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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 大鼠戊四唑点燃模型的建立显示文摘给大鼠戊四唑(PTZ)亚惊厥剂量(30 mg/kg,ip),每日一次,连续给药28 d.建立了戊四唑化学点燃模型。采用七点评分法观察行为惊厥和脑电图变化。凡连续5次获二级或二级以上惊厥者,被认为完全点燃。结果表明,28 d龄大鼠总点燃率为74%,全身性肌阵挛为其典型症状。行为惊厥与脑异常放电同步。凡有行为惊厥者皆伴有恼电图棘波或棘慢波放电。停止处理4周后。点燃大鼠仍保持其点燃状态。提示本文所用PTZ剂量合理,方法可靠且简单易行。 | 王丽 J Ono PD Walson | 1993 | 药学学报1993，28，7： | 67 |
| 3 | 普萘洛尔治疗婴幼儿血管瘤的初步经验显示文摘普萘洛尔是治疗婴幼儿血管瘤的新药物,但目前缺少对该药物治疗效果的系统评价。该文应用回顾性研究的方法.以1个三级脉管性疾病中心的资料为研究对象.评价普萘洛尔治疗增殖期和消退期血管瘤的效果。应用治疗期间患者照片双盲对比及调查问卷,评判治疗效果及并发症。 | Buckmiller LM Munson PD Dyamenahalli U | 2010 | 中国口腔颌面外科杂志2010，8，4： | 23 |
| 4 | 脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients | Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD | 2011 | 中华神经外科疾病研究杂志2011，10，5： | 21 |
| 5 | 13C—尿素呼气试验诊断幽门螺杆菌感染显示文摘 | Klei.,PD 江骥 | 1993 | 中华内科杂志1993，32，3： | 14 |
| 6 | 肝脏移植治疗不可切除结直肠癌肝转移的前瞻性试验性研究显示文摘背景和目的无法手术切除的结直肠癌肝转移(Colorectal Liver Metastases,CLMs)患者预后差,存活时间极少超过5年。尽管对部分肝脏原发及继发恶性肿瘤患者施行肝脏移植可获得较佳的预后,但目前仍普遍认为,结直肠癌肝转移是肝移植的绝对禁忌证。1995年之前,曾针对结直肠癌肝转移患者进行过数例肝脏移植,但预后不良(5年生存率仅为18%),自此放弃对此类患者进行肝脏移植。然而,目前总体肝移植生存率较当时提高30%左右。基于此,结直肠癌肝转移患者肝移植后的5年生存率有望达到50%。因此,本试验性研究旨在探讨CLM患者在接受肝移植后的潜在长期生存获益。方法自2006年11月到2011年3月,在此项前瞻性、试验性研究中,共对21名无法切除的结直肠癌肝转移患者进行肝移植术。患者入选标准包括一般状况良好(ECOG 1分或以下)、结直肠癌伴无法切除的单纯肝转移、原发肿瘤已行根治性切除以及移植前接受过至少6周的化疗。结果入组的患者肝脏肿瘤负荷及原发肠癌T/N分期相异;肝移植术前,76%(16/21)患者存在至少一线化疗进展。Kaplan-Meier推算患者1、3及5年总体生存率分别为95%、68%及60%。与预期相同,移植术后复发转移现象普遍,21例中19例在中位时间6(2~24)个月内发生局部复发或转移。其中,单个肺转移灶7例;其余多部位(包括肺)转移者9例,包括移植肝新发转移7例,骨转移5例,卵巢或肾上腺转移3例,腹膜转移1例,腹主动脉旁淋巴结转移2例。2例发生直肠癌局部复发。然而,绝大多数的转移癌可经手术切除或射频治疗,且经过干预后,中位随访时间27个月(8~60个月),33%(7例)患者无病生存。肝移植术前肝脏肿瘤负荷、初次手术距肝移植的时间(肠癌切除距肝移植超过2年者生存获益更显著)以及化疗后肿瘤进展均为影响预后的显著性因素。结论研究结果表明,对于此类患者人群,肝移植术后总体生存率显著高于化疗,而化疗为该患者人群现有的唯一治疗方式。此外,本研究显示的总体生存率与可切除的结直肠癌肝转移患者以及接受再次肝移植的非恶性肿瘤患者情况相当。同时,对预后因素进行手术策略筛选,应可进一步改善患者预后。(临床研究注册编号ClinicalT rials.gov:NCT01311453)。 | Hagness M Foss A Line PD 张信华 | 2013 | 消化肿瘤杂志(电子版)2013，5，4： | 8 |
| 7 | 硒在重金属中毒处理中的作用显示文摘已证明硒可对抗重金属的毒性,例如镉、无机汞、甲基汞、铊以及在有限的程序上对抗银的毒性。尽管效力不如硒,但维生素E可明显改变甲基汞的毒必并且对抗银毒性比硒更有效。维生素E具有很有力的抗铅毒性的作用,但硒的作用很小,硒对镉和汞毒性的保护作用可能是由于使镉和汞从低分子量蛋白结合转移到高分子量蛋白。并讨论了硒在重金属毒性中的作用对人体健康的意义。 | Whan.,PD 王馨节 | 1993 | 国外医学(医学地理分册)1993，14，4： | 7 |
| 8 | Numerical Modeling on Suspended Sediment Transportation in the Hangzhou Bay显示文摘In this paper the characteristics of tidal flow and seasonal variation of seidment content in theHangzhou Bay and their affecting factors are studied.Field investigations and data analysis indicate thatthe sediment movement is mainly influenced by the Yangtze estuary and the sediment of the Yangtze estua-ry is induced by wind wave and tidal flow.Owing to the variation of dynamic conditions,the instanta-neous sediment content is controlled by tidal flow,wind wave,depth of water and tidal range synthetically.A sediment content relationship formula is established with related factors.A non-equilibrium2-dimensional numerical model of suspended sediment transportation is set up,and the finite element meth-od is applied.The computation results of the model is in accordance with field data. | Zhang, JS Lu, PD Xu, M | 1998 | China Ocean Engineering1998，13，1： | 7 |
| 9 | 骨质疏松:发生率,结局和危险因素显示文摘 | Ross.,PD 张江林 | 1997 | 美国医学会杂志(中文版)1997，16，2： | 6 |
| 10 | 抗痫灵对大鼠点燃模型的抗痫性显示文摘评价国产新药抗痫灵(AES)对大鼠两种点燃模型的抗痫性。戊四唑(PTZ)点燃大鼠随机分4组(n=5),分别口服AESl50、300、500mg/kg/日或溶剂:杏仁核(AM)完全点燃大鼠随机分2组(n=5),分别口服AES500mg/kg/日或溶剂。共维持4周。分别用PTZ或电流刺激测试其抗痫效果,每周一次。结果:AES对PTZ点燃有效,且呈剂量依赖性;AES对AM点燃全然无效。提示AES的抗痫性有惊厥发作类型的选择性,副作用小。 | 王丽 Wals.,PD | 1994 | 北京医科大学学报1994，26，5： | 4 |
| 11 | 屈肌腱修复后弹性牵引支具的研究—三种支具的比较显示文摘 | Purg.,PD 吴瑞森 | 1992 | 手外科杂志1992，8，1： | 3 |
| 12 | 导致成人与儿童患者30天脑室腹腔分流失败的原因分析(英文)显示文摘OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated. | Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD | 2018 | 中华神经外科疾病研究杂志2018，17，3： | 3 |
| 13 | “类代谢物”作为药物库设计和选择的标准显示文摘目前药物筛选库受限于预测'类药物'或'类先导物'理想药动学和结构标码的生物物理性质。然而,近来调查表明,为了进入细胞,多数药物需要溶质载体以正常转运自然产生的中间代谢物,很多药物还可能发生相似的相互作用。人代谢物组日益全面的概述使人们可以对'类代谢物'概念进行评价。我们利用有关的化学信息学分子标码空间比较了已知药物和库化合物与天然代谢物(内源分子)的相似性,其中,已知药物比多数库化合物与这些内源分子更类似。 | 张双庆 李迎 刘克良 张振清 Dobson PD Patel Y Kell DB | 2009 | 国际药学研究杂志2009，36，4： | 3 |
| 14 | 花岗岩类的构造环境判别显示文摘 | Mani.,PD 刘洪涛 | 1992 | 国外地质(北京)1992，，1： | 3 |
| 15 | 叶鞘含水量对甘蔗蔗汁品质的影响显示文摘 | Veka.,PD 肖坤贵 | 1991 | 四川甘蔗1991，，4： | 3 |
| 16 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 17 | Polycystin: new aspects of structure, function, and regulation显示文摘 | Wilson PD | 2001 | JAm Soc Nephrol2001，12，： | 3 |
| 18 | RNAi:double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals显示文摘 | Zamore PD Tuschl T Sharp PA | 2000 | Cell2000，101，1： | 2 |
| 19 | 老年人心脏自主神经活动时相的生物学特征显示文摘目的 本研究旨在以心率变异性 (HRV)为手段 ,探讨老年人心脏自主神经活动时相的生物学特征。 方法 共入选 2组健康受试者 :观察组 33例 ,年龄 65~ 82岁 ,平均 ( 72± 10 )岁 ;对照组 31例 ,2 6~ 35岁 ,平均 ( 30± 4)岁。对 2组对象进行 2 4h动态心电图监测 ,记录每小时HRV的频域指标 (总功率TP ,低频成分LF ,高频成分HF ,及LF/HF)。采用余弦拟合法对所得数据进行处理。 结果 HRV的频域指标呈典型的昼夜节律分布 ;与年轻组相比 ,老年人TP ,LF及HF的均值及振幅明显减低 ;LF/HF的振幅也减低 ,但其均值无显著变化。 2组间各指标的相位无明显变化。 结论 老年人HRV的 2 4h均值及昼夜波动振幅渐低 ,而其相位不变。 | 郭艺芳 宋光耀 Stein PK Domitrovich PD 李绍冰 | 2002 | 实用老年医学2002，16，2： | 2 |
| 20 | Lauch of the bone and joint decade 2000 -2010显示文摘 | Delmas PD Anderson M | 2000 | Osteo Int2000，11，： | 2 |
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