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| 1 | The Hippo signaling pathway in liver regeneration and tumorigenesis显示文摘表明小径的河马是在肝尺寸控制和 tumorigenesis 起关键作用的一个 evolutionarily 保存的发信号的模块。河马小径由在的核心 kinase 串联组成哺乳动物的象 Ste20 一样 kinases (Mst1/2,果蝇河马的 orthologs ) 并且他们的余因子萨尔瓦多(Sav1 ) 形成建筑群到 phosphorylate 并且激活大肿瘤 suppressor (Lats1/2 ) 。Lats1/2 kinases 接着 phosphorylate 并且与 PDZ 有约束力的主题(TAZ ) 禁止抄写激活剂,联系是的蛋白质(笨蛋) 和 transcriptional 激活剂,河马小径的二个主要下游的受动器。河马小径部件的损失导致异常肝肿大和 tumorigenesis,笨蛋在协调房间增长和 apoptosis 的规定并且起一个必要作用。这评论总结在肝新生和 tumorigenesis 发信号的河马的规定的当前的调查结果,集中河马小径的肿瘤 suppressor 部件的损失怎么导致肝癌症并且讨论调整它在肝 tumorigenesis 的下游的受动器笨蛋的表示和激活的分子的机制。 | Lixin Hong Yabo Cai Mingting Jiang Dawang Zhou Lanfen Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 12 |
| 2 | Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy显示文摘Different types of pores ubiquitously form in cell membranes,leading to various types of cell death that profoundly influence the fate of inflammation and the disease status.However,these pores have never truly been visualized to date.Atomic force microscopy(AFM),which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells,is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic resolution.Here,membrane pore structures were clearly visualized using AFM.This visualization not only describes the aperture and depth of the pore complexes but also highlights differences among the pores formed by perforin and gasdermins in tumor cell membranes and by complement in immune cell membranes.Additionally,this type of visualization also reveals the dynamic process of pore formation,fusion,and repair. | Yuying Liu Tianzhen Zhang Yabo Zhou Jiping Li Xiaoyu Liang Nannan Zhou Jiadi Lv Jing Xie Feiran Cheng Yiliang Fang Yunfeng Gao Ning Wang Bo Huang | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 3 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 4 | Phase selection during solidification of undercooled Ni_(70.2)Si_(29.8) eutectic alloy显示文摘在冷却下面的高度(大约 392 K ) 在体积被完成最容易溶解的 Ni 70.2 Si 29.8 合金通过与周期的过热相结合的玻璃 fluxing 融化。这被发现亚稳的阶段 Ni 3 Si 2 并且非最后被获得通过慢团结以后什么时候在冷却下面超过 240 K。亚稳的阶段被使用 X 光检查衍射和微分扫描热量测定(DSC ) 的方法证实。基于免费精力最小和短暂成核理论的原则,阶段选择融化在凉下来的最容易溶解的 Ni 70.2 Si 29.8 融化。从在凉下来的 Ni 70.2 Si 29.8 融化被归功于到竞争成核与在冷却下面,即在冷却下面的高度便于亚稳的阶段的优先的成核。 | Yiping Lu Tingju Li Fu Yabo Sun Jianbo LUO Dawei Gencang Yang Yaohe Zhou | 2009 | Progress in Natural Science:Materials International2009，19，11： | 4 |
| 5 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 6 | Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant显示文摘Dear Editor,Genetic variant Delta(B.1.617.2)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which possesses a remarkable ability to transmit and spread,is currently becoming predominant worldwide.Despite its great harm to human beings,how the Delta variant with T478K,P681R and L452R mutations achieves its ultrafast spread remains elusive.Entry of SARS-CoV-2 into host cells is mediated by a rapid enzymatic hydrolysis. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Wei-Min Tong Jiangning Liu Chuan Qin Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 7 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 8 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 9 | Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages显示文摘Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the lungs.Thus,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the infection.In most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 10 | DNMT3A inhibits E2F1-induced arterial marker expression and impairs angiogenesis in human umbilical artery endothelial cells显示文摘Arterial marker genes EphrinB2 and HEY2 are essential for cardiovascular development and post-natal neovascularization.Our previous study confirmed.that E2F1 could activate the transcription of EphrinB2 and HEY2 in human mesenchymal stem cells;however,the detailed mechanism has not been resolved yet.In this study,we focused on the interaction between E2F1 and DNMT3A,a de novo DNA methyltransferase,on regulating the expression of EphrinB2 and HEY2,and explored the potential mechanisms.Gain-and loss-of-function experiments implicated the positive effect of E2F1 on the expression of EphrinB2 and HEY2 and tube formation in human umbilical artery endothelial cells.Accumulation of DNMT3A decreased the levels of EphrinB2 and HEY2,and impaired tube formation induced by E2F1,while inhibiting DNMT3A by RNA interference aug-mented their expression and angiogenesis in E2F 1-trasfected cells.We then asked whether the low expressions of EphrinB2 and HEY2 induced by DNMT3A are related to the methylation status of their promoters.Surprisingly,the methylation status of the CpG islands in the promoter region was not significantly affected by overexpression of exogenous DNMT3A.Furthermore,the inter-action between E2F1 and DNMT3A was confirmed by co-immunoprecipitation.DNMT3A could inhibit the transcription of EphrinB2 and HEY2 promoters by affecting the binding of E2F1 to its recognition sequences as revealed by luciferase reporter assay and chromatin immunoprecipita-tion.These results identified a novel mechanism underlying the cooperation of DNMT3A with E2F1 on regulating target gene expression,and revealed their roles in the angiogenic process. | Kaiyue Su Ningning Lin Shouqiang Xie Yabo Han Zaiming Yang Hongmin Zhang Hongpeng He Sa Zhou Wenjian Ma Tongcun Zhang Nan Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 1 |
| 11 | Establishment of image-guided radiotherapy of orthotopic hepatocellular carcinoma mouse model显示文摘Background:Hepatocellular carcinoma(HCC)is the most common type of liver cancer.Recently,developments in radiotherapy technology have led to radiotherapy becoming one of the main therapeutics of HCC.Therefore,a suitable animal model for radiotherapy of the orthotopic HCC mouse model is urgently needed.Methods:In the present study,Hepa1-6 cells were injected into the liver of C57BL/6 mice in situ to mimic the pathological characteristics of the original HCC.Tumor formation was monitored by applying magnetic resonance imaging techniques and verified by H&E histopathological staining,AFP staining,and Ki67 staining.A single dose of 10 Gy X-ray was applied to simulate clinical radiotherapy plans using image-guided radiotherapy(IGRT)equipment.The efficiency of radiotherapy was then assessed by examining tumor size and weight one week after radiation.Cleaved-caspase3 staining and TUNEL were used to assess apoptosis in tumor tissues.Results:Intrahepatic tumor development was detected in the liver according using MRI.A high-density shadow could be seen 10 days after cell injection,which indicated the formation of HCC in vivo.The tumors grew steadily bigger,and underwent precision radiotherapy 20 days after injection.The typical pathological characteristics of HCC,such as large,deeply stained nuclei and irregular cell size,were visible with H&E staining.After radiotherapy,significantly higher expression of the immunohistochemical markers Ki67 and AFP were detected in tumor tissue than in the nearby normal tissue.Compared with the control group,the tumor volume(p=0.05)and weight(p<0.05)of the irradiated group were significantly reduced.In addition,a higher frequency of apoptosis was identified in irradiated HCC tumor tissue using the TUNEL and cleaved-caspase3 staining assay.Conclusions:In a well-established orthotopic HCC model,MRI was utilized to monitor the formation of tumors,and IGRT was used to simulate clinical radiotherapy.The present study could provide a suitable preclinical system for HCC radiotherapyrelated studies. | Kaixiao Zhou Yabo Jiang Shuang Feng Wei Mo Jing Nie Jianping Cao Yang Jiao | 2023 | Animal Models and Experimental Medicine2023，6，5： | 0 |
| 12 | Advances in artificial intelligence techniques drive the application of radiomics in the clinical research of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)remains the most common malignancy to threaten public health globally.With advances in artificial intelligence techniques,radiomics for HCC management provides a novel perspective to solve unmet needs in clinical settings,and reveals pixel-level radiological information for medical imaging big data,correlating the radiological phenotype with targeted clinical issues.Conventional radiomics pipelines depend on handcrafted engineering features,and further deep learning-based radiomics pipelines are supplemented with deep features calculated via self-learning strategies.During the past decade,radiomics has been widely applied in accurate diagnoses and pathological or biological behavior evaluation,as well as in prognosis prediction.In this review,we systematically introduce the main pipelines of artificial intelligence-based radiomics and their efficacy in the clinical studies of HCC. | Jingwei Wei Meng Niu Ouyang Yabo Yu Zhou Xiaoke Ma Xue Yang Hanyu Jiang Hui Hui Hongyi Cao Binwei Duan Hongjun Li Dawei Ding Jie Tian | 2022 | iLIVER2022，1，1： | 0 |
| 13 | An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization显示文摘Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent properties.However,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants annually.Moreover,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing by-products.In this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was achieved.Meanwhile,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE molecules.The decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping fashion.Subsequently,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid absorbents.Overall,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers. | Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 14 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 15 | Photovoltaic Properties of the Modified n-Si(111) Electrodes with Ethyl and Carboxyls显示文摘n-Si (111 ) 表面跟踪 -C2H5,-C2H4COOH,-C2H2COOH 被反应在 Si-H 之中准备到 ethyl-Grignard,甲基压克力吃了,丙酸乙酯,和 carboxyls 在 trifluoroacetic 酸的存在下面被形成。合成 n-Si (lll ) 电极被扔磅 nanodots 获得,为这些电极的光电的特征在 I^-/I_3^- 氧化还原作用电解质被学习。到在太阳的照明下面的电极的相片电压和光电流密度的行为与一些 -C2H2COOH>-C2H4COOH>-H>-C2H5.The 相片电压和电极的光电流密度一起定期改变了的 j-U (相片水流密度潜力) 跟踪了 -C2H2COOH 分别地,是 -0.641 V 和 5.25 mA/cm2 比那些更否定非结合的修正。 | Yuxue ZHAO Yabo WEI Wensheng YANG Pudun ZHANG Xin ZHOU Qinghong XU | 2008 | Journal of Materials Science & Technology2008，24，2： | 0 |
| 16 | Combining radiation with immune checkpoint inhibitors therapy for HCC: From the alteration of the immune microenvironment by radiotherapy显示文摘Hepatocellular carcinoma(HCC),one of the deadliest cancers all over the world,had a limited prognosis in the past.Recently,the remarkable efficacy of immune checkpoint inhibitors(ICIs)therapy has been shown in various solid tumors.What's more,the occurrence of HCC is associated with immune escape and therefore various ICIs have been applied to clinical trials for HCC.However,the special immune environment of the liver creates the complex tumor microenvironment(TME)of HCC,which impairs the overall survival(OS)and overall response rate(OCR)of ICIs as a monotherapy.Lately,various therapies have been used in combination with ICIs therapy to improve its clinical efficacy.Among which,radiotherapy is widely concerned because of its unique immunoreaction.A large number of basic and clinical studies have demonstrated that the combined radiotherapy and ICIs therapy has advantages in improving the OCR and efficacy,as compared with ICIs therapy alone.Herein,this article reviews the studies on the advantages and possible mechanisms of the combination of radiotherapy and ICIs therapy for HCC. | Kaixiao Zhou Yabo Jiang Shuang Feng Tingya Wang Lili Wang Jianping Cao Yang Jiao | 2022 | Radiation Medicine and Protection2022，3，4： | 0 |
| 17 | Research on damage failure mechanism and dynamic mechanical behavior of layered shale with different angles under confining pressure显示文摘The hydrostatic or confining pressure of deep rocks has a significant impact on the mechanical behavior of brittle materials.Especially when confining pressure is applied,the mechanical properties of rock materials will undergo significant changes.Considering that the process of shale sample subjected to impact load is in a closed container in the dynamic triaxial SHPB test,the failure process of the sample cannot be observed.Meanwhile,the activation volume of the shale sample would be large and local failure would occur in the test under the high strain rate loading.Therefore,thefinite element model of shale considering the bedding effect under confining pressure was established in this study.Taking shale materials with different bedding dip angles as simulation objects,the dynamic failure characteristics of shale were studied using the dynamic analysis software ANSYS/LS‐DYNA from three aspects:stress‐strain curve,failure growth process,and failure morphology.The research results obtained can serve as the key technical parameters for deep resource extraction. | Ning Luo Haohao Zhang Yabo Chai Penglong Li Cheng Zhai Jianan Zhou Tianran Ma | 2023 | Deep Underground Science and Engineering2023，2，4： | 0 |
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