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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | Novel mechanisms in functional dyspepsia显示文摘机能性消化不良(FD ) 是多重病原的机制涉及的高度流行却异构的混乱。尽管有许多研究,调查了各种各样的 pathophysiologic 机制,与 FD 联系的内在的随便小径仍然保持阴暗。与 FD 联系的当前建议的 pathophysiologic 机制包括基因危险性,推迟以及加速胃的倒空的、内脏的超敏性到酸或机械膨胀,损害胃的住所,反常底的的局面的收缩,反常 antro 十二指肠的活动性,急性、长期的感染,和精神分析社会 comorbidity。位于 FD 下面的畸形的更大的理解可以导致改进管理。这篇社论的目的是在机能性消化不良提供当前的 pathophysiologic 概念的批评概述。 | Rok Son Choung Nicholas J Talley | 2006 | World Journal of Gastroenterology2006，12，5： | 25 |
| 3 | Clarithromycin resistance in Helicobacter pylori and its clinical relevance显示文摘 | Xia HX Fan XG Talley NJ | 1999 | World Journal of Gastroenterology1999，5，3： | 26 |
| 4 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 5 | 功能性消化不良、胃排空延迟和生活质量下降显示文摘功能性消化不良(FD)是一种临床上最常见的综合征,表现为慢性反复性中上腹疼痛或不适,传统的诊断检测方法不能检测出病因。许多FD患者诉说症状与饮食有关,但病理生理情况不明。25%~50%的FD患者发生胃排空延迟症状,这与胃窦部动力降低有关。其他FD的异常表现包括胃底容受性限制、胃扩张过度敏感和幽门螺杆菌(H.pylori)感染。 | Talley NJ Locke Ⅲ GR Lahr B Zinsmeister AR Tougas G Ligozio G Rojavin MA Tack J.Mayo Clinic Rochester MN 陆红 | 2006 | 胃肠病学2006，11，2： | 12 |
| 6 | 埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验显示文摘 | Talley NJ Lauritsen K Tunturi-Hihnala H Lind T Moum B Bang C Schulz T Omland TM Delle M Junghard O 钟捷 | 2003 | 中华消化杂志2003，23，1： | 6 |
| 7 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?显示文摘There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neuroprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphorylation of Akt via its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone(8 mg/kg) at 1(intraperitonally), 6, 24, and 48 hours(subcutaneously) post closed-skull traumatic brain injury. The hippocampus was harvested at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a significant decrease in Akt phosphorylation compared to sham operation. However, mice treated with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our findings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury. | Richard Justin Garling Lora Talley Watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu | 2014 | Neural Regeneration Research2014，9，21： | 6 |
| 8 | Irritable bowel syndrome显示文摘 | Alexander C Ford Nicholas J Talley | 2012 | BMJ (sep )2012，，041： | 4 |
| 9 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Douglas A. Drossman Zhiming Li Eileen Andruzzi Robert D. Temple Nicholas J. Talley W. Grant Thompson William E. Whitehead Josef Janssens Peter Funch-Jensen Enrico Corazziari Joel E. Richter Gary G. Koch | 1993 | Digestive Diseases and Sciences1993，，9： | 4 |
| 10 | Apoptosis in gastric epithelium induced by helicobacter pylori infection: implications in gastric carcinogenesis显示文摘 | XIAHH TALLEY NJ | 2001 | Am J Gastroenterol2001，96，： | 3 |
| 11 | Functional Gastroduodenal Disorders显示文摘 | Jan Tack Nicholas J. Talley Michael Camilleri Gerald Holtmann Pinjin Hu Juan-R. Malagelada Vincenzo Stanghellini | 2006 | Gastroenterology2006，，5： | 3 |
| 12 | Swallowed Fluticasone Improves Histologic but Not Symptomatic Response of Adults With Eosinophilic Esophagitis显示文摘 | Jeffrey A. Alexander Kee Wook Jung Amindra S. Arora Felicity Enders David A. Katzka Gail M. Kephardt Hirohito Kita Lori A. Kryzer Yvonne Romero Thomas C. Smyrk Nicholas J. Talley | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 13 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 14 | Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota显示文摘 | GR Locke NJ Talley SL Fett AR Zinsmeister LJ Melton | 1997 | Gastroenterology1997，，5： | 2 |
| 15 | Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Systematic Review and Meta-analysis显示文摘 | Alexander C. Ford Brennan M.R. Spiegel Nicholas J. Talley Paul Moayyedi | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 2 |
| 16 | 1997年亚太地区关于幽门螺杆菌感染处理的共识会议报告显示文摘1997年8月30~31日在新加坡召开了1997关于幽门螺杆菌(Hp)感染处理的亚太地区共识会议。国际专家们作了有关Hp感染各方面最新进展的讲座。来自亚太地区的知名专家对各个地区的前景作了评估、总结。 正式报告后,与会代表们分组出席了诊断、治疗、消化不良和胃癌四个同时召开的工作组会议。 | SK LAM NJ TALLEY 沈兰兰 | 1998 | 胃肠病学1998，3，2： | 2 |
| 17 | Prevalence of Barrett’s Esophagus in the General Population: An Endoscopic Study显示文摘 | Jukka Ronkainen Pertti Aro Tom Storskrubb Sven–Erik Johansson Tore Lind Elisabeth Bolling–Sternevald Michael Vieth Manfred Stolte Nicholas J. Talley Lars Agréus | 2005 | Gastroenterology2005，，： | 2 |
| 18 | Limited Value of Alarm Features in the Diagnosis of Upper Gastrointestinal Malignancy: Systematic Review and Meta-analysis显示文摘 | Nimish Vakil Paul Moayyedi M. Brian Fennerty Nicholas J. Talley | 2006 | Gastroenterology2006，，2： | 2 |
| 19 | Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy:Is gastroparesis a factor?显示文摘AIM:To determine whether an increased number and duration of non-acid reflux events as measured using the multichannel intraluminal impedance pH(MII-pH)is linked to gastroparesis(GP).METHODS:A case control study was conducted in which 42 patients undergoing clinical evaluation for continued symptoms of gastroesophageal reflux disease(both typical and atypical symptoms)despite acid suppression therapy.MII-pH technology was used over 24 h to detect reflux episodes and record patients’symptoms.Parameters evaluated in patients with documented GP and controls without GP by scintigraphy included total,upright,and supine number of acid and non-acid reflux episodes(pH<4 and pH>4,respectively),the duration of acid and non-acid reflux in a 24-h period,and the number of reflux episodes lasting longer than 5 min.RESULTS:No statistical difference was seen between the patients with GP and controls with respect to the total number or duration of acid reflux events,total number and duration of non-acid reflux events or the duration of longest reflux episodes.The number of nonacid reflux episodes with a pH>7 was higher in subjects with GP than in controls.In addition,acid reflux episodes were more prolonged(lasting longer than 5min)in the GP patients than in controls;however,these values did not reach statistical significance.Thirty-five patients had recorded symptoms during the 24 h study and of the 35 subjects,only 9%(n=3)had a positive symptom association probability(SAP)for acid/non-acid reflux and 91%had a negative SAP.CONCLUSION:The evaluation of patients with a documented history of GP did not show an association between GP and more frequent episodes of non-acid reflux based on MII-pH testing. | Anna Tavakkoli Bisma A Sayed Nicholas J Talley Baharak Moshiree | 2013 | World Journal of Gastroenterology2013，19，37： | 2 |
| 20 | Irritable Bowel Syndrome in Twins: Heredity and Social Learning Both Contribute to Etiology显示文摘 | Rona L. Levy Kenneth R. Jones William E. Whitehead Shara I. Feld Nicholas J. Talley Linda A. Corey | 2001 | Gastroenterology2001，，4： | 2 |
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