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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli显示文摘瞄准:当在在为家庭腺瘤息肉病关口 i (FAP ) 的 proctocolectomy 以后的病人是稀罕的时, Pouchitis 在小袋外科以后在开始的 10 年期间与 ulcerative 在多达 50% 病人在 ileoanal 小袋发展症候群。Defensins 是天生的免疫系统的主要部件并且在胃肠的微生物引起的动态平衡起一个重要作用。小袋 defensin 和 cytokine 表示与小袋发炎的状态被相关在 pouchitis 学习他们的角色。方法:有 ulcerative 和 FAP 症候群的病人在外科以后与小袋被成层进组,小袋没有或与 pouchitis。从从健康的肠或从有 ulcerative 的病人的正常终端回肠的终端回肠的活体检视用作控制。从小袋和控制的 mRNA 为 defensin 和 cytokine 表示被分析。结果:defensins 的表示在外科以后立即在所有小袋被增加,与控制的回肠相比。开始,在 ulcerative 的小袋比 FAP 小袋揭示了更高的 defensin 表示。Defensin 表示在两个耐心的组衰退了并且与 ulcerative 在病人在 pouchitis 稍微再增加了。没有 pouchitis 的 FAP 小袋有 beta-defensin hBD-1 的强壮的表示,当所有另外的 defensins 在底层留下了时。在 ulcerative 小袋的 Cytokine 表示高,当 FAP 小袋仅仅在外科以后显示出中等提高的 cytokines 时。结论:pouchitis 的开发除了 cytokines 的高表示在 ulcerative 与减少的 defensin 表示相关。在 FAP 小袋的 pouchitis 的低发生与低 cytokine 层次联合与 hBD-1 beta-defensin 的增加的表示相关。 | Karlheinz Kiehne Gabriele Brunke Franziska Wegner Tomas Banasiewicz Ulrich R F lsch Karl-Heinz Herzig | 2006 | World Journal of Gastroenterology2006，12，7： | 8 |
| 3 | Antibiotic selective pressure and development of bacterial resistance 显示文摘 | Milan Kola′r Karel Urba′nek Toma′sv La′tal | 2001 | International Journal of Antimicrobial Agents2001，17，： | 1 |
| 4 | Heat transfer simulation in a vertical Bridgman CdTe growth configuration显示文摘 | Martinez- Tomas C Munoz V Triboulet R | 1999 | J Cryst Growth1999，197，： | 1 |
| 5 | Influence of operating conditions on the extent of enzymatic conversion of rice starch in wet extruder显示文摘 | Tomas R L Oliveira J C McCarthy K L | 1997 | Lebensmittel-Wissenschaft und-Technologie-Food Science and Technology1997，30，1： | 1 |
| 6 | Influence of operating conditions on the extent of enzymatic conversion of rice starch in wet extrusion 显示文摘 | Tomas R L Oliveira J C McCarthy K L | 1997 | LWT-Food Science and Technology1997，30，1： | 1 |
| 7 | Intrau-terine in- semination treatment in subfertility: an analysis of factors affecting outcome 显示文摘 | Nuojua-Huttunen S Tomas C Bloigu R | 1999 | Hum Reprod1999，14，3： | 1 |
| 8 | Limiting activity coefficients from differential ebulliometry显示文摘 | Newman B A Nicolaides G L | 1982 | J Chem Eng Data1982，27，3： | 1 |
| 9 | Impact of metformin therapy on ovarian stimulation and outcome in 'coasted' patients with polycystic ovary syndrome undergoing in-vitro fertilization 显示文摘 | Stadtmauer L A Toma S K Riehl R M | 2002 | Reprod Biomed Online2002，5，2： | 1 |
| 10 | Rheological modelling of enzymatic extrusion of rice starch 显示文摘 | Tomas R L Oliveira J C McCarthy K L | 1997 | Journal of Food Engineering1997，32，2： | 1 |
| 11 | Rosiglitazone,an ag- onist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats:role of oxygen free radicals generation显示文摘 | Villegas l Martin A R Toma W | 2004 | Eur J Phar- macol2004，505，： | 1 |
| 12 | In vitro effects of beta-carotene on human oral kerationocytes from precan-cerous iessions and squamous carcinoma显示文摘 | TOMA S ALBANESE E PALUMBO R | 1991 | Anticancer Drugs1991，2，6： | 1 |
| 13 | Red tide blooms of Cochlodinium polykrikoides in a coastal cove 显示文摘 | TOMAS C R SMAYDA T J | 2008 | Harmful Algae2008，7，： | 1 |
| 14 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 15 | Under- standing autophagy in cell death control 显示文摘 | Platini F Perez -Tomas R Ambrosio S | 2010 | Curr Pharm Des2010，16，1： | 1 |
| 16 | ENSO and pacific decadal variability in the community climate system model version 4显示文摘 | Deser C Phillips A S Tomas R A | 2012 | Journal of Climate2012，25，8： | 1 |
| 17 | Manganese:Recent advances in understanding its transport and neurotoxicity显示文摘 | Michael A Tomas R Guilarte J S | 2007 | Toxicology and Applied Pharmacology2007，221，： | 1 |
| 18 | Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists 显示文摘 | NAWROCKI A R RAJALA M W TOMAS E | 2006 | J Biol Chem2006，281，15： | 1 |
| 19 | Status of insecticide resistance in Culex pipiens field populations from north - eastern areas of Italy before the withdrawal of OP compounds显示文摘 | Toma L Menegon M Romi R | 2011 | Pest Manag Sci2011，67，1： | 1 |
| 20 | Lead neurotoxicity: from exposure to molecular effects 显示文摘 | Christopher D Toscano Tomas R Guilarte | 2005 | Brain Res Brain Res Rev2005，49，3： | 1 |
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