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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Functional Gastroduodenal Disorders显示文摘 | Jan Tack Nicholas J. Talley Michael Camilleri Gerald Holtmann Pinjin Hu Juan-R. Malagelada Vincenzo Stanghellini | 2006 | Gastroenterology2006，，5： | 3 |
| 3 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 4 | Immune Activation in Patients With Irritable Bowel Syndrome显示文摘 | Tobias Liebregts Birgit Adam Christoph Bredack Alexander R?th Susanne Heinzel Sue Lester Sarah Downie–Doyle Eric Smith Paul Drew Nicholas J. Talley Gerald Holtmann | 2007 | Gastroenterology2007，，3： | 1 |
| 5 | Non-physician endoscopists: A systematic review显示文摘AIM:To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal(GI) endoscopy services.METHODS:The literature was searched for publications reporting nurse endoscopy using several databases and specific search terms.Studies were screened against eligibility criteria and for relevance.Initial searches yielded 74 eligible and relevant articles; 26 of these studies were primary research articles using original datasets relating to the ability of nonphysician endoscopists.These publications included a total of 28883 procedures performed by non-physician endoscopists.RESULTS:The number of publications in the field of non-specialist gastrointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sigmoidoscopies,5 to upper GI endoscopy and 6 to colonoscopy.All studies were from metropolitan centres with nurses working under strict supervision and guidance by specialist gastroenterologists.Geographic distribution of publications showed the majority of research was conducted in the United States(43%),the United Kingdom(39%)and the Netherlands(7%).Most studies conclude that after appropriate training nurseendoscopists safely perform procedures.However,in relation to endoscopic competency,safety or patient satisfaction,all studies had major methodological limitations.Patients were often not randomized(21/26studies)and not appropriately controlled.In relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due largely to the increased need for subsequent endoscopies,specialist follow-up and primary care consultations.CONCLUSION:Contrary to general beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence suggests the opposite.Overall significant shortcomings and biases limit the validity and generalizability of studies that have explored safety and quality of services delivered by non-medical endoscopists. | Maximilian Stephens Luke F Hourigan Mark Appleyard George Ostapowicz Mark Schoeman Paul V Desmond Jane M Andrews Michael Bourke David Hewitt David A Margolin Gerald J Holtmann | 2015 | World Journal of Gastroenterology2015，21，16： | 1 |
| 6 | Molecular basis of functional gastrointestinal disorders显示文摘 | Gerald Holtmann Tobias Liebregts | 2004 | Best Practice & Research Clinical Gastroenterology2004，，4： | 1 |
| 7 | Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model显示文摘 | Birgit Adam Tobias Liebregts Juergen M. Gschossmann Constanze Krippner Franziska Scholl Marcus Ruwe Gerald Holtmann | 2006 | Pain2006，，1： | 1 |
| 8 | Dyspepsia in healthy blood donors显示文摘 | Dr. Gerald Holtmann Harald Goebell Marianne Holtmann Nicholas J. Talley | 1994 | Digestive Diseases and Sciences1994，，5： | 1 |
| 9 | Relationship Between Symptoms and Dietary Patterns in Patients With Functional Dyspepsia显示文摘 | Amelia N. Pilichiewicz Michael Horowitz Gerald J. Holtmann Nicholas J. Talley Christine Feinle–Bisset | 2009 | Clinical Gastroenterology and Hepatology2009，，3： | 1 |
| 10 | An integrated model of care for inflammatory bowel disease sufferers in Australia: Development and the effects of its implementation显示文摘 | Antonina A. Mikocka‐Walus Deborah Turnbull Gerald Holtmann Jane M. Andrews | 2011 | Inflamm Bowel Dis2011，，8： | 1 |
| 11 | 重组人红细胞生成素抑制顺铂引起的内脏痛觉增敏(英文)显示文摘目的顺铂是肿瘤化疗的常用药物,主要通过损伤细胞DNA发挥细胞毒性作用。在肿瘤治疗过程中,顺铂往往会引起周围神经病变,进而导致痛觉增敏。本文就重组人红细胞生成素(recombinant human erythropoietin,rhEPO)是否能抑制顺铂引起的内脏痛觉增敏进行研究。方法C57BL/6系小鼠经顺铂或顺铂与rhEPO共同作用8周后,用肌电检测法观察在结肠直肠扩张性刺激下内脏运动的变化,并用透射电子显微镜观察背根神经节细胞结构水平的变化。结果顺铂能显著增强结肠直肠扩张性刺激下小鼠的内脏运动反射,而rhEPO则能显著减轻这一作用。此外,透射电子显微镜观察显示rhEPO能显著减轻顺铂引起的背根神经节细胞核膜损伤。结论促红细胞生成素具有神经保护作用。 | Min-Suk Yoon Lars Bechmann杜伊斯堡-埃森大学肠胃肝脏学系 Mark Obermann Olivia Yepnjouo Rupert Egensperger Guido Gerken杜伊斯堡-埃森大学肠胃肝脏学系 Zaza Katsarava Juergen Thomale Gerald Holtmann | 2010 | Neuroscience Bulletin2010，26，4： | 0 |
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