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| 1 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 2 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 2 |
| 3 | Chitosan-DNA Nanoparticles: The Effect of Cell Type and Hydrolysis of Chitosan on In Vitro DNA Transfection显示文摘 | Kadir Turan Kyosuke Nagata | 2006 | Pharmaceutical Development and Technology2006，，4： | 2 |
| 4 | Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells显示文摘 | Kyosuke Yanagisawa Fuminori Moriyasu Takeo Miyahara Miyata Yuki Hiroko Iijima | 2007 | Ultrasound in Medicine & Biology2007，，2： | 2 |
| 5 | Single‐incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum显示文摘 | Masaki Ohi Hiromi Yasuda Yoshito Ishino Masaki Katsurahara Susumu Saigusa Kyosuke Tanaka Koji Tanaka Yasuhiko Mohri Yasuhiro Inoue Keiichi Uchida Masato Kusunoki | 2013 | Asian J Endosc Surg2013，，4： | 2 |
| 6 | Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?显示文摘Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle modi?cation. While most hypertension guidelines recommend moderate- to high-intensity exercise, we decided to explore a mild yet effective type of exercise to add to hypertension management, especially in populations with complications or frailty. After comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers (km)(3 km/h versus 6 km/h) in young, healthy volunteers, we delivered low-speed walking (low-intensity walking, 2.5 metabolic equivalents of task, METs) as exercise therapy in 42 prehypertensive and 43 hypertensive subjects. We found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term bene?ts on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin output. Then we prescribed regular low-intensity walking with a target exercise dose (exercise volume) of 500–1000 METs·min/week (50–60 min/day and 5–7 times/week) in hypertensive subjects in addition to their daily activities. Regular low-intensity walking also showed mild but signi?cant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two months. It is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management. | Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 7 | Analysis of bouncing vibrations of a 2-DOF model of tripad contact slider over a random wavy disk surface显示文摘 | Kohei Lida Kyosuke Ono | 2001 | ASMEJournal of Tribology2001，，123： | 1 |
| 8 | Self-excited Vibratory System for a Flutter Mechanism显示文摘 | Kyosuke O Toru O | 1998 | JSME International Journal Series C1998，41，3： | 1 |
| 9 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 1 |
| 10 | Reduction of NRROin a ball bearing for HDD spindle motors(2nd re-port,experimental analysis of ball bearing with 12balls)显示文摘 | Noguchi Shoji Ono Kyosuke | 1998 | Japan Society of Mechanical Engineers1998，64，624： | 1 |
| 11 | Reduction of NRROin a ball bearing for HDD spindle motors(3rd re-port,influence of lubrication on NRRO of a ballbearing)显示文摘 | Noguchi Shoji Ono Kyosuke | 2000 | Japan Society of Mechanical Engi-neers2000，66，642： | 1 |
| 12 | Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, 'Klotho' Mouse显示文摘 | Kyosuke Takeshita Koji Yamamoto Masafumi Ito Takahisa Kondo Tadashi Matsushita Makoto Hirai Tetsuhito Kojima Masahiko Nishimura Yoichi Nabeshima David Loskutoff Hidehiko Saito Toyoaki Murohara | 2002 | Semin Thromb Hemost2002，，06： | 1 |
| 13 | Isolation of minor alkaloids from Sinomenium acutum显示文摘 | Yoshio S Kyosuke O Osaka O | 1968 | Yakugaku Zasshi1968，88，10： | 1 |
| 14 | Dilated Intrapapillary Capillary Loops By Magnifying Endoscopy: Usefulness for Diagnosis of GERD显示文摘 | Ryo Kosaka Kyosuke Tanaka Hideki Toyoda Yasuhiko Hamada Masatoshi Aoki Tomohiro Noda Ichiro Imoto Yoshiyuki Takei Masato Nagahama | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 15 | Preparation of cellu- lose particles using an ionic liquid显示文摘 | Toyoko S Kyosuke K Kengo S | 2014 | Journal of Colloid and Interface Science2014，418，： | 1 |
| 16 | Comparison between Conventional and Improved Gas Engine-Driven VRF under Same Climate Conditions显示文摘 | Taku Shimizu Kyosuke Yamada Shigeki Kametani Tatsuo Nobe | 2014 | Journal of Energy and Power Engineering2014，8，2： | 1 |
| 17 | Self-excited vibratory system for a flutter mechanism显示文摘 | Kyosuke ONO Toru OKADA | 1998 | JSME Inernational Journal Series C1998，41，3： | 1 |
| 18 | Characterization of CD8+ leukocytes in fugu (Talafugu ru- bripes) with antiserum against fugu CDSα显示文摘 | Kyosuke Araki Kanako Akatsu Hiroaki Suetake | 2008 | Dev Compar Immunol2008，32，7： | 1 |
| 19 | Effects of medicinal mushroom ( Sparassis crispa ) on wound healing in streptozotocin-induced diabetic rats显示文摘 | A.-Hon Kwon Zeyu Qiu Mamiko Hashimoto Kyosuke Yamamoto Takashi Kimura | 2009 | The American Journal of Surgery2009，，4： | 1 |
| 20 | Circulating omentin is associated with coronary artery disease in men显示文摘 | Rei Shibata Noriyuki Ouchi Ryosuke Kikuchi Ryotaro Takahashi Kyosuke Takeshita Yoshiyuki Kataoka Koji Ohashi Nobuo Ikeda Shinji Kihara Toyoaki Murohara | 2011 | Atherosclerosis2011，，2： | 1 |
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