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	题名	作者	年代	出处	被引量
1	Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease显示文摘AIM: To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity. METHODS: A total of 136 patients with NAFLD and 64 healthy individuals were studied. Liver biopsy was performed in 91 patients. Six tag SNPs showing a minor allele frequency > 10% (rs1554483 C/G; rs11932595 A/G; rs4580704 C/G; rs6843722 A/C; rs6850524 C/G and rs4864548 A/G) encompassing 117 kb of chromosome 4 and representing 115 polymorphic sites (r2 > 0.8) were genotyped. RESULTS: rs11932595 and rs6843722 showed signifi cant associations with NAFLD (empiric P = 0.0449 and 0.023, respectively). A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697). Test of haplotypic association showed that CLOCK gene variant haplotypes frequencies in NAFLD individuals significantly differed from those in controls (empiric P = 0.0097). CONCLUSION: Our study suggests a potential role of the CLOCK polymorphisms and their haplotypes insusceptibility to NAFLD and disease severity.	Silvia Sookoian Gustavo Castao Carolina Gemma Tomas Fernández Gianotti Carlos Jose Pirola	2007	World Journal of Gastroenterology2007，13，31：	5
2	Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘	Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas	2013	Journal of Clinical Gastroenterology2013，，2：	5
3	OSI Service Specification:SAP and CEP Modeling显示文摘	JG Tomas J Pavon O Pereda	1987	ACM SIGCOMM Computer Communiation Review1987，17，12：	2
4	Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease显示文摘	Carlos Jose Pirola Tomas Fernández Gianotti Adriana Laura Burgue?o Manuel Rey-Funes Cesar Fabian Loidl Pablo Mallardi Julio San Martino Gustavo Osvaldo Casta?o S Sookoian	2013	Gut2013，，9：	2
5	The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK显示文摘	Weber NC Toma O Wolter JI	2005	Brit J Pharmacol2005，144，1：	1
6	Endoscopic selerotherapy is usefulin Dieulafoy's disease显示文摘	GORTES J A O TOMAS L Q GARICIA-GARCIA A A	1996	Gastroenterol Hepatol1996，19，2：	1
7	The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK显示文摘	Weber NC Toma O Wolter JI	2005	Br J Pharmacol2005，144，：	1
8	Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘	HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O	2008	ISPRS Journal of Photogrammetry and Remote Sensing2008，，：	1
9	Use of ultrasound for the extraction of bioactive principles from plant materials显示文摘	Vinatoru M Toma M Radu O	1997	Ultrasonics Sonochemistry1997，4，2：	1
10	High amino acid variation in the intracellular domain of the pig prolactin receptor(PRLR)and its relation to ovulation rate and piglet survival traits显示文摘	Tomas A Casellas J Ramirez O	2006	J Anim Sci2006，84，8：	1
11	Optimization of single-yoke magnetic testing by surface fields measurement 显示文摘	Stupakov O Tomas I Kadlecova J	2006	J Phys D: Appl Phys2006，39，：	1
12	Optimized View Frustum Culling Algorithms for Bounding Boxes显示文摘	Tomas M(o)ller	2000	Journals of Graphics tools (S1086-7651)2000，5，1：	1
13	Alpha-1 antitrypsin deficiency显示文摘	Emer Kelly Catherine M. Greene Tomas P. Carroll Noel G. McElvaney Shane J. O’Neill	2010	Respiratory Medicine2010，，6：	1
14	Magnetic adaptive testing-low magnetization, high sensitivity assessment of material modifications 显示文摘	Tomas I Stupakov O Kadlecova J	2006	J Magn Magn Mater2006，304，2：	1
15	Diterpenoid alkaloids from Delphinium pictum Willd显示文摘	GABRIEL D L F RAFAEL D A TOMAS O	1989	Heterocycles1989，29，2：	1
16	Global Organizational Learning Capacity in Purchasing: Construct and Measurement 显示文摘	Huh G Tomas M Ferrell O C	1997	Journal of Business Research1997，，40：	1
17	Actibacteriol activity of flavonoids against methicillin-resistant Staphyococcus aureus strains显示文摘	Alcaraz L E Blanco O N Tomas P F	2000	Theor Biol2000，205，：	1
18	High amino acid variation in the intracellular domain of the pig prolactin receptor (PRLR) and its relation to ovulation rate and piglet survival traits显示文摘	Tomas A Casellas J Ramirez O	2006	Journal of Animal Science2006，84，：	1
19	Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity显示文摘	Silvia Sookoian Gustavo O. Casta?o Romina Scian Pablo Mallardi Tomas Fernández Gianotti Adriana L. Burgue?o Julio San Martino Carlos J. Pirola	2015	Hepatology2015，，2：	1
20	A quantitative model of the security intrusion process based on attacker behavior显示文摘	Erland J Tomas O	1997	IEEE Transactions on Software Engineering1997，23，4：	1

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