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| 1 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 2 | Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro显示文摘 | Yan Yan Minao Furumura Takako Gouya Atsufumi Iwanaga Kwesi Teye Sanae Numata Tadashi Karashima Xiao-Guang Li Takashi Hashimoto | 2015 | Chinese Medical Journal2015，，16： | 6 |
| 3 | 精力的文学评论为执行 laparoscopic colorectal 外科采购原料显示文摘 Laparoscopic surgery for colorectal disease has become widespread as a minimally invasive treatment.This is important because the increasing availability of new devices allows us to perform procedures with a reduced length of surgery and decreased blood loss.We herein report the results of a literature review of energy sources for laparoscopic colorectal surgery,focused especially on 6 studies comparing ultrasonic coagulating shears(UCS) and other instruments.We also describe our laparoscopic dissection techniques using UCS for colorectal cancer.The short-term outcomes of surgeries using UCS and Ligasure for laparoscopiccolorectal surgery were superior to conventional electrosurgery.Some authors have reported that the length of surgery or blood loss when Ligasure was used for laparoscopic colorectal surgery is less than when UCS was used.On the other hand,a recent study demonstrated that there were no significant differences between the short-term outcomes of UCS and Ligasure for laparoscopic colorectal surgery.It is therefore suggested that the choice of technique used should be made according to the surgeon’s preference.We also describe our laparoscopic dissection techniques using UCS(Harmonic ACE) for colorectal cancer with regard to the retroperitoneum dissection,dissection technique,dissection technique around the feeding artery,and various other dissection techniques.We therefore review the outcomes of using various energy sources for laparoscopic colorectal surgery and describe our laparoscopic dissection techniques with UCS(Harmonic ACE) for colorectal cancer. | Tsukasa Hotta Katsunari Takifuji Shozo Yokoyama Kenji Matsuda Takashi Higashiguchi Toshiji Tominaga Yoshimasa Oku Takashi Watanabe Toru Nasu Tadamichi Hashimoto Koichi Tamura Junji Ieda Naoyuki Yamamoto Hiromitsu Iwamoto Hiroki Yamaue | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 4 |
| 4 | Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver显示文摘 | Hiroya Yamada Koji Suzuki Naohiro Ichino Yoshitaka Ando Akira Sawada Keisuke Osakabe Keiko Sugimoto Koji Ohashi Ryouji Teradaira Takashi Inoue Nobuyuki Hamajima Shuji Hashimoto | 2013 | Clinica Chimica Acta2013，，： | 3 |
| 5 | Ultrasound demonstration of mammographically detected microcalcifications in patients with ductal carcinomain situ of the breast显示文摘 | Takeshi Nagashima Hideyuki Hashimoto Keiko Oshida Shigeharu Nakano Naoto Tanabe Takashi Nikaido Keiji Koda Masaru Miyazaki | 2005 | Breast Cancer2005，，3： | 2 |
| 6 | 对有静脉内的提高对比的 C 手臂的肝肿瘤的脱离边缘评价计算了断层摄影术显示文摘 AIM:To evaluate the feasibility of intravenous contrastenhanced C-arm computed tomography(CT) for assessing ablative areas and margins of liver tumors.METHODS:Twelve patients(5 men,7 women;mean age,69.5 years) who had liver tumors(8 hepatocellular carcinomas,4 metastatic liver tumors;mean size,16.3 mm;size range,8-20 mm) and who underwent percutaneous radiofrequency ablations(RFAs) with a flatdetector C-arm system were retrospectively reviewed.Intravenously enhanced C-arm CT and multidetector computed tomography(MDCT) images were obtained at the end of the RFA sessions and 3-7 d after RFA to evaluate the ablative areas and margins.The ablated areas and margins were measured using axial plane images acquired by both imaging techniques,with prior contrast-enhanced MDCT images as the reference.The sensitivity,specificity,and positive and negative predictive values of C-arm CT for detecting insufficient ablative margins(< 5 mm) were calculated.Statistical differences in the ablative areas and margins evaluated with both imaging techniques were compared using a paired t-test.RESULTS:All RFA procedures were technically successful.Of 48 total ablative margins,19(39.6%) and 20(41.6%) margins were found to be insufficient with C-arm CT and MDCT,respectively.Moreover,there were no significant differences between these 2 imaging techniques in the detection of these insufficient ablative margins.The sensitivity,specificity,and positive and negative predictive values for detecting insufficient margins by C-arm CT were 90.0%,96.4%,94.7% and 93.1%,respectively.The mean estimated ablative areas calculated from C-arm CT(462.5 ± 202.1 mm 2) and from MDCT(441.2 ± 212.5 mm 2) were not significantly different.The mean ablative margins evaluated by C-arm CT(6.4 ± 2.2 mm) and by MDCT(6.0 ± 2.4 mm) were also not significantly different.CONCLUSION:The efficacy of intravenous contrastenhanced C-arm CT in assessing the ablative areas and margins after RFA of liver tumors is nearly equivalent to that of MDCT. | Jin Iwazawa Shoichi Ohue Naoko Hashimoto Takashi Mitani | 2012 | World Journal of Radiology2012，4，3： | 2 |
| 7 | Anti-neuronal autoantibody in Hashimoto’s encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients显示文摘 | Takashi Oide Takahiko Tokuda Masahide Yazaki Megumi Watarai Shigeaki Mitsuhashi Kazuma Kaneko Takao Hashimoto Shinji Ohara Shu-ichi Ikeda | 2003 | Journal of the Neurological Sciences2003，，1： | 1 |
| 8 | Ru-catalyzed anode materials for direct hydrocarbon SOFCs 显示文摘 | Takashi Hibino Atsuko Hashimoto Masaya Yano | 2003 | Electrochimica Acta2003，48，： | 1 |
| 9 | Increased midkine levels in sera from patients with Alzheimer’s disease显示文摘 | Ragaa H.M. Salama Hisako Muramatsu Eiji Shimizu Kenji Hashimoto Shintaro Ohgake Hiroyuki Watanabe Naoya Komatsu Naoe Okamura Kaori Koike Naoyuki Shinoda Shin-ichi Okada Masaomi Iyo Takashi Muramatsu | 2005 | Progress in Neuropsychopharmacology & Biological Psychiatry2005，，4： | 1 |
| 10 | Safety securing approach against cyber-attacks for process control system显示文摘 | Yoshihiro Hashimoto Takeshi Toyoshima Shuichi Yogo Masato Koike Takashi Hamaguchi Sun Jing Ichiro Koshijima | 2013 | Computers and Chemical Engineering2013，，： | 1 |
| 11 | Purification and properties of rat D-3-Hydroxyacyl-CoA dehydratase D-3-Hydroxyacyl-CoA Dehydratase/ D-3-HydroXyscyl-CoA Dehydrogenase Bifunctional Protein显示文摘 | Lingling Jiang Shoko Miyazawa Takashi Hashimoto | 1996 | J Biochem1996，120，3： | 1 |
| 12 | Purification and Properties of Rat D-3-Hydroxyacyl-CoA Dehydratase D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein显示文摘 | Ling Ling Jiang Shoko Miyazawa Takashi Hashimoto | 1996 | J Biochem1996，120，3： | 1 |
| 13 | Letter to the Editor Re: Transjugular Intrahepatic Portosystemic Shunt for Intractable Esophageal-Gastric Variceal Hemorrhage in a Patient with Idiopathic Myelofibrosis显示文摘 | Naoshi Tanaka M.D. Koichiro Yamakado M.D. Hisakazu Kihira M.D. Akira Hashimoto M.D. Takashi Murayama M.D. Kan Takeda M.D | 2000 | CardioVascular and Interventional Radiology2000，，6： | 1 |
| 14 | Frequency of nonsteroidal anti-inflammatory drug-associated ulcers显示文摘 | Hideyuki Hiraishi Ryo Oki Kohei Tsuchida Naoto Yoshitake Keiichi Tominaga Koji Kusano Takashi Hashimoto Mitsunori Maeda Takako Sasai Tadahito Shimada | 2012 | Clinical Journal of Gastroenterology2012，，： | 1 |
| 15 | New composite evolutionary computation algorithm using interactions among genetic evolution,individual learning and social learning显示文摘 | Hashimoto Takashi Warashin | 2010 | Intelligent Data Analysis2010，14，4： | 1 |
| 16 | Effects of medicinal mushroom ( Sparassis crispa ) on wound healing in streptozotocin-induced diabetic rats显示文摘 | A.-Hon Kwon Zeyu Qiu Mamiko Hashimoto Kyosuke Yamamoto Takashi Kimura | 2009 | The American Journal of Surgery2009，，4： | 1 |
| 17 | Growth and aspartate kinase activity in wheat cell suspension culture: effects of lysine anatogs and asparatate-derived amino acids 显示文摘 | Yasuyuki yamada Rosarin kumpaisal Takashi hashimoto | 1986 | Plant Cell Physiol1986，27，4： | 1 |
| 18 | Role of major spine surgery using kaneda anterior instrumentation for os- teoporotic vertebral collapse 显示文摘 | Masahim Kanayama Takashi lshida Tomoyuki Hashimoto | 2010 | Spinal Disord Tech2010，23，1： | 1 |
| 19 | Early branchings in the evolution of eukaryotes: Ancient divergence of entamoeba that lacks mitochondria revealed by protein sequence data显示文摘 | Masami Hasegawa Tetsuo Hashimoto Jun Adachi Naoyuki Iwabe Takashi Miyata | 1993 | Journal of Molecular Evolution1993，，4： | 1 |
| 20 | An autonomous navigation and guidance system for MUSES-C asteroid landing显示文摘 | Takashi Kubota Tatsuaki Hashimoto Shujiro Sawai | | 0，，2： | 1 |
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