hong Fei Liu Yu Song Ban Tong Bo Zheng Hongyang Cui Hanyang Man Qiang Zhang Kebin He | 2018 | National Science Review2018，5，4： | 5 |
| 12 | Rosuvastatin inhibits the smooth muscle cell proliferation by targeting TNFα mediated Rho kinase pathway显示文摘ObjectiveTo 调查是否肿瘤坏死 Factor-alpha ( TNFα ;)能够激活导致光滑的肌肉房间增长和 Rosuvastatin 的干预功能的 Rho kinase 小径,并且由光滑的肌肉房间是的 Rosuvastatin.MethodsWistar 出生不满一月的婴儿老鼠澄清机制和反动脉粥样硬化的干预举止有教养,并且房间增长的活动被甲基 thiazolyl tetrazolium ( MTT )决定。在 TNFα 的刺激以后的 Rho kinase 基因的表示;被 RT-PCR 评估。西方的污点方法被用来测量增殖的房间的蛋白质表示在 TNFα 以后的原子抗原(PCNA ) ;在光滑的肌肉 cell.ResultsThe TNFα 的刺激和 Rosuvastatin 干预;刺激显著地提高了 Rho kinase 的表示并且在光滑的肌肉房间增加了 PCNA 蛋白质的表示(P <0.05 ) 。而另外的 Rosuvastatin 管理禁止了,这些效果断然与延长处理被相关上述效果(P <0.05 ) TNFα 的 .ConclusionsThe 激活;调停的 Rho kinase 发信号小径能显著地支持光滑的肌肉房间增长,并且 Rosuvastatin 不能仅仅禁止这条小径而且导致的增长。 | Xiao Sun Hao Tong Man Zharlg Xiao-Hang Wang | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 13 | Temperature elevated N ion implantation of Ti6A14V alloys using the plasma source显示文摘Specimens of Ti6A14V alloy were implanted with nitrogen ions of 4× 1018 cm-2 at temperatures from 100 to 600℃. Auger Electron Spectroscopy (AES), microhardness measurements and pin-on-disk wear testing, Scanning Electron Mi- croscopy (SEM), and Glancing angle X-ray Diffraction. (XRD) were utilized to evaluate the surface property improvements. The thickness of implanted layers increased by about an order of magnitude when the temperature was elevated from 100 to 6000℃. Higher surface hardness and wear resistance were also obtained in the high tempera-ture implantation. The XRD image showed the presence of nitrides of titanium at the implanted surface. | ZHAO Qing, ZHENG Yong-Zhen, Mo Zhi-Tao, TONG Hong-Hui, GENG Man (Southwestern Institute of Physics, Chengdu 610041 | 2001 | Nuclear Science and Techniques2001，12，3： | 2 |
| 14 | Effects of the Wollastonite Fiber Modification on the Sliding Wear Behavior of the UHMWPE Composites显示文摘 | Tong Jin Ma Yunhai Jiang Man | 2003 | Wear2003，255，16： | 1 |
| 15 | Once-yearly zoledronic acid for treatment of post-menopausal osteoporosis显示文摘 | Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Krasnow J Hue TF Sellmeyer D Eriksen EF Cummings SR HORIZON Pivotal Fracture Trial | | 0，，： | 1 |
| 16 | Effects of the wollastonite fiber modification on the sliding wear behavior of the UHMWPE composites显示文摘 | Tong Jin Ma Yunhai Jiang Man | 2003 | Wear2003，55，： | 1 |
| 17 | Adaptive approximate nearest neighbor search for fractal image compression显示文摘 | Tong Chong Sze Wang Man | 2002 | IEEE Trans on Image Process2002，11，6： | 1 |
| 18 | Antioxidant protection of edible oils显示文摘 | Sabrina Ching Man Cheung Yim Tong Szeto Irisf f benzie | 2007 | Plant foods for human nutrition2007，62，1： | 1 |
| 19 | A method for improving dispersion of starch nanocrystals in water through crosslinking modification with sodium hexametaphosphate显示文摘 | Lili Ren Man Jiang Liyan Wang Jiang Zhou Jin Tong | 2011 | Carbohydrate Polymers2011，，2： | 1 |
| 20 | Identification of a small molecule 1,4-bis-[4-(3- phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53显示文摘 | Xin LIU Ying ZHANG Man TONG Xiu-ying LIU Guan-zheng LUO Dong-fang XIE Shao-fang REN Dong-hui BAI Liu WANG Qi ZHOU Xiu-jie WANG | 2013 | Acta Pharmacologica Sinica2013，34，6： | 1 |
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