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| 1 | Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease显示文摘AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or dyslipidaemia.RESULTS: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.CONCLUSION: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis. | Christopher Leung Sern Wei Yeoh Desmond Patrick Shara Ket Kaye Marion Paul Gow Peter W Angus | 2015 | World Journal of Gastroenterology2015，21，4： | 24 |
| 2 | Rare complications of pediatric diabetic ketoacidosis显示文摘The incidence of type 1 diabetes(T1D) among youth is steadily increasing across the world. Up to a third of pediatric patients with T1 D present with diabetic ketoacidosis, a diagnosis that continues to be the leading cause of death in this population. Cerebral edema is the most common rare complication of diabetic ketoacidosis in children. Accordingly, treatment and outcome measures of cerebral edema are vastly researched and the pathophysiology is recently the subject of much debate. Nevertheless, cerebral edema is not the onlysequela of diabetic ketoacidosis that warrants close monitoring. The medical literature details various other complications in children with diabetic ketoacidosis, including hypercoagulability leading to stroke and deep vein thrombosis, rhabdomyolysis, pulmonary and gastrointestinal complications, and long-term memory dysfunction. We review the pathophysiology, reported cases, management, and outcomes of each of these rare complications in children. As the incidence of T1 D continues to rise, practitioners will care for an increasing number of pediatric patients with diabetic ketoacidosis and should be aware of the various systems that may be affected in both the acute and chronic setting. | Shara R Bialo Sungeeta Agrawal Charlotte M Boney Jose Bernardo Quintos | 2015 | World Journal of Diabetes2015，6，1： | 9 |
| 3 | Irritable Bowel Syndrome in Twins: Heredity and Social Learning Both Contribute to Etiology显示文摘 | Rona L. Levy Kenneth R. Jones William E. Whitehead Shara I. Feld Nicholas J. Talley Linda A. Corey | 2001 | Gastroenterology2001，，4： | 2 |
| 4 | Mussel-inspired surface chemistry for multifunc-tional coatings显示文摘 | Lee haesin Dellatore Shara M Miller William M etal | 2007 | science2007，318，10： | 1 |
| 5 | A review of the human clinical studies involving Citrus aurantium(bitter orange) extract and its primary protoalkaloid p-synephrine显示文摘 | Stohs S J Preuss HG Shara M | 2012 | Int J Med Sei2012，，9： | 1 |
| 6 | 查看详情显示文摘 | M Deetlefs K R Seddon M Shara | | 0，，05： | 1 |
| 7 | 查看详情显示文摘 | Lépine S Rich R M Shara M M | | 0，，： | 1 |
| 8 | Dietary iron and 2,3,7,8-tetrachlorodibenzo-p-dioxin induced alterations in hepatic lipid peroxidation,glutathione content and body weight显示文摘 | Shara MA Mohammadpour H | 1988 | Drug Chem Toxicol1988，11，1： | 1 |
| 9 | Estimated GFR and incident cardiovascular disease events in American Indians:the Strong Heart Study显示文摘 | Shara NM Wang H Mete M | | 0，，： | 1 |
| 10 | Design and synthesis of cyclic urea compounds:a pharmacological study for retinoidal activity显示文摘 | Masaaki Kurihara Abu Shara Shamsur Rouf Hisao Kansui | 2004 | Bioorg Med Chem Lett2004，14，16： | 1 |
| 11 | Dose and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days显示文摘 | Shara M Ohia S E Yasmin T | 2003 | Mol Cell Bio- chem2003，2003，254： | 1 |
| 12 | Prediction of turbulent convective heat transfer at supercritical pressure in square and triangular channels 显示文摘 | M Shara W Ambrosini | 2008 | Annals of Nuclear Energe2008，，35： | 1 |
| 13 | Induction of lipid peroxidation by hexachlorocyclohexane Dieldrin, TCDD, Carbon tetrachloride and hexaehlorobenzene in rats 显示文摘 | Goel M R Shara M A Stohs S J | 1988 | Bull Environm Contain Toxico1988，，140： | 1 |
| 14 | Dose-and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight,hepatic and testicular lipid peroxidation,DNA fragmentation and histopathological data over a period of 90 days显示文摘 | Shara M Ohia SE Yasmin T | | 0，，1： | 1 |
| 15 | Estimated GFR and in- cident cardiovascular disease events in American Indians: the Strong Heart Study显示文摘 | Shara NM Wang H Mete M | 2012 | Am J Kidney Dis2012，60，5： | 1 |
| 16 | Stochastic Analysis of a Two-unit Warm Standby System with Slow Switching Device 显示文摘 | Shara G C Goel L R Gupa P | 1956 | Microelectronics and Reliability1956，26，： | 1 |
| 17 | Time-dependent effects 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum and urine levels of malondialdehyde, formaldehyde, acetaldehyde, and acetone in rats 显示文摘 | Bagchi D Shara M A Bagchi M | 1993 | Toxicol Appl Pharmacol1993，123，： | 1 |
| 18 | An efficient water filter for use with well -water in rural Rajasthan 显示文摘 | SHARA L L | 1993 | Pollution Research1993，12，3： | 1 |
| 19 | C-reactive pro- tein, fibrinogen, and incident heart failure in the Strong Heart Study population显示文摘 | Barac A Wang H Shara NM | 2013 | J Clin Hypertens (Green- wich)2013，15，4： | 1 |
| 20 | Synthesis and Properties of Biocompatible Water-Soluble Silica-Coated CdSe/ZnS Semiconductor Quantum Dots显示文摘 | Gerion D Pinaud F Shara C | | 0，，： | 1 |
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